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Stefano De Luca

Publications and source records attributed to Stefano De Luca.

2 recordsLinked to original sources

A practical artificial intelligence framework for legal age estimation using clavicle computed tomography scans

Legal age estimation plays a critical role in forensic and medico-legal contexts, where decisions must be supported by accurate, robust, and reproducible methods with explicit uncertainty quantification. While prior artificial intelligence (AI)-based approaches have primarily focused on hand radiographs or dental imaging, clavicle computed tomography (CT) scans remain underexplored despite their documented effectiveness for legal age estimation. In this work, we present an interpretable, multi-stage pipeline for legal age estimation from clavicle CT scans. The proposed framework combines (i) a feature-based connected-component method for automatic clavicle detection that requires minimal manual annotation, (ii) an Integrated Gradients-guided slice selection strategy used to construct the input data for a multi-slice convolutional neural network that estimates legal age, and (iii) conformal prediction intervals to support uncertainty-aware decisions in accordance with established international protocols. The pipeline is evaluated on 1,158 full-body post-mortem CT scans from a public forensic dataset (the New Mexico Decedent Image Database). The final model achieves state-of-the-art performance with a mean absolute error (MAE) of 1.55 $\pm$ 0.16 years on a held-out test set, outperforming both human experts (MAE of approximately 1.90 years) and previous methods (MAEs above 1.75 years in our same dataset). Furthermore, conformal prediction enables configurable coverage levels aligned with forensic requirements. Attribution maps indicate that the model focuses on anatomically relevant regions of the medial clavicular epiphysis. The proposed method, which is currently being added as part of the Skeleton-ID software (https://skeleton-id.com/skeleton-id/), is intended as a decision-support component within multi-factorial forensic workflows.

cs.CV

Estimating the optimal time to perform a PET-PSMA exam in prostatectomized patients based on data from clinical practice

Prostatectomized patients are at risk of resurgence, and for this reason, during a follow-up period, they are monitored for Prostate Specific Antigen (PSA) growth, an indicator of tumor progression. The presence of tumors can be evaluated with an expensive exam, called Positron Emission Tomography with Prostate-Specific Membrane Antigen (PET-PSMA). To justify the high cost of the PET-PSMA and, at the same time, to contain the risk for the patient, this exam should be recommended only when the evidence of tumor progression is strong. With the aim of estimating the optimal time to recommend the exam based on the patient's history and collected data, we build a hierarchical Bayesian model that describes, jointly, the PSA growth curve and the probability of a positive PET-PSMA. With our proposal we process all past and present information about the patients PSA measurement and PET-PSMA results, in order to give an informed estimate of the optimal time, improving current practice.

stat.ME