arXiv subjects

Varghese John

Publications and source records attributed to Varghese John.

3 recordsLinked to original sources

arXiv2025

Supporting Medicinal Chemists in Iterative Hypothesis Generation for Drug Target Identification

While drug discovery is vital for human health, the process remains inefficient. Medicinal chemists must navigate a vast protein space to identify target proteins that meet three criteria: physical and functional interactions, therapeutic impact, and docking potential. Prior approaches have provided fragmented support for each criterion, limiting the generation of promising hypotheses for wet-lab experiments. We present HAPPIER, an AI-powered tool that supports hypothesis generation with integrated multi-criteria support for target identification. HAPPIER enables medicinal chemists to 1) efficiently explore and verify proteins in a single integrated graph component showing multi-criteria satisfaction and 2) validate AI suggestions with domain knowledge. These capabilities facilitate iterative cycles of divergent and convergent thinking, essential for hypothesis generation. We evaluated HAPPIER with ten medicinal chemists, finding that it increased the number of high-confidence hypotheses and support for the iterative cycle, and further demonstrated the relationship between engaging in such cycles and confidence in outputs.

cs.HC↗

arXiv1995

Chern-Simons terms in Noncommutative Geometry and its application to Bilayer Quantum Hall Systems

Considering bilayer systems as extensions of the planar ones by an internal space of two discrete points, we use the ideas of Noncommutative Geometry to construct the gauge theories for these systems. After integrating over the discrete space we find an effective $2+1$ action involving an extra complex scalar field, which can be interpreted as arising from the tunneling between the layers. The gauge fields are found in different phases corresponding to the different correlations due to the Coulomb interaction between the layers. In a particular phase, when the radial part of the complex scalar field is a constant, we recover the Wen-Zee model of Bilayer Quantum Hall systems. There are some circumstances, where this radial part may become dynamical and cause dissipation in the oscillating supercurrent between the layers.

hep-th↗

arXiv1993

Correlation Functions and Multicritical Flows in $c<1$ String Theory

We compute all string tree level correlation functions of vertex operators in $c<1$ string theory. This is done by using the ring structure of the theory. In order to study the multicritical behaviour, we calculate the correlation functions after perturbation by physical vertex operators. We show that the $(2k-1,2)$ models can be obtained from the $(1,2)$ model and the minimal models can be obtained from the $(1,p)$ model by perturbing the action by appropriate physical operators. Our results are consistent with known results from matrix models.

hep-th↗