Václav Šmídl — Page 2

arXiv2016

Adaptive Multiple Importance Sampling for Gaussian Processes

In applications of Gaussian processes where quantification of uncertainty is a strict requirement, it is necessary to accurately characterize the posterior distribution over Gaussian process covariance parameters. Normally, this is done by means of standard Markov chain Monte Carlo (MCMC) algorithms. Motivated by the issues related to the complexity of calculating the marginal likelihood that can make MCMC algorithms inefficient, this paper develops an alternative inference framework based on Adaptive Multiple Importance Sampling (AMIS). This paper studies the application of AMIS in the case of a Gaussian likelihood, and proposes the Pseudo-Marginal AMIS for non-Gaussian likelihoods, where the marginal likelihood is unbiasedly estimated. The results suggest that the proposed framework outperforms MCMC-based inference of covariance parameters in a wide range of scenarios and remains competitive for moderately large dimensional parameter spaces.

stat.CO↗

arXiv2015

Non-parametric Bayesian Models of Response Function in Dynamic Image Sequences

Estimation of response functions is an important task in dynamic medical imaging. This task arises for example in dynamic renal scintigraphy, where impulse response or retention functions are estimated, or in functional magnetic resonance imaging where hemodynamic response functions are required. These functions can not be observed directly and their estimation is complicated because the recorded images are subject to superposition of underlying signals. Therefore, the response functions are estimated via blind source separation and deconvolution. Performance of this algorithm heavily depends on the used models of the response functions. Response functions in real image sequences are rather complicated and finding a suitable parametric form is problematic. In this paper, we study estimation of the response functions using non-parametric Bayesian priors. These priors were designed to favor desirable properties of the functions, such as sparsity or smoothness. These assumptions are used within hierarchical priors of the blind source separation and deconvolution algorithm. Comparison of the resulting algorithms with these priors is performed on synthetic dataset as well as on real datasets from dynamic renal scintigraphy. It is shown that flexible non-parametric priors improve estimation of response functions in both cases. MATLAB implementation of the resulting algorithms is freely available for download.

stat.ML↗