arXiv subjects

Tong Chen

Publications and source records attributed to Tong Chen.

At least 109 records · Page 6Linked to original sources

arXiv2025

Domain-Adaptive Diagnosis of Lewy Body Disease with Transferability Aware Transformer

Lewy Body Disease (LBD) is a common yet understudied form of dementia that imposes a significant burden on public health. It shares clinical similarities with Alzheimer's disease (AD), as both progress through stages of normal cognition, mild cognitive impairment, and dementia. A major obstacle in LBD diagnosis is data scarcity, which limits the effectiveness of deep learning. In contrast, AD datasets are more abundant, offering potential for knowledge transfer. However, LBD and AD data are typically collected from different sites using different machines and protocols, resulting in a distinct domain shift. To effectively leverage AD data while mitigating domain shift, we propose a Transferability Aware Transformer (TAT) that adapts knowledge from AD to enhance LBD diagnosis. Our method utilizes structural connectivity (SC) derived from structural MRI as training data. Built on the attention mechanism, TAT adaptively assigns greater weights to disease-transferable features while suppressing domain-specific ones, thereby reducing domain shift and improving diagnostic accuracy with limited LBD data. The experimental results demonstrate the effectiveness of TAT. To the best of our knowledge, this is the first study to explore domain adaptation from AD to LBD under conditions of data scarcity and domain shift, providing a promising framework for domain-adaptive diagnosis of rare diseases.

cs.LG↗

arXiv2025

Are Synthetic Videos Useful? A Benchmark for Retrieval-Centric Evaluation of Synthetic Videos

Text-to-video (T2V) synthesis has advanced rapidly, yet current evaluation metrics primarily capture visual quality and temporal consistency, offering limited insight into how synthetic videos perform in downstream tasks such as text-to-video retrieval (TVR). In this work, we introduce SynTVA, a new dataset and benchmark designed to evaluate the utility of synthetic videos for building retrieval models. Based on 800 diverse user queries derived from MSRVTT training split, we generate synthetic videos using state-of-the-art T2V models and annotate each video-text pair along four key semantic alignment dimensions: Object \& Scene, Action, Attribute, and Prompt Fidelity. Our evaluation framework correlates general video quality assessment (VQA) metrics with these alignment scores, and examines their predictive power for downstream TVR performance. To explore pathways of scaling up, we further develop an Auto-Evaluator to estimate alignment quality from existing metrics. Beyond benchmarking, our results show that SynTVA is a valuable asset for dataset augmentation, enabling the selection of high-utility synthetic samples that measurably improve TVR outcomes. Project page and dataset can be found at https://jasoncodemaker.github.io/SynTVA/.

cs.CV↗

arXiv2025

Endo-4DGX: Robust Endoscopic Scene Reconstruction and Illumination Correction with Gaussian Splatting

Accurate reconstruction of soft tissue is crucial for advancing automation in image-guided robotic surgery. The recent 3D Gaussian Splatting (3DGS) techniques and their variants, 4DGS, achieve high-quality renderings of dynamic surgical scenes in real-time. However, 3D-GS-based methods still struggle in scenarios with varying illumination, such as low light and over-exposure. Training 3D-GS in such extreme light conditions leads to severe optimization problems and devastating rendering quality. To address these challenges, we present Endo-4DGX, a novel reconstruction method with illumination-adaptive Gaussian Splatting designed specifically for endoscopic scenes with uneven lighting. By incorporating illumination embeddings, our method effectively models view-dependent brightness variations. We introduce a region-aware enhancement module to model the sub-area lightness at the Gaussian level and a spatial-aware adjustment module to learn the view-consistent brightness adjustment. With the illumination adaptive design, Endo-4DGX achieves superior rendering performance under both low-light and over-exposure conditions while maintaining geometric accuracy. Additionally, we employ an exposure control loss to restore the appearance from adverse exposure to the normal level for illumination-adaptive optimization. Experimental results demonstrate that Endo-4DGX significantly outperforms combinations of state-of-the-art reconstruction and restoration methods in challenging lighting environments, underscoring its potential to advance robot-assisted surgical applications. Our code is available at https://github.com/lastbasket/Endo-4DGX.

cs.CV↗

arXiv2025

Trustworthy Prediction with Gaussian Process Knowledge Scores

Probabilistic models are often used to make predictions in regions of the data space where no observations are available, but it is not always clear whether such predictions are well-informed by previously seen data. In this paper, we propose a knowledge score for predictions from Gaussian process regression (GPR) models that quantifies the extent to which observing data have reduced our uncertainty about a prediction. The knowledge score is interpretable and naturally bounded between 0 and 1. We demonstrate in several experiments that the knowledge score can anticipate when predictions from a GPR model are accurate, and that this anticipation improves performance in tasks such as anomaly detection, extrapolation, and missing data imputation. Source code for this project is available online at https://github.com/KurtButler/GP-knowledge.

stat.ML↗

arXiv2025

SurgSora: Object-Aware Diffusion Model for Controllable Surgical Video Generation

Surgical video generation can enhance medical education and research, but existing methods lack fine-grained motion control and realism. We introduce SurgSora, a framework that generates high-fidelity, motion-controllable surgical videos from a single input frame and user-specified motion cues. Unlike prior approaches that treat objects indiscriminately or rely on ground-truth segmentation masks, SurgSora leverages self-predicted object features and depth information to refine RGB appearance and optical flow for precise video synthesis. It consists of three key modules: (1) the Dual Semantic Injector, which extracts object-specific RGB-D features and segmentation cues to enhance spatial representations; (2) the Decoupled Flow Mapper, which fuses multi-scale optical flow with semantic features for realistic motion dynamics; and (3) the Trajectory Controller, which estimates sparse optical flow and enables user-guided object movement. By conditioning these enriched features within the Stable Video Diffusion, SurgSora achieves state-of-the-art visual authenticity and controllability in advancing surgical video synthesis, as demonstrated by extensive quantitative and qualitative comparisons. Our human evaluation in collaboration with expert surgeons further demonstrates the high realism of SurgSora-generated videos, highlighting the potential of our method for surgical training and education. Our project is available at https://surgsora.github.io/surgsora.github.io.

cs.CV↗

arXiv2025

Lightweight Embeddings with Graph Rewiring for Collaborative Filtering

As recommendation services scale rapidly and their deployment now commonly involves resource-constrained edge devices, GNN-based recommender systems face significant challenges, including high embedding storage costs and runtime latency from graph propagations. Our previous work, LEGCF, effectively reduced embedding storage costs but struggled to maintain recommendation performance under stricter storage limits. Additionally, LEGCF did not address the extensive runtime computation costs associated with graph propagation, which involves heavy multiplication and accumulation operations (MACs). These challenges consequently hinder effective training and inference on resource-constrained edge devices. To address these limitations, we propose Lightweight Embeddings with Rewired Graph for Graph Collaborative Filtering (LERG), an improved extension of LEGCF. LERG retains LEGCFs compositional codebook structure but introduces quantization techniques to reduce the storage cost, enabling the inclusion of more meta-embeddings within the same storage. To optimize graph propagation, we pretrain the quantized compositional embedding table using the full interaction graph on resource-rich servers, after which a fine-tuning stage is engaged to identify and prune low-contribution entities via a gradient-free binary integer programming approach, constructing a rewired graph that excludes these entities (i.e., user/item nodes) from propagating signals. The quantized compositional embedding table with selective embedding participation and sparse rewired graph are transferred to edge devices which significantly reduce computation memory and inference time. Experiments on three public benchmark datasets, including an industry-scale dataset, demonstrate that LERG achieves superior recommendation performance while dramatically reducing storage and computation costs for graph-based recommendation services.

cs.IR↗

arXiv2025

Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension

Peptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generative models have shown great promise in peptide generation. However, several challenges remain in designing effective peptide binders. First, not all residues contribute equally to peptide-target interactions. Second, the generated peptides must adopt valid geometries due to the constraints of peptide bonds. Third, realistic tasks for peptide drug development are still lacking. To address these challenges, we introduce PepHAR, a hot-spot-driven autoregressive generative model for designing peptides targeting specific proteins. Building on the observation that certain hot spot residues have higher interaction potentials, we first use an energy-based density model to fit and sample these key residues. Next, to ensure proper peptide geometry, we autoregressively extend peptide fragments by estimating dihedral angles between residue frames. Finally, we apply an optimization process to iteratively refine fragment assembly, ensuring correct peptide structures. By combining hot spot sampling with fragment-based extension, our approach enables de novo peptide design tailored to a target protein and allows the incorporation of key hot spot residues into peptide scaffolds. Extensive experiments, including peptide design and peptide scaffold generation, demonstrate the strong potential of PepHAR in computational peptide binder design. Source code will be available at https://github.com/Ced3-han/PepHAR.

q-bio.BM↗

arXiv2025

Multi-Objective-Guided Discrete Flow Matching for Controllable Biological Sequence Design

Designing biological sequences that satisfy multiple, often conflicting, functional and biophysical criteria remains a central challenge in biomolecule engineering. While discrete flow matching models have recently shown promise for efficient sampling in high-dimensional sequence spaces, existing approaches address only single objectives or require continuous embeddings that can distort discrete distributions. We present Multi-Objective-Guided Discrete Flow Matching (MOG-DFM), a general framework to steer any pretrained discrete flow matching generator toward Pareto-efficient trade-offs across multiple scalar objectives. At each sampling step, MOG-DFM computes a hybrid rank-directional score for candidate transitions and applies an adaptive hypercone filter to enforce consistent multi-objective progression. We also trained two unconditional discrete flow matching models, PepDFM for diverse peptide generation and EnhancerDFM for functional enhancer DNA generation, as base generation models for MOG-DFM. We demonstrate MOG-DFM's effectiveness in generating peptide binders optimized across five properties (hemolysis, non-fouling, solubility, half-life, and binding affinity), and in designing DNA sequences with specific enhancer classes and DNA shapes. In total, MOG-DFM proves to be a powerful tool for multi-property-guided biomolecule sequence design.

cs.LG↗

arXiv2025

Ultra Lowrate Image Compression with Semantic Residual Coding and Compression-aware Diffusion

Existing multimodal large model-based image compression frameworks often rely on a fragmented integration of semantic retrieval, latent compression, and generative models, resulting in suboptimal performance in both reconstruction fidelity and coding efficiency. To address these challenges, we propose a residual-guided ultra lowrate image compression named ResULIC, which incorporates residual signals into both semantic retrieval and the diffusion-based generation process. Specifically, we introduce Semantic Residual Coding (SRC) to capture the semantic disparity between the original image and its compressed latent representation. A perceptual fidelity optimizer is further applied for superior reconstruction quality. Additionally, we present the Compression-aware Diffusion Model (CDM), which establishes an optimal alignment between bitrates and diffusion time steps, improving compression-reconstruction synergy. Extensive experiments demonstrate the effectiveness of ResULIC, achieving superior objective and subjective performance compared to state-of-the-art diffusion-based methods with - 80.7%, -66.3% BD-rate saving in terms of LPIPS and FID. Project page is available at https: //njuvision.github.io/ResULIC/.

cs.CV↗

arXiv2025

RobGC: Towards Robust Graph Condensation

Graph neural networks (GNNs) have attracted widespread attention for their impressive capability of graph representation learning. However, the increasing prevalence of large-scale graphs presents a significant challenge for GNN training due to their computational demands, limiting the applicability of GNNs in various scenarios. In response to this challenge, graph condensation (GC) is proposed as a promising acceleration solution, focusing on generating an informative compact graph that enables efficient training of GNNs while retaining performance. Despite the potential to accelerate GNN training, existing GC methods overlook the quality of large training graphs during both the training and inference stages. They indiscriminately emulate the training graph distributions, making the condensed graphs susceptible to noises within the training graph and significantly impeding the application of GC in intricate real-world scenarios. To address this issue, we propose robust graph condensation (RobGC), a plug-and-play approach for GC to extend the robustness and applicability of condensed graphs in noisy graph structure environments. Specifically, RobGC leverages the condensed graph as a feedback signal to guide the denoising process on the original training graph. A label propagation-based alternating optimization strategy is in place for the condensation and denoising processes, contributing to the mutual purification of the condensed graph and training graph. Additionally, as a GC method designed for inductive graph inference, RobGC facilitates test-time graph denoising by leveraging the noise-free condensed graph to calibrate the structure of the test graph. Extensive experiments show that RobGC is compatible with various GC methods, significantly boosting their robustness under different types and levels of graph structural noises.

cs.LG↗

arXiv2025

Enhancing Treatment Effect Estimation via Active Learning: A Counterfactual Covering Perspective

Although numerous complex algorithms for treatment effect estimation have been developed in recent years, their effectiveness remains limited when handling insufficiently labeled training sets due to the high cost of labeling the effect after treatment, e.g., expensive tumor imaging or biopsy procedures needed to evaluate treatment effects. Therefore, it becomes essential to actively incorporate more high-quality labeled data, all while adhering to a constrained labeling budget. To enable data-efficient treatment effect estimation, we formalize the problem through rigorous theoretical analysis within the active learning context, where the derived key measures -- \textit{factual} and \textit{counterfactual covering radius} determine the risk upper bound. To reduce the bound, we propose a greedy radius reduction algorithm, which excels under an idealized, balanced data distribution. To generalize to more realistic data distributions, we further propose FCCM, which transforms the optimization objective into the \textit{Factual} and \textit{Counterfactual Coverage Maximization} to ensure effective radius reduction during data acquisition. Furthermore, benchmarking FCCM against other baselines demonstrates its superiority across both fully synthetic and semi-synthetic datasets.

cs.LG↗

arXiv2025

Multi-agents based User Values Mining for Recommendation

Recommender systems have rapidly evolved and become integral to many online services. However, existing systems sometimes produce unstable and unsatisfactory recommendations that fail to align with users' fundamental and long-term preferences. This is because they primarily focus on extracting shallow and short-term interests from user behavior data, which is inherently dynamic and challenging to model. Unlike these transient interests, user values are more stable and play a crucial role in shaping user behaviors, such as purchasing items and consuming content. Incorporating user values into recommender systems can help stabilize recommendation performance and ensure results better reflect users' latent preferences. However, acquiring user values is typically difficult and costly. To address this challenge, we leverage the strong language understanding, zero-shot inference, and generalization capabilities of Large Language Models (LLMs) to extract user values from users' historical interactions. Unfortunately, direct extraction using LLMs presents several challenges such as length constraints and hallucination. To overcome these issues, we propose ZOOM, a zero-shot multi-LLM collaborative framework for effective and accurate user value extraction. In ZOOM, we apply text summarization techniques to condense item content while preserving essential meaning. To mitigate hallucinations, ZOOM introduces two specialized agent roles: evaluators and supervisors, to collaboratively generate accurate user values. Extensive experiments on two widely used recommendation datasets with two state-of-the-art recommendation models demonstrate the effectiveness and generalization of our framework in automatic user value mining and recommendation performance improvement.

cs.IR↗

arXiv2025

Towards Distribution Matching between Collaborative and Language Spaces for Generative Recommendation

Generative recommendation aims to learn the underlying generative process over the entire item set to produce recommendations for users. Although it leverages non-linear probabilistic models to surpass the limited modeling capacity of linear factor models, it is often constrained by a trade-off between representation ability and tractability. With the rise of a new generation of generative methods based on pre-trained language models (LMs), incorporating LMs into general recommendation with implicit feedback has gained considerable attention. However, adapting them to generative recommendation remains challenging. The core reason lies in the mismatch between the input-output formats and semantics of generative models and LMs, making it challenging to achieve optimal alignment in the feature space. This work addresses this issue by proposing a model-agnostic generative recommendation framework called DMRec, which introduces a probabilistic meta-network to bridge the outputs of LMs with user interactions, thereby enabling an equivalent probabilistic modeling process. Subsequently, we design three cross-space distribution matching processes aimed at maximizing shared information while preserving the unique semantics of each space and filtering out irrelevant information. We apply DMRec to three different types of generative recommendation methods and conduct extensive experiments on three public datasets. The experimental results demonstrate that DMRec can effectively enhance the recommendation performance of these generative models, and it shows significant advantages over mainstream LM-enhanced recommendation methods.

cs.IR↗

arXiv2025

Causal machine learning for high-dimensional mediation analysis using interventional effects mapped to a target trial

Causal mediation analysis examines causal pathways linking exposures to disease. The estimation of interventional effects, which are mediation estimands that overcome certain identifiability problems of natural effects, has been advanced through causal machine learning methods, particularly for high-dimensional mediators. Recently, it has been proposed interventional effects can be defined in each study by mapping to a target trial assessing specific hypothetical mediator interventions. This provides an appealing framework to directly address real-world research questions about the extent to which such interventions might mitigate an increased disease risk in the exposed. However, existing estimators for interventional effects mapped to a target trial rely on singly-robust parametric approaches, limiting their applicability in high-dimensional settings. Building upon recent developments in causal machine learning for interventional effects, we address this gap by developing causal machine learning estimators for three interventional effect estimands, defined by target trials assessing hypothetical interventions inducing distinct shifts in joint mediator distributions. These estimands are motivated by a case study within the Longitudinal Study of Australian Children, used for illustration, which assessed how intervening on high inflammatory burden and other non-inflammatory adverse metabolomic markers might mitigate the adverse causal effect of overweight or obesity on high blood pressure in adolescence. We develop one-step and (partial) targeted minimum loss-based estimators based on efficient influence functions of those estimands, demonstrating they are root-n consistent, efficient, and multiply robust under certain conditions.

stat.ME↗

arXiv2025

ECG-Chat: A Large ECG-Language Model for Cardiac Disease Diagnosis

The success of Multimodal Large Language Models (MLLMs) in the medical auxiliary field shows great potential, allowing patients to engage in conversations using physiological signal data. However, general MLLMs perform poorly in cardiac disease diagnosis, particularly in the integration of ECG data analysis and medical report generation, mainly due to the complexity of ECG data analysis and the gap between text and ECG signal modalities. To address these issues, we propose ECG-Chat, a multitask MLLMs focused on ECG medical report generation, providing multimodal conversational capabilities based on cardiology knowledge. We propose a contrastive learning approach that integrates ECG waveform data with text reports, aligning ECG features with reports in a fine-grained manner. This method also results in an ECG encoder that excels in zero-shot report retrieval tasks. Additionally, expanding existing datasets, we constructed a 19k ECG diagnosis dataset and a 25k multi-turn dialogue dataset for training and fine-tuning ECG-Chat, which provides professional diagnostic and conversational capabilities. Furthermore, ECG-Chat can generate comprehensive ECG analysis reports through an automated LaTeX generation pipeline. We established a benchmark for the ECG report generation task and tested our model on multiple baselines. ECG-Chat achieved the best performance in classification, retrieval, and medical report generation tasks. Our code is available at https://github.com/YubaoZhao/ECG-Chat.

eess.SP↗

arXiv2025

Limiting on ALP-photon Coupling through GRB221009A

This study investigates the constraints on ALPs parameters through the photon-ALP oscillation model, based on the high-energy photon propagation characteristics of the gamma-ray burst GRB 221009A. We briefly describe the Primakoff process and use it to derive the oscillation probability. Numerical simulations incorporate the GMF, IGMF, and EBL, utilizing the open-source code gammaALPs to simulate photon propagation from the source to Earth. By employing the chi2 statistical method and segmented spectral fitting of low-energy and high-energy observational data from HXMT-GECAM, the dependence of photon survival probability on ALP mass (ma) and coupling strength (ga) is analyzed. Results show that for the ALP mass range 10^-7 < ma < 10^2 neV, the upper limit on the coupling strength is ga < 0.27 * 10^-11 GeV^-1, improving constraints by one order of magnitude compared to the CAST experiment (6.6 * 10^-11 GeV^-1). Notably, high-energy data exhibit significantly stronger constraining power. This work provides a novel theoretical framework and observational basis for indirectly probing ALPs through extreme astrophysical phenomena.

astro-ph.HE↗

arXiv2025

Continual Text-to-Video Retrieval with Frame Fusion and Task-Aware Routing

Text-to-Video Retrieval (TVR) aims to retrieve relevant videos based on textual queries. However, as video content evolves continuously, adapting TVR systems to new data remains a critical yet under-explored challenge. In this paper, we introduce the first benchmark for Continual Text-to-Video Retrieval (CTVR) to address the limitations of existing approaches. Current Pre-Trained Model (PTM)-based TVR methods struggle with maintaining model plasticity when adapting to new tasks, while existing Continual Learning (CL) methods suffer from catastrophic forgetting, leading to semantic misalignment between historical queries and stored video features. To address these two challenges, we propose FrameFusionMoE, a novel CTVR framework that comprises two key components: (1) the Frame Fusion Adapter (FFA), which captures temporal video dynamics while preserving model plasticity, and (2) the Task-Aware Mixture-of-Experts (TAME), which ensures consistent semantic alignment between queries across tasks and the stored video features. Thus, FrameFusionMoE enables effective adaptation to new video content while preserving historical text-video relevance to mitigate catastrophic forgetting. We comprehensively evaluate FrameFusionMoE on two benchmark datasets under various task settings. Results demonstrate that FrameFusionMoE outperforms existing CL and TVR methods, achieving superior retrieval performance with minimal degradation on earlier tasks when handling continuous video streams. Our code is available at: https://github.com/JasonCodeMaker/CTVR.

cs.CV↗

arXiv2025

Diversity-aware Dual-promotion Poisoning Attack on Sequential Recommendation

Sequential recommender systems (SRSs) excel in capturing users' dynamic interests, thus playing a key role in various industrial applications. The popularity of SRSs has also driven emerging research on their security aspects, where data poisoning attack for targeted item promotion is a typical example. Existing attack mechanisms primarily focus on increasing the ranks of target items in the recommendation list by injecting carefully crafted interactions (i.e., poisoning sequences), which comes at the cost of demoting users' real preferences. Consequently, noticeable recommendation accuracy drops are observed, restricting the stealthiness of the attack. Additionally, the generated poisoning sequences are prone to substantial repetition of target items, which is a result of the unitary objective of boosting their overall exposure and lack of effective diversity regularizations. Such homogeneity not only compromises the authenticity of these sequences, but also limits the attack effectiveness, as it ignores the opportunity to establish sequential dependencies between the target and many more items in the SRS. To address the issues outlined, we propose a Diversity-aware Dual-promotion Sequential Poisoning attack method named DDSP for SRSs. Specifically, by theoretically revealing the conflict between recommendation and existing attack objectives, we design a revamped attack objective that promotes the target item while maintaining the relevance of preferred items in a user's ranking list. We further develop a diversity-aware, auto-regressive poisoning sequence generator, where a re-ranking method is in place to sequentially pick the optimal items by integrating diversity constraints.

cs.IR↗