arXiv subjects

Tingting Hou

Publications and source records attributed to Tingting Hou.

3 recordsLinked to original sources

arXiv2026

Hyperon-Nucleon Spectrometer

Chirality lies at the heart of low-energy QCD, governing the symmetry structure that shapes hadron masses and strong interaction dynamics. Among the most compelling open questions tied to chiral dynamics and spontaneous chiral symmetry breaking is the longstanding $Λ$ polarization puzzle, in which $Λ$ hyperons produced in unpolarized hadronic collisions exhibit a surprisingly large transverse polarization that remains theoretically unexplained. This whitepaper presents the proposal for the Hyperon-Nucleon Spectrometer (H-NS) at the High-Intensity heavy-ion Accelerator Facility (HIAF). Leveraging the high energy and high intensity of HIAF's proton and heavy-ion beams, the H-NS experiment will perform systematic studies of hyperon polarization phenomena and their underlying mechanisms in proton-proton ($pp$), proton-nucleus ($pA$), and nucleus-nucleus ($AA$) collisions in the fixed target mode. A wide-range beam energy scan, including proton beams from 3 GeV up to 9.3 GeV (HIAF) and up to 32 GeV (upgraded HIAF), will be conducted to examine the dependence of polarization on collision energy. The spectrometer is designed with specialized detectors capable of high-precision reconstruction of final-state baryon polarizations. Among its many interesting and important measurements, H-NS will simultaneously measure hyperon and proton spin observables to explore the polarization mechanism in hadronic interactions and the spin structure of baryons. Furthermore, the use of $pA$ and $AA$ collisions will enable detailed investigations of cold and hot nuclear matter effects on spin polarization. Its physics program and detector development will significantly benefit the future Electron-ion Collider in China.

physics.ins-det↗

arXiv2023

A Kernel-Based Neural Network Test for High-dimensional Sequencing Data Analysis

The recent development of artificial intelligence (AI) technology, especially the advance of deep neural network (DNN) technology, has revolutionized many fields. While DNN plays a central role in modern AI technology, it has been rarely used in sequencing data analysis due to challenges brought by high-dimensional sequencing data (e.g., overfitting). Moreover, due to the complexity of neural networks and their unknown limiting distributions, building association tests on neural networks for genetic association analysis remains a great challenge. To address these challenges and fill the important gap of using AI in high-dimensional sequencing data analysis, we introduce a new kernel-based neural network (KNN) test for complex association analysis of sequencing data. The test is built on our previously developed KNN framework, which uses random effects to model the overall effects of high-dimensional genetic data and adopts kernel-based neural network structures to model complex genotype-phenotype relationships. Based on KNN, a Wald-type test is then introduced to evaluate the joint association of high-dimensional genetic data with a disease phenotype of interest, considering non-linear and non-additive effects (e.g., interaction effects). Through simulations, we demonstrated that our proposed method attained higher power compared to the sequence kernel association test (SKAT), especially in the presence of non-linear and interaction effects. Finally, we apply the methods to the whole genome sequencing (WGS) dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, investigating new genes associated with the hippocampal volume change over time.

stat.ML↗

arXiv2023

An Association Test Based on Kernel-Based Neural Networks for Complex Genetic Association Analysis

The advent of artificial intelligence, especially the progress of deep neural networks, is expected to revolutionize genetic research and offer unprecedented potential to decode the complex relationships between genetic variants and disease phenotypes, which could mark a significant step toward improving our understanding of the disease etiology. While deep neural networks hold great promise for genetic association analysis, limited research has been focused on developing neural-network-based tests to dissect complex genotype-phenotype associations. This complexity arises from the opaque nature of neural networks and the absence of defined limiting distributions. We have previously developed a kernel-based neural network model (KNN) that synergizes the strengths of linear mixed models with conventional neural networks. KNN adopts a computationally efficient minimum norm quadratic unbiased estimator (MINQUE) algorithm and uses KNN structure to capture the complex relationship between large-scale sequencing data and a disease phenotype of interest. In the KNN framework, we introduce a MINQUE-based test to assess the joint association of genetic variants with the phenotype, which considers non-linear and non-additive effects and follows a mixture of chi-square distributions. We also construct two additional tests to evaluate and interpret linear and non-linear/non-additive genetic effects, including interaction effects. Our simulations show that our method consistently controls the type I error rate under various conditions and achieves greater power than a commonly used sequence kernel association test (SKAT), especially when involving non-linear and interaction effects. When applied to real data from the UK Biobank, our approach identified genes associated with hippocampal volume, which can be further replicated and evaluated for their role in the pathogenesis of Alzheimer's disease.

q-bio.QM↗