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Stefan Feuerriegel

Publications and source records attributed to Stefan Feuerriegel.

At least 163 records · Page 9Linked to original sources

Modeling Longitudinal Dynamics of Comorbidities

In medicine, comorbidities refer to the presence of multiple, co-occurring diseases. Due to their co-occurring nature, the course of one comorbidity is often highly dependent on the course of the other disease and, hence, treatments can have significant spill-over effects. Despite the prevalence of comorbidities among patients, a comprehensive statistical framework for modeling the longitudinal dynamics of comorbidities is missing. In this paper, we propose a probabilistic model for analyzing comorbidity dynamics over time in patients. Specifically, we develop a coupled hidden Markov model with a personalized, non-homogeneous transition mechanism, named Comorbidity-HMM. The specification of our Comorbidity-HMM is informed by clinical research: (1) It accounts for different disease states (i. e., acute, stable) in the disease progression by introducing latent states that are of clinical meaning. (2) It models a coupling among the trajectories from comorbidities to capture co-evolution dynamics. (3) It considers between-patient heterogeneity (e. g., risk factors, treatments) in the transition mechanism. Based on our model, we define a spill-over effect that measures the indirect effect of treatments on patient trajectories through coupling (i. e., through comorbidity co-evolution). We evaluated our proposed Comorbidity-HMM based on 675 health trajectories where we investigate the joint progression of diabetes mellitus and chronic liver disease. Compared to alternative models without coupling, we find that our Comorbidity-HMM achieves a superior fit. Further, we quantify the spill-over effect, that is, to what extent diabetes treatments are associated with a change in the chronic liver disease from an acute to a stable disease state. To this end, our model is of direct relevance for both treatment planning and clinical research in the context of comorbidities.

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Directed particle swarm optimization with Gaussian-process-based function forecasting

Particle swarm optimization (PSO) is an iterative search method that moves a set of candidate solution around a search-space towards the best known global and local solutions with randomized step lengths. PSO frequently accelerates optimization in practical applications, where gradients are not available and function evaluations expensive. Yet the traditional PSO algorithm ignores the potential knowledge that could have been gained of the objective function from the observations by individual particles. Hence, we draw upon concepts from Bayesian optimization and introduce a stochastic surrogate model of the objective function. That is, we fit a Gaussian process to past evaluations of the objective function, forecast its shape and then adapt the particle movements based on it. Our computational experiments demonstrate that baseline implementations of PSO (i.e., SPSO2011) are outperformed. Furthermore, compared to, state-of-art surrogate-assisted evolutionary algorithms, we achieve substantial performance improvements on several popular benchmark functions. Overall, we find that our algorithm attains desirable properties for exploratory and exploitative behavior.

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AttDMM: An Attentive Deep Markov Model for Risk Scoring in Intensive Care Units

Clinical practice in intensive care units (ICUs) requires early warnings when a patient's condition is about to deteriorate so that preventive measures can be undertaken. To this end, prediction algorithms have been developed that estimate the risk of mortality in ICUs. In this work, we propose a novel generative deep probabilistic model for real-time risk scoring in ICUs. Specifically, we develop an attentive deep Markov model called AttDMM. To the best of our knowledge, AttDMM is the first ICU prediction model that jointly learns both long-term disease dynamics (via attention) and different disease states in health trajectory (via a latent variable model). Our evaluations were based on an established baseline dataset (MIMIC-III) with 53,423 ICU stays. The results confirm that compared to state-of-the-art baselines, our AttDMM was superior: AttDMM achieved an area under the receiver operating characteristic curve (AUROC) of 0.876, which yielded an improvement over the state-of-the-art method by 2.2%. In addition, the risk score from the AttDMM provided warnings several hours earlier. Thereby, our model shows a path towards identifying patients at risk so that health practitioners can intervene early and save patient lives.

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DocParser: Hierarchical Structure Parsing of Document Renderings

Translating renderings (e. g. PDFs, scans) into hierarchical document structures is extensively demanded in the daily routines of many real-world applications. However, a holistic, principled approach to inferring the complete hierarchical structure of documents is missing. As a remedy, we developed "DocParser": an end-to-end system for parsing the complete document structure - including all text elements, nested figures, tables, and table cell structures. Our second contribution is to provide a dataset for evaluating hierarchical document structure parsing. Our third contribution is to propose a scalable learning framework for settings where domain-specific data are scarce, which we address by a novel approach to weak supervision that significantly improves the document structure parsing performance. Our experiments confirm the effectiveness of our proposed weak supervision: Compared to the baseline without weak supervision, it improves the mean average precision for detecting document entities by 39.1 % and improves the F1 score of classifying hierarchical relations by 35.8 %.

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Estimating Risk-Adjusted Hospital Performance

The quality of healthcare provided by hospitals is subject to considerable variability. Consequently, accurate measurements of hospital performance are essential for various decision-makers, including patients, hospital managers and health insurers. Hospital performance is assessed via the health outcomes of their patients. However, as the risk profiles of patients between hospitals vary, measuring hospital performance requires adjustment for patient risk. This task is formalized in the state-of-the-art procedure through a hierarchical generalized linear model, that isolates hospital fixed-effects from the effect of patient risk on health outcomes. Due to the linear nature of this approach, any non-linear relations or interaction terms between risk variables are neglected. In this work, we propose a novel method for measuring hospital performance adjusted for patient risk. This method captures non-linear relationships as well as interactions among patient risk variables, specifically the effect of co-occurring health conditions on health outcomes. For this purpose, we develop a tailored neural network architecture that is partially interpretable: a non-linear part is used to encode risk factors, while a linear structure models hospital fixed-effects, such that the risk-adjusted hospital performance can be estimated. We base our evaluation on more than 13 million patient admissions across almost 1,900 US hospitals as provided by the Nationwide Readmissions Database. Our model improves the ROC-AUC over the state-of-the-art by 4.1 percent. These findings demonstrate that a large portion of the variance in health outcomes can be attributed to non-linear relationships between patient risk variables and implicate that the current approach of measuring hospital performance should be expanded.

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Learning a Cost-Effective Annotation Policy for Question Answering

State-of-the-art question answering (QA) relies upon large amounts of training data for which labeling is time consuming and thus expensive. For this reason, customizing QA systems is challenging. As a remedy, we propose a novel framework for annotating QA datasets that entails learning a cost-effective annotation policy and a semi-supervised annotation scheme. The latter reduces the human effort: it leverages the underlying QA system to suggest potential candidate annotations. Human annotators then simply provide binary feedback on these candidates. Our system is designed such that past annotations continuously improve the future performance and thus overall annotation cost. To the best of our knowledge, this is the first paper to address the problem of annotating questions with minimal annotation cost. We compare our framework against traditional manual annotations in an extensive set of experiments. We find that our approach can reduce up to 21.1% of the annotation cost.

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Forecasting electricity prices with machine learning: Predictor sensitivity

Purpose: Trading on electricity markets occurs such that the price settlement takes place before delivery, often day-ahead. In practice, these prices are highly volatile as they largely depend upon a range of variables such as electricity demand and the feed-in from renewable energy sources. Hence, accurate forecasts are demanded. Approach: This paper aims at comparing different predictors stemming from supply-side (solar and wind power generation), demand-side, fuel-related and economic influences. For this reason, we implement a broad range of non-linear models from machine learning and draw upon the information-fusion-based sensitivity analysis. Findings: We disentangle the respective relevance of each predictor. We show that external predictors altogether decrease root mean squared errors by up to 21.96%. A Diebold-Mariano test statistically proves that the forecasting accuracy of the proposed machine learning models is superior. Originality: The benefit of adding further predictors has only recently received traction; however, little is known about how the individual variables contribute to improving forecasts in machine learning.

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Leveraging Mobility Flows from Location Technology Platforms to Test Crime Pattern Theory in Large Cities

Crime has been previously explained by social characteristics of the residential population and, as stipulated by crime pattern theory, might also be linked to human movements of non-residential visitors. Yet a full empirical validation of the latter is lacking. The prime reason is that prior studies are limited to aggregated statistics of human visitors rather than mobility flows and, because of that, neglect the temporal dynamics of individual human movements. As a remedy, we provide the first work which studies the ability of granular human mobility in describing and predicting crime concentrations at an hourly scale. For this purpose, we propose the use of data from location technology platforms. This type of data allows us to trace individual transitions and, therefore, we succeed in distinguishing different mobility flows that (i) are incoming or outgoing from a neighborhood, (ii) remain within it, or (iii) refer to transitions where people only pass through the neighborhood. Our evaluation infers mobility flows by leveraging an anonymized dataset from Foursquare that includes almost 14.8 million consecutive check-ins in three major U.S. cities. According to our empirical results, mobility flows are significantly and positively linked to crime. These findings advance our theoretical understanding, as they provide confirmatory evidence for crime pattern theory. Furthermore, our novel use of digital location services data proves to be an effective tool for crime forecasting. It also offers unprecedented granularity when studying the connection between human mobility and crime.

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Practical Annotation Strategies for Question Answering Datasets

Annotating datasets for question answering (QA) tasks is very costly, as it requires intensive manual labor and often domain-specific knowledge. Yet strategies for annotating QA datasets in a cost-effective manner are scarce. To provide a remedy for practitioners, our objective is to develop heuristic rules for annotating a subset of questions, so that the annotation cost is reduced while maintaining both in- and out-of-domain performance. For this, we conduct a large-scale analysis in order to derive practical recommendations. First, we demonstrate experimentally that more training samples contribute often only to a higher in-domain test-set performance, but do not help the model in generalizing to unseen datasets. Second, we develop a model-guided annotation strategy: it makes a recommendation with regard to which subset of samples should be annotated. Its effectiveness is demonstrated in a case study based on domain customization of QA to a clinical setting. Here, remarkably, annotating a stratified subset with only 1.2% of the original training set achieves 97.7% of the performance as if the complete dataset was annotated. Hence, the labeling effort can be reduced immensely. Altogether, our work fulfills a demand in practice when labeling budgets are limited and where thus recommendations are needed for annotating QA datasets more cost-effectively.

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Sample Complexity Bounds for Recurrent Neural Networks with Application to Combinatorial Graph Problems

Learning to predict solutions to real-valued combinatorial graph problems promises efficient approximations. As demonstrated based on the NP-hard edge clique cover number, recurrent neural networks (RNNs) are particularly suited for this task and can even outperform state-of-the-art heuristics. However, the theoretical framework for estimating real-valued RNNs is understood only poorly. As our primary contribution, this is the first work that upper bounds the sample complexity for learning real-valued RNNs. While such derivations have been made earlier for feed-forward and convolutional neural networks, our work presents the first such attempt for recurrent neural networks. Given a single-layer RNN with $a$ rectified linear units and input of length $b$, we show that a population prediction error of $\varepsilon$ can be realized with at most $\tilde{\mathcal{O}}(a^4b/\varepsilon^2)$ samples. We further derive comparable results for multi-layer RNNs. Accordingly, a size-adaptive RNN fed with graphs of at most $n$ vertices can be learned in $\tilde{\mathcal{O}}(n^6/\varepsilon^2)$, i.e., with only a polynomial number of samples. For combinatorial graph problems, this provides a theoretical foundation that renders RNNs competitive.

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Deep learning in business analytics and operations research: Models, applications and managerial implications

Business analytics refers to methods and practices that create value through data for individuals, firms, and organizations. This field is currently experiencing a radical shift due to the advent of deep learning: deep neural networks promise improvements in prediction performance as compared to models from traditional machine learning. However, our research into the existing body of literature reveals a scarcity of research works utilizing deep learning in our discipline. Accordingly, the objectives of this overview article are as follows: (1) we review research on deep learning for business analytics from an operational point of view. (2) We motivate why researchers and practitioners from business analytics should utilize deep neural networks and review potential use cases, necessary requirements, and benefits. (3) We investigate the added value to operations research in different case studies with real data from entrepreneurial undertakings. All such cases demonstrate improvements in operational performance over traditional machine learning and thus direct value gains. (4) We provide guidelines and implications for researchers, managers and practitioners in operations research who want to advance their capabilities for business analytics with regard to deep learning. (5) Our computational experiments find that default, out-of-the-box architectures are often suboptimal and thus highlight the value of customized architectures by proposing a novel deep-embedded network.

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RankQA: Neural Question Answering with Answer Re-Ranking

The conventional paradigm in neural question answering (QA) for narrative content is limited to a two-stage process: first, relevant text passages are retrieved and, subsequently, a neural network for machine comprehension extracts the likeliest answer. However, both stages are largely isolated in the status quo and, hence, information from the two phases is never properly fused. In contrast, this work proposes RankQA: RankQA extends the conventional two-stage process in neural QA with a third stage that performs an additional answer re-ranking. The re-ranking leverages different features that are directly extracted from the QA pipeline, i.e., a combination of retrieval and comprehension features. While our intentionally simple design allows for an efficient, data-sparse estimation, it nevertheless outperforms more complex QA systems by a significant margin: in fact, RankQA achieves state-of-the-art performance on 3 out of 4 benchmark datasets. Furthermore, its performance is especially superior in settings where the size of the corpus is dynamic. Here the answer re-ranking provides an effective remedy against the underlying noise-information trade-off due to a variable corpus size. As a consequence, RankQA represents a novel, powerful, and thus challenging baseline for future research in content-based QA.

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Forecasting remaining useful life: Interpretable deep learning approach via variational Bayesian inferences

Predicting the remaining useful life of machinery, infrastructure, or other equipment can facilitate preemptive maintenance decisions, whereby a failure is prevented through timely repair or replacement. This allows for a better decision support by considering the anticipated time-to-failure and thus promises to reduce costs. Here a common baseline may be derived by fitting a probability density function to past lifetimes and then utilizing the (conditional) expected remaining useful life as a prognostic. This approach finds widespread use in practice because of its high explanatory power. A more accurate alternative is promised by machine learning, where forecasts incorporate deterioration processes and environmental variables through sensor data. However, machine learning largely functions as a black-box method and its forecasts thus forfeit most of the desired interpretability. As our primary contribution, we propose a structured-effect neural network for predicting the remaining useful life which combines the favorable properties of both approaches: its key innovation is that it offers both a high accountability and the flexibility of deep learning. The parameters are estimated via variational Bayesian inferences. The different approaches are compared based on the actual time-to-failure for aircraft engines. This demonstrates the performance and superior interpretability of our method, while we finally discuss implications for decision support.

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Improving Heart Rate Variability Measurements from Consumer Smartwatches with Machine Learning

The reactions of the human body to physical exercise, psychophysiological stress and heart diseases are reflected in heart rate variability (HRV). Thus, continuous monitoring of HRV can contribute to determining and predicting issues in well-being and mental health. HRV can be measured in everyday life by consumer wearable devices such as smartwatches which are easily accessible and affordable. However, they are arguably accurate due to the stability of the sensor. We hypothesize a systematic error which is related to the wearer movement. Our evidence builds upon explanatory and predictive modeling: we find a statistically significant correlation between error in HRV measurements and the wearer movement. We show that this error can be minimized by bringing into context additional available sensor information, such as accelerometer data. This work demonstrates our research-in-progress on how neural learning can minimize the error of such smartwatch HRV measurements.

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Personalized Purchase Prediction of Market Baskets with Wasserstein-Based Sequence Matching

Personalization in marketing aims at improving the shopping experience of customers by tailoring services to individuals. In order to achieve this, businesses must be able to make personalized predictions regarding the next purchase. That is, one must forecast the exact list of items that will comprise the next purchase, i.e., the so-called market basket. Despite its relevance to firm operations, this problem has received surprisingly little attention in prior research, largely due to its inherent complexity. In fact, state-of-the-art approaches are limited to intuitive decision rules for pattern extraction. However, the simplicity of the pre-coded rules impedes performance, since decision rules operate in an autoregressive fashion: the rules can only make inferences from past purchases of a single customer without taking into account the knowledge transfer that takes place between customers. In contrast, our research overcomes the limitations of pre-set rules by contributing a novel predictor of market baskets from sequential purchase histories: our predictions are based on similarity matching in order to identify similar purchase habits among the complete shopping histories of all customers. Our contributions are as follows: (1) We propose similarity matching based on subsequential dynamic time warping (SDTW) as a novel predictor of market baskets. Thereby, we can effectively identify cross-customer patterns. (2) We leverage the Wasserstein distance for measuring the similarity among embedded purchase histories. (3) We develop a fast approximation algorithm for computing a lower bound of the Wasserstein distance in our setting. An extensive series of computational experiments demonstrates the effectiveness of our approach. The accuracy of identifying the exact market baskets based on state-of-the-art decision rules from the literature is outperformed by a factor of 4.0.

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Public decision support for low population density areas: An imbalance-aware hyper-ensemble for spatio-temporal crime prediction

Crime events are known to reveal spatio-temporal patterns, which can be used for predictive modeling and subsequent decision support. While the focus has hitherto been placed on areas with high population density, we address the challenging undertaking of predicting crime hotspots in regions with low population densities and highly unequally-distributed crime.This results in a severe sparsity (i.e., class imbalance) of the outcome variable, which impedes predictive modeling. To alleviate this, we develop machine learning models for spatio-temporal prediction that are specifically adjusted for an imbalanced distribution of the class labels and test them in an actual setting with state-of-the-art predictors (i.e., socio-economic, geographical, temporal, meteorological, and crime variables in fine resolution). The proposed imbalance-aware hyper-ensemble increases the hit ratio considerably from 18.1% to 24.6% when aiming for the top 5% of hotspots, and from 53.1% to 60.4% when aiming for the top 20% of hotspots.

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Putting Question-Answering Systems into Practice: Transfer Learning for Efficient Domain Customization

Traditional information retrieval (such as that offered by web search engines) impedes users with information overload from extensive result pages and the need to manually locate the desired information therein. Conversely, question-answering systems change how humans interact with information systems: users can now ask specific questions and obtain a tailored answer - both conveniently in natural language. Despite obvious benefits, their use is often limited to an academic context, largely because of expensive domain customizations, which means that the performance in domain-specific applications often fails to meet expectations. This paper proposes cost-efficient remedies: (i) we leverage metadata through a filtering mechanism, which increases the precision of document retrieval, and (ii) we develop a novel fuse-and-oversample approach for transfer learning in order to improve the performance of answer extraction. Here knowledge is inductively transferred from a related, yet different, tasks to the domain-specific application, while accounting for potential differences in the sample sizes across both tasks. The resulting performance is demonstrated with actual use cases from a finance company and the film industry, where fewer than 400 question-answer pairs had to be annotated in order to yield significant performance gains. As a direct implication to management, this presents a promising path to better leveraging of knowledge stored in information systems.

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Sentiment analysis based on rhetorical structure theory: Learning deep neural networks from discourse trees

Prominent applications of sentiment analysis are countless, covering areas such as marketing, customer service and communication. The conventional bag-of-words approach for measuring sentiment merely counts term frequencies; however, it neglects the position of the terms within the discourse. As a remedy, we develop a discourse-aware method that builds upon the discourse structure of documents. For this purpose, we utilize rhetorical structure theory to label (sub-)clauses according to their hierarchical relationships and then assign polarity scores to individual leaves. To learn from the resulting rhetorical structure, we propose a tensor-based, tree-structured deep neural network (named Discourse-LSTM) in order to process the complete discourse tree. The underlying tensors infer the salient passages of narrative materials. In addition, we suggest two algorithms for data augmentation (node reordering and artificial leaf insertion) that increase our training set and reduce overfitting. Our benchmarks demonstrate the superior performance of our approach. Moreover, our tensor structure reveals the salient text passages and thereby provides explanatory insights.

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