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Ulrich Schimmack

Publications and source records attributed to Ulrich Schimmack.

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Beyond Publication-Bias Detection: Estimating Bias under Uncertainty in Heterogeneous Literatures

Meta-analysts routinely test for publication bias, but a nonsignificant test is inconclusive because it may be a Type 2 error. In a large factorial simulation, I show that publication-bias tests have low power even with 1,000 studies once effect sizes are heterogeneous and the data do not meet the model's assumptions. I argue that the goal should shift from detecting bias to estimating it with confidence intervals. A confidence interval does not only bound the hypothesis that bias is absent; its upper bound also indicates how much bias remains compatible with the data. When the interval is wide, the upper bound does not exclude a large amount of bias, even if the formal test is nonsignificant. I then show that confidence intervals from step-function selection models are too narrow, covering the true amount of bias only about half the time. In contrast, z-curve's confidence interval obtained by transforming the expected discovery rate into a selection weight parameter has nominal coverage. Z-curve is therefore a valuable tool for examining publication bias in meta-analyses, especially when heterogeneity is high. I illustrate the implications of bias estimation with a meta-analysis of social priming and a set of applied-psychology meta-analyses.

stat.AP

Z-Curve Plot: A Visual Diagnostic for Publication Bias in Meta-Analysis

Publication bias undermines meta-analytic inference, yet visual diagnostics for detecting and understanding model misfit due to publication bias are lacking. We propose the z-plot, a visual publication bias-focused absolute model fit diagnostic. The z-plot overlays the model-implied distribution of z-statistics on the observed distribution of z-statistics. Models that approximate the data well show minimal discrepancy between the observed and predicted distributions of z-statistics, whereas models that approximate the data poorly show systematic discrepancies. Discontinuities in the observed distribution of z-statistics at significance thresholds or at zero provide visual evidence of publication bias; models that account for this bias track these discontinuities. In addition, the z-plot facilitates visual model fit comparison of competing meta-analytic models within a single figure. We demonstrate the visualization and its interpretation with a Bayesian random-effects meta-analysis, a Bayesian PET model, a Bayesian three-parameter selection model, and RoBMA on simulated datasets and a real meta-analysis. The method is implemented in the RoBMA R package.

stat.ME

Estimating the false discovery risk of (randomized) clinical trials in medical journals based on published p-values

The influential claim that most published results are false raised concerns about the trustworthiness and integrity of science. Since then, there have been numerous attempts to examine the rate of false-positive results that have failed to settle this question empirically. Here we propose a new way to estimate the false positive risk and apply the method to the results of (randomized) clinical trials in top medical journals. Contrary to claims that most published results are false, we find that the traditional significance criterion of $α= .05$ produces a false positive risk of 13%. Adjusting $α$ to .01 lowers the false positive risk to less than 5%. However, our method does provide clear evidence of publication bias that leads to inflated effect size estimates. These results provide a solid empirical foundation for evaluations of the trustworthiness of medical research.

stat.AP