arXiv subjects

Steve Chang

Publications and source records attributed to Steve Chang.

4 recordsLinked to original sources

arXiv2026

Best Practices on QSP Model Reporting for Regulatory Use: perspectives from ISoP QSP SIG Working Group

Quantitative systems pharmacology (QSP) models are increasingly applied to inform decision making across drug development and to support regulatory interactions within model informed drug development (MIDD). QSP supports a broad range of applications across drug development and can be tailored to specific therapeutic areas, mechanisms of action, and contexts of use (CoU). While this diversity is a core strength of QSP, it also presents challenges for reporting for regulatory use. Despite the growing impact of QSP models, there is currently no established guidance on how QSP analyses should be documented and reported for regulatory purposes. This white paper, developed by the International Society of Pharmacometrics (ISoP) QSP Special Interest Group Working Group on Credibility Assessment of QSP for Regulatory Use, seeks to address this gap by proposing best practices for QSP model reporting in regulatory settings. The recommendations are grounded in collective real world experience from regulatory interactions and are aligned with reporting guidance established for physiologically based pharmacokinetic (PBPK) modeling and reporting principles outlined in ICH M15. Rather than prescribing a rigid, one size fits all template, this work proposes a flexible, tiered reporting framework that accounts for development phase and model impact. The proposed framework is intended to facilitate regulatory review and enhance transparency while accommodating the inherent diversity of QSP modeling.

math.DS↗

arXiv2016

Predict Moves

Mobile applications and on-body devices are becoming increasingly ubiquitous tools for physical activity tracking. We propose utilizing a self-tracker's habits to support continuous prediction of whether they will reach their daily step goal, thus enabling a variety of potential persuasive interventions. Our aim is to improve the prediction by leveraging historical data and other qualitative (motivation for using the systems, location, gender) and, quantitative (age) features. We have collected datasets from two activity tracking platforms (Moves and Fitbit) and aim to check if the model we derive from one is generalizable over the other. In the following paper we establish a pipeline for extracting the data and formatting it for modeling. We discuss the approach we took and our findings while selecting the features and classification models for the dataset. We further discuss the notion of generalizability of the model across different types of dataset and the probable inclusion of non standard features to further improve the model's accuracy.

cs.HC↗

arXiv2016

InfraNotes: Inconspicuous Handwritten Trajectory Tracking for Lecture Note Recording with Infrared Sensors

Lecture notes are important for students to review and understand the key points in the class. Unfortunately, the students often miss or lose part of the lecture notes. In this paper, we design and implement an infrared sensor based system, InfraNotes, to automatically record the notes on the board by sensing and analyzing hand gestures of the lecturer. Compared with existing techniques, our system does not require special accessories with lecturers such as sensor-facilitated pens, writing surfaces or the video-taping infrastructure. Instead, it only has an infrared-sensor module on the eraser holder of black/white board to capture handwritten trajectories. With a lightweight framework for handwritten trajectory processing, clear lecture notes can be generated automatically. We evaluate the quality of lecture notes by three standard character recognition techniques. The results indicate that InfraNotes is a promising solution to create clear and complete lectures to promote the education.

cs.HC↗

arXiv2016

Instagram Post Data Analysis

Because of the spread of the Internet, social platforms become big data pools. From there we can learn about the trends, culture and hot topics. This project focuses on analyzing the data from Instagram. It shows the relationship of Instagram filter data with location and number of likes to give users filter suggestion on achieving more likes based on their location. It also analyzes the popular hashtags in different locations to show visual culture differences between different cities.

cs.HC↗