arXiv subjects

Wei Lu

Publications and source records attributed to Wei Lu.

At least 127 records · Page 7Linked to original sources

arXiv2025

Fitness aligned structural modeling enables scalable virtual screening with AuroBind

Most human proteins remain undrugged, over 96% of human proteins remain unexploited by approved therapeutics. While structure-based virtual screening promises to expand the druggable proteome, existing methods lack atomic-level precision and fail to predict binding fitness, limiting translational impact. We present AuroBind, a scalable virtual screening framework that fine-tunes a custom atomic-level structural model on million-scale chemogenomic data. AuroBind integrates direct preference optimization, self-distillation from high-confidence complexes, and a teacher-student acceleration strategy to jointly predict ligand-bound structures and binding fitness. The proposed models outperform state-of-the-art models on structural and functional benchmarks while enabling 100,000-fold faster screening across ultra-large compound libraries. In a prospective screen across ten disease-relevant targets, AuroBind achieved experimental hit rates of 7-69%, with top compounds reaching sub-nanomolar to picomolar potency. For the orphan GPCRs GPR151 and GPR160, AuroBind identified both agonists and antagonists with success rates of 16-30%, and functional assays confirmed GPR160 modulation in liver and prostate cancer models. AuroBind offers a generalizable framework for structure-function learning and high-throughput molecular screening, bridging the gap between structure prediction and therapeutic discovery.

cs.LG↗

arXiv2025

Weakly Supervised Multimodal Temporal Forgery Localization via Multitask Learning

The spread of Deepfake videos has caused a trust crisis and impaired social stability. Although numerous approaches have been proposed to address the challenges of Deepfake detection and localization, there is still a lack of systematic research on the weakly supervised multimodal fine-grained temporal forgery localization (WS-MTFL). In this paper, we propose a novel weakly supervised multimodal temporal forgery localization via multitask learning (WMMT), which addresses the WS-MTFL under the multitask learning paradigm. WMMT achieves multimodal fine-grained Deepfake detection and temporal partial forgery localization using merely video-level annotations. Specifically, visual and audio modality detection are formulated as two binary classification tasks. The multitask learning paradigm is introduced to integrate these tasks into a multimodal task. Furthermore, WMMT utilizes a Mixture-of-Experts structure to adaptively select appropriate features and localization head, achieving excellent flexibility and localization precision in WS-MTFL. A feature enhancement module with temporal property preserving attention mechanism is proposed to identify the intra- and inter-modality feature deviation and construct comprehensive video features. To further explore the temporal information for weakly supervised learning, an extensible deviation perceiving loss has been proposed, which aims to enlarge the deviation of adjacent segments of the forged samples and reduce the deviation of genuine samples. Extensive experiments demonstrate the effectiveness of multitask learning for WS-MTFL, and the WMMT achieves comparable results to fully supervised approaches in several evaluation metrics.

cs.CV↗

arXiv2025

Fine-grained Multiple Supervisory Network for Multi-modal Manipulation Detecting and Grounding

The task of Detecting and Grounding Multi-Modal Media Manipulation (DGM$^4$) is a branch of misinformation detection. Unlike traditional binary classification, it includes complex subtasks such as forgery content localization and forgery method classification. Consider that existing methods are often limited in performance due to neglecting the erroneous interference caused by unreliable unimodal data and failing to establish comprehensive forgery supervision for mining fine-grained tampering traces. In this paper, we present a Fine-grained Multiple Supervisory (FMS) network, which incorporates modality reliability supervision, unimodal internal supervision and cross-modal supervision to provide comprehensive guidance for DGM$^4$ detection. For modality reliability supervision, we propose the Multimodal Decision Supervised Correction (MDSC) module. It leverages unimodal weak supervision to correct the multi-modal decision-making process. For unimodal internal supervision, we propose the Unimodal Forgery Mining Reinforcement (UFMR) module. It amplifies the disparity between real and fake information within unimodal modality from both feature-level and sample-level perspectives. For cross-modal supervision, we propose the Multimodal Forgery Alignment Reasoning (MFAR) module. It utilizes soft-attention interactions to achieve cross-modal feature perception from both consistency and inconsistency perspectives, where we also design the interaction constraints to ensure the interaction quality. Extensive experiments demonstrate the superior performance of our FMS compared to state-of-the-art methods.

cs.CV↗

arXiv2025

A Multimodal Deviation Perceiving Framework for Weakly-Supervised Temporal Forgery Localization

Current researches on Deepfake forensics often treat detection as a classification task or temporal forgery localization problem, which are usually restrictive, time-consuming, and challenging to scale for large datasets. To resolve these issues, we present a multimodal deviation perceiving framework for weakly-supervised temporal forgery localization (MDP), which aims to identify temporal partial forged segments using only video-level annotations. The MDP proposes a novel multimodal interaction mechanism (MI) and an extensible deviation perceiving loss to perceive multimodal deviation, which achieves the refined start and end timestamps localization of forged segments. Specifically, MI introduces a temporal property preserving cross-modal attention to measure the relevance between the visual and audio modalities in the probabilistic embedding space. It could identify the inter-modality deviation and construct comprehensive video features for temporal forgery localization. To explore further temporal deviation for weakly-supervised learning, an extensible deviation perceiving loss has been proposed, aiming at enlarging the deviation of adjacent segments of the forged samples and reducing that of genuine samples. Extensive experiments demonstrate the effectiveness of the proposed framework and achieve comparable results to fully-supervised approaches in several evaluation metrics.

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arXiv2025

Anti-Inpainting: A Proactive Defense Approach against Malicious Diffusion-based Inpainters under Unknown Conditions

With the increasing prevalence of diffusion-based malicious image manipulation, existing proactive defense methods struggle to safeguard images against tampering under unknown conditions. To address this, we propose Anti-Inpainting, a proactive defense approach that achieves protection comprising three novel modules. First, we introduce a multi-level deep feature extractor to obtain intricate features from the diffusion denoising process, enhancing protective effectiveness. Second, we design a multi-scale, semantic-preserving data augmentation technique to enhance the transferability of adversarial perturbations across unknown conditions. Finally, we propose a selection-based distribution deviation optimization strategy to bolster protection against manipulations guided by diverse random seeds. Extensive experiments on InpaintGuardBench and CelebA-HQ demonstrate that Anti-Inpainting effectively defends against diffusion-based inpainters under unknown conditions. Additionally, our approach demonstrates robustness against various image purification methods and transferability across different diffusion model versions.

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arXiv2025

StyleSentinel: Reliable Artistic Copyright Verification via Stylistic Fingerprints

The versatility of diffusion models in generating customized images has led to unauthorized usage of personal artwork, which poses a significant threat to the intellectual property of artists. Existing approaches relying on embedding additional information, such as perturbations, watermarks, and backdoors, suffer from limited defensive capabilities and fail to protect artwork published online. In this paper, we propose StyleSentinel, an approach for copyright protection of artwork by verifying an inherent stylistic fingerprint in the artist's artwork. Specifically, we employ a semantic self-reconstruction process to enhance stylistic expressiveness within the artwork, which establishes a dense and style-consistent manifold foundation for feature learning. Subsequently, we adaptively fuse multi-layer image features to encode abstract artistic style into a compact stylistic fingerprint. Finally, we model the target artist's style as a minimal enclosing hypersphere boundary in the feature space, transforming complex copyright verification into a robust one-class learning task. Extensive experiments demonstrate that compared with the state-of-the-art, StyleSentinel achieves superior performance on the one-sample verification task. We also demonstrate the effectiveness through online platforms.

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arXiv2025

Weakly-Supervised Image Forgery Localization via Vision-Language Collaborative Reasoning Framework

Image forgery localization aims to precisely identify tampered regions within images, but it commonly depends on costly pixel-level annotations. To alleviate this annotation burden, weakly supervised image forgery localization (WSIFL) has emerged, yet existing methods still achieve limited localization performance as they mainly exploit intra-image consistency clues and lack external semantic guidance to compensate for weak supervision. In this paper, we propose ViLaCo, a vision-language collaborative reasoning framework that introduces auxiliary semantic supervision distilled from pre-trained vision-language models (VLMs), enabling accurate pixel-level localization using only image-level labels. Specifically, ViLaCo first incorporates semantic knowledge through a vision-language feature modeling network, which jointly extracts textual and visual priors using pre-trained VLMs. Next, an adaptive vision-language reasoning network aligns textual semantics and visual features through mutual interactions, producing semantically aligned representations. Subsequently, these representations are passed into dual prediction heads, where the coarse head performs image-level classification and the fine head generates pixel-level localization masks, thereby bridging the gap between weak supervision and fine-grained localization. Moreover, a contrastive patch consistency module is introduced to cluster tampered features while separating authentic ones, facilitating more reliable forgery discrimination. Extensive experiments on multiple public datasets demonstrate that ViLaCo substantially outperforms existing WSIFL methods, achieving state-of-the-art performance in both detection and localization accuracy.

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arXiv2025

Diffusion-based Adversarial Identity Manipulation for Facial Privacy Protection

The success of face recognition (FR) systems has led to serious privacy concerns due to potential unauthorized surveillance and user tracking on social networks. Existing methods for enhancing privacy fail to generate natural face images that can protect facial privacy. In this paper, we propose diffusion-based adversarial identity manipulation (DiffAIM) to generate natural and highly transferable adversarial faces against malicious FR systems. To be specific, we manipulate facial identity within the low-dimensional latent space of a diffusion model. This involves iteratively injecting gradient-based adversarial identity guidance during the reverse diffusion process, progressively steering the generation toward the desired adversarial faces. The guidance is optimized for identity convergence towards a target while promoting semantic divergence from the source, facilitating effective impersonation while maintaining visual naturalness. We further incorporate structure-preserving regularization to preserve facial structure consistency during manipulation. Extensive experiments on both face verification and identification tasks demonstrate that compared with the state-of-the-art, DiffAIM achieves stronger black-box attack transferability while maintaining superior visual quality. We also demonstrate the effectiveness of the proposed approach for commercial FR APIs, including Face++ and Aliyun.

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arXiv2025

Vidi: Large Multimodal Models for Video Understanding and Editing

Humans naturally share information with those they are connected to, and video has become one of the dominant mediums for communication and expression on the Internet. To support the creation of high-quality large-scale video content, a modern pipeline requires a comprehensive understanding of both the raw input materials (e.g., the unedited footage captured by cameras) and the editing components (e.g., visual effects). In video editing scenarios, models must process multiple modalities (e.g., vision, audio, text) with strong background knowledge and handle flexible input lengths (e.g., hour-long raw videos), which poses significant challenges for traditional models. In this report, we introduce Vidi, a family of Large Multimodal Models (LMMs) for a wide range of video understand editing scenarios. The first release focuses on temporal retrieval, i.e., identifying the time ranges within the input videos corresponding to a given text query, which plays a critical role in intelligent editing. The model is capable of processing hour-long videos with strong temporal understanding capability, e.g., retrieve time ranges for certain queries. To support a comprehensive evaluation in real-world scenarios, we also present the VUE-TR benchmark, which introduces five key advancements. 1) Video duration: significantly longer than videos of existing temporal retrival datasets, 2) Audio support: includes audio-based queries, 3) Query format: diverse query lengths/formats, 4) Annotation quality: ground-truth time ranges are manually annotated. 5) Evaluation metric: a refined IoU metric to support evaluation over multiple time ranges. Remarkably, Vidi significantly outperforms leading proprietary models, e.g., GPT-4o and Gemini, on the temporal retrieval task, indicating its superiority in video editing scenarios.

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arXiv2025

Reconciling Attribute and Structural Anomalies for Improved Graph Anomaly Detection

Graph anomaly detection is critical in domains such as healthcare and economics, where identifying deviations can prevent substantial losses. Existing unsupervised approaches strive to learn a single model capable of detecting both attribute and structural anomalies. However, they confront the tug-of-war problem between two distinct types of anomalies, resulting in suboptimal performance. This work presents TripleAD, a mutual distillation-based triple-channel graph anomaly detection framework. It includes three estimation modules to identify the attribute, structural, and mixed anomalies while mitigating the interference between different types of anomalies. In the first channel, we design a multiscale attribute estimation module to capture extensive node interactions and ameliorate the over-smoothing issue. To better identify structural anomalies, we introduce a link-enhanced structure estimation module in the second channel that facilitates information flow to topologically isolated nodes. The third channel is powered by an attribute-mixed curvature, a new indicator that encapsulates both attribute and structural information for discriminating mixed anomalies. Moreover, a mutual distillation strategy is introduced to encourage communication and collaboration between the three channels. Extensive experiments demonstrate the effectiveness of the proposed TripleAD model against strong baselines.

cs.LG↗

arXiv2025

Real-World Remote Sensing Image Dehazing: Benchmark and Baseline

Remote Sensing Image Dehazing (RSID) poses significant challenges in real-world scenarios due to the complex atmospheric conditions and severe color distortions that degrade image quality. The scarcity of real-world remote sensing hazy image pairs has compelled existing methods to rely primarily on synthetic datasets. However, these methods struggle with real-world applications due to the inherent domain gap between synthetic and real data. To address this, we introduce Real-World Remote Sensing Hazy Image Dataset (RRSHID), the first large-scale dataset featuring real-world hazy and dehazed image pairs across diverse atmospheric conditions. Based on this, we propose MCAF-Net, a novel framework tailored for real-world RSID. Its effectiveness arises from three innovative components: Multi-branch Feature Integration Block Aggregator (MFIBA), which enables robust feature extraction through cascaded integration blocks and parallel multi-branch processing; Color-Calibrated Self-Supervised Attention Module (CSAM), which mitigates complex color distortions via self-supervised learning and attention-guided refinement; and Multi-Scale Feature Adaptive Fusion Module (MFAFM), which integrates features effectively while preserving local details and global context. Extensive experiments validate that MCAF-Net demonstrates state-of-the-art performance in real-world RSID, while maintaining competitive performance on synthetic datasets. The introduction of RRSHID and MCAF-Net sets new benchmarks for real-world RSID research, advancing practical solutions for this complex task. The code and dataset are publicly available at https://github.com/lwCVer/RRSHID.

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arXiv2025

Satori: Reinforcement Learning with Chain-of-Action-Thought Enhances LLM Reasoning via Autoregressive Search

Large language models (LLMs) have demonstrated remarkable reasoning capabilities across diverse domains. Recent studies have shown that increasing test-time computation enhances LLMs' reasoning capabilities. This typically involves extensive sampling at inference time guided by an external LLM verifier, resulting in a two-player system. Despite external guidance, the effectiveness of this system demonstrates the potential of a single LLM to tackle complex tasks. Thus, we pose a new research problem: Can we internalize the searching capabilities to fundamentally enhance the reasoning abilities of a single LLM? This work explores an orthogonal direction focusing on post-training LLMs for autoregressive searching (i.e., an extended reasoning process with self-reflection and self-exploration of new strategies). To achieve this, we propose the Chain-of-Action-Thought (COAT) reasoning and a two-stage training paradigm: 1) a small-scale format tuning stage to internalize the COAT reasoning format and 2) a large-scale self-improvement stage leveraging reinforcement learning. Our approach results in Satori, a 7B LLM trained on open-source models and data. Extensive empirical evaluations demonstrate that Satori achieves state-of-the-art performance on mathematical reasoning benchmarks while exhibits strong generalization to out-of-domain tasks. Code, data, and models are fully open-sourced.

cs.CL↗

arXiv2025

Context-aware TFL: A Universal Context-aware Contrastive Learning Framework for Temporal Forgery Localization

Most research efforts in the multimedia forensics domain have focused on detecting forgery audio-visual content and reached sound achievements. However, these works only consider deepfake detection as a classification task and ignore the case where partial segments of the video are tampered with. Temporal forgery localization (TFL) of small fake audio-visual clips embedded in real videos is still challenging and more in line with realistic application scenarios. To resolve this issue, we propose a universal context-aware contrastive learning framework (UniCaCLF) for TFL. Our approach leverages supervised contrastive learning to discover and identify forged instants by means of anomaly detection, allowing for the precise localization of temporal forged segments. To this end, we propose a novel context-aware perception layer that utilizes a heterogeneous activation operation and an adaptive context updater to construct a context-aware contrastive objective, which enhances the discriminability of forged instant features by contrasting them with genuine instant features in terms of their distances to the global context. An efficient context-aware contrastive coding is introduced to further push the limit of instant feature distinguishability between genuine and forged instants in a supervised sample-by-sample manner, suppressing the cross-sample influence to improve temporal forgery localization performance. Extensive experimental results over five public datasets demonstrate that our proposed UniCaCLF significantly outperforms the state-of-the-art competing algorithms.

cs.CV↗

arXiv2025

ChatReID: Open-ended Interactive Person Retrieval via Hierarchical Progressive Tuning for Vision Language Models

Person re-identification (Re-ID) is a crucial task in computer vision, aiming to recognize individuals across non-overlapping camera views. While recent advanced vision-language models (VLMs) excel in logical reasoning and multi-task generalization, their applications in Re-ID tasks remain limited. They either struggle to perform accurate matching based on identity-relevant features or assist image-dominated branches as auxiliary semantics. In this paper, we propose a novel framework ChatReID, that shifts the focus towards a text-side-dominated retrieval paradigm, enabling flexible and interactive re-identification. To integrate the reasoning abilities of language models into Re-ID pipelines, We first present a large-scale instruction dataset, which contains more than 8 million prompts to promote the model fine-tuning. Next. we introduce a hierarchical progressive tuning strategy, which endows Re-ID ability through three stages of tuning, i.e., from person attribute understanding to fine-grained image retrieval and to multi-modal task reasoning. Extensive experiments across ten popular benchmarks demonstrate that ChatReID outperforms existing methods, achieving state-of-the-art performance in all Re-ID tasks. More experiments demonstrate that ChatReID not only has the ability to recognize fine-grained details but also to integrate them into a coherent reasoning process.

cs.CV↗

arXiv2025

Zero-Shot Chinese Character Recognition with Hierarchical Multi-Granularity Image-Text Aligning

Chinese Character Recognition (CCR) is a fundamental technology for intelligent document processing. Unlike Latin characters, Chinese characters exhibit unique spatial structures and compositional rules, allowing for the use of fine-grained semantic information in representation. However, existing approaches are usually based on auto-regressive as well as edit distance post-process and typically rely on a single-level character representation. In this paper, we propose a Hierarchical Multi-Granularity Image-Text Aligning (Hi-GITA) framework based on a contrastive paradigm. To leverage the abundant fine-grained semantic information of Chinese characters, we propose multi-granularity encoders on both image and text sides. Specifically, the Image Multi-Granularity Encoder extracts hierarchical image representations from character images, capturing semantic cues from localized strokes to holistic structures. The Text Multi-Granularity Encoder extracts stroke and radical sequence representations at different levels of granularity. To better capture the relationships between strokes and radicals, we introduce Multi-Granularity Fusion Modules on the image and text sides, respectively. Furthermore, to effectively bridge the two modalities, we further introduce a Fine-Grained Decoupled Image-Text Contrastive loss, which aligns image and text representations across multiple granularities. Extensive experiments demonstrate that our proposed Hi-GITA significantly outperforms existing zero-shot CCR methods. For instance, it brings about 20% accuracy improvement in handwritten character and radical zero-shot settings. Code and models will be released soon.

cs.CV↗

arXiv2025

Satori-SWE: Evolutionary Test-Time Scaling for Sample-Efficient Software Engineering

Language models (LMs) perform well on standardized coding benchmarks but struggle with real-world software engineering tasks such as resolving GitHub issues in SWE-Bench, especially when model parameters are less than 100B. While smaller models are preferable in practice due to their lower computational cost, improving their performance remains challenging. Existing approaches primarily rely on supervised fine-tuning (SFT) with high-quality data, which is expensive to curate at scale. An alternative is test-time scaling: generating multiple outputs, scoring them using a verifier, and selecting the best one. Although effective, this strategy often requires excessive sampling and costly scoring, limiting its practical application. We propose Evolutionary Test-Time Scaling (EvoScale), a sample-efficient method that treats generation as an evolutionary process. By iteratively refining outputs via selection and mutation, EvoScale shifts the output distribution toward higher-scoring regions, reducing the number of samples needed to find correct solutions. To reduce the overhead from repeatedly sampling and selection, we train the model to self-evolve using reinforcement learning (RL). Rather than relying on external verifiers at inference time, the model learns to self-improve the scores of its own generations across iterations. Evaluated on SWE-Bench-Verified, EvoScale enables our 32B model, Satori-SWE-32B, to match or exceed the performance of models with over 100B parameters while using a few samples. Code, data, and models will be fully open-sourced.

cs.CL↗

arXiv2025

From Tens of Hours to Tens of Thousands: Scaling Back-Translation for Speech Recognition

Recent advances in Automatic Speech Recognition (ASR) have been largely fueled by massive speech corpora. However, extending coverage to diverse languages with limited resources remains a formidable challenge. This paper introduces Speech Back-Translation, a scalable pipeline that improves multilingual ASR models by converting large-scale text corpora into synthetic speech via off-the-shelf text-to-speech (TTS) models. We demonstrate that just tens of hours of real transcribed speech can effectively train TTS models to generate synthetic speech at hundreds of times the original volume while maintaining high quality. To evaluate synthetic speech quality, we develop an intelligibility-based assessment framework and establish clear thresholds for when synthetic data benefits ASR training. Using Speech Back-Translation, we generate more than 500,000 hours of synthetic speech in ten languages and continue pre-training Whisper-large-v3, achieving average transcription error reductions of over 30\%. These results highlight the scalability and effectiveness of Speech Back-Translation for enhancing multilingual ASR systems.

cs.CL↗

arXiv2025

ARIW-Framework: Adaptive Robust Iterative Watermarking Framework

With the rapid rise of large models, copyright protection for generated image content has become a critical security challenge. Although deep learning watermarking techniques offer an effective solution for digital image copyright protection, they still face limitations in terms of visual quality, robustness and generalization. To address these issues, this paper proposes an adaptive robust iterative watermarking framework (ARIW-Framework) that achieves high-quality watermarked images while maintaining exceptional robustness and generalization performance. Specifically, we introduce an iterative approach to optimize the encoder for generating robust residuals. The encoder incorporates noise layers and a decoder to compute robustness weights for residuals under various noise attacks. By employing a parallel optimization strategy, the framework enhances robustness against multiple types of noise attacks. Furthermore, we leverage image gradients to determine the embedding strength at each pixel location, significantly improving the visual quality of the watermarked images. Extensive experiments demonstrate that the proposed method achieves superior visual quality while exhibiting remarkable robustness and generalization against noise attacks.

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