arXiv subjects

Uwe Aickelin

Publications and source records attributed to Uwe Aickelin.

At least 145 records · Page 8Linked to original sources

arXiv2013

Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data

Biomarkers which predict patient's survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis. In this paper a novel method is proposed to detect the prognostic biomarkers of survival in colorectal cancer patients using wavelet analysis, genetic algorithm, and Bayes classifier. One dimensional discrete wavelet transform (DWT) is normally used to reduce the dimensionality of biomedical data. In this study one dimensional continuous wavelet transform (CWT) was proposed to extract the features of colorectal cancer data. One dimensional CWT has no ability to reduce dimensionality of data, but captures the missing features of DWT, and is complementary part of DWT. Genetic algorithm was performed on extracted wavelet coefficients to select the optimized features, using Bayes classifier to build its fitness function. The corresponding protein markers were located based on the position of optimized features. Kaplan-Meier curve and Cox regression model were used to evaluate the performance of selected biomarkers. Experiments were conducted on colorectal cancer dataset and several significant biomarkers were detected. A new protein biomarker CD46 was found to significantly associate with survival time.

cs.NE↗

arXiv2013

Towards a More Systematic Approach to Secure Systems Design and Analysis

The task of designing secure software systems is fraught with uncertainty, as data on uncommon attacks is limited, costs are difficult to estimate, and technology and tools are continually changing. Consequently, experts may interpret the security risks posed to a system in different ways, leading to variation in assessment. This paper presents research into measuring the variability in decision making between security professionals, with the ultimate goal of improving the quality of security advice given to software system designers. A set of thirty nine cyber-security experts took part in an exercise in which they independently assessed a realistic system scenario. This study quantifies agreement in the opinions of experts, examines methods of aggregating opinions, and produces an assessment of attacks from ratings of their components. We show that when aggregated, a coherent consensus view of security emerges which can be used to inform decisions made during systems design.

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arXiv2013

Investigating Mathematical Models of Immuno-Interactions with Early-Stage Cancer under an Agent-Based Modelling Perspective

Many advances in research regarding immuno-interactions with cancer were developed with the help of ordinary differential equation (ODE) models. These models, however, are not effectively capable of representing problems involving individual localisation, memory and emerging properties, which are common characteristics of cells and molecules of the immune system. Agent-based modelling and simulation is an alternative paradigm to ODE models that overcomes these limitations. In this paper we investigate the potential contribution of agent-based modelling and simulation when compared to ODE modelling and simulation. We seek answers to the following questions: Is it possible to obtain an equivalent agent-based model from the ODE formulation? Do the outcomes differ? Are there any benefits of using one method compared to the other? To answer these questions, we have considered three case studies using established mathematical models of immune interactions with early-stage cancer. These case studies were re-conceptualised under an agent-based perspective and the simulation results were then compared with those from the ODE models. Our results show that it is possible to obtain equivalent agent-based models (i.e. implementing the same mechanisms); the simulation output of both types of models however might differ depending on the attributes of the system to be modelled. In some cases, additional insight from using agent-based modelling was obtained. Overall, we can confirm that agent-based modelling is a useful addition to the tool set of immunologists, as it has extra features that allow for simulations with characteristics that are closer to the biological phenomena.

cs.CE↗

arXiv2013

Theoretical formulation and analysis of the deterministic dendritic cell algorithm

As one of the emerging algorithms in the field of Artificial Immune Systems (AIS), the Dendritic Cell Algorithm (DCA) has been successfully applied to a number of challenging real-world problems. However, one criticism is the lack of a formal definition, which could result in ambiguity for understanding the algorithm. Moreover, previous investigations have mainly focused on its empirical aspects. Therefore, it is necessary to provide a formal definition of the algorithm, as well as to perform runtime analyses to revealits theoretical aspects. In this paper, we define the deterministic version of the DCA, named the dDCA, using set theory and mathematical functions. Runtime analyses of the standard algorithm and the one with additional segmentation are performed. Our analysis suggests that the standard dDCA has a runtime complexity of O(n2) for the worst-case scenario, where n is the number of input data instances. The introduction of segmentation changes the algorithm's worst case runtime complexity to O(max(nN; nz)), for DC population size N with size of each segment z. Finally, two runtime variables of the algorithm are formulated based on the input data, to understand its runtime behaviour as guidelines for further development.

cs.NE↗

arXiv2013

Draw a line on your PDA to authenticate

The trend toward a highly mobile workforce and the ubiquity of graphical interfaces (such as the stylus and touch-screen) has enabled the emergence of graphical authentications in Personal Digital Assistants (PDAs) [1]. However, most of the current graphical password schemes are vulnerable to shoulder-surfing [2,3], a known risk where an attacker can capture a password by direct observation or by recording the authentication session. Several approaches have been developed to deal with this problem, but they have significant usability drawbacks, usually in the time and effort to log in, making them less suitable for authentication [4, 8]. For example, it is time-consuming for users to log in CHC [4] and there are complex text memory requirements in scheme proposed by Hong [5]. With respect to the scheme proposed by Weinshall [6], not only is it intricate to log in, but also the main claim of resisting shoulder-surfing is proven false [7]. In this paper, we introduce a new graphical password scheme which provides a good resistance to shouldersurfing and preserves a desirable usability.

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arXiv2013

A Three-Dimensional Model of Residential Energy Consumer Archetypes for Local Energy Policy Design in the UK

This paper reviews major studies in three traditional lines of research in residential energy consumption in the UK, i.e. economic/infrastructure, behaviour, and load profiling. Based on the review the paper proposes a three-dimensional model for archetyping residential energy consumers in the UK by considering property energy efficiency levels, the greenness of household behaviour of using energy, and the duration of property daytime occupancy. With the proposed model, eight archetypes of residential energy consumers in the UK have been identified. They are: pioneer greens, follower greens, concerned greens, home stayers, unconscientious wasters, regular wasters, daytime wasters, and disengaged wasters. Using a case study, these archetypes of residential energy consumers demonstrate the robustness of the 3-D model in aiding local energy policy/intervention design in the UK.

cs.CY↗

arXiv2013

Against Spyware Using CAPTCHA in Graphical Password Scheme

Text-based password schemes have inherent security and usability problems, leading to the development of graphical password schemes. However, most of these alternate schemes are vulnerable to spyware attacks. We propose a new scheme, using CAPTCHA (Completely Automated Public Turing tests to tell Computers and Humans Apart) that retaining the advantages of graphical password schemes, while simultaneously raising the cost of adversaries by orders of magnitude. Furthermore, some primary experiments are conducted and the results indicate that the usability should be improved in the future work.

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arXiv2013

Dienstplanerstellung in Krankenhaeusern mittels genetischer Algorithmen

This thesis investigates the use of problem-specific knowledge to enhance a genetic algorithm approach to multiple-choice optimisation problems. It shows that such information can significantly enhance performance, but that the choice of information and the way it is included are important factors for success.

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arXiv2013

Adaptive Alert Throttling for Intrusion Detection Systems

Each time that an intrusion detection system raises an alert it must make some attempt to communicate the information to an operator. This communication channel can easily become the target of a denial of service attack because, like all communication channels, it has a fixed capacity. If this channel can become overwhelmed with bogus data, an attacker can quickly achieve complete neutralisation of intrusion detection capability. Although these types of attack are very hard to stop completely, our aim is to present techniques that improve alert throughput and capacity to such an extent that the resources required to successfully mount the attack become prohibitive.

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arXiv2013

Memory Implementations - Current Alternatives

Memory can be defined as the ability to retain and recall information in a diverse range of forms. It is a vital component of the way in which we as human beings operate on a day to day basis. Given a particular situation, decisions are made and actions undertaken in response to that situation based on our memory of related prior events and experiences. By utilising our memory we can anticipate the outcome of our chosen actions to avoid unexpected or unwanted events. In addition, as we subtly alter our actions and recognise altered outcomes we learn and create new memories, enabling us to improve the efficiency of our actions over time. However, as this process occurs so naturally in the subconscious its importance is often overlooked.

cs.AI↗

arXiv2013

Immune System Approaches to Intrusion Detection - A Review (ICARIS)

The use of artificial immune systems in intrusion detection is an appealing concept for two reasons. Firstly, the human immune system provides the human body with a high level of protection from invading pathogens, in a robust, self-organised and distributed manner. Secondly, current techniques used in computer security are not able to cope with the dynamic and increasingly complex nature of computer systems and their security. It is hoped that biologically inspired approaches in this area, including the use of immune-based systems will be able to meet this challenge. Here we collate the algorithms used, the development of the systems and the outcome of their implementation. It provides an introduction and review of the key developments within this field, in addition to making suggestions for future research.

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arXiv2013

Modelling and Analysing Cargo Screening Processes: A Project Outline

The efficiency of current cargo screening processes at sea and air ports is unknown as no benchmarks exists against which they could be measured. Some manufacturer benchmarks exist for individual sensors but we have not found any benchmarks that take a holistic view of the screening procedures assessing a combination of sensors and also taking operator variability into account. Just adding up resources and manpower used is not an effective way for assessing systems where human decision-making and operator compliance to rules play a vital role. For such systems more advanced assessment methods need to be used, taking into account that the cargo screening process is of a dynamic and stochastic nature. Our project aim is to develop a decision support tool (cargo-screening system simulator) that will map the right technology and manpower to the right commodity-threat combination in order to maximize detection rates. In this paper we present a project outline and highlight the research challenges we have identified so far. In addition we introduce our first case study, where we investigate the cargo screening process at the ferry port in Calais.

cs.AI↗

arXiv2011

Comparing System Dynamics and Agent-Based Simulation for Tumour Growth and its Interactions with Effector Cells

There is little research concerning comparisons and combination of System Dynamics Simulation (SDS) and Agent Based Simulation (ABS). ABS is a paradigm used in many levels of abstraction, including those levels covered by SDS. We believe that the establishment of frameworks for the choice between these two simulation approaches would contribute to the simulation research. Hence, our work aims for the establishment of directions for the choice between SDS and ABS approaches for immune system-related problems. Previously, we compared the use of ABS and SDS for modelling agents' behaviour in an environment with nomovement or interactions between these agents. We concluded that for these types of agents it is preferable to use SDS, as it takes up less computational resources and produces the same results as those obtained by the ABS model. In order to move this research forward, our next research question is: if we introduce interactions between these agents will SDS still be the most appropriate paradigm to be used? To answer this question for immune system simulation problems, we will use, as case studies, models involving interactions between tumour cells and immune effector cells. Experiments show that there are cases where SDS and ABS can not be used interchangeably, and therefore, their comparison is not straightforward.

cs.CE↗

arXiv2011

A First Approach on Modelling Staff Proactiveness in Retail Simulation Models

There has been a noticeable shift in the relative composition of the industry in the developed countries in recent years; manufacturing is decreasing while the service sector is becoming more important. However, currently most simulation models for investigating service systems are still built in the same way as manufacturing simulation models, using a process-oriented world view, i.e. they model the flow of passive entities through a system. These kinds of models allow studying aspects of operational management but are not well suited for studying the dynamics that appear in service systems due to human behaviour. For these kinds of studies we require tools that allow modelling the system and entities using an object-oriented world view, where intelligent objects serve as abstract "actors" that are goal directed and can behave proactively. In our work we combine process-oriented discrete event simulation modelling and object-oriented agent based simulation modelling to investigate the impact of people management practices on retail productivity. In this paper, we reveal in a series of experiments what impact considering proactivity can have on the output accuracy of simulation models of human centric systems. The model and data we use for this investigation are based on a case study in a UK department store. We show that considering proactivity positively influences the validity of these kinds of models and therefore allows analysts to make better recommendations regarding strategies to apply people management practises.

cs.AI↗

arXiv2010

Artificial Immune Systems (2010)

The human immune system has numerous properties that make it ripe for exploitation in the computational domain, such as robustness and fault tolerance, and many different algorithms, collectively termed Artificial Immune Systems (AIS), have been inspired by it. Two generations of AIS are currently in use, with the first generation relying on simplified immune models and the second generation utilising interdisciplinary collaboration to develop a deeper understanding of the immune system and hence produce more complex models. Both generations of algorithms have been successfully applied to a variety of problems, including anomaly detection, pattern recognition, optimisation and robotics. In this chapter an overview of AIS is presented, its evolution is discussed, and it is shown that the diversification of the field is linked to the diversity of the immune system itself, leading to a number of algorithms as opposed to one archetypal system. Two case studies are also presented to help provide insight into the mechanisms of AIS; these are the idiotypic network approach and the Dendritic Cell Algorithm.

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arXiv2010

Detecting Danger: The Dendritic Cell Algorithm

The Dendritic Cell Algorithm (DCA) is inspired by the function of the dendritic cells of the human immune system. In nature, dendritic cells are the intrusion detection agents of the human body, policing the tissue and organs for potential invaders in the form of pathogens. In this research, and abstract model of DC behaviour is developed and subsequently used to form an algorithm, the DCA. The abstraction process was facilitated through close collaboration with laboratory- based immunologists, who performed bespoke experiments, the results of which are used as an integral part of this algorithm. The DCA is a population based algorithm, with each agent in the system represented as an 'artificial DC'. Each DC has the ability to combine multiple data streams and can add context to data suspected as anomalous. In this chapter the abstraction process and details of the resultant algorithm are given. The algorithm is applied to numerous intrusion detection problems in computer security including the detection of port scans and botnets, where it has produced impressive results with relatively low rates of false positives.

cs.AI↗

arXiv2010

The Transfer of Evolved Artificial Immune System Behaviours between Small and Large Scale Robotic Platforms

This paper demonstrates that a set of behaviours evolved in simulation on a miniature robot (epuck) can be transferred to a much larger scale platform (a virtual Pioneer P3-DX) that also differs in shape, sensor type, sensor configuration and programming interface. The chosen architecture uses a reinforcement learning-assisted genetic algorithm to evolve the epuck behaviours, which are encoded as a genetic sequence. This sequence is then used by the Pioneers as part of an adaptive, idiotypic artificial immune system (AIS) control architecture. Testing in three different simulated worlds shows that the Pioneer can use these behaviours to navigate and solve object-tracking tasks successfully, as long as its adaptive AIS mechanism is in place.

cs.NE↗

arXiv2010

Towards the Development of a Simulator for Investigating the Impact of People Management Practices on Retail Performance

Often models for understanding the impact of management practices on retail performance are developed under the assumption of stability, equilibrium and linearity, whereas retail operations are considered in reality to be dynamic, non-linear and complex. Alternatively, discrete event and agent-based modelling are approaches that allow the development of simulation models of heterogeneous non-equilibrium systems for testing out different scenarios. When developing simulation models one has to abstract and simplify from the real world, which means that one has to try and capture the 'essence' of the system required for developing a representation of the mechanisms that drive the progression in the real system. Simulation models can be developed at different levels of abstraction. To know the appropriate level of abstraction for a specific application is often more of an art than a science. We have developed a retail branch simulation model to investigate which level of model accuracy is required for such a model to obtain meaningful results for practitioners.

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