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Tomas Woodgate

Publications and source records attributed to Tomas Woodgate.

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SPARC: Slice-to-volume Pipeline for Automated Reconstruction of gated 3D+time fetal Cardiac MRI

Fetal cardiac MRI (fCMR) provides valuable diagnostic information complementary to echocardiography, particularly for complex congenital heart disease (CHD). Dynamic cine imaging captures cardiac motion essential for assessment of cardiac function; however, the reconstruction of 3D+time cine volumes from 2D+time acquired slices remains challenging due to unpredictable fetal motion and the absence of automated and robust processing tools suitable for clinical deployment. We present the SPARC pipeline (Slice-to-volume Pipeline for Automated Reconstruction of gated 3D+time fetal Cardiac MRI) which combines physics-informed slice-to-volume reconstruction (SVR) of Doppler ultrasound (DUS) gated stacks of slices, assisted by deep learning (DL) models for thoracic segmentation and anatomical reorientation. The proposed SVR algorithm achieves a tenfold reduction in reconstruction time relative to existing frame-wise approaches ($4.8 \pm 1.0$ vs $49.0 \pm 14.1$ min, $p < 0.0001$) while improving the reconstruction quality. Thoracic segmentation performance using ensemble aggregation exceeded inter-rater agreement (Dice $84.7 \pm 3.9\%$ vs $81.4 \pm 7.7\%$, $p<0.05$), while anatomical reorientation achieved a success rate of $90.1\%$. End-to-end evaluation on a large held-out clinical cohort ($n = 121$) demonstrated fully automatic processing in $82.6\%$ of cases with a mean runtime of $7.1 \pm 1.3$ min, compatible with clinical deployment. The complete SPARC pipeline is publicly available as a Docker container https://hub.docker.com/r/aboutill/sparc and is currently deployed at our institution as a clinical research tool.

cs.CV

Scanner-based real-time automated volumetry reporting of the fetus, amniotic fluid, placenta and umbilical cord for fetal MRI at 0.55T

Purpose: This work aims to enable real-time automated intra-uterine volumetric reporting and fetal weight estimation for fetal MRI, deployed directly on the scanner. Methods: A multi-region segmentation nnUNet was trained on 146 bSSFP images of 73 fetal subjects (coronal and axial orientations) for the parcellation of the fetal head, fetal body, placenta, amniotic fluid and umbilical cord from whole uterus bSSFP stacks. A reporting tool was then developed to integrate the segmentation outputs into an automated report, providing volumetric measurements, fetal weight estimations, and z-score visualisations. The complete pipeline was subsequently deployed on a 0.55T MRI scanner, enabling real-time inference and fully automated reporting in the duration of the acquisition. Results: The segmentation pipeline was quantitatively and retrospectively evaluated on 36 stacks of 18 fetal subjects and demonstrated sufficient performance for all labels, with high scores (>0.98) for the fetus, placenta and amniotic fluid, and 0.91 for the umbilical cord. The prospective evaluation of the scanner deployment step was successfully performed on 50 cases, with the regional volumetric reports available directly on the scanner. Conclusions: This work demonstrated the feasibility of multi-regional intra-uterine segmentation, fetal weight estimation and automated reporting in real-time. This study provides a robust baseline solution for the integration of fully automated scanner-based measurements into fetal MRI reports.

physics.med-ph

AutOmatic floW planning for fetaL MRI (OWL)

Two subsequent deep learning networks, one localizing the fetal chest and one identifying a set of landmarks on a coronal whole-uterus balanced steady-state free precession scan, were trained on 167 and 71 fetal datasets across field strengths, acquisition parameters, and gestational ages and implemented in a real-time setup. Next, a phase-contrast sequence was modified to use the identified landmarks for planning. The OWL pipeline was evaluated retrospectively in 10 datasets and prospectively in 7 fetal subjects (gestational ages between 36+3 and 39+3 weeks). The prospective cases were additionally manually planned to enable direct comparison both qualitatively, by scoring the planning quality, and quantitatively, by comparing the indexed flow measurements. OWL enabled real-time fully automatic planning of the 2D phase-contrast scans in all but one of the prospective participants. The fetal body localization achieved an overall Dice score of 0.94+-0.05 and the cardiac landmark detection accuracy was 5.77+-2.91 mm for the descending aorta, 4.32+-2.44 mm for the spine, and 4.94+-3.82 mm for the umbilical vein. For the prospective cases, overall planning quality was 2.73/4 for the automated scans, compared to 3.0/4 for manual planning, and the flow quantitative evaluation showed a mean difference of -1.8% (range -14.2% to 14.9%) by comparing the indexed flow measurements obtained from gated automatic and manual acquisitions. Real-time automated planning of 2D phase-contrast MRI was effectively accomplished for 2 major vessels of the fetal vasculature. While demonstrated here on 0.55T, the achieved method has wider implications, and training across multiple field strengths enables generalization. OWL thereby presents an important step towards extending access to this modality beyond specialised centres.

physics.med-ph