arXiv subjects

T. Guérin

Publications and source records attributed to T. Guérin.

At least 19 recordsLinked to original sources

arXiv2026

Optimization of multisite reactions in complex compartmentalized media

In complex media, transport and geometric properties deeply influence the kinetics of random encounters between reactants. Here, we consider the situation where a random walker, moving in a regularly diffusing medium, has to reach and activate a target located inside a compartment characterized by fractal (obstructed) sub-diffusion. We focus on dual-site reactions, which end when two activation events occur within a given time window. Each activation event happens with a finite probability whenever the random walker visits the target. For weakly reactive targets, we demonstrate that the reaction time can be minimized for an optimal compartment size and can even be accelerated when compared to the same system without compartment. Our analytical predictions are validated through simulations of a random walker on a cubic lattice, where some sites inside the compartment are obstructed at the critical percolation threshold. Our theory illustrates the fact that adding a crowded compartment around a target, even if it slows down the motion in its vicinity, can accelerate the kinetics of complex reactions, especially for weakly reactive targets.

cond-mat.stat-mech↗

arXiv2025

In Situ Observation of Proton-Induced DNA Fragmentation in the Bragg Peak: Evidence for a Protective Role of Water

We report in situ single-molecule measurements of proton-induced double-strand breaks (DSBs) in DNA immersed in water, using real-time fluorescence tracking along the entire proton path, including the Bragg peak region. By chemically suppressing radical-mediated processes, we isolate direct DNA damage mechanisms and determine DSB cross sections as a function of depth. Near the Bragg peak, we observe a tenfold reduction in DSB cross sections in aqueous DNA compared to dry DNA, providing quantitative evidence for the protective role of water. These findings highlight the importance of intermolecular energy dissipation in mitigating radiation-induced damage in condensed biological matter, with implications for radiobiology and proton therapy modeling.

physics.bio-ph↗

arXiv2025

Evidence and quantification of memory effects in competitive first passage events

Splitting probabilities quantify the likelihood of a given outcome out of competitive events. This key observable of random walk theory, historically introduced as the gambler's ruin problem, is well understood for memoryless (Markovian) processes. However, in complex systems such as polymer fluids, the motion of a particle should typically be described as a process with memory, for which splitting probabilities are much less characterized analytically. Here, we introduce an analytical approach that provides the splitting probabilities for one-dimensional isotropic non-Markovian Gaussian processes with stationary increments, in the case of two targets. This analysis shows that splitting probabilities are controlled by the out of equilibrium trajectories observed after the first passage. This is directly evidenced in a prototypical experimental reaction scheme in viscoelastic fluids. These results are extended to $d$-dimensional processes in large confining volumes, opening a path towards the study of competitive events in complex media.

cond-mat.stat-mech↗

arXiv2024

Long-term memory induced correction to Arrhenius law

The Kramers escape problem is a paradigmatic model for the kinetics of rare events, which are usually characterized by Arrhenius law. So far, analytical approaches have failed to capture the kinetics of rare events in the important case of non-Markovian processes with long-term memory, as occurs in the context of reactions involving proteins, long polymers, or strongly viscoelastic fluids. Here, based on a minimal model of non-Markovian Gaussian process with long-term memory, we determine quantitatively the mean FPT to a rare configuration and provide its asymptotics in the limit of a large energy barrier $E$. Our analysis unveils a correction to Arrhenius law, induced by long-term memory, which we determine analytically. This correction, which we show can be quantitatively significant, takes the form of a second effective energy barrier $E'<E$ and captures the dependence of rare event kinetics on initial conditions, which is a hallmark of long-term memory. Altogether, our results quantify the impact of long-term memory on rare event kinetics, beyond Arrhenius law.

cond-mat.stat-mech↗

arXiv2024

Self-phoretic oscillatory motion in a harmonic trap

We consider the motion of a harmonically trapped overdamped particle, which is submitted to a self-phoretic force, that is proportional to the gradient of a diffusive field for which the particle itself is the source. In agreement with existing results for free particles or particles in a bounded domain, we find that the system exhibits a transition between an immobile phase, where the particle stays at the center of the trap, and an oscillatory state. We perform an exact analysis giving access to the bifurcation threshold, as well as the frequency of oscillations and their amplitude near the threshold. Our analysis also characterizes the shape of two-dimensional oscillations, that take place along a circle or a straight line. Our results are confirmed by numerical simulations.

cond-mat.stat-mech↗

arXiv2023

Electric Fields in Liquid Water Irradiated with Protons at Ultrahigh Dose Rates

We study the effects of irradiating water with 3 MeV protons at high doses by observing the motion of charged polystyrene beads outside the proton beam. By single-particle tracking, we measure a radial velocity of the order of microns per second. Combining electrokinetic theory with simulations of the beam-generated reaction products and their outward diffusion, we find that the bead motion is due to electrophoresis in the electric field induced by the mobility contrast of cations and anions. This work sheds light on the perturbation of biological systems by high-dose radiations and paves the way for the manipulation of colloid or macromolecular dispersions by radiation-induced diffusiophoresis.

physics.chem-ph↗

arXiv2023

Imperfect Narrow Escape problem

We consider the kinetics of the imperfect narrow escape problem, i.e. the time it takes for a particle diffusing in a confined medium of generic shape to reach and to be adsorbed by a small, imperfectly reactive patch embedded in the boundary of the domain, in two or three dimensions. Imperfect reactivity is modeled by an intrinsic surface reactivity $κ$ of the patch, giving rise to Robin boundary conditions. We present a formalism to calculate the exact asymptotics of the mean reaction time in the limit of large volume of the confining domain. We obtain exact explicit results in the two limits of large and small reactivities of the reactive patch, and a semi-analytical expression in the general case. Our approach reveals an anomalous scaling of the mean reaction time as the inverse square root of the reactivity in the large reactivity limit, valid for an initial position near the extremity of the reactive patch. We compare our exact results with those obtained within the ``constant flux approximation''; we show that this approximation turns out to give exactly the next-to-leading order term of the small reactivity limit, and provides a good approximation of the reaction time far from the reactive patch for all reactivities, but not in the vicinity of the boundary of the reactive patch due to the above mentioned anomalous scaling. These results thus provide a general framework to quantify the mean reaction times for the imperfect narrow escape problem.

cond-mat.stat-mech↗

arXiv2022

Everlasting impact of initial perturbations on first-passage times of non-Markovian random walks

Persistence, defined as the probability that a fluctuating signal has not reached a threshold up to a given observation time, plays a crucial role in the theory of random processes. It quantifies the kinetics of processes as varied as phase ordering, reaction diffusion or interface relaxation dynamics. The fact that persistence can decay algebraically with time with non trivial exponents has triggered a number of experimental and theoretical studies. However, general analytical methods to calculate persistence exponents cannot be applied to the ubiquitous case of non-Markovian systems relaxing transiently after an imposed initial perturbation. Here, we introduce a theoretical framework that enables the non perturbative determination of persistence exponents of $d$-dimensional Gaussian non-Markovian processes with general non stationary dynamics relaxing to a steady state after an initial perturbation. Two prototypical classes of situations are analyzed: either the system is subjected to a temperature quench at initial time, or its past trajectory is assumed to have been observed and thus known. Altogether, our results reveal and quantify, on the basis of Gaussian processes, the deep impact of initial perturbations on first-passage statistics of non-Markovian processes. Our theory covers the case of spatial dimension higher than one, opening the way to characterize non-trivial reaction kinetics for complex systems with non-equilibrium initial conditions.

cond-mat.stat-mech↗

arXiv2021

Effective diffusivity of Brownian particles in a two dimensional square lattice of hard disks

We revisit the classic problem of the effective diffusion constant of a Brownian particle in a square lattice of reflecting impenetrable hard disks. This diffusion constant is also related to the effective conductivity of non-conducting and infinitely conductive disks in the same geometry. We show how a recently derived Green's function for the periodic lattice can be exploited to derive a series expansion of the diffusion constant in terms of the disk's volume fraction $φ$. Secondly we propose a variant of the Fick-Jacobs approximation to study the large volume fraction limit. This combination of analytical results is shown to describe the behavior of the diffusion constant for all volume fractions.

cond-mat.stat-mech↗

arXiv2021

Steady state of overdamped particles in the non-conservative force field of a simple non-linear model of optical trap

Optically trapped particles are often subject to a non-conservative scattering force arising from radiation pressure. In this paper we present an exact solution for the steady state statistics of an overdamped Brownian particle subjected to a commonly used force field model for an optical trap. The model is the simplest of its kind that takes into account non-conservative forces. In particular, we present exact results for certain marginals of the full three dimensional steady state probability distribution as well as results for the toroidal probability currents which are present in the steady state, as well as for the circulation of theses currents. Our analytical results are confirmed by numerical solution of the steady state Fokker-Planck equation.

cond-mat.stat-mech↗

arXiv2019

Survival probability of stochastic processes beyond persistence exponents

For many stochastic processes, the probability $S(t)$ of not-having reached a target in unbounded space up to time $t$ follows a slow algebraic decay at long times, $S(t)\sim S_0/t^θ$. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exponent $θ$ has been studied at length, the prefactor $S_0$, which is quantitatively essential, remains poorly characterized, especially for non-Markovian processes. Here we derive explicit expressions for $S_0$ for a compact random walk in unbounded space by establishing an analytic relation with the mean first-passage time of the same random walk in a large confining volume. Our analytical results for $S_0$ are in good agreement with numerical simulations, even for strongly correlated processes such as Fractional Brownian Motion, and thus provide a refined understanding of the statistics of longest first-passage events in unbounded space.

cond-mat.stat-mech↗

arXiv2018

Dispersion in two-dimensional periodic channels with discontinuous profiles

The effective diffusivity of Brownian tracer particles confined in periodic micro-channels is smaller than the microscopic diffusivity due to entropic trapping. Here, we study diffusion in two-dimensional periodic channels whose cross-section presents singular points, such as abrupt changes of radius or the presence of thin walls, with openings, delimiting periodic compartments composing the channel. Dispersion in such systems is analyzed using the Fick-Jacobs' approximation. This approximation assumes a much faster equilibration in the lateral than in the axial direction, along which the dispersion is measured. If the characteristic width $a$ of the channel is much smaller than the period $L$ of the channel, i.e. $\varepsilon = a/L$ is small, this assumption is clearly valid for Brownian particles. For discontinuous channels, the Fick-Jacobs' approximation is only valid at the lowest order in $\varepsilon$ and provides a rough, though on occasions rather accurate, estimate of the effective diffusivity. Here we provide formulas for the effective diffusivity in discontinuous channels that are asymptotically exact at the next-to-leading order in $\varepsilon$. Each discontinuity leads to a reduction of the effective diffusivity. We show that our theory is consistent with the picture of effective {\em trapping rates} associated with each discontinuity, for which our theory provides explicit and asymptotically exact formulas. Our analytical predictions are confirmed by numerical analysis. Our results provide a precise quantification of the kinetic entropic barriers associated with profile singularities.

cond-mat.stat-mech↗

arXiv2017

Dispersion in two dimensional channels - the Fick-Jacobs approximation revisited

We examine the dispersion of Brownian particles in a symmetric two dimensional channel, this classical problem has been widely studied in the literature using the so called Fick-Jacobs' approximation and its various improvements. Most studies rely on the reduction to an effective one dimensional diffusion equation, here we drive an explicit formula for the diffusion constant which avoids this reduction. Using this formula the effective diffusion constant can be evaluated numerically without resorting to Brownian simulations. In addition a perturbation theory can be developed in $\varepsilon = h_0/L$ where $h_0$ is the characteristic channel height and $L$ the period. This perturbation theory confirms the results of Kalinay and Percus (Phys. Rev. E 74, 041203 (2006)), based on the reduction, to one dimensional diffusion are exact at least to ${\cal O}(\varepsilon^6)$. Furthermore, we show how the Kalinay and Percus pseudo-linear approximation can be straightforwardly recovered. The approach proposed here can also be exploited to yield exact results an appropriate limit $\varepsilon \to \infty$, we show that here the diffusion constant remains finite and show how the result can be obtained with a simple physical argument. Moreover we show that the correction to the effective diffusion constant is of order $1/\varepsilon$ and remarkably has a some universal characteristics. Numerically we compare the analytical results obtained with exact numerical calculations for a number of interesting channel geometries.

cond-mat.stat-mech↗

arXiv2017

Geometry controlled dispersion in periodic corrugated channels

The effective diffusivity $D_e$ of tracer particles diffusing in periodically corrugated axisymmetric two and three dimensional channels is studied. The majority of previous studies of this class of problems are based on perturbative analyses about narrow channels, where the problem can be reduced to an effectively one dimensional one. Here we show how to analyze this class of problems using a much more general approach which even includes the limit of infinitely wide channels. Using the narrow and wide channel asymptotics, we provide a Pad{é} approximant scheme that is able to describe the dispersion properties of a wide class of channels. Furthermore, we systematically identify all the exact asymptotic scaling regimes of $D_e$ and the accompanying physical mechanisms that control dispersion, clarifying the distinction between smooth channels and compartmentalized ones, and identifying the regimes in which $D_e$ can be linked to first passage problems.

cond-mat.stat-mech↗

arXiv2017

Universal first-passage statistics of aging processes

Many out of equilibrium phenomena, such as diffusion-limited reactions or target search processes, are controlled by first-passage events. So far the general determination of the mean first-passage time (FPT) to a target in confinement has left aside aging processes, involved in contexts as varied as glassy dynamics, tracer diffusion in biological membranes or transport of cold atoms in optical lattices. Here we consider general non-Markovian scale-invariant processes in arbitrary dimension, displaying aging, and demonstrate that all the moments of the FPT obey universal scalings with the confining volume with non trivial exponents. Our analysis shows that a nonlinear scaling of the mean FPT with the volume is the hallmark of aging and provides a general tool to quantify its impact on first-passage kinetics in confinement.

cond-mat.stat-mech↗

arXiv2017

Mean first-passage times of non-Markovian random walkers in confinement

The first-passage time (FPT), defined as the time a random walker takes to reach a target point in a confining domain, is a key quantity in the theory of stochastic processes. Its importance comes from its crucial role to quantify the efficiency of processes as varied as diffusion-limited reactions, target search processes or spreading of diseases. Most methods to determine the FPT properties in confined domains have been limited to Markovian (memoryless) processes. However, as soon as the random walker interacts with its environment, memory effects can not be neglected. Examples of non Markovian dynamics include single-file diffusion in narrow channels or the motion of a tracer particle either attached to a polymeric chain or diffusing in simple or complex fluids such as nematics \cite{turiv2013effect}, dense soft colloids or viscoelastic solution. Here, we introduce an analytical approach to calculate, in the limit of a large confining volume, the mean FPT of a Gaussian non-Markovian random walker to a target point. The non-Markovian features of the dynamics are encompassed by determining the statistical properties of the trajectory of the random walker in the future of the first-passage event, which are shown to govern the FPT kinetics.This analysis is applicable to a broad range of stochastic processes, possibly correlated at long-times. Our theoretical predictions are confirmed by numerical simulations for several examples of non-Markovian processes including the emblematic case of the Fractional Brownian Motion in one or higher dimensions. These results show, on the basis of Gaussian processes, the importance of memory effects in first-passage statistics of non-Markovian random walkers in confinement.

cond-mat.stat-mech↗

arXiv2017

Universal time dependent dispersion properties for diffusion in a one-dimensional critically tilted potential

We consider the time dependent dispersion properties of overdamped tracer particles diffusing in a one dimensional periodic potential under the influence of an additional constant tilting force $F$. The system is studied in the region where the force is close to the critical value $F_c$ at which the barriers separating neighboring potential wells disappear. We show that, when $F$ crosses the critical value, the shape of the Mean-Square Displacement (MSD) curves is strongly modified. We identify a diffusive regime at intermediate time scales, with an effective diffusion coefficient which is much larger than the late time diffusion coefficient for $F>F_c$, whereas for $F<F_c$ the late time and intermediate time diffusive regimes are indistinguishable. Explicit asymptotic regimes for the MSD curves are identified at all time scales.

cond-mat.stat-mech↗

arXiv2015

Kubo formulas for dispersion in heterogeneous periodic non-equilibrium systems

We consider the dispersion properties of tracer particles moving in non-equilibrium heterogeneous periodic media. The tracer motion is described by a Fokker-Planck equation with arbitrary spatially periodic (but constant in time) local diffusion tensors and drift, eventually with the presence of obstacles. We derive a Kubo-like formula for the time dependent effective diffusion tensor valid in any dimension. From this general formula, we derive expressions for the late time effective diffusion tensor and drift in these systems. In addition, we find an explicit formula for the late finite time corrections to these transport coefficients. In one dimension, we give closed analytical formula for the transport coefficients. The formulas derived here are very general and provide a straightforward method to compute the dispersion properties in arbitrary non-equilibrium periodic advection-diffusion systems.

cond-mat.stat-mech↗