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Wanting Mao

Publications and source records attributed to Wanting Mao.

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How Well Do Multimodal Models Reason on ECG Signals?

While multimodal large language models offer a promising solution to the "black box" nature of health AI by generating interpretable reasoning traces, verifying the validity of these traces remains a critical challenge. Existing evaluation methods are either unscalable, relying on manual clinician review, or superficial, utilizing proxy metrics (e.g. QA) that fail to capture the semantic correctness of clinical logic. In this work, we introduce a reproducible framework for evaluating reasoning in ECG signals. We propose decomposing reasoning into two distinct, components: (i) Perception, the accurate identification of patterns within the raw signal, and (ii) Deduction, the logical application of domain knowledge to those patterns. To evaluate Perception, we employ an agentic framework that generates code to empirically verify the temporal structures described in the reasoning trace. To evaluate Deduction, we measure the alignment of the model's logic against a structured database of established clinical criteria in a retrieval-based approach. This dual-verification method enables the scalable assessment of "true" reasoning capabilities.

cs.AI

Prototype-based Self-Supervised Multimodal Learning for PPG and Accelerometry Signals

Modeling multi-modal time-series data is critical for capturing system-level dynamics, particularly in biosignals where modalities such as ECG, PPG, EDA, and accelerometry provide complementary perspectives on interconnected physiological processes. While recent self-supervised learning (SSL) advances have improved unimodal representation learning, existing multi-modal approaches often rely on CLIP-style contrastive objectives that overfit to easily aligned features and misclassify valid cross-modal relationships as negatives, resulting in fragmented and non-generalizable embeddings. To overcome these limitations, we propose ProtoMM, a novel SSL framework that introduces a shared prototype dictionary to anchor heterogeneous modalities in a common embedding space. By clustering representations around shared prototypes rather than explicit negative sampling, our method captures complementary information across modalities and provides a coherent "common language" for physiological signals. In this work, we focus on developing a Pulse-Motion foundation model with ProtoMM and demonstrate that our approach outperforms contrastive-only and prior multimodal SSL methods, achieving the best performance among strong prior baselines while offering additional utility for analyzing and interpreting learned features.

cs.LG

Pulse-PPG: An Open-Source Field-Trained PPG Foundation Model for Wearable Applications Across Lab and Field Settings

Photoplethysmography (PPG)-based foundation models are gaining traction due to the widespread use of PPG in biosignal monitoring and their potential to generalize across diverse health applications. In this paper, we introduce Pulse-PPG, the first open-source PPG foundation model trained exclusively on raw PPG data collected over a 100-day field study with 120 participants. Existing PPG foundation models are either open-source but trained on clinical data or closed-source, limiting their applicability in real-world settings. We evaluate Pulse-PPG across multiple datasets and downstream tasks, comparing its performance against a state-of-the-art foundation model trained on clinical data. Our results demonstrate that Pulse-PPG, trained on uncurated field data, exhibits superior generalization across clinical and mobile health applications in both lab and field settings. This suggests that exposure to real-world variability enables the model to learn fine-grained representations, making it more adaptable across tasks. Furthermore, pre-training on field data surprisingly outperforms its pre-training on clinical data in many tasks, reinforcing the importance of training on real-world, diverse datasets. To encourage further advancements in robust foundation models leveraging field data, we plan to release Pulse-PPG, providing researchers with a powerful resource for developing more generalizable PPG-based models.

cs.LG