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Tingting Zhu

Publications and source records attributed to Tingting Zhu.

At least 19 recordsLinked to original sources
arXiv2026

Rethinking Correctness for Uncertainty Estimation in Clinical Prediction with Vision-Language Models

Vision-language models are increasingly explored for clinical prediction from electronic health records and medical images, where identifying unreliable predictions is important for safe deployment. Uncertainty estimation (UE) enables detecting such predictions, but its evaluation depends on a correctness criterion that determines whether each model output is correct. If this criterion disagrees with human judgement or distorts downstream UE performance, conclusions about model reliability can be misleading. We introduce a two-axis framework that evaluates correctness criteria by their agreement with human judgements and fidelity to human-referenced UE performance. We assess eight criteria across three clinical prediction tasks and three models using 450 predictions annotated by two reviewers. Across the audited tasks, canonical exact matching (EM) achieved the highest observed human agreement and lowest UE distortion, while the BERT-based matching (BEM) and LLM-judge also showed strong human agreement. Across four UE methods and 23,254 clinical predictions, criterion choice changed error-detection AUROC by up to 0.146 and reversed the relative ranking of UE methods. The LLM-judge also selectively accepted invalid or uncertain outputs, accepting 16 of 30 such human-identified errors. These results demonstrate that correctness assessment is an integral component of clinical UE evaluation and should be validated before UE methods are compared.

cs.LG↗
arXiv2026

RegimeFormer: A Large Protein Model of Global Perturbation Regimes

Protein language models organize sequence and structure at scale, but a global representation of how proteins respond to mutation remains lacking. We present RegimeFormer, a large protein perturbation model coupled to RegimeAtlas, constructed by harmonizing and indexing 202,556,313 non-redundant protein sequences across the tree of life. A diversity-preserving one-million-protein subset provides the high-resolution training and inference layer, with 995,995 proteins yielding residue-level summaries across 407,048,356 residues and substitution-specific predictions available on demand. Across experimental deep mutational scanning, molecular benchmarks, structural confidence and evolutionary constraint, RegimeFormer identifies reproducible protein-level perturbation regimes that organize residue fragility, adaptability and predictive uncertainty. Regime conditioning improves substitution-specific prediction, with the largest relative gains under unseen-protein, unseen-family and low-homology evaluation. RegimeFormer-derived molecular priors further improve downstream transcriptomic and drug-response modelling. Together, RegimeFormer and RegimeAtlas provide a scalable framework for mapping, predicting and querying protein perturbation landscapes across global sequence space.

q-bio.QM↗
arXiv2026

Why Not Hyperparameter-Friendly Optimisation? A Monotonic Adaptive Norm Rescaling Approach For Long-Tailed Recognition

Long-tailed recognition poses a significant challenge for deep learning. The two-stage decoupling paradigm, which separates representation learning from classifier retraining, offers a promising solution. During the classifier retraining stage, adaptive norm rescaling is a popular technique. It adjusts the per-class weight norms via parameter regularization, which inevitably introduces hyperparameters. However, many studies report that long-tailed recognition is sensitive to these hyperparameters, as their setup significantly impacts performance. In this paper, we first provide a class-conditional distribution perspective to support norm rescaling methods. Furthermore, we propose a simple but effective approach called Self-Adaptive Monotonic Normalization (SAMN). SAMN avoids the need for parameter regularization. It directly enforces monotonicity on per-class weight norms using the Pool Adjacent Violators Algorithm, making the method hyperparameter-friendly. SAMN is a universal strategy that integrates seamlessly with other methods for enhanced performance. Experiments on benchmark datasets demonstrate that our method significantly boosts long-tailed recognition performance, often achieving state-of-the-art results.

cs.CV↗
arXiv2026

ECG-WM: A Physiology-Informed ECG World Model for Clinical Intervention Simulation

Electrocardiogram (ECG)-based models have achieved strong performance in diagnostic tasks, yet they remain limited in modeling how cardiac dynamics evolve under external interventions. In particular, existing approaches focus primarily on static prediction and lack mechanisms to capture ECG variations under different pharmacological conditions. In this work, we propose an ECG World Model for action-conditioned predictive simulation of cardiac electrophysiology. Moving beyond disjoint pipelines, our framework features a principled integration of physiological ordinary differential equation (ODE) priors into latent diffusion dynamics via energy regularization. This structural constraint enables the synthesis of physiologically plausible post-intervention ECG trajectories while effectively mitigating generative hallucinations. Building on this simulation process, we introduce an uncertainty-aware evaluation strategy that leverages the stochasticity of diffusion sampling to characterize both the expected clinical risk and its variability, allowing a more reliable comparative assessment of candidate interventions. We evaluate our method across diverse settings, including controlled drug-response scenarios and real-world clinical records. Beyond standard waveform metrics, experimental results demonstrate improved risk calibration and strong alignment with expert-informed treatment preferences. These results establish our approach as a robust foundation for safe and intervention-aware clinical decision support.

cs.AI↗
arXiv2026

SurvBench: A Standardised Preprocessing Pipeline for Multi-Modal Electronic Health Record Survival Analysis

Deep-learning survival models for electronic health record (EHR) data are hard to compare across papers because the upstream preprocessing step, which includes cohort definition, time discretisation, missingness handling, and censoring rules, is typically undocumented and inconsistent. A reported difference in concordance between two mortality models can therefore reflect any of these choices rather than a modelling contribution. We present SurvBench, an open-source preprocessing pipeline that converts raw PhysioNet exports into model-ready tensors for survival analysis. SurvBench covers four critical-care databases (MIMIC-IV, eICU, MC-MED, HiRID) and four input modalities: time-series vitals and laboratory values, static demographics, International Classification of Diseases (ICD) codes, and radiology report embeddings. Every preprocessing decision is controlled through YAML configuration. Imputation, scaling, and feature filtering are fit on the training fold only. Missingness is recorded as a binary mask alongside each feature tensor. The pipeline handles single-risk endpoints (in-hospital and in-ICU mortality) and competing-risks endpoints (a three-way emergency-department admission pathway, with home discharge treated as administrative censoring). We also provide support for harmonised cross-dataset external validation between eICU and MIMIC-IV. SurvBench is publicly available at https://github.com/munibmesinovic/SurvBench, providing a robust platform that future deep-learning EHR survival work, especially nascent multi-modal approaches, can be measured against under matched preprocessing.

cs.LG↗
arXiv2026

From Token to Token Pair: Efficient Prompt Compression for Large Language Models in Clinical Prediction

By processing electronic health records (EHRs) as natural language sequences, large language models (LLMs) have shown potential in clinical prediction tasks such as mortality prediction and phenotyping. However, longitudinal or highly frequent EHRs often yield excessively long token sequences that result in high computational costs and even reduced performance. Existing solutions either add modules for compression or remove less important tokens, which introduce additional inference latency or risk losing clinical information. To achieve lossless compression of token sequences without additional cost or loss of performance, we propose Medical Token-Pair Encoding (MedTPE), a layered method that extends standard tokenisation for EHR sequences. MedTPE merges frequently co-occurring medical token pairs into composite tokens, providing lossless compression while preserving the computational complexity through a dependency-aware replacement strategy. Only the embeddings of the newly introduced tokens of merely 0.5-1.0% of the LLM's parameters are fine-tuned via self-supervised learning. Experiments on real-world datasets for two clinical scenarios demonstrate that MedTPE reduces input token length by up to 31% and inference latency by 34-63%, while maintaining or even improving both predictive performance and output format compliance across multiple LLMs and four clinical prediction tasks. Furthermore, MedTPE demonstrates robustness across different input context lengths and generalisability to scientific and financial domains and different languages.

cs.CL↗
arXiv2026

Towards Generation-Efficient Uncertainty Estimation in Large Language Models

Uncertainty estimation is important for deploying LLMs in high-stakes applications such as healthcare and finance, where hallucinations can appear fluent and plausible while being factually incorrect, making it difficult for users to judge whether an output should be trusted. Existing methods require one or more full autoregressive generations to estimate uncertainty, which introduces substantial inference cost and often delays uncertainty assessment. In this paper, we investigate whether effective uncertainty estimation can be achieved with partial generation or even input-only information. Specifically, we first develop a unified framework that formulates uncertainty estimation as an early estimation problem over the autoregressive generation process of LLMs. This framework organises existing and proposed estimators by the information they observe, ranging from multi-generation to input-only prediction, and clarifies the performance-cost trade-off underlying different uncertainty estimation methods. Building on this view, we study two largely underexplored low-cost settings: estimating uncertainty with part of the generation, and predicting uncertainty from the input prompt. We propose Logit Magnitude, which uses top-M logit evidence to estimate uncertainty from an early-stopped generation prefix, and MetaUE, which distils generation-based uncertainty into a lightweight input-only estimator trained with uncertainty scores. Extensive experiments on general and domain-specific benchmarks show that Logit Magnitude achieves strong performance, and partial generations of LLMs are often sufficient for effective uncertainty estimation. MetaUE further provides a competitive input-only approximation in several settings. These findings suggest that effective uncertainty estimation requires less generation than commonly assumed, enabling unreliable responses to be identified earlier.

cs.LG↗
arXiv2026

Causal Graph Neural Networks for Healthcare

Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from learning statistical associations rather than causal mechanisms. Causal graph neural networks address this by combining graph-based representations of biomedical data with causal inference to learn invariant mechanisms instead of just spurious correlations. This Perspective reviews the methodology of structural causal models, disentangled causal representation learning, and techniques for interventional prediction and counterfactual reasoning on graphs. We discuss applications across psychiatric diagnosis and brain network analysis, cancer subtyping with multi-omics causal integration, continuous physiological monitoring, and drug recommendations. These methods provide building blocks for patient-specific Causal Digital Twins that could support in silico clinical experimentation. Remaining challenges include computational costs that preclude real-time deployment, validation challenges that go beyond standard cross-validation, and the risk of causal-washing where methods adopt causal terminology without rigorous evidentiary support. We propose a tiered framework distinguishing causally-inspired architectures from causally-validated discoveries and outline future directions, including scalable causal discovery, multi-modal data integration, and regulatory pathways for these methods. Making practical Causal Digital Twins possible will require an honest assessment of what current methods deliver, sustained collaboration across disciplines, and validation standards that match the strength of the causal claims being made.

cs.LG↗
arXiv2026

The Taxonomies, Training, and Applications of Event Stream Modelling for Electronic Health Records

The widespread adoption of electronic health records (EHRs) enables the acquisition of heterogeneous clinical data, spanning lab tests, vital signs, medications, and procedures, which offer transformative potential for artificial intelligence in healthcare. Although traditional modelling approaches have typically relied on multivariate time series, they often struggle to accommodate the inherent sparsity and irregularity of real-world clinical workflows. Consequently, research has shifted toward event stream representation, which treats patient records as continuous sequences, thereby preserving the precise temporal structure of the patient journey. However, the existing literature remains fragmented, characterised by inconsistent definitions, disparate modelling architectures, and varying training protocols. To address these gaps, this review establishes a unified definition of EHR event streams and introduces a novel taxonomy that categorises models based on their handling of event time, type, and value. We systematically review training strategies, ranging from supervised learning to self-supervised methods, and provide a comprehensive discussion of applications across clinical scenarios. Finally, we identify open critical challenges and future directions, with the aim of clarifying the current landscape and guiding the development of next-generation healthcare models.

eess.SP↗
arXiv2026

From Toil to Thought: Designing for Strategic Exploration and Responsible AI in Systematic Literature Reviews

Systematic Literature Reviews (SLRs) are fundamental to scientific progress, yet the process is hindered by a fragmented tool ecosystem that imposes a high cognitive load. This friction suppresses the iterative, exploratory nature of scholarly work. To investigate these challenges, we conducted an exploratory design study with 20 experienced researchers. This study identified key friction points: 1) the high cognitive load of managing iterative query refinement across multiple databases, 2) the overwhelming scale and pace of publication of modern literature, and 3) the tension between automation and scholarly agency. Informed by these findings, we developed ARC, a design probe that operationalizes solutions for multi-database integration, transparent iterative search, and verifiable AI-assisted screening. A comparative user study with 8 researchers suggests that an integrated environment facilitates a transition in scholarly work, moving researchers from managing administrative overhead to engaging in strategic exploration. By utilizing external representations to scaffold strategic exploration and transparent AI reasoning, our system supports verifiable judgment, aiming to augment expert contributions from initial creation through long-term maintenance of knowledge synthesis.

cs.HC↗
arXiv2026

Standing on the Shoulders of Giants: Rethinking EEG Foundation Model Pretraining via Multi-Teacher Distillation

Pretraining for electroencephalogram (EEG) foundation models has predominantly relied on self-supervised masked reconstruction, a paradigm largely adapted from and inspired by the success of vision and language foundation models. However, unlike images and text, EEG datasets are notoriously expensive to collect and characterized by low signal-to-noise ratio. These challenges introduce difficulties in scaling the EEG foundation models and capturing the underlying neural semantics through reconstruction. In this work, we ask the question: can we stand on the shoulders of well-established foundation models from well-represented modalities to bootstrap the pretraining of EEG foundation models? We first demonstrate that mainstream foundation models, such as those from vision and time series, transfer surprisingly well to EEG domain. To this end, we propose the Multi-Teacher Distillation Pretraining (MTDP) framework for pretraining EEG foundation models via a two-stage multi-teacher distillation. In the first stage, we introduce a learnable gating network to fuse representations from diverse teachers (e.g., DINOv3 and Chronos) via a masked latent denoising objective. In the second stage, we distill the fused representation into an EEG foundation model. Extensive evaluations across 9 downstream tasks and 12 datasets demonstrate that our MTDP-based EEG foundation model outperforms its self-supervised counterparts while requiring only 25% of the pretraining data.

cs.LG↗
arXiv2026

BioX-Bridge: Model Bridging for Unsupervised Cross-Modal Knowledge Transfer across Biosignals

Biosignals offer valuable insights into the physiological states of the human body. Although biosignal modalities differ in functionality, signal fidelity, sensor comfort, and cost, they are often intercorrelated, reflecting the holistic and interconnected nature of human physiology. This opens up the possibility of performing the same tasks using alternative biosignal modalities, thereby improving the accessibility, usability, and adaptability of health monitoring systems. However, the limited availability of large labeled datasets presents challenges for training models tailored to specific tasks and modalities of interest. Unsupervised cross-modal knowledge transfer offers a promising solution by leveraging knowledge from an existing modality to support model training for a new modality. Existing methods are typically based on knowledge distillation, which requires running a teacher model alongside student model training, resulting in high computational and memory overhead. This challenge is further exacerbated by the recent development of foundation models that demonstrate superior performance and generalization across tasks at the cost of large model sizes. To this end, we explore a new framework for unsupervised cross-modal knowledge transfer of biosignals by training a lightweight bridge network to align the intermediate representations and enable information flow between foundation models and across modalities. Specifically, we introduce an efficient strategy for selecting alignment positions where the bridge should be constructed, along with a flexible prototype network as the bridge architecture. Extensive experiments across multiple biosignal modalities, tasks, and datasets show that BioX-Bridge reduces the number of trainable parameters by 88--99\% while maintaining or even improving transfer performance compared to state-of-the-art methods.

cs.AI↗
arXiv2026

Navigating the Ethical and Societal Impacts of Generative AI in Higher Computing Education

Generative AI (GenAI) presents societal and ethical challenges related to equity, academic integrity, bias, and data provenance. In this paper, we outline the goals, methodology and deliverables of their collaborative research, considering the ethical and societal impacts of GenAI in higher computing education. A systematic literature review that addresses a wide set of issues and topics covering the rapidly emerging technology of GenAI from the perspective of its ethical and societal impacts is presented. This paper then presents an evaluation of a broad international review of a set of university adoption, guidelines, and policies related to the use of GenAI and the implications for computing education. The Ethical and Societal Impacts-Framework (ESI-Framework), derived from the literature and policy review and evaluation, outlines the ethical and societal impacts of GenAI in computing education. This work synthesizes existing research and considers the implications for computing higher education. Educators, computing professionals and policy makers facing dilemmas related to the integration of GenAI in their respective contexts may use this framework to guide decision-making in the age of GenAI.

cs.CY↗
arXiv2026

VQ-DSC-R: Robust Vector Quantized-Enabled Digital Semantic Communication With OFDM Transmission

Digital mapping of semantic features is essential for achieving interoperability between semantic communication and practical digital infrastructure. However, current research efforts predominantly concentrate on analog semantic communication with simplified channel models. To bridge these gaps, we develop a robust vector quantized-enabled digital semantic communication (VQ-DSC-R) system built upon orthogonal frequency division multiplexing (OFDM) transmission. Our work encompasses the framework design of VQ-DSC-R, followed by a comprehensive optimization study. Firstly, we design a Swin Transformer-based backbone for hierarchical semantic feature extraction, integrated with VQ modules that map the features into a shared semantic quantized codebook (SQC) for efficient index transmission. Secondly, we propose a differentiable vector quantization with adaptive noise-variance (ANDVQ) scheme to mitigate quantization errors in SQC, which dynamically adjusts the quantization process using K-nearest neighbor statistics, while exponential moving average mechanism stabilizes SQC training. Thirdly, for robust index transmission over multipath fading channel and noise, we develop a conditional diffusion model (CDM) to refine channel state information, and design an attention-based module to dynamically adapt to channel noise. The entire VQ-DSC-R system is optimized via a three-stage training strategy. Extensive experiments demonstrate superiority of VQ-DSC-R over benchmark schemes, achieving high compression ratios and robust performance in practical scenarios.

cs.IT↗
arXiv2026

SliceGX: Layer-wise GNN Explanation with Model-slicing

Ensuring the trustworthiness of graph neural networks (GNNs), which are often treated as black-box models, requires effective explanation techniques. Existing GNN explanations typically apply input perturbations to identify subgraphs that are responsible for the occurrence of the final output of GNNs. However, such approaches lack finer-grained, layer-wise analysis of how intermediate representations contribute to the final result, capabilities that are crucial for model diagnosis and architecture optimization. This paper introduces SliceGX, a novel GNN explanation approach that generates explanations at specific GNN layers in a progressive manner. Given a GNN model M, a set of selected intermediate layers, and a target layer, SliceGX slices M into layer blocks("model slice") and discovers high-quality explanatory subgraphs within each block that elucidate how the model output arises at the target layer. Although finding such layer-wise explanations is computationally challenging, we develop efficient algorithms and optimization techniques that incrementally construct and maintain these subgraphs with provable approximation guarantees. Extensive experiments on synthetic and real-world benchmarks demonstrate the effectiveness and efficiency of SliceGX, and illustrate its practical utility in supporting model debugging.

cs.LG↗
arXiv2026

From Generative Engines to Actionable Simulators: The Imperative of Physical Grounding in World Models

A world model is an AI system that simulates how an environment evolves under actions, enabling planning through imagined futures rather than reactive perception. Current world models, however, suffer from visual conflation: the mistaken assumption that high-fidelity video generation implies an understanding of physical and causal dynamics. We show that while modern models excel at predicting pixels, they frequently violate invariant constraints, fail under intervention, and break down in safety-critical decision-making. This survey argues that visual realism is an unreliable proxy for world understanding. Instead, effective world models must encode causal structure, respect domain-specific constraints, and remain stable over long horizons. We propose a reframing of world models as actionable simulators rather than visual engines, emphasizing structured 4D interfaces, constraint-aware dynamics, and closed-loop evaluation. Using medical decision-making as an epistemic stress test, where trial-and-error is impossible and errors are irreversible, we demonstrate that a world model's value is determined not by how realistic its rollouts appear, but by its ability to support counterfactual reasoning, intervention planning, and robust long-horizon foresight.

cs.AI↗
arXiv2025

From Coefficients to Directions: Rethinking Model Merging with Directional Alignment

Model merging has emerged as a practical paradigm for integrating multiple independently trained models into a single model without joint retraining. Previous studies have demonstrated the effectiveness of combining parameters through strategies such as parameter decomposition, coefficient optimization, and subspace learning, significantly reducing the need for expensive joint training and achieving strong empirical performance across diverse tasks. However, these approaches predominantly treat merging as a problem of parameter space decomposition or fusion coefficient optimization, while overlooking the critical role of directional information in both parameter and feature spaces. In practice, naïve merging introduces inconsistencies in dominant parameter directions and disrupts structural coherence across models, which can degrade performance. Moreover, coefficient-based optimization methods implicitly assume compatible feature-space directions across models. However, Neural Collapse indicates that class features follow structured directional patterns, which may differ across independently trained models, making coefficient optimization alone insufficient. In this work, we emphasize the importance of \emph{directional alignment} and introduce a unified geometric framework, \emph{Merging with Directional Alignment} (\method{}), which aligns directional structures consistently in both the parameter and feature spaces. Our analysis shows that directional alignment improves structural coherence, and extensive experiments across benchmarks, model scales, and task configurations further validate the effectiveness of our approach.

cs.LG↗
arXiv2025

Attention-Guided Fair AI Modeling for Skin Cancer Diagnosis

Artificial intelligence (AI) has shown remarkable promise in dermatology, offering accurate and non-invasive diagnosis of skin cancer. While extensive research has addressed skin tone-related bias, gender bias in dermatologic AI remains underexplored, leading to unequal care and reinforcing existing gender disparities. In this study, we developed LesionAttn, a fairness-aware algorithm that integrates clinical knowledge into model design by directing attention toward lesion regions, mirroring the diagnostic focus of clinicians. Combined with Pareto-frontier optimization for dual-objective model selection, LesionAttn balances fairness and predictive accuracy. Validated on two large-scale dermatological datasets, LesionAttn significantly mitigates gender bias while maintaining high diagnostic performance, outperforming existing bias mitigation algorithms. Our study highlights the potential of embedding clinical knowledge into AI development to advance both model performance and fairness, and further to foster interdisciplinary collaboration between clinicians and AI developers.

eess.IV↗