Stella Flampouri | Searcharxiv

arXiv2026

Planned, delivered and variable RBE dose difference analysis for a patient cohort with base-of-tongue cancer treated with IMPT

Background: To our knowledge, no tools have been installed in clinic for delivered and planned dose differences evaluation. This difference could be large for head and neck patients who suffer the most anatomy changes compared with other treatment sites due to long treatment courses and difficulty in eating. At the same time, variable RBE dose is an increasing concern for proton therapy. The constant RBE 1.1 is widely applied in clinics, however, the real RBE is larger than 1.1 especially at the end of beam range. How they are different and what the influence on plan evaluation are an interesting topic to investigate.

physics.med-ph↗

arXiv2025

Applying voxel-based analysis to oropharyngeal cancer proton therapy patients: a correlation study on radiation-induced acute dysphagia

Background: Voxel-based analysis (VBA) is an analytic approach to evaluate correlations between local dose and the development of different toxicities. DVHs are used for toxicity prediction as well. Compared with DVH, no contours are required for VBA technique and results tell specific voxels that may be related to the toxicity instead of the whole contoured area. The VBA has been used on different cancer sites and for different toxicities. Most of these studies included patients treated with photon, all published studies were based on planned dose and VBA tools used were developed in house. In our study, patient cohort were treated with proton, our VBA tool was developed based on RayStation and doses fed to the VBA tool were delivered doses with constant and two variable RBE models.

physics.med-ph↗