arXiv subjects

Ulrik Lund Andersen

Publications and source records attributed to Ulrik Lund Andersen.

At least 37 records · Page 2Linked to original sources

arXiv2022

Microscopic-scale recording of brain neuronal electrical activity using a diamond quantum sensor

An important tool in the investigation of the early stages of neurodegenerative disease is the study of dissected living tissue from the brain of an animal model. Such investigations allow the physical structure of individual neurons and neural circuits to be probed alongside neuronal electrical activity, disruption of which can shed light on the mechanisms of emergence of disease. Existing techniques for recording activity rely on potentially damaging direct interaction with the sample, either mechanically as point electrical probes or via intense focused laser light combined with highly specific genetic modification and/or potentially toxic fluorescent dyes. In this work, we instead perform passive, microscopic-scale recording of electrical activity using a biocompatible quantum sensor based on colour centres in diamond. We record biomagnetic field induced by ionic currents in mouse corpus callosum axons without direct sample interaction, accurately recovering signals corresponding to action potential propagation while demonstrating in situ pharmacology during biomagnetic recording through tetrodotoxin inhibition of voltage gated sodium channels. Our results open a promising new avenue for the microscopic recording of neuronal signals, offering the prospect of high resolution imaging of electrical circuits in the living mammalian brain.

physics.bio-ph↗

arXiv2022

Ultra-coherent nanomechanical resonators based on density phononic crystal engineering

Micro- and nanomechanical systems with exceptionally low dissipation rates are enabling the next-generation technologies of ultra-sensitive detectors and quantum information systems. New techniques and methods for lowering the dissipation rate have in recent years been discovered and allowed for the engineering of mechanical oscillators with phononic modes that are extremely well isolated from the environment and thus possessing quality factors close to and beyond 1 billion. A powerful strategy for isolating and controlling a single phononic mode is based on phononic crystal engineering. Here we propose a new method for phononic crystal engineering of nanomechanical oscillators that is based on a periodic variation of the material density. To circumvent the introduction of additional bending losses resulting from the variation of material density, the added mass constitutes an array of nanopillars in which the losses will be diluted. Using this novel technique for phononic crystal engineering, we design and fabricate corrugated mechanical oscillators with quality factors approaching one billion in a room temperature environment. The flexibility space of these new phononic crystals is large and further advancement can be attained through optimized phononic crystal patterning and strain engineering via topology optimization. This will allow for the engineering of mechanical membranes with quality factors approaching 10 billion. Such extremely low mechanical dissipation rates will enable the development of radically new technologies such as quantum-limited atomic force microscopy at room-temperature, ultra-sensitive detectors of dark matter, spontaneous waveform collapses, gravity, and high-efficiency quantum information transducers.

cond-mat.mes-hall↗

arXiv2022

40 km Fiber Transmission of Squeezed Light Measured with a Real Local Oscillator

We demonstrate the generation, 40 km fiber transmission, and homodyne detection of single-mode squeezed states of light at 1550 nm using real-time phase control of a locally generated local oscillator, often called a "real local oscillator" or "local local oscillator". The system was able to stably measure up to around 3.7 dB of noise suppression with a phase noise uncertainty of around 2.5$^\circ$, using only standard telecom-compatible components and a field-programmable gate array (FPGA). The compactness, low degree of complexity and efficacy of the implemented scheme makes it a relevant candidate for long distance quantum communication in future photonic quantum networks.

quant-ph↗

arXiv2021

Laser stimulation of muscle activity with simultaneous detection using a diamond colour centre biosensor

The detection of physiological activity at the microscopic level is key for understanding the function of biosystems and relating this to physical structure. Current sensing methods often rely on invasive probes to stimulate and detect activity, bearing the risk of inducing damage in the target system. In recent years, a new type of biosensor based on color centers in diamond offers the possibility to passively, noninvasively sense and image living biological systems. Here, we use such a sensor for the \textit{in-vitro} recording of the local magnetic field generated by tightly focused, high intensity pulsed laser optogenetic neuromuscular stimulation of the extensor digitorum longus muscles. Recordings captured a compound action potential response and a slow signal component which we seek to explain using a detailed model of the biological system. We show that our sensor is capable of recording localized neuromuscular activity from the laser stimulation site without photovoltaic or fluorescence artifacts associated with alternative techniques. Our work represents an important step towards selective induction of localized neurobiological activity while performing passive sensing and imaging with diamond sensors, motivating further research into mapping of neural activity and intra-cellular processes.

physics.bio-ph↗

arXiv2021

Deterministic quantum phase estimation beyond the ideal NOON state limit

The measurement of physical parameters is one of the main pillars of science. A classic example is the measurement of the optical phase enabled by optical interferometry where the best sensitivity achievable with N photons scales as 1/N - known as the Heisenberg limit . To achieve phase estimation at the Heisenberg limit, it has been common to consider protocols based on highly complex NOON states of light. However, despite decades of research and several experimental explorations, there has been no demonstration of deterministic phase estimation with NOON states reaching the Heisenberg limit or even surpassing the shot noise limit. Here we use a phase estimation scheme based on a deterministic source of Gaussian squeezed vacuum states and high-efficiency homodyne detection to obtain phase estimates with an extreme sensitivity that significantly surpasses the shot noise limit and even beats the performance of an ideal, and thus unrealistic, NOON state protocol. Using a high-efficiency setup with a total loss of about 11% we achieve a Fisher Information of 15.8(6) rad^2 per photon unparalleled by any other optical phase estimation technology. The work represents a fundamental achievement in quantum metrology, and it opens the door to future quantum sensing technologies for the interrogation of light-sensitive biological systems.

quant-ph↗

arXiv2021

Investigation and comparison of measurement schemes in the low frequency biosensing regime using solid-state defect centers

Ensembles of solid state defects in diamond make promising quantum sensors with high sensitivity and spatiotemporal resolution. The inhomogeneous broadening and drive amplitude variations across such ensembles have differing impacts on the sensitivity depending on the sensing scheme used, adding to the challenge of choosing the optimal sensing scheme for a particular sensing regime. In this work, we numerically investigate and compare the predicted sensitivity of schemes based on continuous-wave (CW) optically detected magnetic resonance (ODMR) spectroscopy, pi-pulse ODMR and Ramsey interferometry for sensing using nitrogen-vacancy centers in the low-frequency (<10 kHz) range typical for signals from biological sources. We show that inhomogeneous broadening has the strongest impact on the sensitivity of Ramsey interferometry, and drive amplitude variations least impact the sensitivity of CW ODMR, with all methods constrained by the Rabi frequency. Based on our results, we can identify three different regions of interest. For inhomogeneous broadening less than 0.3 MHz, typical of diamonds used in state of the art sensing experiments, Ramsey interferometry yields the highest sensitivity. In the regime where inhomogeneous broadening is greater than 0.3 MHz, such as for standard optical grade diamonds or in miniaturized integrated devices, drive amplitude variations determine the optimal protocol to use. For low to medium drive amplitude variations, the highest sensitivity is reached using pi-pulse ODMR. For high drive amplitude variations, relevant for widefield microscopic imaging, CW ODMR can yield the best sensing performance.

quant-ph↗

arXiv2021

All-optical cat-code quantum error correction

The cat code is a promising encoding scheme for bosonic quantum error correction as it allows for correction against losses--the dominant error mechanism in most bosonic systems. However, for losses to be detected efficiently without disturbing the encoded logical information, one needs to implement a parity measurement of the excitation number. While such a measurement has been demonstrated in the microwave regime using a superconducting transmon ancilla, it has remained unclear how it can be implemented in the optical regime. Here, we introduce a teleportation-based error-correction scheme for the cat code, using elements suitable for an optical setting. The scheme detects and corrects single-photon losses while restoring the amplitude of the cat states, thereby greatly suppressing the accumulation of errors in lossy channels.

quant-ph↗

arXiv2021

High speed microcircuit and synthetic biosignal widefield imaging using nitrogen vacancies in diamond

The ability to measure the passage of electrical current with high spatial and temporal resolution is vital for applications ranging from inspection of microscopic electronic circuits to biosensing. Being able to image such signals passively and remotely at the same time is of high importance, to measure without invasive disruption of the system under study or the signal itself. A new approach to achieve this utilises point defects in solid state materials, in particular nitrogen vacancy (NV) centres in diamond. Acting as a high density array of independent sensors, addressable opto-electronically and highly sensitive to factors including temperature and magnetic field, these are ideally suited to microscopic widefield imaging. In this work we demonstrate such imaging of signals from a microscopic lithographically patterned circuit at the micrometer scale. Using a new type of lock-in amplifier camera, we demonstrate sub-millisecond (up to 3500 frames-per-second) spatially resolved recovery of AC and pulsed electrical current signals, without aliasing or undersampling. Finally, we demonstrate as a proof of principle the recovery of synthetic signals replicating the exact form of signals in a biological neural network: the hippocampus of a mouse.

quant-ph↗

arXiv2021

Universal unitary transfer of continuous-variable quantum states into a few qubits

We present a protocol for transferring arbitrary continuous-variable quantum states into a few discrete-variable qubits and back. The protocol is deterministic and utilizes only two-mode Rabi-type interactions which are readily available in trapped-ion and superconducting circuit platforms. The inevitable errors caused by transferring an infinite-dimensional state into a finite-dimensional register are suppressed exponentially with the number of qubits. Furthermore, the encoded states exhibit robustness against noise, such as dephasing and amplitude damping, acting on the qubits. Our protocol thus provides a powerful and flexible tool for discrete-continuous hybrid quantum systems.

quant-ph↗

arXiv2021

Ultra-coherent nanomechanical resonators based on inverse design

Engineered micro- and nanomechanical resonators with ultra-low dissipation constitute the ideal systems for applications ranging from high-precision sensing such as magnetic resonance force microscopy, to quantum transduction between disparate quantum systems. Traditionally, the improvement of the resonator's performance - often quantified by its Qf product (where Q is quality factor and f is frequency) - through nanomechanical engineering such as dissipation dilution and strain engineering, has been driven by human intuition and insight. Such an approach is inefficient and leaves aside a plethora of unexplored mechanical designs that potentially achieve better performance. Here, we use a computer-aided inverse design approach known as topology optimization to structurally design mechanical resonators with optimal performance of the fundamental mechanical mode. Using the outcomes of this approach, we fabricate and characterize ultra-coherent nanomechanical resonators with record-high Qf products, entering a quantum coherent regime where coherent oscillations are observed at room temperature. Further refinements to the model describing the mechanical system are likely to improve the Qf product even more. The proposed approach - which can be also used to improve phononic crystal and coupled-mode resonators - opens up a new paradigm for designing ultra-coherent micro- and nanomechanical resonators for cutting-edge technology, enabling e.g. novel experiments in fundamental physics (e.g. search for dark matter and quantum nature of gravity) and extreme sensing of magnetic fields, electric fields and mass with unprecedented sensitivities at room temperature.

cond-mat.mes-hall↗

arXiv2021

Optimal control of a nitrogen-vacancy spin ensemble in diamond for sensing in the pulsed domain

Defects in solid state materials provide an ideal, robust platform for quantum sensing. To deliver maximum sensitivity, a large ensemble of non-interacting defects hosting coherent quantum states are required. Control of such an ensemble is challenging due to the spatial variation in both the defect energy levels and in any control field across a macroscopic sample. In this work we experimentally demonstrate that we can overcome these challenges using Floquet theory and optimal control optimization methods to efficiently and coherently control a large defect ensemble, suitable for sensing. We apply our methods experimentally to a spin ensemble of up to 4 $\times$ 10$^9$ nitrogen vacancy (NV) centers in diamond. By considering the physics of the system and explicitly including the hyperfine interaction in the optimization, we design shaped microwave control pulses that can outperform conventional ($π$-) pulses when applied to sensing of temperature or magnetic field, with a potential sensitivity improvement between 11 and 78\%. Through dynamical modelling of the behaviour of the ensemble, we shed light on the physical behaviour of the ensemble system and propose new routes for further improvement.

quant-ph↗

arXiv2021

Laser threshold magnetometry using green light absorption by diamond nitrogen vacancies in an external cavity laser

Nitrogen vacancy (NV) centers in diamond have attracted considerable recent interest for use in quantum sensing, promising increased sensitivity for applications ranging from geophysics to biomedicine. Conventional sensing schemes involve monitoring the change in red fluorescence from the NV center under green laser and microwave illumination. Due to the strong fluorescence background from emission in the NV triplet state and low relative contrast of any change in output, sensitivity is severely restricted by a high optical shot noise level. Here, we propose a means to avoid this issue, by using the change in green pump absorption through the diamond as part of a semiconductor external cavity laser run close to lasing threshold. We show theoretical sensitivity to magnetic field on the pT/sqrt(Hz) level is possible using a diamond with an optimal density of NV centers. We discuss the physical requirements and limitations of the method, particularly the role of amplified spontaneous emission near threshold and explore realistic implementations using current technology.

quant-ph↗

arXiv2020

Improved readout of qubit-coupled Gottesman-Kitaev-Preskill states

The Gottesman-Kitaev-Preskill encoding of a qubit in a harmonic oscillator is a promising building block towards fault-tolerant quantum computation. Recently, this encoding was experimentally demonstrated for the first time in trapped-ion and superconducting circuit systems. However, these systems lack some of the Gaussian operations which are critical to efficiently manipulate the encoded qubits. In particular, homodyne detection, which is the preferred method for readout of the encoded qubit, is not readily available, heavily limiting the readout fidelity. Here, we present an alternative read-out strategy designed for qubit-coupled systems. Our method can improve the readout fidelity with several orders of magnitude for such systems and, surprisingly, even surpass the fidelity of homodyne detection in the low squeezing regime.

quant-ph↗

arXiv2020

Optimisation of a diamond nitrogen vacancy centre magnetometer for sensing of biological signals

Sensing of signals from biological processes, such as action potential propagation in nerves, are essential for clinical diagnosis and basic understanding of physiology. Sensing can be performed electrically by placing sensor probes near or inside a living specimen or dissected tissue using well established electrophysiology techniques. However, these electrical probe techniques have poor spatial resolution and cannot easily access tissue deep within a living subject, in particular within the brain. An alternative approach is to detect the magnetic field induced by the passage of the electrical signal, giving the equivalent readout without direct electrical contact. Such measurements are performed today using bulky and expensive superconducting sensors with poor spatial resolution. An alternative is to use nitrogen vacancy (NV) centres in diamond that promise biocompatibilty and high sensitivity without cryogenic cooling. In this work we present advances in biomagnetometry using NV centres, demonstrating magnetic field sensitivity of approximately 100 pT/$\sqrt{Hz}$ in the DC/low frequency range using a setup designed for biological measurements. Biocompatibility of the setup with a living sample (mouse brain slice) is studied and optimized, and we show work toward sensitivity improvements using a pulsed magnetometry scheme. In addition to the bulk magnetometry study, systematic artifacts in NV-ensemble widefield fluorescence imaging are investigated.

quant-ph↗

arXiv2020

Detection of biological signals from a live mammalian muscle using a diamond quantum sensor

The ability to perform noninvasive, non-contact measurements of electric signals produced by action potentials is essential in biomedicine. A key method to do this is to remotely sense signals by the magnetic field they induce. Existing methods for magnetic field sensing of mammalian tissue, used in techniques such as magnetoencephalography of the brain, require cryogenically cooled superconducting detectors. These have many disadvantages in terms of high cost, flexibility and limited portability as well as poor spatial and temporal resolution. In this work we demonstrate an alternative technique for detecting magnetic fields generated by the current from action potentials in living tissue using nitrogen vacancy centres in diamond. With 50pT/$\sqrt{Hz}$ sensitivity, we show the first measurements of sensing from mammalian tissue with a diamond sensor using mouse muscle optogenetically activated with blue light. We show these measurements can be performed in an ordinary, unshielded lab environment and that the signal can be easily recovered by digital signal processing techniques.

physics.bio-ph↗

arXiv2020

Cavity-Enhanced Photon Emission from a Single Germanium-Vacancy Center in a Diamond Membrane

The nitrogen-vacancy center in diamond has been explored extensively as a light-matter interface for quantum information applications, however it is limited by low coherent photon emission and spectral instability. Here, we present a promising interface based on an alternate defect with superior optical properties (the germanium-vacancy) coupled to a finesse $\approx11{,}000$ fiber cavity, resulting in a $31^{+11}_{-15}$-fold increase in the spectral density of emission. This work sets the stage for cryogenic experiments, where we predict a measurable increase in the spontaneous emission rate.

quant-ph↗

arXiv2020

Multi-edge-type LDPC code design with G-EXIT charts for continuous-variable quantum key distribution

Continuous-variable quantum key distribution utilizes an ensemble of coherent states of light to distribute secret encryption keys between two parties. One of the challenges is thereby the requirement of capacity approaching error correcting codes in the low signal-to-noise (SNR) regime (SNR < 0 dB). Multilevel coding (MLC) combined with multistage decoding (MSD) can solve this challenge in combination with multi-edge-type low-density parity-check (MET-LDPC) codes which are ideal for low code rates in the low SNR regime due to degree-one variable nodes. However, the complexity of designing such highly efficient codes remains an open issue. Here, we introduce the concept of generalized extrinsic information transfer (G-EXIT) charts for MET-LDPC codes and demonstrate how this tool can be used to analyze their convergence behavior. We calculate the capacity for each level in the MLC-MSD scheme and use G-EXIT charts to exemplary find codes for some given rates which provide a better decoding threshold compared to previously reported codes. In comparison to the traditional density evolution method, G-EXIT charts offer a simple and fast asymptotic analysis tool for MET-LDPC codes.

cs.IT↗

arXiv2019

Measurement-free preparation of grid states

Quantum computing potentially offers exponential speed-ups over classical computing for certain tasks. A central, outstanding challenge to making quantum computing practical is to achieve fault tolerance, meaning that computations of any length or size can be realised in the presence of noise. The Gottesman-Kitaev-Preskill code is a promising approach towards fault-tolerant quantum computing, encoding logical qubits into grid states of harmonic oscillators. However, for the code to be fault tolerant, the quality of the grid states has to be extremely high. Approximate grid states have recently been realized experimentally, but their quality is still insufficient for fault tolerance. Current implementable protocols for generating grid states rely on measurements of ancillary qubits combined with either postselection or feed forward. Implementing such measurements take up significant time during which the states decohere, thus limiting their quality. Here we propose a measurement-free preparation protocol which deterministically prepares arbitrary logical grid states with a rectangular or hexagonal lattice. The protocol can be readily implemented in trapped-ion or superconducting-circuit platforms to generate high-quality grid states using only a few interactions, even with the noise levels found in current systems.

quant-ph↗