arXiv subjects

Vanessa Didelez

Publications and source records attributed to Vanessa Didelez.

27 records · Page 2Linked to original sources

arXiv2015

Robustness and efficiency of covariate adjusted linear instrumental variable estimators

Two-stage least squares (TSLS) estimators and variants thereof are widely used to infer the effect of an exposure on an outcome using instrumental variables (IVs). They belong to a wider class of two-stage IV estimators, which are based on fitting a conditional mean model for the exposure, and then using the fitted exposure values along with the covariates as predictors in a linear model for the outcome. We show that standard TSLS estimators enjoy greater robustness to model misspecification than more general two-stage estimators. However, by potentially using a wrong exposure model, e.g. when the exposure is binary, they tend to be inefficient. In view of this, we study double-robust G-estimators instead. These use working models for the exposure, IV and outcome but only require correct specification of either the IV model or the outcome model to guarantee consistent estimation of the exposure effect. As the finite sample performance of the locally efficient G-estimator can be poor, we further develop G-estimation procedures with improved efficiency and robustness properties under misspecification of some or all working models. Simulation studies and a data analysis demonstrate drastic improvements, with remarkably good performance even when one or more working models are misspecified.

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arXiv2012

Direct and Indirect Effects of Sequential Treatments

In this paper we review the notion of direct causal effect as introduced by Pearl (2001). We show how it can be formulated without counterfactuals, using intervention indicators instead. This allows to consider the natural direct effect as a special case of sequential treatments discussed by Dawid and Didelez (2005) which immediately yields conditions for identifiability as well as a graphical way of checking identifiability. The results are contrasted with the criteria given by Pearl (2001) and Robins (2003).

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arXiv2012

Asymmetric separation for local independence graphs

Directed possibly cyclic graphs have been proposed by Didelez (2000) and Nodelmann et al. (2002) in order to represent the dynamic dependencies among stochastic processes. These dependencies are based on a generalization of Granger-causality to continuous time, first developed by Schweder (1970) for Markov processes, who called them local dependencies. They deserve special attention as they are asymmetric unlike stochastic (in)dependence. In this paper we focus on their graphical representation and develop a suitable, i.e. asymmetric notion of separation, called delta-separation. The properties of this graph separation as well as of local independence are investigated in detail within a framework of asymmetric (semi)graphoids allowing a deeper insight into what information can be read off these graphs.

cs.AI↗

arXiv2012

Causal Reasoning in Graphical Time Series Models

We propose a definition of causality for time series in terms of the effect of an intervention in one component of a multivariate time series on another component at some later point in time. Conditions for identifiability, comparable to the back-door and front-door criteria, are presented and can also be verified graphically. Computation of the causal effect is derived and illustrated for the linear case.

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arXiv2012

Identifying Optimal Sequential Decisions

We consider conditions that allow us to find an optimal strategy for sequential decisions from a given data situation. For the case where all interventions are unconditional (atomic), identifiability has been discussed by Pearl & Robins (1995). We argue here that an optimal strategy must be conditional, i.e. take the information available at each decision point into account. We show that the identification of an optimal sequential decision strategy is more restrictive, in the sense that conditional interventions might not always be identified when atomic interventions are. We further demonstrate that a simple graphical criterion for the identifiability of an optimal strategy can be given.

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arXiv2011

Graphical Models for Inference Under Outcome-Dependent Sampling

We consider situations where data have been collected such that the sampling depends on the outcome of interest and possibly further covariates, as for instance in case-control studies. Graphical models represent assumptions about the conditional independencies among the variables. By including a node for the sampling indicator, assumptions about sampling processes can be made explicit. We demonstrate how to read off such graphs whether consistent estimation of the association between exposure and outcome is possible. Moreover, we give sufficient graphical conditions for testing and estimating the causal effect of exposure on outcome. The practical use is illustrated with a number of examples.

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arXiv2010

Assumptions of IV Methods for Observational Epidemiology

Instrumental variable (IV) methods are becoming increasingly popular as they seem to offer the only viable way to overcome the problem of unobserved confounding in observational studies. However, some attention has to be paid to the details, as not all such methods target the same causal parameters and some rely on more restrictive parametric assumptions than others. We therefore discuss and contrast the most common IV approaches with relevance to typical applications in observational epidemiology. Further, we illustrate and compare the asymptotic bias of these IV estimators when underlying assumptions are violated in a numerical study. One of our conclusions is that all IV methods encounter problems in the presence of effect modification by unobserved confounders. Since this can never be ruled out for sure, we recommend that practical applications of IV estimators be accompanied routinely by a sensitivity analysis.

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arXiv2010

Identifying the consequences of dynamic treatment strategies: A decision-theoretic overview

We consider the problem of learning about and comparing the consequences of dynamic treatment strategies on the basis of observational data. We formulate this within a probabilistic decision-theoretic framework. Our approach is compared with related work by Robins and others: in particular, we show how Robins's 'G-computation' algorithm arises naturally from this decision-theoretic perspective. Careful attention is paid to the mathematical and substantive conditions required to justify the use of this formula. These conditions revolve around a property we term stability, which relates the probabilistic behaviours of observational and interventional regimes. We show how an assumption of 'sequential randomization' (or 'no unmeasured confounders'), or an alternative assumption of 'sequential irrelevance', can be used to infer stability. Probabilistic influence diagrams are used to simplify manipulations, and their power and limitations are discussed. We compare our approach with alternative formulations based on causal DAGs or potential response models. We aim to show that formulating the problem of assessing dynamic treatment strategies as a problem of decision analysis brings clarity, simplicity and generality.

math.ST↗

arXiv2007

Graphical models for marked point processes based on local independence

A new class of graphical models capturing the dependence structure of events that occur in time is proposed. The graphs represent so-called local independences, meaning that the intensities of certain types of events are independent of some (but not necessarily all) events in the past. This dynamic concept of independence is asymmetric, similar to Granger non-causality, so that the corresponding local independence graphs differ considerably from classical graphical models. Hence a new notion of graph separation, called delta-separation, is introduced and implications for the underlying model as well as for likelihood inference are explored. Benefits regarding facilitation of reasoning about and understanding of dynamic dependencies as well as computational simplifications are discussed.

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