arXiv subjects

Thorsten A. Bley

Publications and source records attributed to Thorsten A. Bley.

3 recordsLinked to original sources

arXiv2026

First in-vivo human magnetic particle imaging

Magnetic particle imaging (MPI) is a tracer-based technique that directly detects the distribution of magnetic iron-oxide nanoparticles with millisecond temporal resolution and no tissue background. Despite extensive preclinical work, in-vivo application of MPI in humans has not previously been reported. Here, we report the first in-vivo human MPI angiography, visualizing venous perfusion of the upper extremity using a human-scale scanner and clinically approved ferucarbotran. Under identical procedural conditions, we performed X-ray digital subtraction angiography as the clinical gold standard. MPI visualized major superficial and deep veins, including inflow, branching, valve filling, and clearance dynamics in real time with 2 frames per second. These results establish magnetic particle imaging as a clinically translatable modality for radiation-free vascular imaging in humans and mark the transition of MPI from preclinical research to first clinical application.

physics.med-ph↗

arXiv2024

Joint image reconstruction and segmentation of real-time cardiac MRI in free-breathing using a model based on disentangled representation learning

A joint image reconstruction and segmentation approach based on disentangled representation learning was trained to enable cardiac cine MR imaging in real-time and under free-breathing. An exploratory feasibility study tested the proposed method in undersampled real-time acquisitions based on an in-house developed spiral bSSFP pulse sequence in eight healthy participants and five patients with intermittent atrial fibrillation. Images and predicted LV segmentations were compared to the reference standard of ECG-gated segmented Cartesian cine in repeated breath-holds and corresponding manual segmentation. On a 5-point Likert scale, image quality of the real-time breath-hold approach and Cartesian cine was comparable in healthy participants (RT-BH: 1.99 $\pm$ .98, Cartesian: 1.94 $\pm$ .86, p=.052), but slightly inferior in free-breathing (RT-FB: 2.40 $\pm$ .98, p<.001). In patients with arrhythmia, image quality from both real-time approaches was favourable (RT-BH: 2.10 $\pm$ 1.28, p<.001, RT-FB: 2.40 $\pm$ 1.13, p<.001, Cartesian: 2.68 $\pm$ 1.13). Intra-observer reliability was good (ICC=.77, 95%-confidence interval [.75, .79], p<.001). In functional analysis, a positive bias was observed for ejection fractions derived from the proposed model compared to the clinical reference standard (RT-BH mean EF: 58.5 $\pm$ 5.6%, bias: +3.47%, 95%-confidence interval [-.86, 7.79%], RT-FB mean: 57.9 $\pm$ 10.6%, bias: +1.45%, [-3.02, 5.91%], Cartesian mean: 54.9 $\pm$ 6.7%). The introduced real-time MR imaging technique is capable of acquiring high-quality cardiac cine data in 1-2 minutes without the need for ECG gating and breath-holds. It thus offers a promising alternative to the current clinical practice of segmented acquisition, with shorter scan times, higher patient comfort and increased robustness to arrhythmia and patient incompliance.

eess.IV↗

arXiv2022

Robust Centerline Prediction for Accurate Vessel Wall Visualization of Intracranial Vessels in Multi-Contrast 3D MRI Data

An accurate planar visualization (curved planar reformation - CPR) of intracranial arteries is mandatory for an improved luminal and mural assessment especially in low resolution Magnetic Resonance Imaging (MRI) data sets acquired in standard clinical settings. CPR visualization methods based on the centerline of the desired structure are fast and easy to implement but the accuracy strongly depends on the spatial resolution of the 3D data set and the size of the desired vessel. In the manuscript, a novel algorithm for fast and robust centerline calculation in multi-contrast 3D MRI data is presented. It considers the extracted surface of the vessel structure for a more accurate centerline prediction resulting in an enhanced CPR visualization of small vessels.

physics.med-ph↗