arXiv subjects

Walia Farzana

Publications and source records attributed to Walia Farzana.

3 recordsLinked to original sources

arXiv2026

CarveMix-RC: Addressing Rare-Class Imbalance Through Lesion-Aware Synthetic Augmentation for Brain Metastasis Segmentation

Accurate segmentation of post-treatment brain metastases is essential for treatment planning, longitudinal disease monitoring, and quantitative assessment of therapeutic response. The BraTS-MET 2026 Task 1 challenge introduces a clinically relevant segmentation problem involving four anatomically distinct tumor subregions: non-enhancing tumor core (NETC), surrounding non-enhancing FLAIR hyperintensity (SNFH), enhancing tumor (ET), and the resection cavity (RC). Among these, RC segmentation is particularly challenging because of its low prevalence, heterogeneous postoperative appearance, and lesion-wise evaluation protocol, leading conventional segmentation networks to prioritize dominant tumor classes during optimization. The proposed nnU-Net-based framework explicitly addresses RC segmentation through four complementary components: (i) RC-weighted Dice and Cross-Entropy optimization to alleviate class imbalance, (ii) anatomically consistent cavity augmentation to increase the diversity of postoperative cavity appearances, (iii) a residual encoder architecture for enhanced multi-scale feature learning, and (iv) lesion-aware morphological post-processing to suppress false-positive cavity predictions while preserving anatomically plausible structures. The framework is evaluated on the BraTS-MET 2026 Task 1 online validation benchmark. Among the evaluated configurations, the ensemble model (Residual Encoder nnU-Net + nnU-Net + RC-aware CarveMix) achieves the best performance, with lesion-wise Dice scores of 0.732, 0.752, 0.708, and 0.575 and corresponding NSD scores of 0.794, 0.798, 0.727, and 0.474 for ET, TC, WT, and RC, respectively. These experimental results show that integrating RC-aware optimization, anatomically consistent augmentation, and lesion-aware post-processing provides an effective strategy for improving rare resection cavity segmentation in post-treatment brain metastases.

cs.CV↗

arXiv2026

CoMNet: A MedNeXt-CorrDiff Framework for Multi-Site Brain Tumor Segmentation

Accurate brain tumor segmentation from multiparametric magnetic resonance imaging (MRI) is critical for treatment planning, response assessment, and neuro-oncology research. However, automated segmentation remains a difficult task in computer vision because of variation in tumor appearance and MRI protocols across patient scans. Moreover, clinically important regions such as enhancing tumor and tumor core are often small relative to the full brain volume, further increasing the difficulty of achieving high voxel-level precision. These challenges are amplified in multi-site datasets, where differences in scanner hardware and acquisition parameters can introduce non-biological variation. To address this, networks must learn tumor-specific features while remaining robust to site-dependent noise. In this paper, we show that an ensemble of multi-fold predictions from a modern 3D convolutional segmentation network with corrective diffusion (CorrDiff) post-processing improves brain tumor segmentation across datasets. We propose CoMNet, an ensembled MedNeXt-CorrDiff framework for accurate multi-site brain tumor segmentation. In this framework, we use MedNeXt as the primary segmentation model for feature learning, while a corrective diffusion block learns to refine the residual errors in the individual prediction maps before probabilistic thresholding. This process reduces the variance across fold predictions by correcting fold-specific residual errors and aggregating them into a consensus mask that is less sensitive to site-dependent imaging variability. Our proposed framework achieved the highest Dice score compared to two baseline models on the UTSW-Glioma and BraTS-SSA datasets. Experimental results support the use of corrective diffusion and fold-level probability ensembling as meaningful additions to existing state-of-the-art models for accurate glioma segmentation on multi-site datasets.

cs.CV↗

arXiv2023

Prediction of Rapid Early Progression and Survival Risk with Pre-Radiation MRI in WHO Grade 4 Glioma Patients

Recent clinical research describes a subset of glioblastoma patients that exhibit REP prior to start of radiation therapy. Current literature has thus far described this population using clinicopathologic features. To our knowledge, this study is the first to investigate the potential of conventional ra-diomics, sophisticated multi-resolution fractal texture features, and different molecular features (MGMT, IDH mutations) as a diagnostic and prognostic tool for prediction of REP from non-REP cases using computational and statistical modeling methods. Radiation-planning T1 post-contrast (T1C) MRI sequences of 70 patients are analyzed. Ensemble method with 5-fold cross validation over 1000 iterations offers AUC of 0.793 with standard deviation of 0.082 for REP and non-REP classification. In addition, copula-based modeling under dependent censoring (where a subset of the patients may not be followed up until death) identifies significant features (p-value <0.05) for survival probability and prognostic grouping of patient cases. The prediction of survival for the patients cohort produces precision of 0.881 with standard deviation of 0.056. The prognostic index (PI) calculated using the fused features suggests that 84.62% of REP cases fall under the bad prognostic group, suggesting potentiality of fused features to predict a higher percentage of REP cases. The experimental result further shows that mul-ti-resolution fractal texture features perform better than conventional radiomics features for REP and survival outcomes.

cs.LG↗