arXiv subjects

Timo Jakumeit

Publications and source records attributed to Timo Jakumeit.

7 recordsLinked to original sources

arXiv2026

Source Distance Estimation in Turbulent Airflow: Exploiting Molecule Degradation Diversity

In nature, estimating the location of a molecule source in turbulent airflow is a central, and yet highly challenging problem for mate search and foraging. Recently, it has also received increasing attention in synthetic molecular communication (SMC), e.g., for leakage detection. One important aspect of source localization is to estimate the distance to the molecule source, e.g., to determine whether it is worth to travel to a potential mating partner or food source, or to decide whether a leak is close enough for inspection. In this study, based on realistic simulations, we show that the diversity induced by molecule mixtures can aid source localization. In particular, when different molecule types in a mixture are subject to atmospheric degradation with different degradation rates, the relative abundance of the different species observed at the receiver enables low-complexity estimation of the source distance. Furthermore, this feature can be combined with already established concentration-based and temporal features of observed molecular signals to further increase estimation accuracy. Thereby, we show that molecule degradation diversity of molecule mixtures can help to realize one of the important envisioned SMC applications, namely source localization, even in turbulent airflow, opening new opportunities for the exploitation of SMC to solve real-world problems.

cs.ET↗

arXiv2026

Multipath Channel Metrics and Detection in Vascular Molecular Communication: A Wireless-Inspired Perspective

Motivated by classical communications engineering, early works in molecular communication (MC) largely adopted established modeling and signal processing concepts from wireless electromagnetic communication systems. In the context of the human cardiovascular system (CVS), MC channel models evolved from simple unbounded and single-duct environments mimicking individual blood vessels to complex vessel network (VN) topologies, generally at the expense of analytical tractability. Up until now, this has largely prohibited rigorous communication-theoretic analysis of large-scale VNs. In this work, we leverage a recently established closed-form analytical channel model for VNs, named mixture of inverse Gaussians for hemodynamic transport (MIGHT), to conduct the first systematic communication-theoretic study of MC in complex, large-scale VNs. Based on MIGHT, we derive a Poisson channel noise model and unveil structural analogies between multipath wireless communications (MWC) and advective-diffusive MC in VNs. In particular, we establish classical MWC metrics, namely the root mean squared (RMS) delay spread, the mean excess delay, and the coherence bandwidth, for MC in VNs and derive closed-form expressions for the channel frequency response and power delay profile (PDP). Building on this characterization, we propose a VN-adapted, coherent decision-feedback (DF) detector and show how the derived multipath metrics can inform the choice of critical system parameters like the symbol duration, the sampling time, and the memory length. Additionally, we evaluate the detector's performance in different VNs exhibiting inter-symbol interference (ISI). Together, these contributions open the door to a systematic, MWC-inspired MC system design for large-scale VNs.

cs.IT↗

arXiv2026

Matched Filter-Based Molecule Source Localization in Advection-Diffusion-Driven Pipe Networks with Known Topology

Synthetic molecular communication (MC) has emerged as a powerful framework for modeling, analyzing, and designing communication systems where information is encoded into properties of molecules. Among the envisioned applications of MC is the localization of molecule sources in pipe networks (PNs) like the human cardiovascular system (CVS), sewage networks (SNs), and industrial plants. While existing algorithms mostly focus on simplified scenarios, in this paper, we propose the first framework for source localization in complex PNs with known topology, by leveraging the mixture of inverse Gaussians for hemodynamic transport (MIGHT) model as a closed-form representation for advection-diffusion-driven MC in PNs. We propose a matched filter (MF)-based approach to identify molecule sources under realistic conditions such as unknown release times, random numbers of released molecules, sensor noise, and limited sensor sampling rate. We apply the algorithm to localize a source of viral markers in a real-world SN and show that the proposed scheme outperforms randomly guessing sources even at low signal-to-noise ratios (SNRs) at the sensor and achieves error-free localization under favorable conditions, i.e., high SNRs and sampling rates. Furthermore, by identifying clusters of frequently confused sources, reliable cluster-level localization is possible at substantially lower SNRs and sampling rates.

eess.SY↗

arXiv2025

Vessel Network Topology in Molecular Communication: Insights from Experiments and Theory

The notion of synthetic molecular communication (MC) refers to the transmission of information via signaling molecules and is foreseen to enable innovative medical applications in the human cardiovascular system (CVS). Crucially, the design of such applications requires accurate and experimentally validated channel models that characterize the propagation of signaling molecules, not just in individual blood vessels, but in complex vessel networks (VNs), as prevalent in the CVS. However, experimentally validated models for MC in VNs remain scarce. To address this gap, we propose a novel channel model for MC in complex VN topologies, which captures molecular transport via advection, molecular and turbulent diffusion, as well as adsorption and desorption at the vessel walls. We specialize this model for superparamagnetic iron-oxide nanoparticles (SPIONs) as signaling molecules by introducing a new receiver (RX) model for planar coil inductive sensors, enabling end-to-end experimental validation with a dedicated SPION testbed. Validation covers a range of channel topologies, from single-vessel topologies to branched VNs with multiple paths between transmitter (TX) and RX. Additionally, to quantify how the VN topology impacts signal quality, and inspired by multi-path propagation models in conventional wireless communications, we introduce two metrics, namely molecule delay and multi-path spread. We show that these metrics link the VN structure to molecule dispersion induced by the VN and mediately to the resulting signal-to-noise ratio (SNR) at the RX. The proposed VN structure-SNR link is validated experimentally, demonstrating that the proposed framework can support tasks such as optimal sensor placement in the CVS or the identification of suitable testbed topologies for specific SNR requirements. All experimental data are openly available on Zenodo.

q-bio.QM↗

arXiv2025

Mixture of Inverse Gaussians for Hemodynamic Transport (MIGHT) in Multiple-Input Multiple-Output Vascular Networks

Synthetic molecular communication (MC) in the cardiovascular system is a key enabler for many envisioned medical applications inside the human body, such as targeted drug delivery, early disease detection, and continuous health monitoring. The design of synthetic MC systems for such applications requires suitable models for the signaling molecule propagation through complex vessel networks (VNs). Existing theoretical models offer limited analytical tractability and lack closed-form solutions, making the analysis of realistic large-scale VNs either infeasible or not insightful. To overcome these limitations, in this paper, we propose a novel closed-form physical model, termed mixture of inverse Gaussians for hemodynamic transport (MIGHT), for the advection-diffusion-driven transport of signaling molecules through complex VNs. The model represents the received molecule flux as a weighted sum of inverse Gaussian distributions, parameterized by the physical properties of the underlying VN. We show that MIGHT is capable of accurately representing the transport dynamics of signaling molecules in large-scale VNs ranging from simple single-input single-output (SISO) to complex multiple-input multiple-output (MIMO) network topologies. The accuracy of the proposed model is validated by comparison to the results from an existing convolution-based model and numerical finite-element simulations, with all finite-element simulation data available on Zenodo. Furthermore, we investigate three applications of the model, namely the reduction of SISO-VNs to obtain simplified representations preserving the essential transport dynamics, the identification and analysis of network regions that are most important for molecule transport in MIMO-VNs comprising multiple transmitters and multiple receivers, and the estimation of representative SISO-VNs that can reproduce the received signal of an unknown SISO-VN.

q-bio.QM↗

arXiv2025

Closed-Loop Molecular Communication with Local and Global Degradation: Modeling and ISI Analysis

This paper presents a novel physics-based model for signal propagation in closed-loop molecular communication (MC) systems, which are particularly relevant for many envisioned biomedical applications, such as health monitoring or drug delivery within the closed-loop human cardiovascular system (CVS). Compared to open-loop systems, which are mostly considered in MC, closed-loop systems exhibit different characteristic effects influencing signaling molecule (SM) propagation. One key phenomenon are the periodic SM arrivals at the receiver (RX), leading to various types of inter-symbol interference (ISI) inherent to closed-loop system. To capture these characteristic effects, we propose an analytical model for the SM propagation inside closed-loop systems. The model accounts for arbitrary spatio-temporal SM release patterns at the transmitter (TX), and incorporates several environmental effects such as fluid flow, SM diffusion, and SM degradation. Moreover, to capture a wide range of practically relevant degradation and clearance mechanisms, the model includes both local removal (e.g., due to SM absorption into organs) and global removal (e.g., due to chemical degradation) of SMs. The accuracy of the proposed model is validated with three-dimensional (3-D) particle-based simulations (PBSs). Moreover, we utilize the proposed model to develop a rigorous characterization of the various types of ISI encountered in closed-loop MC systems.

eess.SY↗

arXiv2024

Molecular Signal Reception in Complex Vessel Networks: The Role of the Network Topology

The notion of synthetic molecular communication (MC) refers to the transmission of information via molecules and is largely foreseen for use within the human body, where traditional electromagnetic wave (EM)-based communication is impractical. MC is anticipated to enable innovative medical applications, such as early-stage tumor detection, targeted drug delivery, and holistic approaches like the Internet of Bio-Nano Things (IoBNT). Many of these applications involve parts of the human cardiovascular system (CVS), here referred to as networks, posing challenges for MC due to their complex, highly branched vessel structures. To gain a better understanding of how the topology of such branched vessel networks affects the reception of a molecular signal at a target location, e.g., the network outlet, we present a generic analytical end-to-end model that characterizes molecule propagation and reception in linear branched vessel networks (LBVNs). We specialize this generic model to any MC system employing superparamagnetic iron-oxide nanoparticles (SPIONs) as signaling molecules and a planar coil as receiver (RX). By considering components that have been previously established in testbeds, we effectively isolate the impact of the network topology and validate our theoretical model with testbed data. Additionally, we propose two metrics, namely the molecule delay and the multi-path spread, that relate the LBVN topology to the molecule dispersion induced by the network, thereby linking the network structure to the signal-to-noise ratio (SNR) at the target location. This allows the characterization of the SNR at any point in the network solely based on the network topology. Consequently, our framework can, e.g., be exploited for optimal sensor placement in the CVS or identification of suitable testbed topologies for given SNR requirements.

cs.ET↗