arXiv subjects

Tasadduk Chowdhury

Publications and source records attributed to Tasadduk Chowdhury.

3 recordsLinked to original sources

arXiv2023

Enhancement Pattern Mapping for Detection of Hepatocellular Carcinoma in Patients with Cirrhosis

Background and Aims: Limited methods exist to accurately characterize risk of malignant progression of liver lesions in patients undergoing surveillance for hepatocellular carcinoma (HCC). Enhancement pattern mapping (EPM) measures voxel-based root mean square deviation (RMSD) and improves the contrast-to-noise ratio (CNR) of liver lesions on standard of care imaging. This study investigates the utilization of EPM to differentiate between HCC versus benign cirrhotic tissue. Methods: Patients with liver cirrhosis undergoing MRI surveillance at a single, tertiary-care hospital were studied prospectively. Controls (n=99) were patients without lesions during surveillance or progression to HCC. Cases (n=48) were defined as patients with LI-RADS 3 and 4 lesions who developed HCC within the study period. RMSD measured with EPM was compared to the signal from MRI arterial and portovenous (PV) phases. EPM signals of liver parenchyma between cases and controls were quantitatively validated on an independent patient set using cross validation. Results: With EPM, RMSD of 0.37 was identified as a quantitative cutoff for distinguishing lesions that progress to HCC from background parenchyma on pre-diagnostic scans with an area under the curve (AUC) of 0.83 (CI: 0.73-0.94) and a sensitivity, specificity, and accuracy of 0.65, 0.97, and 0.89, respectively. At the time of diagnostic scans, a sensitivity, specificity, and accuracy of 0.79, 0.93, and 0.88 was achieved with an AUC of 0.89 (CI: 0.82-0.96). EPM RMSD signals of background parenchyma in cases and controls were similar (case EPM: 0.22 +/- 0.08, control EPM: 0.22 +/- 0.09, p=0.8). Conclusions: EPM differentiates between HCC and non-cancerous parenchyma in a surveillance population and may aid in early detection of HCC. Future directions involve applying EPM for risk stratification of indeterminate lesions.

physics.med-ph↗

arXiv2018

Calculating the Midsagittal Plane for Symmetrical Bilateral Shapes: Applications to Clinical Facial Surgical Planning

It is difficult to estimate the midsagittal plane of human subjects with craniomaxillofacial (CMF) deformities. We have developed a LAndmark GEometric Routine (LAGER), which automatically estimates a midsagittal plane for such subjects. The LAGER algorithm was based on the assumption that the optimal midsagittal plane of a patient with a deformity is the premorbid midsagittal plane of the patient (i.e. hypothetically normal without deformity). The LAGER algorithm consists of three steps. The first step quantifies the asymmetry of the landmarks using a Euclidean distance matrix analysis and ranks the landmarks according to their degree of asymmetry. The second step uses a recursive algorithm to drop outlier landmarks. The third step inputs the remaining landmarks into an optimization algorithm to determine an optimal midsaggital plane. We validate LAGER on 20 synthetic models mimicking the skulls of real patients with CMF deformities. The results indicated that all the LAGER algorithm-generated midsagittal planes met clinical criteria. Thus it can be used clinically to determine the midsagittal plane for patients with CMF deformities.

cs.CV↗

arXiv2016

Region-of-Interest reconstruction from truncated cone-beam projections

Region-of-Interest (ROI) tomography aims at reconstructing a region of interest $C$ inside a body using only x-ray projections intersecting $C$ with the goal to reduce overall radiation exposure when only a small specific region of the body needs to be examined. We consider x-ray acquisition from sources located on a smooth curve $Γ$ in $\mathbb{R}^3$ verifying classical Tuy's condition. In this situation, the {\it non-trucated} cone-beam transform $D f$ of smooth densities $f$ admits an explicit inverse $Z$; however $Z$ cannot directly reconstruct $f$ from ROI-truncated projections. To deal with the ROI tomography problem, we introduce a novel reconstruction approach. For densities $f$ in $L^{\infty}(B)$ where $B$ is a bounded ball in $\mathbb{R}^3$, our method iterates an operator $U$ combining ROI-truncated projections, inversion by the operator $Z$ and appropriate regularization operators. Assuming only knowledge of projections corresponding to a spherical ROI $C \subset B$, given $ε>0$, we prove that if $C$ is sufficiently large our iterative reconstruction algorithm converges uniformly to an $ε$-accurate approximation of $f$, where the accuracy depends on the regularity of $f$ quantified in the Sobolev norm $W^5(B)$. This result shows the existence of a critical ROI radius ensuring the convergence of the ROI reconstruction algorithm to $ε$-accurate approximations of $f$. We numerically verified these theoretical results using simulated acquisition of ROI-truncated cone-beam projection data for multiple acquisition geometries. Numerical experiments indicate that the critical ROI radius is fairly small with respect to the support region~$B$.

math-ph↗