arXiv subjects

Steven J. Large

Publications and source records attributed to Steven J. Large.

4 recordsLinked to original sources

arXiv2022

Optimal Control of the F${_1}$-ATPase Molecular Motor

F$_{1}$-ATPase is a rotary molecular motor that \emph{in vivo} is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy transduction. Here we use a near-equilibrium framework to design a non-trivial control protocol to minimize dissipation in rotating F$_{1}$ to synthesize ATP. We find that the designed protocol requires much less work than a naive (constant-velocity) protocol across a wide range of protocol durations. Our analysis points to a possible mechanism for energetically efficient driving of F$_{1}$ \emph{in vivo} and provides insight into free-energy transduction for a broader class of biomolecular and synthetic machines.

cond-mat.stat-mech↗

arXiv2019

Optimal discrete control: minimizing dissipation in discretely driven nonequilibrium systems

Microscopic machines utilize free energy to create and maintain out-of-equilibrium organization in virtually all living things. Often this takes the form of converting the free energy stored in nonequilibrium chemical potential differences into useful work, via a series of reactions involving the binding, chemical catalysis, and unbinding of small molecules. Such chemical reactions occur on timescales much faster than the protein conformational rearrangements they induce. Here, we derive the energetic cost for driving a system out of equilibrium via a series of such effectively instantaneous (and hence discrete) perturbations. This analysis significantly generalizes previously established results, and provides insight into qualitative, as well as quantitative, aspects of finite-time, minimum-dissipation discrete control protocols. We compare our theoretical formalism to an exactly solvable model system and also demonstrate the dissipation reduction achievable in a simple multistable model for a discretely driven molecular machine.

cond-mat.stat-mech↗

arXiv2018

Stochastic control in microscopic nonequilibrium systems

Quantifying energy flows at nanometer scales promises to guide future research in a variety of disciplines, from microscopic control and manipulation, to autonomously operating molecular machines. A general understanding of the thermodynamic costs of nonequilibrium processes would illuminate the design principles for efficient microscopic machines. Considerable effort has gone into finding and classifying the deterministic control protocols that drive a system rapidly between states at minimum energetic cost. But for autonomous microscopic systems, driving processes are themselves stochastic. Here we generalize a linear-response framework to incorporate such protocol variability, deriving a lower bound on the work that is realized at finite protocol duration, far from the quasistatic limit. Our findings are confirmed in model systems. This theory provides a thermodynamic rationale for rapid operation, independent of functional incentives.

cond-mat.stat-mech↗

arXiv2014

Perfect quantum state transfer of hard-core bosons on weighted path graphs

The ability to accurately transfer quantum information through networks is an important primitive in distributed quantum systems. While perfect quantum state transfer (PST) can be effected by a single particle undergoing continuous-time quantum walks on a variety of graphs, it is not known if PST persists for many particles in the presence of interactions. We show that if single-particle PST occurs on one-dimensional weighted path graphs, then systems of hard-core bosons undergoing quantum walks on these paths also undergo PST. The analysis extends the Tonks-Girardeau ansatz to weighted graphs using techniques in algebraic graph theory. The results suggest that hard-core bosons do not generically undergo PST, even on graphs which exhibit single-particle PST.

quant-ph↗