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Theerawit Wilaiprasitporn

Publications and source records attributed to Theerawit Wilaiprasitporn.

At least 19 recordsLinked to original sources

ApSense: Data-driven Algorithm in PPG-based Sleep Apnea Sensing

Detecting obstructive sleep apnea (OSA) is essential for diagnosing and managing sleep health. Traditionally, this involves clinical settings with hardly accessible processes. We propose that the automated detection of OSA events is achievable using features extracted from fingertip photoplethysmography (PPG) signals combined with modern deep learning (DL) techniques. Utilizing two benchmark data sets with extensive PPG recordings, we introduce ApSense, a DL model designed for the OSA event onset recognition from PPG features. ApSense presents a custom neural architecture and domain-specific feature extraction from PPG waveforms. We benchmark it against the state-of-the-art (SOTA) algorithms, including RRWaveNet, PPGNetSA, AIOSA, DRIVEN, and LeNet-5. In our evaluations, ApSense demonstrated improved sensitivity, specificity, and area under the receiver operating characteristic (AUROC) on the test data sets. Furthermore, an ablation study highlighted strategic customizations of ApSense, enhancing its performance and adaptability to different data sets. ApSense demonstrates high reliability, as its outstanding results were confirmed even in high-variance data sets. By detecting OSA events, ApSense enables the estimation of the predicted apnea-hypopnea index (pAHI), which can be used for prescreening individuals for sleep apnea in a low-cost setup. ApSense shows the potential for the PPG-based OSA detection and clinical applications for prescreening in the future.

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MixNet: Joining Force of Classical and Modern Approaches Toward the Comprehensive Pipeline in Motor Imagery EEG Classification

Recent advances in deep learning (DL) have significantly impacted motor imagery (MI)-based brain-computer interface (BCI) systems, enhancing the decoding of electroencephalography (EEG) signals. However, most studies struggle to identify discriminative patterns across subjects during MI tasks, limiting MI classification performance. In this article, we propose MixNet, a novel classification framework designed to overcome this limitation by utilizing spectral-spatial signals from MI data, along with a multitask learning architecture named MIN2Net, for classification. Here, the spectral-spatial signals are generated using the filter-bank common spatial patterns (FBCSPs) method on MI data. Since the multitask learning architecture is used for the classification task, the learning in each task may exhibit different generalization rates and potential overfitting across tasks. To address this issue, we implement adaptive gradient blending, simultaneously regulating multiple loss weights and adjusting the learning pace for each task based on its generalization/overfitting tendencies. Experimental results on six benchmark data sets of different data sizes demonstrate that MixNet consistently outperforms all state-of-the-art algorithms in subject-dependent and -independent settings. Finally, the low-density EEG MI classification results show that MixNet outperforms all state-of-the-art algorithms, offering promising implications for Internet of Thing (IoT) applications, such as lightweight and portable EEG wearable devices based on low-density montages.

cs.LG↗

Combining EEG and NLP Features for Predicting Students' Lecture Comprehension using Ensemble Classification

Electroencephalography (EEG) and Natural Language Processing (NLP) can be applied for education to measure students' comprehension in classroom lectures; currently, the two measures have been used separately. In this work, we propose a classification framework for predicting students' lecture comprehension in two tasks: (i) students' confusion after listening to the simulated lecture and (ii) the correctness of students' responses to the post-lecture assessment. The proposed framework includes EEG and NLP feature extraction, processing, and classification. EEG and NLP features are extracted to construct integrated features obtained from recorded EEG signals and sentence-level syntactic analysis, which provide information about specific biomarkers and sentence structures. An ensemble stacking classification method -- a combination of multiple individual models that produces an enhanced predictive model -- is studied to learn from the features to make predictions accurately. Furthermore, we also utilized subjective confusion ratings as another integrated feature to enhance classification performance. By doing so, experiment results show that this framework performs better than the baselines, which achieved F1 up to 0.65 for predicting confusion and 0.78 for predicting correctness, highlighting that utilizing this has helped improve the classification performance.

cs.CL↗

PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection

Patch classification models based on deep learning have been utilized in whole-slide images (WSI) of H&E-stained tissue samples to assist pathologists in grading follicular lymphoma patients. However, these approaches still require pathologists to manually identify centroblast cells and provide refined labels for optimal performance. To address this, we propose PseudoCell, an object detection framework to automate centroblast detection in WSI (source code is available at https://github.com/IoBT-VISTEC/PseudoCell.git). This framework incorporates centroblast labels from pathologists and combines them with pseudo-negative labels obtained from undersampled false-positive predictions using the cell's morphological features. By employing PseudoCell, pathologists' workload can be reduced as it accurately narrows down the areas requiring their attention during examining tissue. Depending on the confidence threshold, PseudoCell can eliminate 58.18-99.35% of non-centroblasts tissue areas on WSI. This study presents a practical centroblast prescreening method that does not require pathologists' refined labels for improvement. Detailed guidance on the practical implementation of PseudoCell is provided in the discussion section.

q-bio.QM↗

RRWaveNet: A Compact End-to-End Multi-Scale Residual CNN for Robust PPG Respiratory Rate Estimation

Respiratory rate (RR) is an important biomarker as RR changes can reflect severe medical events such as heart disease, lung disease, and sleep disorders. Unfortunately, standard manual RR counting is prone to human error and cannot be performed continuously. This study proposes a method for continuously estimating RR, RRWaveNet. The method is a compact end-to-end deep learning model which does not require feature engineering and can use low-cost raw photoplethysmography (PPG) as input signal. RRWaveNet was tested subject-independently and compared to baseline in four datasets (BIDMC, CapnoBase, WESAD, and SensAI) and using three window sizes (16, 32, and 64 seconds). RRWaveNet outperformed current state-of-the-art methods with mean absolute errors at optimal window size of 1.66 \pm 1.01, 1.59 \pm 1.08, 1.92 \pm 0.96 and 1.23 \pm 0.61 breaths per minute for each dataset. In remote monitoring settings, such as in the WESAD and SensAI datasets, we apply transfer learning to improve the performance using two other ICU datasets as pretraining datasets, reducing the MAE by up to 21$\%$. This shows that this model allows accurate and practical estimation of RR on affordable and wearable devices. Our study also shows feasibility of remote RR monitoring in the context of telemedicine and at home.

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PACMAN: a framework for pulse oximeter digit detection and reading in a low-resource setting

In light of the COVID-19 pandemic, patients were required to manually input their daily oxygen saturation (SpO2) and pulse rate (PR) values into a health monitoring system-unfortunately, such a process trend to be an error in typing. Several studies attempted to detect the physiological value from the captured image using optical character recognition (OCR). However, the technology has limited availability with high cost. Thus, this study aimed to propose a novel framework called PACMAN (Pandemic Accelerated Human-Machine Collaboration) with a low-resource deep learning-based computer vision. We compared state-of-the-art object detection algorithms (scaled YOLOv4, YOLOv5, and YOLOR), including the commercial OCR tools for digit recognition on the captured images from pulse oximeter display. All images were derived from crowdsourced data collection with varying quality and alignment. YOLOv5 was the best-performing model against the given model comparison across all datasets, notably the correctly orientated image dataset. We further improved the model performance with the digits auto-orientation algorithm and applied a clustering algorithm to extract SpO2 and PR values. The accuracy performance of YOLOv5 with the implementations was approximately 81.0-89.5%, which was enhanced compared to without any additional implementation. Accordingly, this study highlighted the completion of PACMAN framework to detect and read digits in real-world datasets. The proposed framework has been currently integrated into the patient monitoring system utilized by hospitals nationwide.

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ANet: Autoencoder-Based Local Field Potential Feature Extractor for Evaluating An Antidepressant Effect in Mice after Administering Kratom Leaf Extracts

Kratom (KT) typically exerts antidepressant (AD) effects. However, evaluating which form of KT extracts possesses AD properties similar to the standard AD fluoxetine (flu) remained challenging. Here, we adopted an autoencoder (AE)-based anomaly detector called ANet to measure the similarity of mice's local field potential (LFP) features that responded to KT leave extracts and AD flu. The features that responded to KT syrup had the highest similarity to those that responded to the AD flu at 85.62 $\pm$ 0.29%. This finding presents the higher feasibility of using KT syrup as an alternative substance for depressant therapy than KT alkaloids and KT aqueous, which are the other candidates in this study. Apart from the similarity measurement, we utilized ANet as a multi-task AE and evaluated the performance in discriminating multi-class LFP responses corresponding to the effect of different KT extracts and AD flu simultaneously. Furthermore, we visualized learned latent features among LFP responses qualitatively and quantitatively as t-SNE projection and maximum mean discrepancy distance, respectively. The classification results reported the accuracy and F1-score of 79.78 $\pm$ 0.39% and 79.53 $\pm$ 0.00%. In summary, the outcomes of this research might help therapeutic design devices for an alternative substance profile evaluation, such as Kratom-based form in real-world applications.

q-bio.QM↗

EEG-BBNet: a Hybrid Framework for Brain Biometric using Graph Connectivity

Brain biometrics based on electroencephalography (EEG) have been used increasingly for personal identification. Traditional machine learning techniques as well as modern day deep learning methods have been applied with promising results. In this paper we present EEG-BBNet, a hybrid network which integrates convolutional neural networks (CNN) with graph convolutional neural networks (GCNN). The benefit of the CNN in automatic feature extraction and the capability of GCNN in learning connectivity between EEG electrodes through graph representation are jointly exploited. We examine various connectivity measures, namely the Euclidean distance, Pearson's correlation coefficient, phase-locked value, phase-lag index, and Rho index. The performance of the proposed method is assessed on a benchmark dataset consisting of various brain-computer interface (BCI) tasks and compared to other state-of-the-art approaches. We found that our models outperform all baselines in the event-related potential (ERP) task with an average correct recognition rates up to 99.26% using intra-session data. EEG-BBNet with Pearson's correlation and RHO index provide the best classification results. In addition, our model demonstrates greater adaptability using inter-session and inter-task data. We also investigate the practicality of our proposed model with smaller number of electrodes. Electrode placements over the frontal lobe region appears to be most appropriate with minimal lost in performance.

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OCTAve: 2D en face Optical Coherence Tomography Angiography Vessel Segmentation in Weakly-Supervised Learning with Locality Augmentation

While there have been increased researches using deep learning techniques for the extraction of vascular structure from the 2D en face OCTA, for such approach, it is known that the data annotation process on the curvilinear structure like the retinal vasculature is very costly and time consuming, albeit few tried to address the annotation problem. In this work, we propose the application of the scribble-base weakly-supervised learning method to automate the pixel-level annotation. The proposed method, called OCTAve, combines the weakly-supervised learning using scribble-annotated ground truth augmented with an adversarial and a novel self-supervised deep supervision. Our novel mechanism is designed to utilize the discriminative outputs from the discrimination layer of a UNet-like architecture where the Kullback-Liebler Divergence between the aggregate discriminative outputs and the segmentation map predicate is minimized during the training. This combined method leads to the better localization of the vascular structure as shown in our experiments. We validate our proposed method on the large public datasets i.e., ROSE, OCTA-500. The segmentation performance is compared against both state-of-the-art fully-supervised and scribble-based weakly-supervised approaches. The implementation of our work used in the experiments is located at [LINK].

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MIN2Net: End-to-End Multi-Task Learning for Subject-Independent Motor Imagery EEG Classification

Advances in the motor imagery (MI)-based brain-computer interfaces (BCIs) allow control of several applications by decoding neurophysiological phenomena, which are usually recorded by electroencephalography (EEG) using a non-invasive technique. Despite great advances in MI-based BCI, EEG rhythms are specific to a subject and various changes over time. These issues point to significant challenges to enhance the classification performance, especially in a subject-independent manner. To overcome these challenges, we propose MIN2Net, a novel end-to-end multi-task learning to tackle this task. We integrate deep metric learning into a multi-task autoencoder to learn a compact and discriminative latent representation from EEG and perform classification simultaneously. This approach reduces the complexity in pre-processing, results in significant performance improvement on EEG classification. Experimental results in a subject-independent manner show that MIN2Net outperforms the state-of-the-art techniques, achieving an F1-score improvement of 6.72%, and 2.23% on the SMR-BCI, and OpenBMI datasets, respectively. We demonstrate that MIN2Net improves discriminative information in the latent representation. This study indicates the possibility and practicality of using this model to develop MI-based BCI applications for new users without the need for calibration.

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A Pilot Study on Visually Stimulated Cognitive Tasks for EEG-Based Dementia Recognition

In the status quo, dementia is yet to be cured. Precise diagnosis prior to the onset of the symptoms can prevent the rapid progression of the emerging cognitive impairment. Recent progress has shown that Electroencephalography (EEG) is the promising and cost-effective test to facilitate the detection of neurocognitive disorders. However, most of the existing works have been using only resting-state EEG. The efficiencies of EEG signals from various cognitive tasks, for dementia classification, have yet to be thoroughly investigated. In this study, we designed four cognitive tasks that engage different cognitive performances: attention, working memory, and executive function. We investigated these tasks by using statistical analysis on both time and frequency domains of EEG signals from three classes of human subjects: Dementia (DEM), Mild Cognitive Impairment (MCI), and Normal Control (NC). We also further evaluated the classification performances of two features extraction methods: Principal Component Analysis (PCA) and Filter Bank Common Spatial Pattern (FBCSP). We found that the working memory related tasks yielded good performances for dementia recognition in both cases using PCA and FBCSP. Moreover, FBCSP with features combination from four tasks revealed the best sensitivity of 0.87 and the specificity of 0.80. To our best knowledge, this is the first work that concurrently investigated several cognitive tasks for dementia recognition using both statistical analysis and classification scores. Our results yielded essential information to design and aid in conducting further experimental tasks to early diagnose dementia patients.

cs.LG↗

Deep Reinforcement Learning Models Predict Visual Responses in the Brain: A Preliminary Result

Supervised deep convolutional neural networks (DCNNs) are currently one of the best computational models that can explain how the primate ventral visual stream solves object recognition. However, embodied cognition has not been considered in the existing visual processing models. From the ecological standpoint, humans learn to recognize objects by interacting with them, allowing better classification, specialization, and generalization. Here, we ask if computational models under the embodied learning framework can explain mechanisms underlying object recognition in the primate visual system better than the existing supervised models? To address this question, we use reinforcement learning to train neural network models to play a 3D computer game and we find that these reinforcement learning models achieve neural response prediction accuracy scores in the early visual areas (e.g., V1 and V2) in the levels that are comparable to those accomplished by the supervised neural network model. In contrast, the supervised neural network models yield better neural response predictions in the higher visual areas, compared to the reinforcement learning models. Our preliminary results suggest the future direction of visual neuroscience in which deep reinforcement learning should be included to fill the missing embodiment concept.

cs.LG↗

Parkinson's Disease Recognition Using SPECT Image and Interpretable AI: A Tutorial

In the past few years, there are several researches on Parkinson's disease (PD) recognition using single-photon emission computed tomography (SPECT) images with deep learning (DL) approach. However, the DL model's complexity usually results in difficult model interpretation when used in clinical. Even though there are multiple interpretation methods available for the DL model, there is no evidence of which method is suitable for PD recognition application. This tutorial aims to demonstrate the procedure to choose a suitable interpretation method for the PD recognition model. We exhibit four DCNN architectures as an example and introduce six well-known interpretation methods. Finally, we propose an evaluation method to measure the interpretation performance and a method to use the interpreted feedback for assisting in model selection. The evaluation demonstrates that the guided backpropagation and SHAP interpretation methods are suitable for PD recognition methods in different aspects. Guided backpropagation has the best ability to show fine-grained importance, which is proven by the highest Dice coefficient and lowest mean square error. On the other hand, SHAP can generate a better quality heatmap at the uptake depletion location, which outperforms other methods in discriminating the difference between PD and NC subjects. Shortly, the introduced interpretation methods can contribute to not only the PD recognition application but also to sensor data processing in an AI Era (interpretable-AI) as feedback in constructing well-suited deep learning architectures for specific applications.

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Revealing Preference in Popular Music Through Familiarity and Brain Response

Music preference was reported as a factor, which could elicit innermost music emotion, entailing accurate ground-truth data and music therapy efficiency. This study executes statistical analysis to investigate the distinction of music preference through familiarity scores, response times (response rates), and brain response (EEG). Twenty participants did self-assessment after listening to two types of popular music's chorus section: music without lyrics (Melody) and music with lyrics (Song). \textcolor{red}{We then conduct a music preference classification using a support vector machine, random forest, and k-nearest neighbors with the familiarity scores, the response rates, and EEG as the feature vectors. The statistical analysis and F1-score of EEG are congruent, which is the brain's right side outperformed its left side in classification performance.} Finally, these behavioral and brain studies support that preference, familiarity, and response rates can contribute to the music emotion experiment's design to understand music, emotion, and listener. Not only to the music industry, the biomedical and healthcare industry can also exploit this experiment to collect data from patients to improve the efficiency of healing by music.

cs.HC↗

MetaSleepLearner: A Pilot Study on Fast Adaptation of Bio-signals-Based Sleep Stage Classifier to New Individual Subject Using Meta-Learning

Identifying bio-signals based-sleep stages requires time-consuming and tedious labor of skilled clinicians. Deep learning approaches have been introduced in order to challenge the automatic sleep stage classification conundrum. However, the difficulties can be posed in replacing the clinicians with the automatic system due to the differences in many aspects found in individual bio-signals, causing the inconsistency in the performance of the model on every incoming individual. Thus, we aim to explore the feasibility of using a novel approach, capable of assisting the clinicians and lessening the workload. We propose the transfer learning framework, entitled MetaSleepLearner, based on Model Agnostic Meta-Learning (MAML), in order to transfer the acquired sleep staging knowledge from a large dataset to new individual subjects. The framework was demonstrated to require the labelling of only a few sleep epochs by the clinicians and allow the remainder to be handled by the system. Layer-wise Relevance Propagation (LRP) was also applied to understand the learning course of our approach. In all acquired datasets, in comparison to the conventional approach, MetaSleepLearner achieved a range of 5.4\% to 17.7\% improvement with statistical difference in the mean of both approaches. The illustration of the model interpretation after the adaptation to each subject also confirmed that the performance was directed towards reasonable learning. MetaSleepLearner outperformed the conventional approaches as a result from the fine-tuning using the recordings of both healthy subjects and patients. This is the first work that investigated a non-conventional pre-training method, MAML, resulting in a possibility for human-machine collaboration in sleep stage classification and easing the burden of the clinicians in labelling the sleep stages through only several epochs rather than an entire recording.

q-bio.NC↗

SleepPoseNet: Multi-View Learning for Sleep Postural Transition Recognition Using UWB

Recognizing movements during sleep is crucial for the monitoring of patients with sleep disorders, and the utilization of ultra-wideband (UWB) radar for the classification of human sleep postures has not been explored widely. This study investigates the performance of an off-the-shelf single antenna UWB in a novel application of sleep postural transition (SPT) recognition. The proposed Multi-View Learning, entitled SleepPoseNet or SPN, with time series data augmentation aims to classify four standard SPTs. SPN exhibits an ability to capture both time and frequency features, including the movement and direction of sleeping positions. The data recorded from 38 volunteers displayed that SPN with a mean accuracy of $73.7 \pm 0.8 \%$ significantly outperformed the mean accuracy of $59.9 \pm 0.7 \%$ obtained from deep convolution neural network (DCNN) in recent state-of-the-art work on human activity recognition using UWB. Apart from UWB system, SPN with the data augmentation can ultimately be adopted to learn and classify time series data in various applications.

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Decoding EEG Rhythms During Action Observation, Motor Imagery, and Execution for Standing and Sitting

Event-related desynchronization and synchronization (ERD/S) and movement-related cortical potential (MRCP) play an important role in brain-computer interfaces (BCI) for lower limb rehabilitation, particularly in standing and sitting. However, little is known about the differences in the cortical activation between standing and sitting, especially how the brain's intention modulates the pre-movement sensorimotor rhythm as they do for switching movements. In this study, we aim to investigate the decoding of continuous EEG rhythms during action observation (AO), motor imagery (MI), and motor execution (ME) for the actions of standing and sitting. We developed a behavioral task in which participants were instructed to perform both AO and MI/ME in regard to the transitioning actions of sit-to-stand and stand-to-sit. Our results demonstrated that the ERD was prominent during AO, whereas ERS was typical during MI at the alpha band across the sensorimotor area. A combination of the filter bank common spatial pattern (FBCSP) and support vector machine (SVM) for classification was used for both offline and classifier testing analyses. The offline analysis indicated the classification of AO and MI providing the highest mean accuracy at 82.73$\pm$2.54\% in the stand-to-sit transition. By applying the classifier testing analysis, we demonstrated the higher performance of decoding neural intentions from the MI paradigm in comparison to the ME paradigm. These observations led us to the promising aspect of using our developed tasks based on the integration of both AO and MI to build future exoskeleton-based rehabilitation systems.

cs.HC↗

Improving Heart Rate Estimation on Consumer Grade Wrist-Worn Device Using Post-Calibration Approach

The technological advancement in wireless health monitoring through the direct contact of the skin allows the development of light-weight wrist-worn wearable devices to be equipped with different sensors such as photoplethysmography (PPG) sensors. However, the motion artifact (MA) is possible to occur during daily activities. In this study, we attempted to perform a post-calibration of the heart rate (HR) estimation during the three possible states of average daily activity (resting, \textcolor{red}{laying down}, and intense treadmill activity states) in 29 participants (130 minutes/person) on four popular wearable devices: Fitbit Charge HR, Apple Watch Series 4, TicWatch Pro, and Empatica E4. In comparison to the standard measurement (HR$_\text{ECG}$), HR provided by Fitbit Charge HR (HR$_\text{Fitbit}$) yielded the highest error of $3.26 \pm 0.34$ bpm in resting, $2.33 \pm 0.23$ bpm in \textcolor{red}{laying down}, $9.53 \pm 1.47$ bpm in intense treadmill activity states, and $5.02 \pm 0.64$ bpm in all states combined among the four chosen devices. Following our improving HR estimation model with rolling windows as feature (HR$_\text{R}$), the mean absolute error (MAE) was significantly reduced by $33.44\%$ in resting, $15.88\%$ in \textcolor{red}{laying down}, $9.55\%$ in intense treadmill activity states, and $18.73\%$ in all states combined. This demonstrates the feasibility of our proposed methods in order to correct and provide HR monitoring post-calibrated with high accuracy, raising further awareness of individual fitness in the daily application.

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