SearcharxivSearch

arXiv subjects

Suzanne Lenhart

Publications and source records attributed to Suzanne Lenhart.

6 recordsLinked to original sources

Discrete-Time Optimal Control of Species Augmentation for Predator-Prey Model

Species augmentation is one of the methods used to promote biodiversity and prevent endangered species loss and extinction. The current work applies discrete-time optimal control theory to two models of species augmentation for predator-prey relationships. In discrete-time models, the order in which events occur can give different qualitative results. Two models representing different orders of events of optimal augmentation timing are considered. In one model, the population grows and predator-prey action occurs before the translocation of reserve species for augmentation. In the second model, the augmentation happens first and is followed by growth and then predator-prey action. The reserve and target populations are subjected to strong Allee effects. The optimal augmentation models employed in this work aim to maximize the prey (target population) and reserve population at the final time and minimize the associated cost at each time step. Numerical simulations in the two models are conducted using the discrete version of the forward-backward sweep method and the sequential quadratic programming iterative method, respectively. The simulation results show different population levels in the two models under varying parameter scenarios. Objective functional values showing percentage increases with optimal controls are calculated for each simulation. Different optimal augmentation strategies for the two orders of events are discussed. This work represents the first optimal augmentation results for models incorporating the predator-prey relationship with discrete events.

math.OC

Data-Driven Modeling of Amyloid-beta Targeted Antibodies for Alzheimer's Disease

Alzheimer's disease (AD) is driven by the accumulation of amyloid-beta (Abeta) proteins in the brain, leading to memory loss and cognitive decline. While monoclonal antibodies targeting Abetahave been approved, optimizing their use to maximize benefits while minimizing side effects remains a challenge. This study develops a mathematical model to describe Abeta aggregation, capturing its progression from monomers to toxic oligomers, protofibrils, and fibrils using mass-action kinetics and coarse-grained modeling. The model is calibrated with experimental data, incorporating parameter estimation and sensitivity analysis to ensure accuracy. An optimal control framework is introduced to determine the best drug dosing strategy that reduces toxic Abeta aggregates while minimizing adverse effects, such as amyloid-related imaging abnormalities (ARIA). Results indicate that Donanemab achieves the greatest reduction in fibrils. This work provides a quantitative framework for optimizing AD treatment strategies, offering insights into balancing therapeutic efficacy and safety.

q-bio.QM

Optimal control of treatment in a free boundary problem modeling multilayered tumor growth

We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor tissue and mitigates side effects. The existence of an optimal control is established, and the uniqueness and characterization of the optimal control are investigated. Numerical simulations are presented for some scenarios, including the steady-state and parabolic cases.

math.AP

Optimally Controlling Nutrition and Propulsion Force in a Long Distance Running Race

Runners competing in races are looking to optimize their performance. In this paper, a runner's performance in a race, such as a marathon, is formulated as an optimal control problem where the controls are: the nutrition intake throughout the race and the propulsion force of the runner. As nutrition is an integral part of successfully running long distance races, it needs to be included in models of running strategies. We formulate a system of ordinary differential equations to represent the velocity, fat energy, glycogen energy, and nutrition for a runner competing in a long-distance race. The energy compartments represent the energy sources available in the runner's body. We allocate the energy source from which the runner draws, based on how fast the runner is moving. The food consumed during the race is a source term for the nutrition differential equation. With our model, we are investigating strategies to manage the nutrition and propulsion force in order to minimize the running time in a fixed distance race. This requires the solution of a nontrivial singular control problem. Our results confirm the belief that the most effective way to run a race is to run approximately the same pace the entire race without letting one's energies hit zero.

math.OC

PaPaS: A Portable, Lightweight, and Generic Framework for Parallel Parameter Studies

The current landscape of scientific research is widely based on modeling and simulation, typically with complexity in the simulation's flow of execution and parameterization properties. Execution flows are not necessarily straightforward since they may need multiple processing tasks and iterations. Furthermore, parameter and performance studies are common approaches used to characterize a simulation, often requiring traversal of a large parameter space. High-performance computers offer practical resources at the expense of users handling the setup, submission, and management of jobs. This work presents the design of PaPaS, a portable, lightweight, and generic workflow framework for conducting parallel parameter and performance studies. Workflows are defined using parameter files based on keyword-value pairs syntax, thus removing from the user the overhead of creating complex scripts to manage the workflow. A parameter set consists of any combination of environment variables, files, partial file contents, and command line arguments. PaPaS is being developed in Python 3 with support for distributed parallelization using SSH, batch systems, and C++ MPI. The PaPaS framework will run as user processes, and can be used in single/multi-node and multi-tenant computing systems. An example simulation using the BehaviorSpace tool from NetLogo and a matrix multiply using OpenMP are presented as parameter and performance studies, respectively. The results demonstrate that the PaPaS framework offers a simple method for defining and managing parameter studies, while increasing resource utilization.

cs.DC

Immune Therapeutic Strategies Using Optimal Controls with $L^1$ and $L^2$ Type Objectives

Therapeutic strategies to correct an excessive immune response to pathogenic infection is investigated as an optimal control problem. The control problem is formulated around a four dimensional mathematical model describing the inflammatory response to a pathogenic insult with two therapeutic control inputs which have either a direct pro- or anti-inflammatory effect in the given system. We use Pontryagin's maximum principle and discuss necessary optimality conditions. We consider both an $L^1$ type objective functional as well as an $L^2$ type objective. For the former, the presence of singular control will be addressed. For each case, numerical simulations using a nonlinear programming optimization solver to acquire different drug treatment strategies are presented and discussed. The results provide insight for possible treatment strategies and the methods could be a relevant tool for future practice to assist in better prediction of clinical outcomes and subsequently better treatment for patients.

math.OC