arXiv subjects

Tyman E. Stanford

Publications and source records attributed to Tyman E. Stanford.

3 recordsLinked to original sources

arXiv2025

Bayesian multilevel compositional data analysis: introduction, evaluation, and application

Multilevel compositional data are data that are repeatedly measured or clustered within groups and are non-negative and sum to a constant value. These data arise in various settings, such as intensive, longitudinal studies using ecological momentary assessments and wearable devices. Examples include 24h sleep-wake behaviours, sleep architecture, and macronutrients. This article presents a novel method for analysing multilevel compositional data using Bayesian inference. We describe the theoretical details of the data and the models, and outline the steps necessary to implement this method. We introduce the R package multilevelcoda to facilitate the application of this method and illustrate using a real data example. An extensive parameter recovery simulation study verified the robust performance of the method. Across all conditions investigated in the simulation study, the fitted models had minimal convergence issues (convergence rate > 99%) and achieved excellent quality parameter estimates and inference, with an average bias of 0.00 (range -0.09, 0.05) and coverage of 0.95 (range 0.93, 0.97). We conclude the article with recommendations on the use of the Bayesian multilevel compositional data analysis. We hope to promote wider application of this method to gain novel and robust answers to scientific questions.

stat.ME↗

arXiv2024

Bayesian multilevel compositional data analysis with the R package multilevelcoda

Multilevel compositional data, such as data sampled over time that are non-negative and sum to a constant value, are common in various fields. However, there is currently no software specifically built to model compositional data in a multilevel framework. The R package multilevelcoda implements a collection of tools for modelling compositional data in a Bayesian multivariate, multilevel pipeline. The user-friendly setup only requires the data, model formula, and minimal specification of the analysis. This paper outlines the statistical theory underlying the Bayesian compositional multilevel modelling approach and details the implementation of the functions available in multilevelcoda, using an example dataset of compositional daily sleep-wake behaviours. This innovative method can be used to gain robust answers to scientific questions using the increasingly available multilevel compositional data from intensive, longitudinal studies.

stat.ME↗

arXiv2016

Informed baseline subtraction of proteomic mass spectrometry data aided by a novel sliding window algorithm

Proteomic matrix-assisted laser desorption/ionisation (MALDI) linear time-of-flight (TOF) mass spectrometry (MS) may be used to produce protein profiles from biological samples with the aim of discovering biomarkers for disease. However, the raw protein profiles suffer from several sources of bias or systematic variation which need to be removed via pre-processing before meaningful downstream analysis of the data can be undertaken. Baseline subtraction, an early pre-processing step that removes the non-peptide signal from the spectra, is complicated by the following: (i) each spectrum has, on average, wider peaks for peptides with higher mass-to-charge ratios (m/z), and (ii) the time-consuming and error-prone trial-and-error process for optimising the baseline subtraction input arguments. With reference to the aforementioned complications, we present an automated pipeline that includes (i) a novel `continuous' line segment algorithm that efficiently operates over data with a transformed m/z-axis to remove the relationship between peptide mass and peak width, and (ii) an input-free algorithm to estimate peak widths on the transformed m/z scale. The automated baseline subtraction method was deployed on six publicly available proteomic MS datasets using six different m/z-axis transformations. Optimality of the automated baseline subtraction pipeline was assessed quantitatively using the mean absolute scaled error (MASE) when compared to a gold-standard baseline subtracted signal. Near-optimal baseline subtraction was achieved using the automated pipeline. The advantages of the proposed pipeline include informed and data specific input arguments for baseline subtraction methods, the avoidance of time-intensive and subjective piecewise baseline subtraction, and the ability to automate baseline subtraction completely. Moreover, individual steps can be adopted as stand-alone routines.

q-bio.QM↗