arXiv subjects

Volker C. Behr

Publications and source records attributed to Volker C. Behr.

3 recordsLinked to original sources

arXiv2026

First in-vivo human magnetic particle imaging

Magnetic particle imaging (MPI) is a tracer-based technique that directly detects the distribution of magnetic iron-oxide nanoparticles with millisecond temporal resolution and no tissue background. Despite extensive preclinical work, in-vivo application of MPI in humans has not previously been reported. Here, we report the first in-vivo human MPI angiography, visualizing venous perfusion of the upper extremity using a human-scale scanner and clinically approved ferucarbotran. Under identical procedural conditions, we performed X-ray digital subtraction angiography as the clinical gold standard. MPI visualized major superficial and deep veins, including inflow, branching, valve filling, and clearance dynamics in real time with 2 frames per second. These results establish magnetic particle imaging as a clinically translatable modality for radiation-free vascular imaging in humans and mark the transition of MPI from preclinical research to first clinical application.

physics.med-ph↗

arXiv2022

Highly Flexible and Modular Simulation Framework for Magnetic Particle Imaging

Simulations with high accuracy are an essential part of scientific research to accelerate the innovation process. They are especially useful for finding novel approaches or optimizing existing methods. Today, powerful software tools are available consisting of multiple packages with a wide variety of features, methods, and models meet the requirements for different questions in multiple fields of research. Unfortunately, the complexity and often inflexibility of such unspecific software tools can hinder an optimal workflow. Especially in the case of a novel research fields, e.g., Magnetic Particle Imaging (MPI), the requirements on a software tool are a high degree of flexibility paired with a manageable number of highly specific features to provide fast and easy access. Thus, often research sites generates their own software solution to address their specific demands. Until now, only few simulation frameworks are available, which partially fulfil most requirements of the young field of MPI. However, the coverage of the entire process of emulating a full MPI experiment from magnetic field and particle dynamic simulations, hardware and sequence programming over signal generation and data processing to final reconstruction and visualization combined with an easy-to-use graphical user interface (GUI) and without the need of complex combination of different software packages cannot be found in the literature or MPI community so far. With the presented modular simulation framework consisting of multiple interconnected software packages to specific purposes, all necessary simulation steps are provided. The high degree of flexibility and modularity allow the simulation and emulation of almost any kind of MPI scanners known in the MPI community. Furthermore, the modular framework allows an easy connection of third-party software using dedicated interfaces between important steps.

physics.med-ph↗

arXiv2011

Active split-ring metamaterial slabs for magnetic resonance imaging

In this work, it is analyzed the ability of split-ring metamaterial slabs with zero/high permeability to reject/confine the radiofrequency magnetic field in magnetic resonance imaging systems. Using an homogenization procedure, split-ring slabs have been designed and fabricated to work in a 1.5T system. Active elements consisting of pairs of crossed diodes are inserted in the split-rings. With these elements, the permeability of the slabs can be automatically switched between a unity value when interacting with the strong excitation field of the transmitting body coil, and zero or high values when interacting with the weak field produced by protons in tissue. Experiments are shown for different configurations where these slabs can help to locally increase the signal-to-noise-ratio.

physics.med-ph↗