Tongchuan Suo | Searcharxiv

arXiv2016

Protein corona composition of PEGylated nanoparticles correlates strongly with amino acid composition of protein surface

Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol)(PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding polar ones. A solvent-accessible-surface-area model of protein adsorption on PEGylated nanoparticles accurately fits a large set of data on the composition of the protein corona recently obtained by label-free proteomic mass spectrometry.

physics.bio-ph↗

arXiv2009

The Phase Behaviors of A Polymer Solution Confined between Two Concentric Cylinders

A theoretical study on the phase behaviors of a polymer solution confined between two coaxial cylindrical walls is presented. For the case of a neutral inner cylinder, the spinodal point derived through the Gaussian fluctuation theory is confinement-independent because of the existence of a free dimension in the system. The kinetic analysis indicates that the fluctuation modes always have a component of a plane wave along the axial direction, which can lead to the formation of a periodic-like concentration pattern. On the other hand, the equilibrium structure of the system is obtained by using the self-consistent mean-field theory (SCMFT) and the interplay between the "wetting" phenomenon and the phase separation is observed by modifying the property of the inner cylinderical wall.

cond-mat.soft↗