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Vinuyan Sivakolunthu

Publications and source records attributed to Vinuyan Sivakolunthu.

3 recordsLinked to original sources

Uncertain but Useful: Leveraging CNN Training Variability into Data Augmentation

Deep learning (DL) has transformed neuroimaging by delivering state-of-the-art performance with reduced computation times. Yet, the numerical uncertainty inherent to DL training remains largely underexplored despite its potential to significantly impact the reliability of model outcomes. We show that training the FastSurfer segmentation model introduces substantial numerical uncertainty that exceeds its non-DL counterpart (FreeSurfer 7.3.2) in cortical regions, potentially impacting downstream clinical results. We also characterize this training-time uncertainty using random seed perturbations and demonstrate that seed-induced variability is structurally comparable to numerical variability. We then show that seed variability can be leveraged as a data augmentation technique through ensembling to improve downstream brain age regression performance. These findings position numerical uncertainty during DL training as a substantive factor in neuroimaging reliability, with measurable consequences for downstream tasks, and demonstrate that it can simultaneously be harnessed as a data augmentation technique.

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Conservative & Aggressive NaNs Accelerate U-Nets for Neuroimaging

Deep learning models for neuroimaging increasingly rely on large architectures, making efficiency a persistent concern despite advances in hardware. Through an analysis of numerical uncertainty of convolutional neural networks (CNNs), we observe that many operations are applied to values dominated by numerical noise and have negligible influence on model outputs. In some models, up to two-thirds of convolution operations appear redundant. We introduce Conservative & Aggressive NaNs, two novel variants of max pooling and unpooling that identify numerically unstable voxels and replace them with NaNs, allowing subsequent layers to skip computations on irrelevant data. Both methods are implemented within PyTorch and require no architectural changes. We evaluate these approaches on four CNN models spanning neuroimaging and image classification tasks. For inputs containing at least 50% NaNs, we observe consistent runtime improvements; for data with more than two-thirds NaNs )common in several neuroimaging settings) we achieve an average inference speedup of 1.67x. Conservative NaNs reduces convolution operations by an average of 30% across models and datasets, with no measurable performance degradation, and can skip up to 64.64% of convolutions in specific layers. Aggressive NaNs can skip up to 69.30% of convolutions but may occasionally affect performance. Overall, these methods demonstrate that numerical uncertainty can be exploited to reduce redundant computation and improve inference efficiency in CNNs.

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Numerical Uncertainty of Convolutional Neural Networks Inference for Structural Brain MRI Analysis

This paper investigates the numerical uncertainty of Convolutional Neural Networks (CNNs) inference for structural brain MRI analysis. It applies Random Rounding -- a stochastic arithmetic technique -- to CNN models employed in non-linear registration (SynthMorph) and whole-brain segmentation (FastSurfer), and compares the resulting numerical uncertainty to the one measured in a reference image-processing pipeline (FreeSurfer recon-all). Results obtained on 32 representative subjects show that CNN predictions are substantially more accurate numerically than traditional image-processing results (non-linear registration: 19 vs 13 significant bits on average; whole-brain segmentation: 0.99 vs 0.92 Sørensen-Dice score on average), which suggests a better reproducibility of CNN results across execution environments.

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