arXiv subjects

Ulrich Behn

Publications and source records attributed to Ulrich Behn.

17 recordsLinked to original sources

arXiv2016

Self-tolerance and autoimmunity in a minimal model of the idiotypic network

We consider self-tolerance and its failure -autoimmunity- in a minimal mathematical model of the idiotypic network. A node in the network represents a clone of B-lymphocytes and its antibodies of the same idiotype which is encoded by a bitstring. The links between nodes represent possible interactions between clones of almost complementary idiotype. A clone survives only if the number of populated neighbored nodes is neither too small nor too large. The dynamics is driven by the influx of lymphocytes with randomly generated idiotype from the bone marrow. Previous work has revealed that the network evolves towards a highly organized modular architecture, characterized by groups of nodes which share statistical properties. The structural properties of the architecture can be described analytically, the statistical properties determined from simulations are confirmed by a modular mean-field theory. To model the presence of self we permanently occupy one or several nodes. These nodes influence their linked neighbors, the autoreactive clones, but are themselves not affected by idiotypic interactions. The architecture is very similar to the case without self, but organized such that the neighbors of self are only weakly occupied, thus providing self-tolerance. This supports the perspective that self-reactive clones, which regularly occur in healthy organisms, are controlled by anti-idiotypic clones. We discuss how perturbations, like an infection with foreign antigen, a change in the influx of new idiotypes, or the random removal of idiotypes, may lead to autoreactivity and devise protocols which cause a reconstitution of the self-tolerant state. The results could be helpful to understand network and probabilistic aspects of autoimmune disorders.

q-bio.CB↗

arXiv2016

Discontinuous transitions in globally coupled potential systems with additive noise

An infinite array of globally coupled overdamped constituents moving in a double-well potential with $n$-th order saturation term under the influence of additive Gaussian white noise is investigated. The system exhibits a continuous phase transition from a symmetric phase to a symmetry-broken phase. The qualitative behavior is independent on $n$. The critical point is calculated for strong and for weak noise, these limits are also bounds for the critical point. Introducing an additional nonlinearity, such that the potential can have up to three minima, leads to richer behavior. There the parameter space divides in three regions, a region with a symmetric phase, a region with a phase of broken symmetry and a region where both phases coexist. The region of coexistence collapses into one of the others via a discontinuous phase transition whereas the transition between the symmetric phase and the phase of broken symmetry is continuous. The tricritical point where the three regions intersect, can be calculated for strong and for weak noise. These limiting values form optimal bounds on the tricritical point. In the region of coexistence simulations of finite systems are performed. One finds that the stationary distribution of finite but large systems differs qualitatively from the one of the infinite system. Hence the limits of stationarity and large system size do not commute.

cond-mat.stat-mech↗

arXiv2015

Patchwork Sampling of Stochastic Differential Equations

We propose a method to sample stationary properties of solutions of stochastic differential equations, which is accurate and efficient if there are rarely visited regions or rare transitions between distinct regions of the state space. The method is based on a complete, non-overlapping partition of the state space into patches on which the stochastic process is ergodic. On each of these patches we run simulations of the process strictly truncated to the corresponding patch, which allows effective simulations also in rarely visited regions. The correct weight for each patch is obtained by counting the attempted transitions between all different patches. The results are patchworked to cover the whole state space. We extend the concept of truncated Markov chains which is originally formulated for processes which obey detailed balance to processes not fulfilling detailed balance. The method is illustrated by three examples, describing the one-dimensional diffusion of an overdamped particle in a double-well potential, a system of many globally coupled overdamped particles in double-well potentials subject to additive Gaussian white noise, and the overdamped motion of a particle on the circle in a periodic potential subject to a deterministic drift and additive noise. In the appendix we explain how other well-known Markov chain Monte Carlo algorithms can be related to truncated Markov chains.

cond-mat.stat-mech↗

arXiv2013

Self tolerance in a minimal model of the idiotypic network

We consider the problem of self tolerance in the frame of a minimalistic model of the idiotypic network. A node of this network represents a population of B lymphocytes of the same idiotype which is encoded by a bit string. The links of the network connect nodes with (nearly) complementary strings. The population of a node survives if the number of occupied neighbours is not too small and not too large. There is an influx of lymphocytes with random idiotype from the bone marrow. Previous investigations have shown that this system evolves toward highly organized architectures, where the nodes can be classified into groups according to their statistical properties. The building principles of these architectures can be analytically described and the statistical results of simulations agree very well with results of a modular mean field theory. In this paper we present simulation results for the case that one or several nodes, playing the role of self, are permanently occupied. We observe that the group structure of the architecture is very similar to the case without self antigen, but organized such that the neighbours of the self are only weakly occupied, thus providing self tolerance. We also treat this situation in mean field theory which give results in good agreement with data from simulation.

q-bio.CB↗

arXiv2013

Critical manifold of globally coupled overdamped anharmonic oscillators driven by additive Gaussian white noise

We prove for an infinite array of globally coupled overdamped anharmonic oscillators subject to additive Gaussian white noise the existence of a well-behaved critical manifold in the parameter space which separates a symmetric phase from a symmetry broken phase. Given two of the system parameters there is an unique critical value of the third. The proof exploits that the critical control parameter a_c is bounded by its limit values for weak and for strong noise. In these limits the mechanism of symmetry breaking differs. For weak noise the distribution is Gaussian and the symmetry is broken as the whole distribution is shifted in either the positive or the negative direction. For strong noise there is a symmetric double-peak distribution and the symmetry is broken as the weights of the peaks become different. We derive an ordinary differential equation whose solution describes the critical manifold. Using a series ansatz to solve this differential equation we determine the critical manifold for weak and for strong noise and compare it to numerical results. We derive analytic expressions for the order parameter and the susceptibility close to the critical manifold.

cond-mat.stat-mech↗

arXiv2012

Randomly Evolving Idiotypic Networks: Structural Properties and Architecture

We consider a minimalistic dynamic model of the idiotypic network of B-lymphocytes. A network node represents a population of B-lymphocytes of the same specificity (idiotype), which is encoded by a bitstring. The links of the network connect nodes with complementary and nearly complementary bitstrings, allowing for a few mismatches. A node is occupied if a lymphocyte clone of the corresponding idiotype exists, otherwise it is empty. There is a continuous influx of new B-lymphocytes of random idiotype from the bone marrow. B-lymphocytes are stimulated by cross-linking their receptors with complementary structures. If there are too many complementary structures, steric hindrance prevents cross-linking. Stimulated cells proliferate and secrete antibodies of the same idiotype as their receptors, unstimulated lymphocytes die. Depending on few parameters, the autonomous system evolves randomly towards patterns of highly organized architecture, where the nodes can be classified into groups according to their statistical properties. We observe and describe analytically the building principles of these patterns, which allow to calculate number and size of the node groups and the number of links between them. The architecture of all patterns observed so far in simulations can be explained this way. A tool for real-time pattern identification is proposed.

q-bio.CB↗

arXiv2012

Randomly Evolving Idiotypic Networks: Modular Mean Field Theory

We develop a modular mean field theory for a minimalistic model of the idiotypic network. The model comprises the random influx of new idiotypes and a deterministic selection. It describes the evolution of the idiotypic network towards complex modular architectures, the building principles of which are known. The nodes of the network can be classified into groups of nodes, the modules, which share statistical properties. Each node experiences only the mean influence of the groups to which it is linked. Given the size of the groups and linking between them the statistical properties such as mean occupation, mean life time, and mean number of occupied neighbors are calculated for a variety of patterns and compared with simulations. For a pattern which consists of pairs of occupied nodes correlations are taken into account.

q-bio.CB↗

arXiv2010

First-passage and first-exit times of a Bessel-like stochastic process

We study a stochastic process $X_t$ related to the Bessel and the Rayleigh processes, with various applications in physics, chemistry, biology, economics, finance and other fields. The stochastic differential equation is $dX_t = (nD/X_t) dt + \sqrt{2D} dW_t$, where $W_t$ is the Wiener process. Due to the singularity of the drift term for $X_t = 0$, different natures of boundary at the origin arise depending on the real parameter $n$: entrance, exit, and regular. For each of them we calculate analytically and numerically the probability density functions of first-passage times or first-exit times. Nontrivial behaviour is observed in the case of a regular boundary.

cond-mat.stat-mech↗

arXiv2010

Mathematical Modelling of Allergy and Specific Immunotherapy: Th1-Th2-Treg Interactions

Regulatory T cells (Treg) have recently been identified as playing a central role in allergy and during allergen-specific immunotherapy. We have extended our previous mathematical model describing the nonlinear dynamics of Th1-Th2 regulation by including Treg cells and their major cytokines. We hypothesize that immunotherapy mainly acts on the T cell level and that the decisive process can be regarded as a dynamical phenomenon. The model consists of nonlinear differential equations which describe the proliferation and mutual suppression of different T cell subsets. The old version of the model was based upon the Th1-Th2 paradigm and is successful in describing the "Th1-Th2 switch" which was considered the decisive event during specific immunotherapy. In recent years, however, the Th1-Th2 paradigm has been questioned and therefore, we have investigated a modified model in order to account for the influence of a regulatory T cell type. We examined the extended model by means of numerical simulations and analytical methods. As the modified model is more complex, we had to develop new methods to portray its characteristics. The concept of stable manifolds of fixed points of a stroboscobic map turned out to be especially important. We found that when including regulatory T cells, our model can describe the events in allergen-specific immunotherapy more accurately. Our results suggest that the decisive effect of immunotherapy, the increased proliferation of Treg and suppression of Th2 cells, crucially depends on the administration of high dose injections right before the maintenance phase sets in. Empirical protocols could therefore be improved by optimizing this step of therapy.

q-bio.CB↗

arXiv2009

Nonequilibrium phase transitions in finite arrays of globally coupled Stratonovich models: Strong coupling limit

A finite array of $N$ globally coupled Stratonovich models exhibits a continuous nonequilibrium phase transition. In the limit of strong coupling there is a clear separation of time scales of center of mass and relative coordinates. The latter relax very fast to zero and the array behaves as a single entity described by the center of mass coordinate. We compute analytically the stationary probability and the moments of the center of mass coordinate. The scaling behaviour of the moments near the critical value of the control parameter $a_c(N)$ is determined. We identify a crossover from linear to square root scaling with increasing distance from $a_c$. The crossover point approaches $a_c$ in the limit $N \to \infty$ which reproduces previous results for infinite arrays. The results are obtained in both the Fokker-Planck and the Langevin approach and are corroborated by numerical simulations. For a general class of models we show that the transition manifold in the parameter space depends on $N$ and is determined by the scaling behaviour near a fixed point of the stochastic flow.

cond-mat.stat-mech↗

arXiv2003

Generation of spatiotemporal correlated noise in 1+1 dimensions

We propose a generalization of the Ornstein-Uhlenbeck process in 1+1 dimensions which is the product of a temporal Ornstein-Uhlenbeck process with a spatial one and has exponentially decaying autocorrelation. The generalized Langevin equation of the process, the corresponding Fokker-Planck equation, and a discrete integral algorithm for numerical simulation is given. The process is an alternative to a recently proposed spatiotemporal correlated model process [J. Garcia-Ojalvo et al., Phys. Rev. A 46, 4670 (1992)] for which we calculate explicitely the hitherto not known autocorrelation function in real space.

cond-mat.stat-mech↗

arXiv2001

Phase diagram of the random field Ising model on the Bethe lattice

The phase diagram of the random field Ising model on the Bethe lattice with a symmetric dichotomous random field is closely investigated with respect to the transition between the ferromagnetic and paramagnetic regime. Refining arguments of Bleher, Ruiz and Zagrebnov [J. Stat. Phys. 93, 33 (1998)] an exact upper bound for the existence of a unique paramagnetic phase is found which considerably improves the earlier results. Several numerical estimates of transition lines between a ferromagnetic and a paramagnetic regime are presented. The obtained results do not coincide with a lower bound for the onset of ferromagnetism proposed by Bruinsma [Phys. Rev. B 30, 289 (1984)]. If the latter one proves correct this would hint to a region of coexistence of stable ferromagnetic phases and a stable paramagnetic phase.

cond-mat.dis-nn↗

arXiv2001

Convolution of multifractals and the local magnetization in a random field Ising chain

The local magnetization in the one-dimensional random-field Ising model is essentially the sum of two effective fields with multifractal probability measure. The probability measure of the local magnetization is thus the convolution of two multifractals. In this paper we prove relations between the multifractal properties of two measures and the multifractal properties of their convolution. The pointwise dimension at the boundary of the support of the convolution is the sum of the pointwise dimensions at the boundary of the support of the convoluted measures and the generalized box dimensions of the convolution are bounded from above by the sum of the generalized box dimensions of the convoluted measures. The generalized box dimensions of the convolution of Cantor sets with weights can be calculated analytically for certain parameter ranges and illustrate effects we also encounter in the case of the measure of the local magnetization. Returning to the study of this measure we apply the general inequalities and present numerical approximations of the D_q-spectrum. For the first time we are able to obtain results on multifractal properties of a physical quantity in the one-dimensional random-field Ising model which in principle could be measured experimentally. The numerically generated probability densities for the local magnetization show impressively the gradual transition from a monomodal to a bimodal distribution for growing random field strength h.

cond-mat.dis-nn↗

arXiv2001

Critical Behaviour of Non-Equilibrium Phase Transitions to Magnetically Ordered States

We describe non-equilibrium phase transitions in arrays of dynamical systems with cubic nonlinearity driven by multiplicative Gaussian white noise. Depending on the sign of the spatial coupling we observe transitions to ferromagnetic or antiferromagnetic ordered states. We discuss the phase diagram, the order of the transitions, and the critical behaviour. For global coupling we show analytically that the critical exponent of the magnetization exhibits a transition from the value 1/2 to a non-universal behaviour depending on the ratio of noise strength to the magnitude of the spatial coupling.

cond-mat.stat-mech↗

arXiv2001

The Architecture of Idiotypic Networks: Percolation and Scaling Behaviour

We investigate a model where idiotypes (characterizing B-lymphocytes and antibodies of an immune system) and anti-idiotypes are represented by complementary bitstrings of a given length d allowing for a number of mismatches (matching rules). In this model, the vertices of the hypercube in dimension d represent the potential repertoire of idiotypes. A random set of (with probability p) occupied vertices corresponds to the expressed repertoire of idiotypes at a given moment. Vertices of this set linked by the above matching rules build random clusters. We give a structural and statistical characterisation of these clusters - or in other words - of the architecture of the idiotypic network. Increasing the probability p one finds at a critical p a percolation transition where for the first time a large connected graph occures with probability one. Increasing p further, there is a second transition above which the repertoire is complete in the sense that any newly introduced idiotype finds a complementary anti-idiotype. We introduce structural characteristics such as the mass distributions and the fragmentation rate for random clusters, and determine the scaling behaviour of the cluster size distribution near the percolation transition, including finite size corrections. We find that slightly above the percolation transition the large connected cluster (the central part of the idiotypic network) consists typically of one highly connected part and a number of weakly connected constituents and coexists with a number of small, isolated clusters. This is in accordance with the picture of a central and a peripheral part of the idiotypic network and gives some support to idealized architectures of the central part used in recent dynamical mean field models.

physics.bio-ph↗

arXiv2000

Orbits and phase transitions in the multifractal spectrum

We consider the one dimensional classical Ising model in a symmetric dichotomous random field. The problem is reduced to a random iterated function system for an effective field. The D_q-spectrum of the invariant measure of this effective field exhibits a sharp drop of all D_q with q < 0 at some critical strength of the random field. We introduce the concept of orbits which naturally group the points of the support of the invariant measure. We then show that the pointwise dimension at all points of an orbit has the same value and calculate it for a class of periodic orbits and their so-called offshoots as well as for generic orbits in the non-overlapping case. The sharp drop in the D_q-spectrum is analytically explained by a drastic change of the scaling properties of the measure near the points of a certain periodic orbit at a critical strength of the random field which is explicitly given. A similar drastic change near the points of a special family of periodic orbits explains a second, hitherto unnoticed transition in the D_q-spectrum. As it turns out, a decisive role in this mechanism is played by a specific offshoot. We furthermore give rigorous upper and/or lower bounds on all D_q in a wide parameter range. In most cases the numerically obtained D_q coincide with either the upper or the lower bound. The results in this paper are relevant for the understanding of random iterated function systems in the case of moderate overlap in which periodic orbits with weak singularity can play a decisive role.

cond-mat.dis-nn↗

arXiv1999

On-off Intermittency in Stochastically Driven Electrohydrodynamic Convection in Nematics

We report on-off intermittency in electroconvection of nematic liquid crystals driven by a dichotomous stochastic electric voltage. With increasing voltage amplitude we observe laminar phases of undistorted director state interrupted by shorter bursts of spatially regular stripes. Near a critical value of the amplitude the distribution of the duration of laminar phases is governed over several decades by a power law with exponent -3/2. The experimental findings agree with simulations of the linearized electrohydrodynamic equations near the sample stability threshold.

patt-sol↗