arXiv subjects

Svetlana Cherlin

Publications and source records attributed to Svetlana Cherlin.

5 recordsLinked to original sources

arXiv2024

Augmented Binary Method for Basket Trials (ABBA)

In several clinical areas, traditional clinical trials often use a responder outcome, a composite endpoint that involves dichotomising a continuous measure. An augmented binary method that improves power whilst retaining the original responder endpoint has previously been proposed. The method leverages information from the the undichotomised component to improve power. We extend this method for basket trials, which are gaining popularity in many clinical areas. For clinical areas where response outcomes are used, we propose the new Augmented Binary method for BAsket trials (ABBA) enhances efficiency by borrowing information on the treatment effect between subtrials. The method is developed within a latent variable framework using a Bayesian hierarchical modelling approach. We investigate the properties of the proposed methodology by analysing point estimates and credible intervals in various simulation scenarios, comparing them to the standard analysis for basket trials that assumes binary outcome. Our method results in a reduction of 95% high density interval of the posterior distribution of the log odds ratio and an increase in power when the treatment effect is consistent across subtrials. We illustrate our approach using real data from two clinical trials in rheumatology.

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arXiv2024

Developing a predictive signature for two trial endpoints using the cross-validated risk scores method

The existing cross-validated risk scores (CVRS) design has been proposed for developing and testing the efficacy of a treatment in a high-efficacy patient group (the sensitive group) using high-dimensional data (such as genetic data). The design is based on computing a risk score for each patient and dividing them into clusters using a non-parametric clustering procedure. In some settings it is desirable to consider the trade-off between two outcomes, such as efficacy and toxicity, or cost and effectiveness. With this motivation, we extend the CVRS design (CVRS2) to consider two outcomes. The design employs bivariate risk scores that are divided into clusters. We assess the properties of the CVRS2 using simulated data and illustrate its application on a randomised psychiatry trial. We show that CVRS2 is able to reliably identify the sensitive group (the group for which the new treatment provides benefit on both outcomes) in the simulated data. We apply the CVRS2 design to a psychology clinical trial that had offender status and substance use status as two outcomes and collected a large number of baseline covariates. The CVRS2 design yields a significant treatment effect for both outcomes, while the CVRS approach identified a significant effect for the offender status only after pre-filtering the covariates.

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arXiv2024

Cross-validated risk scores adaptive enrichment (CADEN) design

We propose a Cross-validated ADaptive ENrichment design (CADEN) in which a trial population is enriched with a subpopulation of patients who are predicted to benefit from the treatment more than an average patient (the sensitive group). This subpopulation is found using a risk score constructed from the baseline (potentially high-dimensional) information about patients. The design incorporates an early stopping rule for futility. Simulation studies are used to assess the properties of CADEN against the original (non-enrichment) cross-validated risk scores (CVRS) design that constructs a risk score at the end of the trial. We show that when there exists a sensitive group of patients, CADEN achieves a higher power and a reduction in the expected sample size, in comparison to the CVRS design. We illustrate the application of the design in two real clinical trials. We conclude that the new design offers improved statistical efficiency in comparison to the existing non-enrichment method, as well as increased benefit to patients. The method has been implemented in an R package caden.

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arXiv2024

Utilising high-dimensional data in randomised clinical trials: a review of methods and practice

Introduction: Even in effectively conducted randomised trials, the probability of a successful study remains relatively low. With recent advances in the next-generation sequencing technologies, there is a rapidly growing number of high-dimensional data, including genetic, molecular and phenotypic information, that have improved our understanding of driver genes, drug targets, and drug mechanisms of action. The leveraging of high-dimensional data holds promise for increased success of clinical trials. Methods: We provide an overview of methods for utilising high-dimensional data in clinical trials. We also investigate the use of these methods in practice through a review of recently published randomised clinical trials that utilise high-dimensional genetic data. The review includes articles that were published between 2019 and 2021, identified through the PubMed database. Results: Out of 174 screened articles, 100 (57.5%) were randomised clinical trials that collected high-dimensional data. The most common clinical area was oncology (30%), followed by chronic diseases (28%), nutrition and ageing (18%) and cardiovascular diseases (7%). The most common types of data analysed were gene expression data (70%), followed by DNA data (21%). The most common method of analysis (36.3%) was univariable analysis. Articles that described multivariable analyses used standard statistical methods. Most of the clinical trials had two arms. Discussion: New methodological approaches are required for more efficient analysis of the increasing amount of high-dimensional data collected in randomised clinical trials. We highlight the limitations and barriers to the current use of high-dimensional data in trials, and suggest potential avenues for improvement and future work.

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arXiv2019

Generalising rate heterogeneity across sites in statistical phylogenetics

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees relating species. Along branches, sequence evolution is modelled using a continuous-time Markov process characterised by an instantaneous rate matrix. Early models assumed the same rate matrix governed substitutions at all sites of the alignment, ignoring variation in evolutionary pressures. Substantial improvements in phylogenetic inference and model fit were achieved by augmenting these models with multiplicative random effects that describe the result of variation in selective constraints and allow sites to evolve at different rates which linearly scale a baseline rate matrix. Motivated by this pioneering work, we consider an extension using a quadratic, rather than linear, transformation. The resulting models allow for variation in the selective coefficients of different types of point mutation at a site in addition to variation in selective constraints. We derive properties of the extended models. For certain non-stationary processes, the extension gives a model that allows variation in sequence composition both across sites and taxa. We adopt a Bayesian approach, describe an MCMC algorithm for posterior inference and provide software. Our quadratic models are applied to alignments spanning the tree of life and compared with site-homogeneous and linear models.

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