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Stefan Kramer

Publications and source records attributed to Stefan Kramer.

38 records · Page 3Linked to original sources

Graph Clustering with Density-Cut

How can we find a good graph clustering of a real-world network, that allows insight into its underlying structure and also potential functions? In this paper, we introduce a new graph clustering algorithm Dcut from a density point of view. The basic idea is to envision the graph clustering as a density-cut problem, such that the vertices in the same cluster are densely connected and the vertices between clusters are sparsely connected. To identify meaningful clusters (communities) in a graph, a density-connected tree is first constructed in a local fashion. Owing to the density-connected tree, Dcut allows partitioning a graph into multiple densely tight-knit clusters directly. We demonstrate that our method has several attractive benefits: (a) Dcut provides an intuitive criterion to evaluate the goodness of a graph clustering in a more natural and precise way; (b) Built upon the density-connected tree, Dcut allows identifying the meaningful graph clusters of densely connected vertices efficiently; (c) The density-connected tree provides a connectivity map of vertices in a graph from a local density perspective. We systematically evaluate our new clustering approach on synthetic as well as real data to demonstrate its good performance.

cs.SI↗

Survival analysis, the infinite Gaussian mixture model, FDG-PET and non-imaging data in the prediction of progression from mild cognitive impairment

We present a method to discover interesting brain regions in [18F] fluorodeoxyglucose positron emission tomography (PET) scans, showing also the benefits when PET scans are in combined use with non-imaging variables. The discriminative brain regions facilitate a better understanding of Alzheimer's disease (AD) progression, and they can also be used for predicting conversion from mild cognitive impairment (MCI) to AD. A survival analysis(Cox regression) and infinite Gaussian mixture model (IGMM) are introduced to identify the informative brain regions, which can be further used to make a prediction of conversion (in two years) from MCI to AD using only the baseline PET scan. Further, the predictive accuracy can be enhanced when non-imaging variables are used together with identified informative brain voxels. The results suggest that PET scan imaging data is more predictive than other non-imaging data, revealing even better performance when both imaging and non-imaging data are combined.

q-bio.NC↗