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U. Rajendra Acharya

Publications and source records attributed to U. Rajendra Acharya.

At least 19 recordsLinked to original sources

From Density to Biopsy Decisions and Malignancy Prediction: A Benchmark Study of Multimodal Large Language Models Against Radiologists in Digital and Contrast-Enhanced Mammography

Purpose: To compare four multimodal large language models (MLLMs) with radiologists of varying expertise in breast density assessment, BI-RADS assessment, biopsy candidacy determination, and continuous malignancy probability estimation using digital mammography (DM) and contrast-enhanced mammography (CEM). Methods: This study included 179 women with paired DM/CEM examinations and reference standards. Four MLLMs (ChatGPT-5.2, Gemini-3.1 Pro, Sonnet-4.6, Muse Spark) interpreted images with and without masks; three radiologists interpreted non-masked images. Results: For binary density classification on DM, radiologist accuracies ranged from 55.81% to 78.60%, exceeding most MLLM values (62.33%-71.63%), while masks added limited benefit. Five-category BI-RADS accuracies were higher for radiologists on DM (56.74-67.44%) and CEM (62.33-82.79%) compared with MLLMs (DM 31.16-45.12%; CEM 40.00-55.81%). Binary biopsy-candidacy accuracies were likewise higher for radiologists (DM 85.12-89.77%; CEM 86.98-92.09%) than for MLLMs (DM 61.39-75.35%; CEM 69.30-82.79%), although CEM improved performance across all readers. Lesion masks substantially improved MLLM continuous malignancy-probability accuracies from 64.65%-71.63% to 72.56-78.60% on DM and from 67.91%-77.21% to 72.56%-81.86% on CEM, approaching radiologist ranges (DM 63.72-82.79%; CEM 81.86-88.84%). The corresponding AUCs for the top masked models overlapped those of the human readers. Overall, Muse Spark, followed by Sonnet-4.6, demonstrated the strongest performance among the MLLMs across domains. Conclusion: Radiologists generally outperformed MLLMs in categorical tasks, while selected masked models approached human performance for continuous malignancy probability estimation, suggesting a potential adjunctive role.

cs.CV↗

Artificial intelligence applications in Parkinson's disease via retinal imaging

Parkinson's disease (PD) is projected to increase substantially due to population aging, making early diagnosis increasingly important, as timely detection may delay progression and reduce long-term complications. Retinal microvasculature has emerged as a promising anatomical biomarker of neurodegeneration, and when combined with artificial intelligence AI, retinal imaging may provide an advanced, noninvasive, and cost-effective screening strategy for PD. This study evaluated the evidence from the past 35 years regarding the capability of AI to detect early PD-related changes in retinal vascular structure. Five electronic databases including PubMed, Web of Science, Scopus, ScienceDirect, and ProQuest were systematically searched from January 1990 to January 2025. In addition, Annals of Neurology and Frontiers in Neuroscience were hand-searched, and the reference lists of included studies were screened for additional eligible publications. Nineteen studies met the inclusion criteria. Three principal diagnostic AI tasks were identified, including disease classification, retinal vessel segmentation, and PD risk stratification. The best-performing models were ShAMBi-LSTM on the Drishti dataset with 97.2 percent accuracy, 99.5 percent precision, 96.9 percent sensitivity, and an F1 score of 0.981 for classification, nnU-Net with 99.7 percent accuracy, 98.7 percent precision, 98.9 percent sensitivity, 99.8 percent specificity, and a Dice score of 98.9 percent for segmentation, and AlexNet for risk prediction with area under the curve values of 0.77, 0.68, and 0.73 across datasets. Overall, application of AI algorithms to retinal vasculature for detecting early signs of PD and predicting disease severity suggests that integration of AI with retinal biomarkers holds substantial potential for earlier and more accurate detection compared with traditional clinical evaluation alone.

q-bio.TO↗

UCTECG-Net: Uncertainty-aware Convolution Transformer ECG Network for Arrhythmia Detection

Deep learning has improved automated electrocardiogram (ECG) classification, but limited insight into prediction reliability hinders its use in safety-critical settings. This paper proposes UCTECG-Net, an uncertainty-aware hybrid architecture that combines one-dimensional convolutions and Transformer encoders to process raw ECG signals and their spectrograms jointly. Evaluated on the MIT-BIH Arrhythmia and PTB Diagnostic datasets, UCTECG-Net outperforms LSTM, CNN1D, and Transformer baselines in terms of accuracy, precision, recall and F1 score, achieving up to 98.58% accuracy on MIT-BIH and 99.14% on PTB. To assess predictive reliability, we integrate three uncertainty quantification methods (Monte Carlo Dropout, Deep Ensembles, and Ensemble Monte Carlo Dropout) into all models and analyze their behavior using an uncertainty-aware confusion matrix and derived metrics. The results show that UCTECG-Net, particularly with Ensemble or EMCD, provides more reliable and better-aligned uncertainty estimates than competing architectures, offering a stronger basis for risk-aware ECG decision support.

cs.LG↗

SSI-GAN: Semi-Supervised Swin-Inspired Generative Adversarial Networks for Neuronal Spike Classification

Mosquitos are the main transmissive agents of arboviral diseases. Manual classification of their neuronal spike patterns is very labor-intensive and expensive. Most available deep learning solutions require fully labeled spike datasets and highly preprocessed neuronal signals. This reduces the feasibility of mass adoption in actual field scenarios. To address the scarcity of labeled data problems, we propose a new Generative Adversarial Network (GAN) architecture that we call the Semi-supervised Swin-Inspired GAN (SSI-GAN). The Swin-inspired, shifted-window discriminator, together with a transformer-based generator, is used to classify neuronal spike trains and, consequently, detect viral neurotropism. We use a multi-head self-attention model in a flat, window-based transformer discriminator that learns to capture sparser high-frequency spike features. Using just 1 to 3% labeled data, SSI-GAN was trained with more than 15 million spike samples collected at five-time post-infection and recording classification into Zika-infected, dengue-infected, or uninfected categories. Hyperparameters were optimized using the Bayesian Optuna framework, and performance for robustness was validated under fivefold Monte Carlo cross-validation. SSI-GAN reached 99.93% classification accuracy on the third day post-infection with only 3% labeled data. It maintained high accuracy across all stages of infection with just 1% supervision. This shows a 97-99% reduction in manual labeling effort relative to standard supervised approaches at the same performance level. The shifted-window transformer design proposed here beat all baselines by a wide margin and set new best marks in spike-based neuronal infection classification.

cs.LG↗

Functional Classification of Spiking Signal Data Using Artificial Intelligence Techniques: A Review

Human brain neuron activities are incredibly significant nowadays. Neuronal behavior is assessed by analyzing signal data such as electroencephalography (EEG), which can offer scientists valuable information about diseases and human-computer interaction. One of the difficulties researchers confront while evaluating these signals is the existence of large volumes of spike data. Spikes are some considerable parts of signal data that can happen as a consequence of vital biomarkers or physical issues such as electrode movements. Hence, distinguishing types of spikes is important. From this spot, the spike classification concept commences. Previously, researchers classified spikes manually. The manual classification was not precise enough as it involves extensive analysis. Consequently, Artificial Intelligence (AI) was introduced into neuroscience to assist clinicians in classifying spikes correctly. This review discusses the importance and use of AI in spike classification, focusing on the recognition of neural activity noises. The task is divided into three main components: preprocessing, classification, and evaluation. Existing methods are introduced and their importance is determined. The review also highlights the need for more efficient algorithms. The primary goal is to provide a perspective on spike classification for future research and provide a comprehensive understanding of the methodologies and issues involved. The review organizes materials in the spike classification field for future studies. In this work, numerous studies were extracted from different databases. The PRISMA-related research guidelines were then used to choose papers. Then, research studies based on spike classification using machine learning and deep learning approaches with effective preprocessing were selected.

cs.AI↗

Rewiring Human Brain Networks via Lightweight Dynamic Connectivity Framework: An EEG-Based Stress Validation

In recent years, Electroencephalographic analysis has gained prominence in stress research when combined with AI and Machine Learning models for validation. In this study, a lightweight dynamic brain connectivity framework based on Time Varying Directed Transfer Function is proposed, where TV DTF features were validated through ML based stress classification. TV DTF estimates the directional information flow between brain regions across distinct EEG frequency bands, thereby capturing temporal and causal influences that are often overlooked by static functional connectivity measures. EEG recordings from the 32 channel SAM 40 dataset were employed, focusing on mental arithmetic task trials. The dynamic EEG-based TV-DTF features were validated through ML classifiers such as Support Vector Machine, Random Forest, Gradient Boosting, Adaptive Boosting, and Extreme Gradient Boosting. Experimental results show that alpha-TV-DTF provided the strongest discriminative power, with SVM achieving 89.73% accuracy in 3-class classification and with XGBoost achieving 93.69% accuracy in 2 class classification. Relative to absolute power and phase locking based functional connectivity features, alpha TV DTF and beta TV DTF achieved higher performance across the ML models, highlighting the advantages of dynamic over static measures. Feature importance analysis further highlighted dominant long-range frontal parietal and frontal occipital informational influences, emphasizing the regulatory role of frontal regions under stress. These findings validate the lightweight TV-DTF as a robust framework, revealing spatiotemporal brain dynamics and directional influences across different stress levels.

q-bio.NC↗

A Quad-Step Approach to Uncertainty-Aware Deep Learning for Skin Cancer Classification

Accurate skin cancer diagnosis is vital for early treatment and improved patient outcomes. Deep learning (DL) models have shown promise in automating skin cancer classification, yet challenges remain due to data scarcity and limited uncertainty awareness. This study presents a comprehensive evaluation of DL-based skin lesion classification with transfer learning and uncertainty quantification (UQ) on the HAM10000 dataset. We benchmark several pre-trained feature extractors -- including CLIP variants, ResNet50, DenseNet121, VGG16, and EfficientNet-V2-Large -- combined with traditional classifiers such as SVM, XGBoost, and logistic regression. Multiple principal component analysis (PCA) settings (64, 128, 256, 512) are explored, with LAION CLIP ViT-H/14 and ViT-L/14 at PCA-256 achieving the strongest baseline results. In the UQ phase, Monte Carlo Dropout (MCD), Ensemble, and Ensemble Monte Carlo Dropout (EMCD) are applied and evaluated using uncertainty-aware metrics (UAcc, USen, USpe, UPre). Ensemble methods with PCA-256 provide the best balance between accuracy and reliability. Further improvements are obtained through feature fusion of top-performing extractors at PCA-256. Finally, we propose a feature-fusion based model trained with a predictive entropy (PE) loss function, which outperforms all prior configurations across both standard and uncertainty-aware evaluations, advancing trustworthy DL-based skin cancer diagnosis.

cs.CV↗

Artificial Intelligence in Assessing Cardiovascular Diseases and Risk Factors via Retinal Fundus Images: A Review of the Last Decade

Background: Cardiovascular diseases (CVDs) are the leading cause of death globally. The use of artificial intelligence (AI) methods - in particular, deep learning (DL) - has been on the rise lately for the analysis of different CVD-related topics. The use of fundus images and optical coherence tomography angiography (OCTA) in the diagnosis of retinal diseases has also been extensively studied. To better understand heart function and anticipate changes based on microvascular characteristics and function, researchers are currently exploring the integration of AI with non-invasive retinal scanning. There is great potential to reduce the number of cardiovascular events and the financial strain on healthcare systems by utilizing AI-assisted early detection and prediction of cardiovascular diseases on a large scale. Method: A comprehensive search was conducted across various databases, including PubMed, Medline, Google Scholar, Scopus, Web of Sciences, IEEE Xplore, and ACM Digital Library, using specific keywords related to cardiovascular diseases and artificial intelligence. Results: The study included 87 English-language publications selected for relevance, and additional references were considered. This paper provides an overview of the recent developments and difficulties in using artificial intelligence and retinal imaging to diagnose cardiovascular diseases. It provides insights for further exploration in this field. Conclusion: Researchers are trying to develop precise disease prognosis patterns in response to the aging population and the growing global burden of CVD. AI and deep learning are revolutionizing healthcare by potentially diagnosing multiple CVDs from a single retinal image. However, swifter adoption of these technologies in healthcare systems is required.

q-bio.QM↗

Designing Interpretable ML System to Enhance Trust in Healthcare: A Systematic Review to Proposed Responsible Clinician-AI-Collaboration Framework

This paper explores the significant impact of AI-based medical devices, including wearables, telemedicine, large language models, and digital twins, on clinical decision support systems. It emphasizes the importance of producing outcomes that are not only accurate but also interpretable and understandable to clinicians, addressing the risk that lack of interpretability poses in terms of mistrust and reluctance to adopt these technologies in healthcare. The paper reviews interpretable AI processes, methods, applications, and the challenges of implementation in healthcare, focusing on quality control to facilitate responsible communication between AI systems and clinicians. It breaks down the interpretability process into data pre-processing, model selection, and post-processing, aiming to foster a comprehensive understanding of the crucial role of a robust interpretability approach in healthcare and to guide future research in this area. with insights for creating responsible clinician-AI tools for healthcare, as well as to offer a deeper understanding of the challenges they might face. Our research questions, eligibility criteria and primary goals were identified using Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline and PICO method; PubMed, Scopus and Web of Science databases were systematically searched using sensitive and specific search strings. In the end, 52 publications were selected for data extraction which included 8 existing reviews and 44 related experimental studies. The paper offers general concepts of interpretable AI in healthcare and discuss three-levels interpretability process. Additionally, it provides a comprehensive discussion of evaluating robust interpretability AI in healthcare. Moreover, this survey introduces a step-by-step roadmap for implementing responsible AI in healthcare.

cs.AI↗

Artificial Intelligence and Diabetes Mellitus: An Inside Look Through the Retina

Diabetes mellitus (DM) predisposes patients to vascular complications. Retinal images and vasculature reflect the body's micro- and macrovascular health. They can be used to diagnose DM complications, including diabetic retinopathy (DR), neuropathy, nephropathy, and atherosclerotic cardiovascular disease, as well as forecast the risk of cardiovascular events. Artificial intelligence (AI)-enabled systems developed for high-throughput detection of DR using digitized retinal images have become clinically adopted. Beyond DR screening, AI integration also holds immense potential to address challenges associated with the holistic care of the patient with DM. In this work, we aim to comprehensively review the literature for studies on AI applications based on retinal images related to DM diagnosis, prognostication, and management. We will describe the findings of holistic AI-assisted diabetes care, including but not limited to DR screening, and discuss barriers to implementing such systems, including issues concerning ethics, data privacy, equitable access, and explainability. With the ability to evaluate the patient's health status vis a vis DM complication as well as risk prognostication of future cardiovascular complications, AI-assisted retinal image analysis has the potential to become a central tool for modern personalized medicine in patients with DM.

eess.IV↗

Current and future roles of artificial intelligence in retinopathy of prematurity

Retinopathy of prematurity (ROP) is a severe condition affecting premature infants, leading to abnormal retinal blood vessel growth, retinal detachment, and potential blindness. While semi-automated systems have been used in the past to diagnose ROP-related plus disease by quantifying retinal vessel features, traditional machine learning (ML) models face challenges like accuracy and overfitting. Recent advancements in deep learning (DL), especially convolutional neural networks (CNNs), have significantly improved ROP detection and classification. The i-ROP deep learning (i-ROP-DL) system also shows promise in detecting plus disease, offering reliable ROP diagnosis potential. This research comprehensively examines the contemporary progress and challenges associated with using retinal imaging and artificial intelligence (AI) to detect ROP, offering valuable insights that can guide further investigation in this domain. Based on 89 original studies in this field (out of 1487 studies that were comprehensively reviewed), we concluded that traditional methods for ROP diagnosis suffer from subjectivity and manual analysis, leading to inconsistent clinical decisions. AI holds great promise for improving ROP management. This review explores AI's potential in ROP detection, classification, diagnosis, and prognosis.

eess.IV↗

Automated Detection and Forecasting of COVID-19 using Deep Learning Techniques: A Review

Coronavirus, or COVID-19, is a hazardous disease that has endangered the health of many people around the world by directly affecting the lungs. COVID-19 is a medium-sized, coated virus with a single-stranded RNA, and also has one of the largest RNA genomes and is approximately 120 nm. The X-Ray and computed tomography (CT) imaging modalities are widely used to obtain a fast and accurate medical diagnosis. Identifying COVID-19 from these medical images is extremely challenging as it is time-consuming and prone to human errors. Hence, artificial intelligence (AI) methodologies can be used to obtain consistent high performance. Among the AI methods, deep learning (DL) networks have gained popularity recently compared to conventional machine learning (ML). Unlike ML, all stages of feature extraction, feature selection, and classification are accomplished automatically in DL models. In this paper, a complete survey of studies on the application of DL techniques for COVID-19 diagnostic and segmentation of lungs is discussed, concentrating on works that used X-Ray and CT images. Additionally, a review of papers on the forecasting of coronavirus prevalence in different parts of the world with DL is presented. Lastly, the challenges faced in the detection of COVID-19 using DL techniques and directions for future research are discussed.

cs.LG↗

Automated detection of Zika and dengue in Aedes aegypti using neural spiking analysis

Mosquito-borne diseases present considerable risks to the health of both animals and humans. Aedes aegypti mosquitoes are the primary vectors for numerous medically important viruses such as dengue, Zika, yellow fever, and chikungunya. To characterize this mosquito neural activity, it is essential to classify the generated electrical spikes. However, no open-source neural spike classification method is currently available for mosquitoes. Our work presented in this paper provides an innovative artificial intelligence-based method to classify the neural spikes in uninfected, dengue-infected, and Zika-infected mosquitoes. Aiming for outstanding performance, the method employs a fusion of normalization, feature importance, and dimension reduction for the preprocessing and combines convolutional neural network and extra gradient boosting (XGBoost) for classification. The method uses the electrical spiking activity data of mosquito neurons recorded by microelectrode array technology. We used data from 0, 1, 2, 3, and 7 days post-infection, containing over 15 million samples, to analyze the method's performance. The performance of the proposed method was evaluated using accuracy, precision, recall, and the F1 scores. The results obtained from the method highlight its remarkable performance in differentiating infected vs uninfected mosquito samples, achieving an average of 98.1%. The performance was also compared with 6 other machine learning algorithms to further assess the method's capability. The method outperformed all other machine learning algorithms' performance. Overall, this research serves as an efficient method to classify the neural spikes of Aedes aegypti mosquitoes and can assist in unraveling the complex interactions between pathogens and mosquitoes.

cs.LG↗

Automatic Diagnosis of Myocarditis Disease in Cardiac MRI Modality using Deep Transformers and Explainable Artificial Intelligence

Myocarditis is a significant cardiovascular disease (CVD) that poses a threat to the health of many individuals by causing damage to the myocardium. The occurrence of microbes and viruses, including the likes of HIV, plays a crucial role in the development of myocarditis disease (MCD). The images produced during cardiac magnetic resonance imaging (CMRI) scans are low contrast, which can make it challenging to diagnose cardiovascular diseases. In other hand, checking numerous CMRI slices for each CVD patient can be a challenging task for medical doctors. To overcome the existing challenges, researchers have suggested the use of artificial intelligence (AI)-based computer-aided diagnosis systems (CADS). The presented paper outlines a CADS for the detection of MCD from CMR images, utilizing deep learning (DL) methods. The proposed CADS consists of several steps, including dataset, preprocessing, feature extraction, classification, and post-processing. First, the Z-Alizadeh dataset was selected for the experiments. Subsequently, the CMR images underwent various preprocessing steps, including denoising, resizing, as well as data augmentation (DA) via CutMix and MixUp techniques. In the following, the most current deep pre-trained and transformer models are used for feature extraction and classification on the CMR images. The findings of our study reveal that transformer models exhibit superior performance in detecting MCD as opposed to pre-trained architectures. In terms of DL architectures, the Turbulence Neural Transformer (TNT) model exhibited impressive accuracy, reaching 99.73% utilizing a 10-fold cross-validation approach. Additionally, to pinpoint areas of suspicion for MCD in CMRI images, the Explainable-based Grad Cam method was employed.

cs.CV↗

Solving the multiplication problem of a large language model system using a graph-based method

The generative pre-trained transformer (GPT)-based chatbot software ChatGPT possesses excellent natural language processing capabilities but is inadequate for solving arithmetic problems, especially multiplication. Its GPT structure uses a computational graph for multiplication, which has limited accuracy beyond simple multiplication operations. We developed a graph-based multiplication algorithm that emulated human-like numerical operations by incorporating a 10k operator, where k represents the maximum power to base 10 of the larger of two input numbers. Our proposed algorithm attained 100% accuracy for 1,000,000 large number multiplication tasks, effectively solving the multiplication challenge of GPT-based and other large language models. Our work highlights the importance of blending simple human insights into the design of artificial intelligence algorithms. Keywords: Graph-based multiplication; ChatGPT; Multiplication problem

cs.OH↗

Empowering Precision Medicine: AI-Driven Schizophrenia Diagnosis via EEG Signals: A Comprehensive Review from 2002-2023

Schizophrenia (SZ) is a prevalent mental disorder characterized by cognitive, emotional, and behavioral changes. Symptoms of SZ include hallucinations, illusions, delusions, lack of motivation, and difficulties in concentration. Diagnosing SZ involves employing various tools, including clinical interviews, physical examinations, psychological evaluations, the Diagnostic and Statistical Manual of Mental Disorders (DSM), and neuroimaging techniques. Electroencephalography (EEG) recording is a significant functional neuroimaging modality that provides valuable insights into brain function during SZ. However, EEG signal analysis poses challenges for neurologists and scientists due to the presence of artifacts, long-term recordings, and the utilization of multiple channels. To address these challenges, researchers have introduced artificial intelligence (AI) techniques, encompassing conventional machine learning (ML) and deep learning (DL) methods, to aid in SZ diagnosis. This study reviews papers focused on SZ diagnosis utilizing EEG signals and AI methods. The introduction section provides a comprehensive explanation of SZ diagnosis methods and intervention techniques. Subsequently, review papers in this field are discussed, followed by an introduction to the AI methods employed for SZ diagnosis and a summary of relevant papers presented in tabular form. Additionally, this study reports on the most significant challenges encountered in SZ diagnosis, as identified through a review of papers in this field. Future directions to overcome these challenges are also addressed. The discussion section examines the specific details of each paper, culminating in the presentation of conclusions and findings.

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RECOMED: A Comprehensive Pharmaceutical Recommendation System

A comprehensive pharmaceutical recommendation system was designed based on the patients and drugs features extracted from Drugs.com and Druglib.com. First, data from these databases were combined, and a dataset of patients and drug information was built. Secondly, the patients and drugs were clustered, and then the recommendation was performed using different ratings provided by patients, and importantly by the knowledge obtained from patients and drug specifications, and considering drug interactions. To the best of our knowledge, we are the first group to consider patients conditions and history in the proposed approach for selecting a specific medicine appropriate for that particular user. Our approach applies artificial intelligence (AI) models for the implementation. Sentiment analysis using natural language processing approaches is employed in pre-processing along with neural network-based methods and recommender system algorithms for modeling the system. In our work, patients conditions and drugs features are used for making two models based on matrix factorization. Then we used drug interaction to filter drugs with severe or mild interactions with other drugs. We developed a deep learning model for recommending drugs by using data from 2304 patients as a training set, and then we used data from 660 patients as our validation set. After that, we used knowledge from critical information about drugs and combined the outcome of the model into a knowledge-based system with the rules obtained from constraints on taking medicine.

cs.IR↗

A Hybrid Deep Spatio-Temporal Attention-Based Model for Parkinson's Disease Diagnosis Using Resting State EEG Signals

Parkinson's disease (PD), a severe and progressive neurological illness, affects millions of individuals worldwide. For effective treatment and management of PD, an accurate and early diagnosis is crucial. This study presents a deep learning-based model for the diagnosis of PD using resting state electroencephalogram (EEG) signal. The objective of the study is to develop an automated model that can extract complex hidden nonlinear features from EEG and demonstrate its generalizability on unseen data. The model is designed using a hybrid model, consists of convolutional neural network (CNN), bidirectional gated recurrent unit (Bi-GRU), and attention mechanism. The proposed method is evaluated on three public datasets (Uc San Diego Dataset, PRED-CT, and University of Iowa (UI) dataset), with one dataset used for training and the other two for evaluation. The results show that the proposed model can accurately diagnose PD with high performance on both the training and hold-out datasets. The model also performs well even when some part of the input information is missing. The results of this work have significant implications for patient treatment and for ongoing investigations into the early detection of Parkinson's disease. The suggested model holds promise as a non-invasive and reliable technique for PD early detection utilizing resting state EEG.

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