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Tony Pourmohamad

Publications and source records attributed to Tony Pourmohamad.

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Calibrated Bayesian Nonparametric Tolerance Intervals

Tolerance intervals provide bounds that contain a specified proportion of a population with a given confidence level, yet their construction remains challenging when parametric assumptions fail or sample sizes are small. Traditional nonparametric methods, such as Wilks' intervals, lack flexibility and often require large samples to be valid. We propose a fully nonparametric approach for constructing one-sided and two-sided tolerance intervals using a calibrated Gibbs posterior. Leveraging the connection between tolerance limits and population quantiles, we employ a Gibbs posterior based on the asymmetric Laplace (check) loss function. A key feature of our method is the calibration of the learning rate, which ensures nominal frequentist coverage across diverse distributional shapes. Simulation studies show that the proposed approach often yields shorter intervals than classical nonparametric benchmarks while maintaining reliable coverage. The framework's practical utility is illustrated through applications in ecology, biopharmaceutical manufacturing, and environmental monitoring, demonstrating its flexibility and robustness across diverse applications.

stat.ME

Tolerance Intervals Using Dirichlet Processes

In nonclinical pharmaceutical development, tolerance intervals are critical in ensuring product and process quality. They are statistical intervals designed to contain a specified proportion of the population with a given confidence level. Parametric and non-parametric methods have been developed to obtain tolerance intervals. The former work with small samples but can be affected by distribution misspecification. The latter offer larger flexibility but require large sample sizes. As an alternative, we propose Dirichlet process-based Bayesian nonparametric tolerance intervals to overcome the limitations. We develop a computationally efficient tolerance interval construction algorithm based on the analytically tractable quantile process of the Dirichlet process. Simulation studies show that our new approach is very robust to distributional assumptions and performs as efficiently as existing tolerance interval methods. To illustrate how the model works in practice, we apply our method to the tolerance interval estimation for potency data.

stat.ME

Understanding an Acquisition Function Family for Bayesian Optimization

Bayesian optimization (BO) developed as an approach for the efficient optimization of expensive black-box functions without gradient information. A typical BO paper introduces a new approach and compares it to some alternatives on simulated and possibly real examples to show its efficacy. Yet on a different example, this new algorithm might not be as effective as the alternatives. This paper looks at a broader family of approaches to explain the strengths and weaknesses of algorithms in the family, with guidance on what choices might work best on different classes of problems.

stat.CO

CompModels: A suite of computer model test functions for Bayesian optimization

The CompModels package for R provides a suite of computer model test functions that can be used for computer model prediction/emulation, uncertainty quantification, and calibration, but in particular, the sequential optimization of computer models. The package is a mix of real-world physics problems, known mathematical functions, and black-box functions that have been converted into computer models with the goal of Bayesian (i.e., sequential) optimization in mind. Likewise, the package contains computer models that represent either the constrained or unconstrained optimization case, each with varying levels of difficulty. In this paper, we illustrate the use of the package with both real-world examples and black-box functions by solving constrained optimization problems via Bayesian optimization. Ultimately, the package is shown to provide users with a source of computer model test functions that are reproducible, shareable, and that can be used for benchmarking of novel optimization methods.

stat.CO