arXiv subjects

Wan-Fai Ng

Publications and source records attributed to Wan-Fai Ng.

5 recordsLinked to original sources

arXiv2026

Mobile Interaction for Assessing Fatigue, Sleep, and Activity in Neurodegenerative and Chronic Diseases

Fatigue, sleep, or disturbances in daily activities are common symptoms among patients with neurodegenerative disorders (NDD) and immune-mediated inflammatory diseases (IMID). The current assessment of such symptoms is usually conducted using patient reported outcomes (PROs) based on standardized questionnaires that patients usually complete every few months. This assessment protocol has raised some concerns, due to its propensity to exhibit biases derived from its subjectivity nature, or the low sensibility to changes, which may lead to a failure when trying to capture variability over time. In this work, we explore the use of smartphone data, which can serve as a proxy for how patients interact with their devices, to provide an effective, reliable, and objective assessment of the symptoms mentioned above. Our study comprises data from 137 participants belonging to 6 different disease groups, plus a healthy control group. We conducted statistical analysis based on repeated measures correlation, in which we analyze the correlation between screen-time and app-usage features with scores obtained from the PROs collected from the participants using a smartphone application.

cs.HC↗

arXiv2021

Towards Automated Fatigue Assessment using Wearable Sensing and Mixed-Effects Models

Fatigue is a broad, multifactorial concept that includes the subjective perception of reduced physical and mental energy levels. It is also one of the key factors that strongly affect patients' health-related quality of life. To date, most fatigue assessment methods were based on self-reporting, which may suffer from many factors such as recall bias. To address this issue, in this work, we recorded multi-modal physiological data (including ECG, accelerometer, skin temperature and respiratory rate, as well as demographic information such as age, BMI) in free-living environments and developed automated fatigue assessment models. Specifically, we extracted features from each modality and employed the random forest-based mixed-effects models, which can take advantage of the demographic information for improved performance. We conducted experiments on our collected dataset, and very promising preliminary results were achieved. Our results suggested ECG played an important role in the fatigue assessment tasks.

cs.HC↗

arXiv2020

Fatigue Assessment using ECG and Actigraphy Sensors

Fatigue is one of the key factors in the loss of work efficiency and health-related quality of life, and most fatigue assessment methods were based on self-reporting, which may suffer from many factors such as recall bias. To address this issue, we developed an automated system using wearable sensing and machine learning techniques for objective fatigue assessment. ECG/Actigraphy data were collected from subjects in free-living environments. Preprocessing and feature engineering methods were applied, before interpretable solution and deep learning solution were introduced. Specifically, for interpretable solution, we proposed a feature selection approach which can select less correlated and high informative features for better understanding system's decision-making process. For deep learning solution, we used state-of-the-art self-attention model, based on which we further proposed a consistency self-attention (CSA) mechanism for fatigue assessment. Extensive experiments were conducted, and very promising results were achieved.

cs.LG↗

arXiv2018

Between a ROC and a Hard Place: Using prevalence plots to understand the likely real world performance of biomarkers in the clinic

The Receiver Operating Characteristic (ROC) curve and the Area Under the Curve (AUC) of the ROC curve are widely used to compare the performance of diagnostic and prognostic assays. The ROC curve has the advantage that it is independent of disease prevalence. However, in this note we remind readers that the performance of an assay upon translation to the clinic is critically dependent upon that very same prevalence. Without an understanding of prevalence in the test population, even robust bioassays with excellent ROC characteristics may perform poorly in the clinic. Instead, simple plots of candidate assay performance as a function of prevalence rate give a more realistic understanding of the likely real-world performance and a greater understanding of the likely impact of variation in that prevalence on translational performance in the clinic.

stat.AP↗

arXiv2018

Building Reality Checks into the Translational Pathway for Diagnostic and Prognostic Models

There has been a significant increase in the number of diagnostic and prognostic models published in the last decade. Testing such models in an independent, external validation cohort gives some assurance the model will transfer to a naturalistic, healthcare setting. Of 2,147 published models in the PubMed database, we found just 120 included some kind of separate external validation cohort. Of these studies not all were sufficiently well documented to allow a judgement about whether that model was likely to transfer to other centres, with other patients, treated by other clinicians, using data scored or analysed by other laboratories. We offer a solution to better characterizing the validation cohort and identify the key steps on the translational pathway for diagnostic and prognostic models.

stat.AP↗