arXiv subjects

V. Palmieri

Publications and source records attributed to V. Palmieri.

At least 19 recordsLinked to original sources

arXiv2023

Optical rogue waves in spheroids of tumor cells

Rogue waves are intense and unexpected wavepackets ubiquitous in complex systems. In optics, they are promising as robust and noise-resistant beams for probing and manipulating the underlying material. Localizing large optical power is crucial especially in biomedical systems, where, however, extremely intense beams have not yet been observed. We here discover that tumor-cell spheroids manifest optical rogue waves when illuminated by randomly modulated laser beams. The intensity of light transmitted through bio-printed three-dimensional tumor models follows a signature Weibull statistical distribution, where extreme events correspond to spatially-localized optical modes propagating within the cell network. Experiments varying the input beam power and size indicate the rogue waves have a nonlinear origin. We show these optical filaments form high-transmission channels with enhanced transmission. They deliver large optical power through the tumor spheroid, which can be exploited to achieve a local temperature increase controlled by the input wave shape. Our findings shed new light on optical propagation in biological aggregates and demonstrate how extreme event formation allows light concentration in deep tissues, paving the way to using rogue waves in biomedical applications such as light-activated therapies.

physics.optics↗

arXiv2018

Deep optical neural network by living tumour brain cells

The new era of artificial intelligence demands large-scale ultrafast hardware for machine learning. Optical artificial neural networks process classical and quantum information at the speed of light, and are compatible with silicon technology, but lack scalability and need expensive manufacturing of many computational layers. New paradigms, as reservoir computing and the extreme learning machine, suggest that disordered and biological materials may realize artificial neural networks with thousands of computational nodes trained only at the input and at the readout. Here we employ biological complex systems, i.e., living three-dimensional tumour brain models, and demonstrate a random neural network (RNN) trained to detect tumour morphodynamics via image transmission. The RNN, with the tumour spheroid as a three-dimensional deep computational reservoir, performs programmed optical functions and detects cancer morphodynamics from laser-induced hyperthermia inaccessible by optical imaging. Moreover, the RNN quantifies the effect of chemotherapy inhibiting tumour growth. We realize a non-invasive smart probe for cytotoxicity assay, which is at least one order of magnitude more sensitive with respect to conventional imaging. Our random and hybrid photonic/living system is a novel artificial machine for computing and for the real-time investigation of tumour dynamics.

physics.med-ph↗

arXiv2018

Double-beta decay of ${}^{130}$Te to the first $0^+$ excited state of ${}^{130}$Xe with CUORE-0

We report on a search for double beta decay of $^{130}$Te to the first $0^{+}$ excited state of $^{130}$Xe using a 9.8 kg$\cdot$yr exposure of $^{130}$Te collected with the CUORE-0 experiment. In this work we exploit different topologies of coincident events to search for both the neutrinoless and two-neutrino double-decay modes. We find no evidence for either mode and place lower bounds on the half-lives: $τ^{0ν}_{0^+}>7.9\cdot 10^{23}$ yr and $τ^{2ν}_{0^+}>2.4\cdot 10^{23}$ yr. Combining our results with those obtained by the CUORICINO experiment, we achieve the most stringent constraints available for these processes: $τ^{0ν}_{0^+}>1.4\cdot 10^{24}$ yr and $τ^{2ν}_{0^+}>2.5\cdot 10^{23}$ yr.

nucl-ex↗

arXiv2018

Search of the neutrino-less double beta decay of $^{82}$Se into the excited states of $^{82}$Kr with CUPID-0

The CUPID0 experiment searches for double beta decay using cryogenic calorimeters with double (heat and light) read-out. The detector, consisting of 24 ZnSe crystals 95$\%$ enriched in $^{82}$Se and 2 natural ZnSe crystals, started data-taking in 2017 at Laboratori Nazionali del Gran Sasso. We present the search for the neutrino-less double beta decay of $^{82}$Se into the 0$_1^+$, 2$_1^+$ and 2$_2^+$ excited states of $^{82}$Kr with an exposure of 5.74 kg$\cdot$yr (2.24$\times$10$^{25}$ emitters$\cdot$yr). We found no evidence of the decays and set the most stringent limits on the widths of these processes: $Γ$($^{82}$Se $\rightarrow ^{82}$Kr$_{0_1^+}$)$<$8.55$\times$10$^{-24}$ yr$^{-1}$, $Γ$($^{82}$Se $\rightarrow ^{82}$Kr$_{2_1^+}$)$<6.25 \times10^{-24}$ yr$^{-1}$, $Γ$($^{82}$Se $\rightarrow ^{82}$Kr$_{2_2^+}$)$<$8.25$\times$10$^{-24}$ yr$^{-1}$ (90$\%$ credible interval

nucl-ex↗

arXiv2018

Update on the recent progress of the CUORE experiment

CUORE is a 741 kg array of 988 TeO$_2$ bolometeric crystals designed to search for the neutrinoless double beta decay of $^{130}$Te and other rare processes. CUORE has been taking data since summer 2017, and as of summer 2018 collected a total of 86.3 kg$\cdot$yr of TeO$_2$ exposure. Based on this exposure, we were able to set a limit on the $0νββ$ half-life of $^{130}$Te of $T^{0ν}_{1/2}>1.5\times10^{25}$ yr at 90% C.L. At this conference, we showed the decomposition of the CUORE background and were able to extract a $^{130}$Te $2νββ$ half-life of $T_{1/2}^{2ν}=[7.9\pm0.1 \mathrm{(stat.)}\pm0.2 \mathrm{(syst.)}]\times10^{20}$ yr. This is the most precise measurement of this half-life and is consistent with previous measurements.

nucl-ex↗

arXiv2018

Analysis of cryogenic calorimeters with light and heat read-out for double beta decay searches

The suppression of spurious events in the region of interest for neutrinoless double beta decay will play a major role in next generation experiments. The background of detectors based on the technology of cryogenic calorimeters is expected to be dominated by α particles, that could be disentangled from double beta decay signals by exploiting the difference in the emission of the scintillation light. CUPID-0, an array of enriched Zn$^{82}$Se scintillating calorimeters, is the first large mass demonstrator of this technology. The detector started data-taking in 2017 at the Laboratori Nazionali del Gran Sasso with the aim of proving that dual read-out of light and heat allows for an efficient suppression of the α background. In this paper we describe the software tools we developed for the analysis of scintillating calorimeters and we demonstrate that this technology allows to reach an unprecedented background for cryogenic calorimeters.

physics.ins-det↗

arXiv2018

First Result on the Neutrinoless Double Beta Decay of $^{82}$Se with CUPID-0

We report the result of the search for neutrinoless double beta decay of $^{82}$Se obtained with CUPID-0, the first large array of scintillating Zn$^{82}$Se cryogenic calorimeters implementing particle identification. We observe no signal in a 1.83 kg yr $^{82}$Se exposure and we set the most stringent lower limit on the \onu $^{82}$Se half-life T$^{0ν}_{1/2}>$ 2.4$\times \mathrm{10}^{24}$ yr (90\% credible interval), which corresponds to an effective Majorana neutrino mass m$_{ββ} <$ (376-770) meV depending on the nuclear matrix element calculations. The heat-light readout provides a powerful tool for the rejection of \al\ particles and allows to suppress the background in the region of interest down to (3.6$^{+1.9}_{-1.4}$)$\times$10$^{-3}$\ckky, an unprecedented level for this technique.

nucl-ex↗

arXiv2018

CUPID-0: the first array of enriched scintillating bolometers for 0νββdecay investigations

The CUPID-0 detector hosted at the Laboratori Nazionali del Gran Sasso, Italy, is the first large array of enriched scintillating cryogenic detectors for the investigation of $^{82}$Se neutrinoless double-beta decay (0$νββ$). CUPID-0 aims at measuring a background index in the region of interest (RoI) for 0$νββ$ at the level of 10$^{-3}$ c/keV/kg/y, the lowest value ever measured using cryogenic detectors. This result can be achieved by a state of the art technology for background suppression and thorough protocols and procedures for detector preparation and construction. In this paper, the different phases of the detector design and construction will be presented, from the material selection (for the absorber production) to the new and innovative detector structure. The successful construction of the detector lead to promising detector performance which are here preliminarily discussed

physics.ins-det↗

arXiv2018

Study of Rare Nuclear Processes with CUORE

TeO2 bolometers have been used for many years to search for neutrinoless double beta decay in 130-Te. CUORE, a tonne-scale TeO2 detector array, recently published the most sensitive limit on the half-life, $T_{1/2}^{0ν} > 1.5 \times 10^{25}\,$yr, which corresponds to an upper bound of $140-400$~meV on the effective Majorana mass of the neutrino. While it makes CUORE a world-leading experiment looking for neutrinoless double beta decay, it is not the only study that CUORE will contribute to in the field of nuclear and particle physics. As already done over the years with many small-scale experiments, CUORE will investigate both rare decays (such as the two-neutrino double beta decay of 130-Te and the hypothesized electron capture in 123-Te), and rare processes (e.g., dark matter and axion interactions). This paper describes some of the achievements of past experiments that used TeO2 bolometers, and perspectives for CUORE.

nucl-ex↗

arXiv2017

Low Energy Analysis Techniques for CUORE

CUORE is a tonne-scale cryogenic detector operating at the Laboratori Nazionali del Gran Sasso (LNGS) that uses tellurium dioxide bolometers to search for neutrinoless double-beta decay of $^{130}$Te. CUORE is also suitable to search for low energy rare events such as solar axions or WIMP scattering, thanks to its ultra-low background and large target mass. However, to conduct such sensitive searches requires improving the energy threshold to 10 keV. In this paper, we describe the analysis techniques developed for the low energy analysis of CUORE-like detectors, using the data acquired from November 2013 to March 2015 by CUORE-0, a single-tower prototype designed to validate the assembly procedure and new cleaning techniques of CUORE. We explain the energy threshold optimization, continuous monitoring of the trigger efficiency, data and event selection, and energy calibration at low energies in detail. We also present the low energy background spectrum of CUORE-0 below 60keV. Finally, we report the sensitivity of CUORE to WIMP annual modulation using the CUORE-0 energy threshold and background, as well as an estimate of the uncertainty on the nuclear quenching factor from nuclear recoils in CUORE-0.

physics.ins-det↗

arXiv2017

Search for Neutrinoless $β^{+}\hspace{-0.2em}EC$ Decay of $^{120}$Te with CUORE-0

We have performed a search for neutrinoless $β^{+}\hspace{-0.2em}EC$ decay of $^{120}$Te using the final CUORE-0 data release. We describe a new analysis method for the simultaneous fit of signatures with different event topology, and of data subsets with different signal efficiency, obtaining a limit on the half-life of the decay of $T_{1/2}>1.6\cdot10^{21}$ yr at $90\%$ CI. Combining this with results from Cuoricino, a predecessor experiment, we obtain the strongest limit to date, corresponding to $T_{1/2}>2.7\cdot10^{21}$ yr at $90\%$ CI.

nucl-ex↗

arXiv2017

The projected background for the CUORE experiment

The Cryogenic Underground Observatory for Rare Events (CUORE) is designed to search for neutrinoless double beta decay of 130Te with an array of 988 TeO2 bolometers operating at temperatures around 10 mK. The experiment is currently being commissioned in Hall A of Laboratori Nazionali del Gran Sasso, Italy. The goal of CUORE is to reach a 90\% C.L. exclusion sensitivity on the \tect decay half-life of 9$\times$10$^{25}$ years after 5\,years of data taking. The main issue to be addressed to accomplish this aim is the rate of background events in the region of interest, which must not be higher than 10$^{-2}$\,counts/keV/kg/y. We developed a detailed Monte Carlo simulation, based on results from a campaign of material screening, radioassays, and bolometric measurements, to evaluate the expected background. This was used over the years to guide the construction strategies of the experiment and we use it here to project a background model for CUORE. In this paper we report the results of our study and our expectations for the background rate in the energy region where the peak signature of neutrinoless double beta decay of 130Te is expected.

physics.ins-det↗

arXiv2017

CUORE Sensitivity to $0νββ$ Decay

We report a study of the CUORE sensitivity to neutrinoless double beta ($0νββ$) decay. We used a Bayesian analysis based on a toy Monte Carlo (MC) approach to extract the exclusion sensitivity to the $0νββ$ decay half-life ($T_{1/2}^{0ν}$) at $90\%$ credibility interval (CI) -- i.e. the interval containing the true value of $T_{1/2}^{0ν}$ with $90\%$ probability -- and the $3 σ$ discovery sensitivity. We consider various background levels and energy resolutions, and describe the influence of the data division in subsets with different background levels. If the background level and the energy resolution meet the expectation, CUORE will reach a $90\%$ CI exclusion sensitivity of $2\cdot10^{25}$ yr with $3$ months, and $9\cdot10^{25}$ yr with $5$ years of live time. Under the same conditions, the discovery sensitivity after $3$ months and $5$ years will be $7\cdot10^{24}$ yr and $4\cdot10^{25}$ yr, respectively.

physics.ins-det↗

arXiv2017

Measurement of the Two-Neutrino Double Beta Decay Half-life of $^{130}$Te with the CUORE-0 Experiment

We report on the measurement of the two-neutrino double beta decay half-life of $^{130}$Te with the CUORE-0 detector. From an exposure of 33.4 kg$\cdot$y of TeO$_2$, the half-life is determined to be $T_{1/2}^{2ν}$ = [8.2 $\pm$ 0.2 (stat.) $\pm$ 0.6 (syst.)] $\times$ 10$^{20}$y. This result is obtained after a detailed reconstruction of the sources responsible for the CUORE-0 counting rate, with a specific study of those contributing to the $^{130}$Te neutrinoless double beta decay region of interest.

nucl-ex↗

arXiv2016

The CUORE and CUORE-0 experiments at LNGS

The Cryogenic Underground Observatory for Rare Events (CUORE) is a 1-ton scale bolometric experiment devoted to the search of the neutrinoless double-beta decay (0ν\b{eta}\b{eta}) in 130Te. The CUORE detector consists of an array of 988 TeO2 crystals operated at 10 mK. CUORE-0 is the CUORE demonstrator: it has been built to test the performance of the upcoming CUORE experiment and represents the largest 130Te bolometric setup ever operated. CUORE-0 has been running at Laboratori Nazionali del Gran Sasso (Italy) from 2013 to 2015. The final CUORE-0 analysis on 0ν\b{eta}\b{eta} and the corresponding detector performance are presented. The present status of the CUORE experiment, now in its final construction and commissioning phase, are discussed. The results from assembly of the detector and the commissioning of the cryostat are reported.

physics.ins-det↗

arXiv2016

First array of enriched Zn$^{82}$Se bolometers to search for double beta decay

The R&D activity performed during the last years proved the potential of ZnSe scintillating bolometers to the search for neutrino-less double beta decay, motivating the realization of the first large-mass experiment based on this technology: CUPID-0. The isotopic enrichment in $^{82}$Se, the Zn$^{82}$Se crystals growth, as well as the light detectors production have been accomplished, and the experiment is now in construction at Laboratori Nazionali del Gran Sasso (Italy). In this paper we present the results obtained testing the first three Zn$^{82}$Se crystals operated as scintillating bolometers, and we prove that their performance in terms of energy resolution, background rejection capability and intrinsic radio-purity complies with the requirements of CUPID-0.

physics.ins-det↗

arXiv2016

Analysis Techniques for the Evaluation of the Neutrinoless Double-Beta Decay Lifetime in $^{130}$Te with CUORE-0

We describe in detail the methods used to obtain the lower bound on the lifetime of neutrinoless double-beta ($0νββ$) decay in $^{130}$Te and the associated limit on the effective Majorana mass of the neutrino using the CUORE-0 detector. CUORE-0 is a bolometric detector array located at the Laboratori Nazionali del Gran Sasso that was designed to validate the background reduction techniques developed for CUORE, a next-generation experiment scheduled to come online in 2016. CUORE-0 is also a competitive $0νββ$ decay search in its own right and functions as a platform to further develop the analysis tools and procedures to be used in CUORE. These include data collection, event selection and processing, as well as an evaluation of signal efficiency. In particular, we describe the amplitude evaluation, thermal gain stabilization, energy calibration methods, and the analysis event selection used to create our final $0νββ$ decay search spectrum. We define our high level analysis procedures, with emphasis on the new insights gained and challenges encountered. We outline in detail our fitting methods near the hypothesized $0νββ$ decay peak and catalog the main sources of systematic uncertainty. Finally, we derive the $0νββ$ decay half-life limits previously reported for CUORE-0, $T^{0ν}_{1/2}>2.7\times10^{24}$ yr, and in combination with the Cuoricino limit, $T^{0ν}_{1/2}>4.0\times10^{24}$ yr.

nucl-ex↗

arXiv2015

Search for Neutrinoless Double-Beta Decay of $^{130}$Te with CUORE-0

We report the results of a search for neutrinoless double-beta decay in a 9.8~kg$\cdot$yr exposure of $^{130}$Te using a bolometric detector array, CUORE-0. The characteristic detector energy resolution and background level in the region of interest are $5.1\pm 0.3{\rm~keV}$ FWHM and $0.058 \pm 0.004\,(\mathrm{stat.})\pm 0.002\,(\mathrm{syst.})$~counts/(keV$\cdot$kg$\cdot$yr), respectively. The median 90%~C.L. lower-limit sensitivity of the experiment is $2.9\times 10^{24}~{\rm yr}$ and surpasses the sensitivity of previous searches. We find no evidence for neutrinoless double-beta decay of $^{130}$Te and place a Bayesian lower bound on the decay half-life, $T^{0ν}_{1/2}>$~$ 2.7\times 10^{24}~{\rm yr}$ at 90%~C.L. Combining CUORE-0 data with the 19.75~kg$\cdot$yr exposure of $^{130}$Te from the Cuoricino experiment we obtain $T^{0ν}_{1/2} > 4.0\times 10^{24}~\mathrm{yr}$ at 90%~C.L.~(Bayesian), the most stringent limit to date on this half-life. Using a range of nuclear matrix element estimates we interpret this as a limit on the effective Majorana neutrino mass, $m_{ββ}< 270$ -- $760~\mathrm{meV}$.

nucl-ex↗