arXiv subjects

Stephanie Combs

Publications and source records attributed to Stephanie Combs.

3 recordsLinked to original sources

arXiv2019

Neighborhood Watch: Representation Learning with Local-Margin Triplet Loss and Sampling Strategy for K-Nearest-Neighbor Image Classification

Deep representation learning using triplet network for classification suffers from a lack of theoretical foundation and difficulty in tuning both the network and classifiers for performance. To address the problem, local-margin triplet loss along with local positive and negative mining strategy is proposed with theory on how the strategy integrate nearest-neighbor hyper-parameter with triplet learning to increase subsequent classification performance. Results in experiments with 2 public datasets, MNIST and Cifar-10, and 2 small medical image datasets demonstrate that proposed strategy outperforms end-to-end softmax and typical triplet loss in settings without data augmentation while maintaining utility of transferable feature for related tasks. The method serves as a good performance baseline where end-to-end methods encounter difficulties such as small sample data with limited allowable data augmentation.

cs.CV↗

arXiv2019

Shape-Aware Complementary-Task Learning for Multi-Organ Segmentation

Multi-organ segmentation in whole-body computed tomography (CT) is a constant pre-processing step which finds its application in organ-specific image retrieval, radiotherapy planning, and interventional image analysis. We address this problem from an organ-specific shape-prior learning perspective. We introduce the idea of complementary-task learning to enforce shape-prior leveraging the existing target labels. We propose two complementary-tasks namely i) distance map regression and ii) contour map detection to explicitly encode the geometric properties of each organ. We evaluate the proposed solution on the public VISCERAL dataset containing CT scans of multiple organs. We report a significant improvement of overall dice score from 0.8849 to 0.9018 due to the incorporation of complementary-task learning.

cs.CV↗

arXiv2018

Personalized Radiotherapy Design for Glioblastoma: Integrating Mathematical Tumor Models, Multimodal Scans and Bayesian Inference

Glioblastoma is a highly invasive brain tumor, whose cells infiltrate surrounding normal brain tissue beyond the lesion outlines visible in the current medical scans. These infiltrative cells are treated mainly by radiotherapy. Existing radiotherapy plans for brain tumors derive from population studies and scarcely account for patient-specific conditions. Here we provide a Bayesian machine learning framework for the rational design of improved, personalized radiotherapy plans using mathematical modeling and patient multimodal medical scans. Our method, for the first time, integrates complementary information from high resolution MRI scans and highly specific FET-PET metabolic maps to infer tumor cell density in glioblastoma patients. The Bayesian framework quantifies imaging and modeling uncertainties and predicts patient-specific tumor cell density with confidence intervals. The proposed methodology relies only on data acquired at a single time point and thus is applicable to standard clinical settings. An initial clinical population study shows that the radiotherapy plans generated from the inferred tumor cell infiltration maps spare more healthy tissue thereby reducing radiation toxicity while yielding comparable accuracy with standard radiotherapy protocols. Moreover, the inferred regions of high tumor cell densities coincide with the tumor radioresistant areas, providing guidance for personalized dose-escalation. The proposed integration of multimodal scans and mathematical modeling provides a robust, non-invasive tool to assist personalized radiotherapy design.

cs.CE↗