arXiv subjects

Thomas Huang

Publications and source records attributed to Thomas Huang.

At least 19 recordsLinked to original sources

arXiv2025

Rethinking Retrieval-Augmented Generation for Medicine: A Large-Scale, Systematic Expert Evaluation and Practical Insights

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented generation (RAG) has been widely adopted to address these limitations by supplementing model outputs with retrieved evidence. However, whether RAG reliably achieves these goals remains unclear. Here, we present the most comprehensive expert evaluation of RAG in medicine to date. Eighteen medical experts contributed a total of 80,502 annotations, assessing 800 model outputs generated by GPT-4o and Llama-3.1-8B across 200 real-world patient and USMLE-style queries. We systematically decomposed the RAG pipeline into three components: (i) evidence retrieval (relevance of retrieved passages), (ii) evidence selection (accuracy of evidence usage), and (iii) response generation (factuality and completeness of outputs). Contrary to expectation, standard RAG often degraded performance: only 22% of top-16 passages were relevant, evidence selection remained weak (precision 41-43%, recall 27-49%), and factuality and completeness dropped by up to 6% and 5%, respectively, compared with non-RAG variants. Retrieval and evidence selection remain key failure points for the model, contributing to the overall performance drop. We further show that simple yet effective strategies, including evidence filtering and query reformulation, substantially mitigate these issues, improving performance on MedMCQA and MedXpertQA by up to 12% and 8.2%, respectively. These findings call for re-examining RAG's role in medicine and highlight the importance of stage-aware evaluation and deliberate system design for reliable medical LLM applications.

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arXiv2024

AgentMD: Empowering Language Agents for Risk Prediction with Large-Scale Clinical Tool Learning

Clinical calculators play a vital role in healthcare by offering accurate evidence-based predictions for various purposes such as prognosis. Nevertheless, their widespread utilization is frequently hindered by usability challenges, poor dissemination, and restricted functionality. Augmenting large language models with extensive collections of clinical calculators presents an opportunity to overcome these obstacles and improve workflow efficiency, but the scalability of the manual curation process poses a significant challenge. In response, we introduce AgentMD, a novel language agent capable of curating and applying clinical calculators across various clinical contexts. Using the published literature, AgentMD has automatically curated a collection of 2,164 diverse clinical calculators with executable functions and structured documentation, collectively named RiskCalcs. Manual evaluations show that RiskCalcs tools achieve an accuracy of over 80% on three quality metrics. At inference time, AgentMD can automatically select and apply the relevant RiskCalcs tools given any patient description. On the newly established RiskQA benchmark, AgentMD significantly outperforms chain-of-thought prompting with GPT-4 (87.7% vs. 40.9% in accuracy). Additionally, we also applied AgentMD to real-world clinical notes for analyzing both population-level and risk-level patient characteristics. In summary, our study illustrates the utility of language agents augmented with clinical calculators for healthcare analytics and patient care.

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arXiv2021

Revisiting Hierarchical Approach for Persistent Long-Term Video Prediction

Learning to predict the long-term future of video frames is notoriously challenging due to inherent ambiguities in the distant future and dramatic amplifications of prediction error through time. Despite the recent advances in the literature, existing approaches are limited to moderately short-term prediction (less than a few seconds), while extrapolating it to a longer future quickly leads to destruction in structure and content. In this work, we revisit hierarchical models in video prediction. Our method predicts future frames by first estimating a sequence of semantic structures and subsequently translating the structures to pixels by video-to-video translation. Despite the simplicity, we show that modeling structures and their dynamics in the discrete semantic structure space with a stochastic recurrent estimator leads to surprisingly successful long-term prediction. We evaluate our method on three challenging datasets involving car driving and human dancing, and demonstrate that it can generate complicated scene structures and motions over a very long time horizon (i.e., thousands frames), setting a new standard of video prediction with orders of magnitude longer prediction time than existing approaches. Full videos and codes are available at https://1konny.github.io/HVP/.

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arXiv2020

Decoupled Classification Refinement: Hard False Positive Suppression for Object Detection

In this paper, we analyze failure cases of state-of-the-art detectors and observe that most hard false positives result from classification instead of localization and they have a large negative impact on the performance of object detectors. We conjecture there are three factors: (1) Shared feature representation is not optimal due to the mismatched goals of feature learning for classification and localization; (2) multi-task learning helps, yet optimization of the multi-task loss may result in sub-optimal for individual tasks; (3) large receptive field for different scales leads to redundant context information for small objects. We demonstrate the potential of detector classification power by a simple, effective, and widely-applicable Decoupled Classification Refinement (DCR) network. In particular, DCR places a separate classification network in parallel with the localization network (base detector). With ROI Pooling placed on the early stage of the classification network, we enforce an adaptive receptive field in DCR. During training, DCR samples hard false positives from the base detector and trains a strong classifier to refine classification results. During testing, DCR refines all boxes from the base detector. Experiments show competitive results on PASCAL VOC and COCO without any bells and whistles. Our codes are available at: https://github.com/bowenc0221/Decoupled-Classification-Refinement.

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arXiv2020

Inner Cell Mass and Trophectoderm Segmentation in Human Blastocyst Images using Deep Neural Network

Embryo quality assessment based on morphological attributes is important for achieving higher pregnancy rates from in vitro fertilization (IVF). The accurate segmentation of the embryo's inner cell mass (ICM) and trophectoderm epithelium (TE) is important, as these parameters can help to predict the embryo viability and live birth potential. However, segmentation of the ICM and TE is difficult due to variations in their shape and similarities in their textures, both with each other and with their surroundings. To tackle this problem, a deep neural network (DNN) based segmentation approach was implemented. The DNN can identify the ICM region with 99.1% accuracy, 94.9% precision, 93.8% recall, a 94.3% Dice Coefficient, and a 89.3% Jaccard Index. It can extract the TE region with 98.3% accuracy, 91.8% precision, 93.2% recall, a 92.5% Dice Coefficient, and a 85.3% Jaccard Index.

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arXiv2020

Image Segmentation of Zona-Ablated Human Blastocysts

Automating human preimplantation embryo grading offers the potential for higher success rates with in vitro fertilization (IVF) by providing new quantitative and objective measures of embryo quality. Current IVF procedures typically use only qualitative manual grading, which is limited in the identification of genetically abnormal embryos. The automatic quantitative assessment of blastocyst expansion can potentially improve sustained pregnancy rates and reduce health risks from abnormal pregnancies through a more accurate identification of genetic abnormality. The expansion rate of a blastocyst is an important morphological feature to determine the quality of a developing embryo. In this work, a deep learning based human blastocyst image segmentation method is presented, with the goal of facilitating the challenging task of segmenting irregularly shaped blastocysts. The type of blastocysts evaluated here has undergone laser ablation of the zona pellucida, which is required prior to trophectoderm biopsy. This complicates the manual measurements of the expanded blastocyst's size, which shows a correlation with genetic abnormalities. The experimental results on the test set demonstrate segmentation greatly improves the accuracy of expansion measurements, resulting in up to 99.4% accuracy, 98.1% precision, 98.8% recall, a 98.4% Dice Coefficient, and a 96.9% Jaccard Index.

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arXiv2020

FOAL: Fast Online Adaptive Learning for Cardiac Motion Estimation

Motion estimation of cardiac MRI videos is crucial for the evaluation of human heart anatomy and function. Recent researches show promising results with deep learning-based methods. In clinical deployment, however, they suffer dramatic performance drops due to mismatched distributions between training and testing datasets, commonly encountered in the clinical environment. On the other hand, it is arguably impossible to collect all representative datasets and to train a universal tracker before deployment. In this context, we proposed a novel fast online adaptive learning (FOAL) framework: an online gradient descent based optimizer that is optimized by a meta-learner. The meta-learner enables the online optimizer to perform a fast and robust adaptation. We evaluated our method through extensive experiments on two public clinical datasets. The results showed the superior performance of FOAL in accuracy compared to the offline-trained tracking method. On average, the FOAL took only $0.4$ second per video for online optimization.

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arXiv2020

BigNAS: Scaling Up Neural Architecture Search with Big Single-Stage Models

Neural architecture search (NAS) has shown promising results discovering models that are both accurate and fast. For NAS, training a one-shot model has become a popular strategy to rank the relative quality of different architectures (child models) using a single set of shared weights. However, while one-shot model weights can effectively rank different network architectures, the absolute accuracies from these shared weights are typically far below those obtained from stand-alone training. To compensate, existing methods assume that the weights must be retrained, finetuned, or otherwise post-processed after the search is completed. These steps significantly increase the compute requirements and complexity of the architecture search and model deployment. In this work, we propose BigNAS, an approach that challenges the conventional wisdom that post-processing of the weights is necessary to get good prediction accuracies. Without extra retraining or post-processing steps, we are able to train a single set of shared weights on ImageNet and use these weights to obtain child models whose sizes range from 200 to 1000 MFLOPs. Our discovered model family, BigNASModels, achieve top-1 accuracies ranging from 76.5% to 80.9%, surpassing state-of-the-art models in this range including EfficientNets and Once-for-All networks without extra retraining or post-processing. We present ablative study and analysis to further understand the proposed BigNASModels.

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arXiv2020

SG-One: Similarity Guidance Network for One-Shot Semantic Segmentation

One-shot image semantic segmentation poses a challenging task of recognizing the object regions from unseen categories with only one annotated example as supervision. In this paper, we propose a simple yet effective Similarity Guidance network to tackle the One-shot (SG-One) segmentation problem. We aim at predicting the segmentation mask of a query image with the reference to one densely labeled support image of the same category. To obtain the robust representative feature of the support image, we firstly adopt a masked average pooling strategy for producing the guidance features by only taking the pixels belonging to the support image into account. We then leverage the cosine similarity to build the relationship between the guidance features and features of pixels from the query image. In this way, the possibilities embedded in the produced similarity maps can be adapted to guide the process of segmenting objects. Furthermore, our SG-One is a unified framework which can efficiently process both support and query images within one network and be learned in an end-to-end manner. We conduct extensive experiments on Pascal VOC 2012. In particular, our SGOne achieves the mIoU score of 46.3%, surpassing the baseline methods.

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arXiv2020

NTIRE 2020 Challenge on Real Image Denoising: Dataset, Methods and Results

This paper reviews the NTIRE 2020 challenge on real image denoising with focus on the newly introduced dataset, the proposed methods and their results. The challenge is a new version of the previous NTIRE 2019 challenge on real image denoising that was based on the SIDD benchmark. This challenge is based on a newly collected validation and testing image datasets, and hence, named SIDD+. This challenge has two tracks for quantitatively evaluating image denoising performance in (1) the Bayer-pattern rawRGB and (2) the standard RGB (sRGB) color spaces. Each track ~250 registered participants. A total of 22 teams, proposing 24 methods, competed in the final phase of the challenge. The proposed methods by the participating teams represent the current state-of-the-art performance in image denoising targeting real noisy images. The newly collected SIDD+ datasets are publicly available at: https://bit.ly/siddplus_data.

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arXiv2020

SkyNet: a Hardware-Efficient Method for Object Detection and Tracking on Embedded Systems

Object detection and tracking are challenging tasks for resource-constrained embedded systems. While these tasks are among the most compute-intensive tasks from the artificial intelligence domain, they are only allowed to use limited computation and memory resources on embedded devices. In the meanwhile, such resource-constrained implementations are often required to satisfy additional demanding requirements such as real-time response, high-throughput performance, and reliable inference accuracy. To overcome these challenges, we propose SkyNet, a hardware-efficient neural network to deliver the state-of-the-art detection accuracy and speed for embedded systems. Instead of following the common top-down flow for compact DNN (Deep Neural Network) design, SkyNet provides a bottom-up DNN design approach with comprehensive understanding of the hardware constraints at the very beginning to deliver hardware-efficient DNNs. The effectiveness of SkyNet is demonstrated by winning the competitive System Design Contest for low power object detection in the 56th IEEE/ACM Design Automation Conference (DAC-SDC), where our SkyNet significantly outperforms all other 100+ competitors: it delivers 0.731 Intersection over Union (IoU) and 67.33 frames per second (FPS) on a TX2 embedded GPU; and 0.716 IoU and 25.05 FPS on an Ultra96 embedded FPGA. The evaluation of SkyNet is also extended to GOT-10K, a recent large-scale high-diversity benchmark for generic object tracking in the wild. For state-of-the-art object trackers SiamRPN++ and SiamMask, where ResNet-50 is employed as the backbone, implementations using our SkyNet as the backbone DNN are 1.60X and 1.73X faster with better or similar accuracy when running on a 1080Ti GPU, and 37.20X smaller in terms of parameter size for significantly better memory and storage footprint.

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arXiv2019

FLNet: Landmark Driven Fetching and Learning Network for Faithful Talking Facial Animation Synthesis

Talking face synthesis has been widely studied in either appearance-based or warping-based methods. Previous works mostly utilize single face image as a source, and generate novel facial animations by merging other person's facial features. However, some facial regions like eyes or teeth, which may be hidden in the source image, can not be synthesized faithfully and stably. In this paper, We present a landmark driven two-stream network to generate faithful talking facial animation, in which more facial details are created, preserved and transferred from multiple source images instead of a single one. Specifically, we propose a network consisting of a learning and fetching stream. The fetching sub-net directly learns to attentively warp and merge facial regions from five source images of distinctive landmarks, while the learning pipeline renders facial organs from the training face space to compensate. Compared to baseline algorithms, extensive experiments demonstrate that the proposed method achieves a higher performance both quantitatively and qualitatively. Codes are at https://github.com/kgu3/FLNet_AAAI2020.

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arXiv2019

When AWGN-based Denoiser Meets Real Noises

Discriminative learning-based image denoisers have achieved promising performance on synthetic noises such as Additive White Gaussian Noise (AWGN). The synthetic noises adopted in most previous work are pixel-independent, but real noises are mostly spatially/channel-correlated and spatially/channel-variant. This domain gap yields unsatisfied performance on images with real noises if the model is only trained with AWGN. In this paper, we propose a novel approach to boost the performance of a real image denoiser which is trained only with synthetic pixel-independent noise data dominated by AWGN. First, we train a deep model that consists of a noise estimator and a denoiser with mixed AWGN and Random Value Impulse Noise (RVIN). We then investigate Pixel-shuffle Down-sampling (PD) strategy to adapt the trained model to real noises. Extensive experiments demonstrate the effectiveness and generalization of the proposed approach. Notably, our method achieves state-of-the-art performance on real sRGB images in the DND benchmark among models trained with synthetic noises. Codes are available at https://github.com/yzhouas/PD-Denoising-pytorch.

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arXiv2019

Free-Form Image Inpainting with Gated Convolution

We present a generative image inpainting system to complete images with free-form mask and guidance. The system is based on gated convolutions learned from millions of images without additional labelling efforts. The proposed gated convolution solves the issue of vanilla convolution that treats all input pixels as valid ones, generalizes partial convolution by providing a learnable dynamic feature selection mechanism for each channel at each spatial location across all layers. Moreover, as free-form masks may appear anywhere in images with any shape, global and local GANs designed for a single rectangular mask are not applicable. Thus, we also present a patch-based GAN loss, named SN-PatchGAN, by applying spectral-normalized discriminator on dense image patches. SN-PatchGAN is simple in formulation, fast and stable in training. Results on automatic image inpainting and user-guided extension demonstrate that our system generates higher-quality and more flexible results than previous methods. Our system helps user quickly remove distracting objects, modify image layouts, clear watermarks and edit faces. Code, demo and models are available at: https://github.com/JiahuiYu/generative_inpainting

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arXiv2019

Universally Slimmable Networks and Improved Training Techniques

Slimmable networks are a family of neural networks that can instantly adjust the runtime width. The width can be chosen from a predefined widths set to adaptively optimize accuracy-efficiency trade-offs at runtime. In this work, we propose a systematic approach to train universally slimmable networks (US-Nets), extending slimmable networks to execute at arbitrary width, and generalizing to networks both with and without batch normalization layers. We further propose two improved training techniques for US-Nets, named the sandwich rule and inplace distillation, to enhance training process and boost testing accuracy. We show improved performance of universally slimmable MobileNet v1 and MobileNet v2 on ImageNet classification task, compared with individually trained ones and 4-switch slimmable network baselines. We also evaluate the proposed US-Nets and improved training techniques on tasks of image super-resolution and deep reinforcement learning. Extensive ablation experiments on these representative tasks demonstrate the effectiveness of our proposed methods. Our discovery opens up the possibility to directly evaluate FLOPs-Accuracy spectrum of network architectures. Code and models are available at: https://github.com/JiahuiYu/slimmable_networks

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arXiv2019

Self-similarity Grouping: A Simple Unsupervised Cross Domain Adaptation Approach for Person Re-identification

Domain adaptation in person re-identification (re-ID) has always been a challenging task. In this work, we explore how to harness the natural similar characteristics existing in the samples from the target domain for learning to conduct person re-ID in an unsupervised manner. Concretely, we propose a Self-similarity Grouping (SSG) approach, which exploits the potential similarity (from global body to local parts) of unlabeled samples to automatically build multiple clusters from different views. These independent clusters are then assigned with labels, which serve as the pseudo identities to supervise the training process. We repeatedly and alternatively conduct such a grouping and training process until the model is stable. Despite the apparent simplify, our SSG outperforms the state-of-the-arts by more than 4.6% (DukeMTMC to Market1501) and 4.4% (Market1501 to DukeMTMC) in mAP, respectively. Upon our SSG, we further introduce a clustering-guided semisupervised approach named SSG ++ to conduct the one-shot domain adaption in an open set setting (i.e. the number of independent identities from the target domain is unknown). Without spending much effort on labeling, our SSG ++ can further promote the mAP upon SSG by 10.7% and 6.9%, respectively. Our Code is available at: https://github.com/OasisYang/SSG .

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arXiv2019

SPGNet: Semantic Prediction Guidance for Scene Parsing

Multi-scale context module and single-stage encoder-decoder structure are commonly employed for semantic segmentation. The multi-scale context module refers to the operations to aggregate feature responses from a large spatial extent, while the single-stage encoder-decoder structure encodes the high-level semantic information in the encoder path and recovers the boundary information in the decoder path. In contrast, multi-stage encoder-decoder networks have been widely used in human pose estimation and show superior performance than their single-stage counterpart. However, few efforts have been attempted to bring this effective design to semantic segmentation. In this work, we propose a Semantic Prediction Guidance (SPG) module which learns to re-weight the local features through the guidance from pixel-wise semantic prediction. We find that by carefully re-weighting features across stages, a two-stage encoder-decoder network coupled with our proposed SPG module can significantly outperform its one-stage counterpart with similar parameters and computations. Finally, we report experimental results on the semantic segmentation benchmark Cityscapes, in which our SPGNet attains 81.1% on the test set using only 'fine' annotations.

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arXiv2019

SkyNet: A Champion Model for DAC-SDC on Low Power Object Detection

Developing artificial intelligence (AI) at the edge is always challenging, since edge devices have limited computation capability and memory resources but need to meet demanding requirements, such as real-time processing, high throughput performance, and high inference accuracy. To overcome these challenges, we propose SkyNet, an extremely lightweight DNN with 12 convolutional (Conv) layers and only 1.82 megabyte (MB) of parameters following a bottom-up DNN design approach. SkyNet is demonstrated in the 56th IEEE/ACM Design Automation Conference System Design Contest (DAC-SDC), a low power object detection challenge in images captured by unmanned aerial vehicles (UAVs). SkyNet won the first place award for both the GPU and FPGA tracks of the contest: we deliver 0.731 Intersection over Union (IoU) and 67.33 frames per second (FPS) on a TX2 GPU and deliver 0.716 IoU and 25.05 FPS on an Ultra96 FPGA.

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