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Tan Huu Nguyen

Publications and source records attributed to Tan Huu Nguyen.

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An Efficient MaxSAT-DDD Approach for Train Rescheduling via Precedence Propagation and Hybrid AMO Encodings

Train rescheduling repairs disturbed timetables while enforcing train-path precedence, resource capacity, and delay objectives. Dynamic Discretization Discovery (DDD) avoids full time discretization by refining only time points needed to certify feasibility and optimality. We strengthen a recent MaxSAT-DDD model through two encoding changes. First, resource conflicts are encoded as time-dependent at-most-one cliques, using pairwise clauses for small cliques and a sequential counter for large cliques. Second, earliest feasible times are propagated along train paths before the first DDD iteration. We evaluate four MaxSAT variants, two SAT optimization backends, Gurobi/CPLEX MILP models, and CPLEX CP on 72 instances and three delay objectives. MaxSAT-DDD solves all stepwise instances in about 23 ms on average. MaxSAT-Default reduces rounded-cost runtime from 794 to 479 ms, and the ablation study reports up to 79.6\% runtime reduction on the common-solved subset of hard continuous track instances.

cs.LO

Label-free quantitative screening of breast tissue using Spatial Light Interference Microscopy (SLIM)

Breast cancer is the most common type of cancer among women worldwide. The standard histopathology of breast tissue, the primary means of disease diagnosis, involves manual microscopic examination of stained tissue by a pathologist. Because this method relies on qualitative information, it can result in inter-observer variation. Furthermore, for difficult cases the pathologist often needs additional markers of malignancy to help in making a diagnosis. We present a quantitative method for label-free tissue screening using Spatial Light Interference Microscopy (SLIM). By extracting tissue markers of malignancy based on the nanostructure revealed by the optical path-length, our method provides an objective and potentially automatable method for rapidly flagging suspicious tissue. We demonstrated our method by imaging a tissue microarray comprising 68 different subjects - 34 with malignant and 34 with benign tissues. Three-fold cross validation results showed a sensitivity of 94% and specificity of 85% for detecting cancer. The quantitative biomarkers we extract provide a repeatable and objective basis for determining malignancy. Thus, these disease signatures can be automatically classified through machine learning packages, since our images do not vary from scan to scan or instrument to instrument, i.e., they represent intrinsic physical attributes of the sample, independent of staining quality.

q-bio.QM