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Tianni Zhang

Publications and source records attributed to Tianni Zhang.

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Group-Sparse Smoothing for Longitudinal Models with Time-Varying Coefficients

Longitudinal associations may vary over time, yet allowing every regression effect to be dynamic can inflate estimation variance and obscure interpretable structure. We develop time-varying-effect selection (TV-Select), a group-sparse smoothing framework that classifies covariate effects as zero, constant, or time varying. Each coefficient is decomposed into a constant mean and a centered temporal deviation represented by a full-rank, L2-normalized effective spline basis. A group penalty identifies varying components, while a roughness penalty controls their curvature. The resulting convex criterion is solved by cyclic block proximal-gradient updates and followed by smooth refitting. Under a full-column-rank unpenalized design and an effective model dimension that is small relative to the total number of observations, we establish prediction and parameter rates, blockwise function-estimation bounds, and exact recovery of the varying set under irrepresentability and beta-min conditions. A stable classification refit further separates zero from constant effects. For fixed-dimensional contrasts, we construct an oracle-equivalent one-step estimator with cluster-robust asymptotic normality and consistent sandwich variance estimation. Simulations demonstrate that TV-Select combines low false-positive rates with accurate function estimation and competitive prediction across a range of longitudinal settings. An application to Sleep-EDF data produces smooth and parsimonious temporal effect estimates with essentially unchanged held-out predictive performance.

stat.ME

Adaptive Penalized Doubly Robust Regression for Longitudinal Data

Longitudinal data often involve heterogeneity, sparse signals, and contamination from response outliers or high-leverage observations especially in biomedical science. Existing methods usually address only part of this problem, either emphasizing penalized mixed effects modeling without robustness or robust mixed effects estimation without high-dimensional variable selection. We propose a doubly adaptive robust regression (DAR-R) framework for longitudinal linear mixed effects models. It combines a robust pilot fit, doubly adaptive observation weights for residual outliers and leverage points, and folded concave penalization for fixed effect selection, together with weighted updates of random effects and variance components. We develop an iterative reweighting algorithm and establish estimation and prediction error bounds, support recovery consistency, and oracle-type asymptotic normality. Simulations show that DAR-R improves estimation accuracy, false-positive control, and covariance estimation under both vertical outliers and bad leverage contamination. In the TADPOLE/ADNI Alzheimer's disease application, DAR-R achieves accurate and stable prediction of ADAS13 while selecting clinically meaningful predictors with strong resampling stability.

stat.ME

Block Empirical Likelihood Inference for Longitudinal Generalized Partially Linear Single-Index Models

Generalized partially linear single-index models (GPLSIMs) provide a flexible and interpretable semiparametric framework for longitudinal outcomes by combining a low-dimensional parametric component with a nonparametric index component. For repeated measurements, valid inference is challenging because within-subject correlation induces nuisance parameters and variance estimation can be unstable in semiparametric settings. We propose a profile estimating-equation approach based on spline approximation of the unknown link function and construct a subject-level block empirical likelihood (BEL) for joint inference on the parametric coefficients and the single-index direction. The resulting BEL ratio statistic enjoys a Wilks-type chi-square limit, yielding likelihood-free confidence regions without explicit sandwich variance estimation. We also discuss practical implementation, including constrained optimization for the index parameter, working-correlation choices, and bootstrap-based confidence bands for the nonparametric component. Simulation studies and an application to the epilepsy longitudinal study illustrate the finite-sample performance.

stat.ME