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Thomas G. Kurtz

Publications and source records attributed to Thomas G. Kurtz.

At least 19 recordsLinked to original sources

A reverse ergodic theorem for inhomogeneous killed Markov chains and application to a new uniqueness result for reflecting diffusions

Bass and Pardoux (1987) deduce from the Krein-Rutman theorem a reverse ergodic theorem for a sub-probability transition function, which turns out to be a key tool in proving uniqueness of reflecting Brownian Motion in cones in Kwon and Williams (1991) and Taylor and Williams (1993). By a different approach, we are able to prove an analogous reverse ergodic theorem for a family of inhomogeneous sub-probability transition functions. This allows us to prove existence and uniqueness for a semimartingale diffusion process with varying, oblique direction of reflection, in a domain with one singular point that can be approximated, near the singular point, by a smooth cone, under natural, easily verifiable geometric conditions. Along the way we also show that if the reflecting Brownian motion in a smooth cone is a semimartingale then the parameter $α$ of Kwon and Williams (1991) is strictly less than 1, thus partially extending the results of Williams (1985) to higher dimension.

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Looking forwards and backwards: dynamics and genealogies of locally regulated populations

We introduce a broad class of spatial models to describe how spatially heterogeneous populations live, die, and reproduce. Individuals are represented by points of a point measure, whose birth and death rates can depend both on spatial position and local population density, defined via the convolution of the point measure with a nonnegative kernel. We pass to three different scaling limits: an interacting superprocess, a nonlocal partial differential equation (PDE), and a classical PDE. The classical PDE is obtained both by first scaling time and population size to pass to the nonlocal PDE, and then scaling the kernel that determines local population density; and also (when the limit is a reaction-diffusion equation) by simultaneously scaling the kernel width, timescale and population size in our individual based model. A novelty of our model is that we explicitly model a juvenile phase: offspring are thrown off in a Gaussian distribution around the location of the parent, and reach (instant) maturity with a probability that can depend on the population density at the location at which they land. Although we only record mature individuals, a trace of this two-step description remains in our population models, resulting in novel limits governed by a nonlinear diffusion. Using a lookdown representation, we retain information about genealogies and, in the case of deterministic limiting models, use this to deduce the backwards in time motion of the ancestral lineage of a sampled individual. We observe that knowing the history of the population density is not enough to determine the motion of ancestral lineages in our model. We also investigate the behaviour of lineages for three different deterministic models of a population expanding its range as a travelling wave: the Fisher-KPP equation, the Allen-Cahn equation, and a porous medium equation with logistic growth.

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Localization for constrained martingale problems and optimal conditions for uniqueness of reflecting diffusions in 2-dimensional domains

We prove existence and uniqueness for semimartingale reflecting diffusions in 2-dimensional piecewise smooth domains with varying, oblique directions of reflection on each "side", under geometric, easily verifiable conditions. Our conditions are optimal in the sense that, in the case of a convex polygon with constant direction of reflection on each side, they reduce to the conditions of Dai and Williams (1996), which are necessary for existence of Reflecting Brownian Motion. Moreover our conditions allow for cusps. Our argument is based on a new localization result for constrained martingale problems which holds quite generally: as an additional example, we show that it holds for diffusions with jump boundary conditions.

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Particle representation for the solution of the filtering problem. Application to the error expansion of filtering discretizations

We introduce a weighted particle representation for the solution of the filtering problem based on a suitably chosen variation of the classical de Finetti theorem. This representation has important theoretical and numerical applications. In this paper, we explore some of its theoretical consequences. The first is to deduce the equations satisfied by the solution of the filtering problem in three different frameworks: the signal independent Brownian measurement noise model, the spatial observations with additive white noise model and the cluster detection model in spatial point processes. Secondly we use the representation to show that a suitably chosen filtering discretisation converges to the filtering solution. Thirdly we study the leading error coefficient for the discretisation. We show that it satisfies a stochastic partial differential equation by exploiting the weighted particle representation for both the approximation and the limiting filtering solution.

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Finite Markov chains coupled to general Markov processes and an application to metastability I

We consider a diffusion given by a small noise perturbation of a dynamical system driven by a potential function with a finite number of local minima. The classical results of Freidlin and Wentzell show that the time this diffusion spends in the domain of attraction of one of these local minima is approximately exponentially distributed and hence the diffusion should behave approximately like a Markov chain on the local minima. By the work of Bovier and collaborators, the local minima can be associated with the small eigenvalues of the diffusion generator. Applying a Markov mapping theorem, we use the eigenfunctions of the generator to couple this diffusion to a Markov chain whose generator has eigenvalues equal to the eigenvalues of the diffusion generator that are associated with the local minima and establish explicit formulas for conditional probabilities associated with this coupling. The fundamental question then becomes to relate the coupled Markov chain to the approximate Markov chain suggested by the results of Freidlin and Wentzel. In Part II of this work, we provide a complete analysis of this relationship in the special case of a double-well potential in one dimension. More generally, the coupling can be constructed for a general class of Markov processes and any finite set of eigenvalues of the generator.

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Finite Markov chains coupled to general Markov processes and an application to metastability II

We consider a diffusion given by a small noise perturbation of a dynamical system driven by a potential function with a finite number of local minima. The classical results of Freidlin and Wentzell show that the time this diffusion spends in the domain of attraction of one of these local minima is approximately exponentially distributed and hence the diffusion should behave approximately like a Markov chain on the local minima. By the work of Bovier and collaborators, the local minima can be associated with the small eigenvalues of the diffusion generator. In Part I of this work, by applying a Markov mapping theorem, we used the eigenfunctions of the generator to couple this diffusion to a Markov chain whose generator has eigenvalues equal to the eigenvalues of the diffusion generator that are associated with the local minima and established explicit formulas for conditional probabilities associated with this coupling. The fundamental question now becomes to relate the coupled Markov chain to the approximate Markov chain suggested by the results of Freidlin and Wentzel. In this paper, we take up this question and provide a complete analysis of this relationship in the special case of a double-well potential in one dimension.

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Markov selection for constrained martingale problems

Constrained Markov processes, such as reflecting diffusions, behave as an unconstrained process in the interior of a domain but upon reaching the boundary are controlled in some way so that they do not leave the closure of the domain. In this paper, the behavior in the interior is specified by a generator of a Markov process, and the constraints are specified by a controlled generator. Together, the generators define a "constrained martingale problem". The desired constrained processes are constructed by first solving a simpler "controlled martingale problem" and then obtaining the desired process as a time-change of the controlled process. As for ordinary martingale problems, it is rarely obvious that the process constructed in this manner is unique. The primary goal of the paper is to show that from among the processes constructed in this way one can "select", in the sense of Krylov, a strong Markov process. Corollaries to these constructions include the observation that uniqueness among strong Markov solutions implies uniqueness among all solutions. These results provide useful tools for proving uniqueness for constrained processes including reflecting diffusions. The constructions also yield viscosity semisolutions of the resolvent equation and, if uniqueness holds, a viscosity solution, without proving a comparison principle. We illustrate our results by applying them to reflecting diffusions in piecewise smooth domains. We prove existence of a strong Markov solution to the SDE with reflection, under conditions more general than in Dupuis and Ishii (1993): In fact our conditions are known to be optimal in the case of simple, convex polyhedrons with constant direction of reflection on each face (Dai and Williams (1995)). We also indicate how the results can be applied to processes with Wentzell boundary conditions and nonlocal boundary conditions.

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Particle representations for stochastic partial differential equations with boundary conditions

In this article, we study a weighted particle representation for a class of stochastic partial differential equations with Dirichlet boundary conditions. The locations and weights of the particles satisfy an infinite system of stochastic differential equations (SDEs). The evolution of the particles is modeled by an infinite system of stochastic differential equations with reflecting boundary condition and driven by independent finite dimensional Brownian motions. The weights of the particles evolve according to an infinite system of stochastic differential equations driven by a common cylindrical noise $W$ and interact through $V$, the associated weighted empirical measure. When the particles hit the boundary their corresponding weights are assigned a pre-specified value. We show the existence and uniqueness of a solution of the infinite dimensional system of stochastic differential equations modeling the location and the weights of the particles. We also prove that the associated weighted empirical measure $V$ is the unique solution of a nonlinear stochastic partial differential equation driven by $W$ with Dirichlet boundary condition. The work is motivated by and applied to the stochastic Allen-Cahn equation and extends the earlier of work of Kurtz and Xiong.

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Genealogical constructions of population models

Representations of population models in terms of countable systems of particles are constructed, in which each particle has a `type', typically recording both spatial position and genetic type, and a level. For finite intensity models, the levels are distributed on $[0,λ]$, whereas in the infinite intensity limit $λ\rightarrow\infty$, at each time $t$, the joint distribution of types and levels is conditionally Poisson, with mean measure $Ξ(t)\times \ell$ where $\ell$ denotes Lebesgue measure and $Ξ(t)$ is a measure-valued population process. The time-evolution of the levels captures the genealogies of the particles in the population. Key forces of ecology and genetics can be captured within this common framework. Models covered incorporate both individual and event based births and deaths, one-for-one replacement, immigration, independent `thinning' and independent or exchangeable spatial motion and mutation of individuals. Since birth and death probabilities can depend on type, they also include natural selection. The primary goal of the paper is to present particle-with-level or lookdown constructions for each of these elements of a population model. Then the elements can be combined to specify the desired model. In particular, a non-trivial extension of the spatial $Λ$-Fleming-Viot process is constructed.

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Existence and uniqueness of reflecting diffusions in cusps

We consider stochastic differential equations with (oblique) reflection in a $2$-dimensional domain that has a cusp at the origin, i..e. in a neighborhood of the origin has the form $\{(x_1,x_2):0 0$, $i=1,2$, and $e^{*}_1>0$, we prove weak existence and uniqueness of the solution starting at the origin and strong existence and uniqueness starting away from the origin. Our proof uses a new scaling result and a coupling argument.

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Linear Programming Formulations of Singular Stochastic Control Problems: Time-Homogeneous Problems

Conditions are established under which the optimal control of processes having both absolutely continuous and singular (with respect to time) controls are equivalent to linear programs over a space of measures on the state and control spaces. This paper considers long-term average and discounted criteria and includes budget and resource constraints. The linear programs optimize over measures representing the expected occupation measure of the state and absolutely continuous control processes and a similar expected occupation measure of the state and control when the singular action of the process occurs. The evolution of these processes is characterized through an adjoint equation which the measures must satisfy in relation to the absolutely continuous and singular generators of the process. Existence of optimal relaxed controls of feedback type are established in general while existence of an optimal form of strict control is proven under additional closedness and compactness conditions.

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Finite time distributions of stochastically modeled chemical systems with absolute concentration robustness

Recent research in both the experimental and mathematical communities has focused on biochemical interaction systems that satisfy an "absolute concentration robustness" (ACR) property. The ACR property was first discovered experimentally when, in a number of different systems, the concentrations of key system components at equilibrium were observed to be robust to the total concentration levels of the system. Followup mathematical work focused on deterministic models of biochemical systems and demonstrated how chemical reaction network theory can be utilized to explain this robustness. Later mathematical work focused on the behavior of this same class of reaction networks, though under the assumption that the dynamics were stochastic. Under the stochastic assumption, it was proven that the system will undergo an extinction event with a probability of one so long as the system is conservative, showing starkly different long-time behavior than in the deterministic setting. Here we consider a general class of stochastic models that intersects with the class of ACR systems studied previously. We consider a specific system scaling over compact time intervals and prove that in a limit of this scaling the distribution of the abundances of the ACR species converges to a certain product-form Poisson distribution whose mean is the ACR value of the deterministic model. This result is in agreement with recent conjectures pertaining to the behavior of ACR networks endowed with stochastic kinetics, and helps to resolve the conflicting theoretical results pertaining to deterministic and stochastic models in this setting.

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Viscosity methods giving uniqueness for martingale problems

Let $E$ be a complete, separable metric space and $A$ be an operator on $C_b(E)$. We give an abstract definition of viscosity sub/supersolution of the resolvent equation $λu-Au=h$ and show that, if the comparison principle holds, then the martingale problem for $A$ has a unique solution. Our proofs work also under two alternative definitions of viscosity sub/supersolution which might be useful, in particular, in infinite dimensional spaces, for instance to study measure-valued processes. We prove the analogous result for stochastic processes that must satisfy boundary conditions, modeled as solutions of constrained martingale problems. In the case of reflecting diffusions in $D\subset {\bf R}^d$, our assumptions allow $ D$ to be nonsmooth and the direction of reflection to be degenerate. Two examples are presented: A diffusion with degenerate oblique direction of reflection and a class of jump diffusion processes with infinite variation jump component and possibly degenerate diffusion matrix.

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Central limit theorems and diffusion approximations for multiscale Markov chain models

Ordinary differential equations obtained as limits of Markov processes appear in many settings. They may arise by scaling large systems, or by averaging rapidly fluctuating systems, or in systems involving multiple time-scales, by a combination of the two. Motivated by models with multiple time-scales arising in systems biology, we present a general approach to proving a central limit theorem capturing the fluctuations of the original model around the deterministic limit. The central limit theorem provides a method for deriving an appropriate diffusion (Langevin) approximation.

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Weak and strong solutions of general stochastic models

Typically, a stochastic model relates stochastic "inputs" and, perhaps, controls to stochastic "outputs". A general version of the Yamada-Watanabe and Engelbert theorems relating existence and uniqueness of weak and strong solutions of stochastic equations is given in this context. A notion of {\em compatibility} between inputs and outputs is critical in relating the general result to its classical forebears. The relationship between the compatibility condition and the usual formulation of stochastic differential equations driven by semimartingales is discussed.

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Error analysis of tau-leap simulation methods

We perform an error analysis for numerical approximation methods of continuous time Markov chain models commonly found in the chemistry and biochemistry literature. The motivation for the analysis is to be able to compare the accuracy of different approximation methods and, specifically, Euler tau-leaping and midpoint tau-leaping. We perform our analysis under a scaling in which the size of the time discretization is inversely proportional to some (bounded) power of the norm of the state of the system. We argue that this is a more appropriate scaling than that found in previous error analyses in which the size of the time discretization goes to zero independent of the rest of the model. Under the present scaling, we show that midpoint tau-leaping achieves a higher order of accuracy, in both a weak and a strong sense, than Euler tau-leaping; a result that is in contrast to previous analyses. We present examples that demonstrate our findings.

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Poisson representations of branching Markov and measure-valued branching processes

Representations of branching Markov processes and their measure-valued limits in terms of countable systems of particles are constructed for models with spatially varying birth and death rates. Each particle has a location and a "level," but unlike earlier constructions, the levels change with time. In fact, death of a particle occurs only when the level of the particle crosses a specified level $r$, or for the limiting models, hits infinity. For branching Markov processes, at each time $t$, conditioned on the state of the process, the levels are independent and uniformly distributed on $[0,r]$. For the limiting measure-valued process, at each time $t$, the joint distribution of locations and levels is conditionally Poisson distributed with mean measure $K(t)\times\varLambda$, where $\varLambda$ denotes Lebesgue measure, and $K$ is the desired measure-valued process. The representation simplifies or gives alternative proofs for a variety of calculations and results including conditioning on extinction or nonextinction, Harris's convergence theorem for supercritical branching processes, and diffusion approximations for processes in random environments.

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