Teresa Pinheiro | Searcharxiv

arXiv2026

LiDRoSIS: An Automated MATLAB-Python Platform for Image Processing and Quantitative Analysis of Lipid Droplets and ROS in Irradiated Cells

LiDRoSIS is an automated MATLAB-Python software suite for the segmentation and quantification of lipid droplets (LDs) and reactive oxygen species (ROS) in fluorescence microscopy images of irradiated A549 and MCF7 cells exposed to gold-based nanoparticles. It combines classical image processing algorithms with statistical post-analysis through a companion Python tool, StatLysis. The platform enables reproducible, high-throughput analysis of morphological and spectral parameters linked to nanoparticle-enhanced radiobiological responses. By bridging imaging and quantitative analytics, LiDRoSIS provides a robust framework for nanomedicine and radiation biology research.

physics.med-ph↗

arXiv2025

Synthesis and characterization of gold-coated nanodiamonds through green chemistry as potential radiosensitizers for proton therapy

In this work the synthesis and characterization of novel gold-nanodiamond nanoparticles was performed. The synthesis was based on the reduction of gold onto the different types of nanodiamond (annealed or annealed and oxidized, 50 or 230 nm) using root extracts of Nympheaea alba as a reducing agent. These gold-coated nanodiamonds were characterized by UV-Vis, PXRD, DLS, zeta-potential, PIXE, Raman, SEM, and TEM, assessing particle size, stability, and gold coating effectiveness. Cellular studies in the A549 and Panc1 cancer cell lines assessed uptake, cytotoxicity, and colony formation to evaluate NDAu's biological activity. NDAu demonstrated strong cellular uptake and cytotoxic effects in A549 and Panc1 cell lines, reducing cell survival in clonogenic assay. Futher research in the capabilites of these nanoparticles for proton therapy will be performed.

hep-ex↗