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Vikram Singh

Publications and source records attributed to Vikram Singh.

41 records · Page 3Linked to original sources

Bifurcation in cell cycle dynamics regulated by p53

We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases. The IR induced p53 dynamics undergo collapse of oscillation with collapse time Δt which depends on IR strength. The stress p53 via IR drive cell cycle molecular species MPF and cyclin dynamics to different states, namely, oscillation death, oscillations of periods, chaotic and sustain oscillation in their bifurcation diagram. We predict that there could be a critical Δt_c induced by p53 via IR_c, where, if Δt < Δt_c the cell cycle may come back to normal state, otherwise it will go to cell cycle arrest (apoptosis).

q-bio.MN↗

Integrating User's Domain Knowledge with Association Rule Mining

This paper presents a variation of Apriori algorithm that includes the role of domain expert to guide and speed up the overall knowledge discovery task. Usually, the user is interested in finding relationships between certain attributes instead of the whole dataset. Moreover, he can help the mining algorithm to select the target database which in turn takes less time to find the desired association rules. Variants of the standard Apriori and Interactive Apriori algorithms have been run on artificial datasets. The results show that incorporating user's preference in selection of target attribute helps to search the association rules efficiently both in terms of space and time.

cs.DB↗

ICT in Universities of the Western Himalayan Region of India II: A Comparative SWOT Analysis

This study presents a comparative SWOT analysis to comprehend the pattern of development of ICT within six universities of western Himalayan region of India. With the objective of achieving quality and excellence in higher education system in the region, this study provides a basis to decision makers to exploit opportunities and minimize the external threats. The SWOT analysis of different universities, placed under three categories, has been undertaken within the four-tier framework used earlier by the authors. Guided by the initiatives of National Mission on Education through ICT (NMEICT) for SWOT analysis, findings of this paper reveal, relative consistency of these three categories of universities, with the earlier study. A few suggestions, as opportunities, with an emphasis on problem solving orientation in higher education, have been made to strengthen the leadership of universities in the field of ICT.

cs.OH↗

Including beta- and gamma- Vibrations in Evaluating the Ground State Rotational Band of Deformed Even-Even Nuclei

From the semi-empirical formalisms of Bohr-Mottelson, a new model, based on the effect of beta- and gamma- head energies and the variable moment of inertia, was developed to calculate the ground state rotational band of almost all deformed e-e nuclei. The model can be tuned for nuclei with experimentally available beta- and gamma-vibrational energies as well as for those with unmeasured beta- and gamma-vibrations.

nucl-th↗

Ground States Rotational Band in Deformed e-e Nuclei

In the frame work of the hydrodynamical model, a new model of the ground state rotational bands of deformed e-e nuclei is developed by introducing the variable moment of inertia, and the effect of beta- and gamma- vibrational bands. The model is applied to calculate the energies of the ground state band of 158Dy. The results of our calculations are in close agreement with data compared with other existing models.

nucl-th↗