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Sylvianne Schnebert

Publications and source records attributed to Sylvianne Schnebert.

2 recordsLinked to original sources

Breaking Batch Normalization for better explainability of Deep Neural Networks through Layer-wise Relevance Propagation

The lack of transparency of neural networks stays a major break for their use. The Layerwise Relevance Propagation technique builds heat-maps representing the relevance of each input in the model s decision. The relevance spreads backward from the last to the first layer of the Deep Neural Network. Layer-wise Relevance Propagation does not manage normalization layers, in this work we suggest a method to include normalization layers. Specifically, we build an equivalent network fusing normalization layers and convolutional or fully connected layers. Heatmaps obtained with our method on MNIST and CIFAR 10 datasets are more accurate for convolutional layers. Our study also prevents from using Layerwise Relevance Propagation with networks including a combination of connected layers and normalization layer.

cs.LG↗

Modeling Epidermis Homeostasis and Psoriasis Pathogenesis

We present a computational model to study the spatiotemporal dynamics of the epidermis homeostasis under normal and pathological conditions. The model consists of a population kinetics model of the central transition pathway of keratinocyte proliferation, differentiation and loss and an agent-based model that propagates cell movements and generates the stratified epidermis. The model recapitulates observed homeostatic cell density distribution, the epidermal turnover time and the multilayered tissue structure. We extend the model to study the onset, recurrence and phototherapy-induced remission of psoriasis. The model considers the psoriasis as a parallel homeostasis of normal and psoriatic keratinocytes originated from a shared stem-cell niche environment and predicts two homeostatic modes of the psoriasis: a disease mode and a quiescent mode. Interconversion between the two modes can be controlled by interactions between psoriatic stem cells and the immune system and by the normal and psoriatic stem cells competing for growth niches. The prediction of a quiescent state potentially explains the efficacy of the multi-episode UVB irradiation therapy and recurrence of psoriasis plaques, which can further guide designs of therapeutics that specifically target the immune system and/or the keratinocytes.

q-bio.MN↗