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Suyeon Kang

Publications and source records attributed to Suyeon Kang.

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Bayesian low-rank latent-cluster regression for mixed health outcomes

High-dimensional health and surveillance studies often involve many collinear predictors, multiple correlated outcomes of different types, and latent heterogeneity across observational units. We propose a Bayesian latent-cluster reduced-rank regression model for multivariate mixed outcomes. The model is a finite mixture of regression surfaces: each latent cluster has a cluster-specific mean shift and a low-rank coefficient matrix, yielding simultaneous clustering, dimension reduction, and component-wise interpretability. Response coordinates may be Gaussian, Bernoulli, or negative binomial. Multiplicative gamma process shrinkage adapts the effective rank within each cluster, and a WAIC-based criterion is used to tune the number of clusters and the nominal maximal rank. We establish posterior contraction for the identifiable component-specific regression surfaces and mean shifts, up to label permutation, and derive corresponding contraction for predictor-side singular subspaces. We also analyze the default label-invariant reporting pipeline based on the posterior similarity matrix: an eigenspace embedding followed by mean shift is shown to consistently recover the latent partition under an additional strong separation margin. Simulation experiments spanning all-Gaussian, all-Bernoulli, all-negative-binomial, and mixed Gaussian--Bernoulli--negative-binomial regimes show accurate recovery of the number of clusters and competitive clustering performance against $K$-means, mclust, PCA-based clustering, and a Gaussian reduced-rank mixture benchmark. We illustrate the method in three applications that show how the model separates individual-level utilization groups and produces interpretable county- and state-level cluster maps together with response-specific posterior predictive maps.

stat.ME

Simulation-Based Sensitivity Analysis in Optimal Treatment Regimes and Causal Decomposition with Individualized Interventions

Causal decomposition analysis aims to assess the effect of modifying risk factors on reducing social disparities in outcomes. Recently, this analysis has incorporated individual characteristics when modifying risk factors by utilizing optimal treatment regimes (OTRs). Since the newly defined individualized effects rely on the no omitted confounding assumption, developing sensitivity analyses to account for potential omitted confounding is essential. Moreover, OTRs and individualized effects are primarily based on binary risk factors, and no formal approach currently exists to benchmark the strength of omitted confounding using observed covariates for binary risk factors. To address this gap, we extend a simulation-based sensitivity analysis that simulates unmeasured confounders, addressing two sources of bias emerging from deriving OTRs and estimating individualized effects. Additionally, we propose a formal bounding strategy that benchmarks the strength of omitted confounding for binary risk factors. Using the High School Longitudinal Study 2009 (HSLS:09), we demonstrate this sensitivity analysis and benchmarking method.

stat.ML

Partial identification and unmeasured confounding with multiple treatments and multiple outcomes

Estimating the health effects of multiple air pollutants is a crucial problem in public health, but one that is difficult due to unmeasured confounding bias. Motivated by this issue, we develop a framework for partial identification of causal effects in the presence of unmeasured confounding in settings with multiple treatments and multiple outcomes. Under a factor confounding assumption, we show that joint partial identification regions for multiple estimands can be more informative than considering partial identification for individual estimands one at a time. We show how assumptions related to the strength of confounding or magnitude of plausible effect sizes for one estimand can reduce the partial identification regions for other estimands. As a special case of this result, we explore how negative control assumptions reduce partial identification regions and discuss conditions under which point identification can be obtained. We develop novel computational approaches to finding partial identification regions under a variety of these assumptions. We then estimate the causal effect of PM$_{2.5}$ components on a variety of public health outcomes in the United States Medicare cohort, where we find that the detrimental effect of certain air pollutants are robust to the potential presence of unmeasured confounding bias.

stat.ME

Sensitivity Analysis for Causal Decomposition Analysis: Assessing Robustness Toward Omitted Variable Bias

A key objective of decomposition analysis is to identify a factor (the 'mediator') contributing to disparities in an outcome between social groups. In decomposition analysis, a scholarly interest often centers on estimating how much the disparity (e.g., health disparities between Black women and White men) would be reduced/remain if we set the mediator (e.g., education) distribution of one social group equal to another. However, causally identifying disparity reduction and remaining depends on the no omitted mediator-outcome confounding assumption, which is not empirically testable. Therefore, we propose a set of sensitivity analyses to assess the robustness of disparity reduction to possible unobserved confounding. We provide sensitivity analysis techniques based on regression coefficients and $R^2$ values. The proposed techniques are flexible to address unobserved confounding measured before and after the group status. In addition, $R^2$-based sensitivity analysis offers a straightforward interpretation of sensitivity parameters and a standard way to report the robustness of research findings. Although we introduce sensitivity analysis techniques in the context of decomposition analysis, they can be utilized in any mediation setting based on interventional indirect effects.

stat.ME

Choosing an Optimal Method for Causal Decomposition Analysis: A Better Practice for Identifying Contributing Factors to Health Disparities

Causal decomposition analysis provides a way to identify mediators that contribute to health disparities between marginalized and non-marginalized groups. In particular, the degree to which a disparity would be reduced or remain after intervening on a mediator is of interest. Yet, estimating disparity reduction and remaining might be challenging for many researchers, possibly because there is a lack of understanding of how each estimation method differs from other methods. In addition, there is no appropriate estimation method available for a certain setting (i.e., a regression-based approach with a categorical mediator). Therefore, we review the merits and limitations of the existing three estimation methods (i.e., regression, weighting, and imputation) and provide two new extensions that are useful in practical settings. A flexible new method uses an extended imputation approach to address a categorical and continuous mediator or outcome while incorporating any nonlinear relationships. A new regression method provides a simple estimator that performs well in terms of bias and variance but at the cost of assuming linearity, except for exposure and mediator interactions. Recommendations are given for choosing methods based on a review of different methods and simulation studies. We demonstrate the practice of choosing an optimal method by identifying mediators that reduce race and gender disparity in cardiovascular health, using data from the Midlife Development in the US study.

stat.ME