arXiv subjects

Tao Long

Publications and source records attributed to Tao Long.

22 records · Page 2Linked to original sources

arXiv2023

Challenges and Opportunities for the Design of Smart Speakers

Advances in voice technology and voice user interfaces (VUIs) -- such as Alexa, Siri, and Google Home -- have opened up the potential for many new types of interaction. However, despite the potential of these devices reflected by the growing market and body of VUI research, there is a lingering sense that the technology is still underused. In this paper, we conducted a systematic literature review of 35 papers to identify and synthesize 127 VUI design guidelines into five themes. Additionally, we conducted semi-structured interviews with 15 smart speaker users to understand their use and non-use of the technology. From the interviews, we distill four design challenges that contribute the most to non-use. Based on their (non-)use, we identify four opportunity spaces for designers to explore such as focusing on information support while multitasking (cooking, driving, childcare, etc), incorporating users' mental models for smart speakers, and integrating calm design principles.

cs.HC↗

arXiv2010

Measurement of the copy number of the master quorum-sensing regulator of a bacterial cell

Quorum sensing is the mechanism by which bacteria communicate and synchronize group behaviors. Quantitative information on parameters such as the copy number of particular quorum-sensing proteins should contribute strongly to understanding how the quorum-sensing network functions. Here we show that the copy number of the master regulator protein LuxR in Vibrio harveyi, can be determined in vivo by exploiting small-number fluctuations of the protein distribution when cells undergo division. When a cell divides, both its volume and LuxR protein copy number N are partitioned with slight asymmetries. We have measured the distribution functions describing the partitioning of the protein fluorescence and the cell volume. The fluorescence distribution is found to narrow systematically as the LuxR population increases while the volume partitioning is unchanged. Analyzing these changes statistically, we have determined that N = 80-135 dimers at low cell density and 575 dimers at high cell density. In addition, we have measured the static distribution of LuxR over a large (3,000) clonal population. Combining the static and time-lapse experiments, we determine the magnitude of the Fano factor of the distribution. This technique has broad applicability as a general, in vivo technique for measuring protein copy number and burst size.

q-bio.QM↗

arXiv2009

Information processing and signal integration in bacterial quorum sensing

Bacteria communicate using secreted chemical signaling molecules called autoinducers in a process known as quorum sensing. The quorum-sensing network of the marine bacterium {\it Vibrio harveyi} employs three autoinducers, each known to encode distinct ecological information. Yet how cells integrate and interpret the information contained within the three autoinducer signals remains a mystery. Here, we develop a new framework for analyzing signal integration based on Information Theory and use it to analyze quorum sensing in {\it V. harveyi}. We quantify how much the cells can learn about individual autoinducers and explain the experimentally observed input-output relation of the {\it V. harveyi} quorum-sensing circuit. Our results suggest that the need to limit interference between input signals places strong constraints on the architecture of bacterial signal-integration networks, and that bacteria likely have evolved active strategies for minimizing this interference. Here we analyze two such strategies: manipulation of autoinducer production and feedback on receptor number ratios.

q-bio.MN↗

arXiv2004

The Yeast Cell-Cycle Network Is Robustly Designed

The interactions between proteins, DNA, and RNA in living cells constitute molecular networks that govern various cellular functions. To investigate the global dynamical properties and stabilities of such networks, we studied the cell-cycle regulatory network of the budding yeast. With the use of a simple dynamical model, it was demonstrated that the cell-cycle network is extremely stable and robust for its function. The biological stationary state--the G1 state--is a global attractor of the dynamics. The biological pathway--the cell-cycle sequence of protein states--is a globally attracting trajectory of the dynamics. These properties are largely preserved with respect to small perturbations to the network. These results suggest that cellular regulatory networks are robustly designed for their functions.

q-bio.MN↗