arXiv subjects

Sung Hak Lee

Publications and source records attributed to Sung Hak Lee.

4 recordsLinked to original sources

arXiv2026

Patch-to-Global: Random Patch Diffusion for Globally Consistent Megapixel Artifact Inpainting in Whole Slide Images

Although deep learning has advanced Whole Slide Image (WSI) Analysis, tissue artifacts like bubbles and folds often cause silent failures by concealing essential morphology. Current pathology image restoration methods are mostly restricted to small patches, struggling to maintain global structural coherence at a megapixel scale. We introduce RestorePath, a framework for globally consistent megapixel scale inpainting that reconstructs diagnostic structures in histological image to prevent incorrect high-confidence predictions and lower error rates. Our model utilizes a Latent Diffusion Model (LDM) conditioned on Pathology Foundation Model (PFM) embeddings, integrating Large Kernel Attention (LKA) to manage long-range dependencies during random patch diffusion. Enhanced by Distance-Weighted Interpolation (DWI) and an Adaptive Guidance Scale (AGS), RestorePath ensures structural consistency and fidelity by modulating information from surrounding patches. Evaluations across TCGA-BRCA, BACH, and Camelyon16 datasets for images ranging from 512 to 4608 pixels demonstrate state-of-the-art performance in maintaining histological consistency. RestorePath significantly improves downstream Computational Pathology (CP) tasks, outperforming both raw artifact images and the conventional Detect-and-Discard (D&D) approach. The code is available at https://github.com/PathfinderLab/RestorePath

cs.CV↗

arXiv2025

Normal and Abnormal Pathology Knowledge-Augmented Vision-Language Model for Anomaly Detection in Pathology Images

Anomaly detection in computational pathology aims to identify rare and scarce anomalies where disease-related data are often limited or missing. Existing anomaly detection methods, primarily designed for industrial settings, face limitations in pathology due to computational constraints, diverse tissue structures, and lack of interpretability. To address these challenges, we propose Ano-NAViLa, a Normal and Abnormal pathology knowledge-augmented Vision-Language model for Anomaly detection in pathology images. Ano-NAViLa is built on a pre-trained vision-language model with a lightweight trainable MLP. By incorporating both normal and abnormal pathology knowledge, Ano-NAViLa enhances accuracy and robustness to variability in pathology images and provides interpretability through image-text associations. Evaluated on two lymph node datasets from different organs, Ano-NAViLa achieves the state-of-the-art performance in anomaly detection and localization, outperforming competing models.

cs.CV↗

arXiv2025

Pathology-Informed Latent Diffusion Model for Anomaly Detection in Lymph Node Metastasis

Anomaly detection is an emerging approach in digital pathology for its ability to efficiently and effectively utilize data for disease diagnosis. While supervised learning approaches deliver high accuracy, they rely on extensively annotated datasets, suffering from data scarcity in digital pathology. Unsupervised anomaly detection, however, offers a viable alternative by identifying deviations from normal tissue distributions without requiring exhaustive annotations. Recently, denoising diffusion probabilistic models have gained popularity in unsupervised anomaly detection, achieving promising performance in both natural and medical imaging datasets. Building on this, we incorporate a vision-language model with a diffusion model for unsupervised anomaly detection in digital pathology, utilizing histopathology prompts during reconstruction. Our approach employs a set of pathology-related keywords associated with normal tissues to guide the reconstruction process, facilitating the differentiation between normal and abnormal tissues. To evaluate the effectiveness of the proposed method, we conduct experiments on a gastric lymph node dataset from a local hospital and assess its generalization ability under domain shift using a public breast lymph node dataset. The experimental results highlight the potential of the proposed method for unsupervised anomaly detection across various organs in digital pathology. Code: https://github.com/QuIIL/AnoPILaD.

eess.IV↗

arXiv2024

Clinical-grade Multi-Organ Pathology Report Generation for Multi-scale Whole Slide Images via a Semantically Guided Medical Text Foundation Model

Vision language models (VLM) have achieved success in both natural language comprehension and image recognition tasks. However, their use in pathology report generation for whole slide images (WSIs) is still limited due to the huge size of multi-scale WSIs and the high cost of WSI annotation. Moreover, in most of the existing research on pathology report generation, sufficient validation regarding clinical efficacy has not been conducted. Herein, we propose a novel Patient-level Multi-organ Pathology Report Generation (PMPRG) model, which utilizes the multi-scale WSI features from our proposed multi-scale regional vision transformer (MR-ViT) model and their real pathology reports to guide VLM training for accurate pathology report generation. The model then automatically generates a report based on the provided key features attended regional features. We assessed our model using a WSI dataset consisting of multiple organs, including the colon and kidney. Our model achieved a METEOR score of 0.68, demonstrating the effectiveness of our approach. This model allows pathologists to efficiently generate pathology reports for patients, regardless of the number of WSIs involved.

cs.CV↗