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Timothy Kassis

Publications and source records attributed to Timothy Kassis.

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mimeo: Compiling Public Expert Corpora into Agent Skills and Testing What Transfers

Giving an agent a file about a named expert can supply hard-to-find material, produce a recognizable persona, or change what the agent decides. These are different claims. We test each one. mimeo is an open-source tool that finds a person's public work, checks each extracted quotation against the cached source text, and writes a file an agent can load. Eight logged builds averaged 38 model calls; the check rejects 13.2% of extracted quotations. We tested four expert files with one coding-agent harness. Knowledge access was clearest: mimeo answered all 20 obscure, quotation-heavy questions; no closed-book condition answered more than 10. Keyword search (BM25) over the same pages answered 15-17, a gap this sample cannot resolve. Grounding showed one clear benefit: personas written from model memory misstated a documented position on 1-4 of 20 answers under every grader; the plain agent and mimeo never did. Every persona was easy to spot on short open prompts, and adding task material lowered identification by 18-23 points. mimeo was no more identifiable than a from-memory profile. Judgment transfer remained unresolved because both tests hit their ceiling: every condition found 94-97% of the problems planted in engineering tasks and scored 94-100% on 16 new application scenarios. An AI-judged "sounds like the expert" score changed with the judge: two of four preferred answers based on a model's stereotype, while two found no difference on the same text. That is a caution against relying on a single AI judge. The evidence supports mimeo as a compact, inspectable reference on a person, not as a demonstrated transfer of their judgment. Toolkit and expert profiles: https://github.com/K-Dense-AI/mimeo

cs.AI

Scientific Agent Skills: A Library of Procedural Knowledge for Research Agents

A language-model agent asked to analyse an experiment will usually return working code. Whether the analysis is defensible is a different question. A defensible analysis depends on procedural choices: which test the field accepts, which identifier namespace is authoritative, and which caveats must accompany a result. We present Scientific Agent Skills, an open library of 163 such procedures in 16 areas of practice, including genomics, cheminformatics, medical imaging, study design and scientific communication. Each skill is a directory built around a versioned, human-readable instruction file. An agent loads the file only when a task calls for it; the directory often also contains reference material and runnable scripts. We report no task-level evaluation and no host selection rate. We measure two properties of the documentation corpus: the always-resident descriptions of all 163 skills cost 7.1% of a 200,000-token window, and the median documented workflow fits within 23.9% of it, although 29 of 46 would overflow if every reference file were loaded. Openly licensed and available at https://github.com/K-Dense-AI/scientific-agent-skills.

cs.CL

K-Bench: measuring model performance on real scientific agent requests

Benchmarks for scientific artificial intelligence are mostly written to be scored: multiple-choice questions, curated agent tasks with reference solutions, or simulators with a known generative structure. Real scientific requests arrive differently. They are underspecified, they carry attachments, and they lack ground truth. We report K-Bench 01, an evaluation built from first-turn requests sampled from live user traffic on K-Dense Web and run end to end by nine frontier models in identical sandboxes, yielding 1,602 completed agent runs. Three blinded language-model judges scored every run against an eight-dimension rubric. On a rubric whose 8-anchor is defined as work a domain scientist would accept with minor edits, no model clears the line under all three judges. gpt-5.6-sol has the highest pooled mean, 8.04, but its 95% interval [7.80, 8.23] spans the threshold, and two of the three judges rank claude-opus-5 first instead. We therefore report the ordering of systems as the reproducible quantity, the absolute level as an attribute of the instrument, and the top of the table as unresolved. Across all 39,934 scored judgments -- the eight dimension scores plus a holistic overall for each assessment, excluding not-applicable cells -- 47.6% fall below the 8-point threshold. Difficulty is not uniform across the rubric: scientific accuracy averages 6.22 against 7.33 for communication, on identical denominators and in the same direction within every one of the nine models. The single leading failure tag is overclaiming, on 31.4% of assessments. We argue that the informative quantity for scientific agents is not a leaderboard position but the joint distribution of what was delivered, what was claimed, and what artifacts were produced.

cs.AI

K-Dense Analyst: Towards Fully Automated Scientific Analysis

The complexity of modern bioinformatics analysis has created a critical gap between data generation and developing scientific insights. While large language models (LLMs) have shown promise in scientific reasoning, they remain fundamentally limited when dealing with real-world analytical workflows that demand iterative computation, tool integration and rigorous validation. We introduce K-Dense Analyst, a hierarchical multi-agent system that achieves autonomous bioinformatics analysis through a dual-loop architecture. K-Dense Analyst, part of the broader K-Dense platform, couples planning with validated execution using specialized agents to decompose complex objectives into executable, verifiable tasks within secure computational environments. On BixBench, a comprehensive benchmark for open-ended biological analysis, K-Dense Analyst achieves 29.2% accuracy, surpassing the best-performing language model (GPT-5) by 6.3 percentage points, representing nearly 27% improvement over what is widely considered the most powerful LLM available. Remarkably, K-Dense Analyst achieves this performance using Gemini 2.5 Pro, which attains only 18.3% accuracy when used directly, demonstrating that our architectural innovations unlock capabilities far beyond the underlying model's baseline performance. Our insights demonstrate that autonomous scientific reasoning requires more than enhanced language models, it demands purpose-built systems that can bridge the gap between high-level scientific objectives and low-level computational execution. These results represent a significant advance toward fully autonomous computational biologists capable of accelerating discovery across the life sciences.

cs.AI