arXiv subjects

Weihua Meng

Publications and source records attributed to Weihua Meng.

3 recordsLinked to original sources

arXiv2026

Radiology-Report Semantic Modelling and Host-Response Laboratory Biomarkers for Multimodal Survival Prediction in Lung Cancer

TNM staging is essential for lung cancer management, but patients within the same anatomic stage often show heterogeneous survival outcomes. We developed a multimodal adaptive risk score (AMRS) that integrates radiology-report semantics with routinely available clinical laboratory biomarkers. In a retrospective two-center cohort, 1129 patients diagnosed between December 2017 and February 2026 were screened; 574 patients were included after exclusion for short follow-up or missing imaging reports and were split into training (n = 459) and test (n = 115) cohorts. Radiology reports were encoded with a domain-adapted MC-BERT branch to capture imaging-derived semantic information, while clinical and laboratory variables were modeled after Mahalanobis-distance-based imputation using random survival forests. Weighted risk fusion generated the final patient-level score. AMRS achieved C-index values of 0.920 in training and 0.849 in testing, and separated survival trajectories across clinical subgroups and TNM-related strata. SHAP analysis identified hematologic, inflammatory, coagulation, nutritional, tumor-marker, organ-function, and age-related contributors. AMRS may complement TNM staging in imaging-centered oncology workflows, but prospective validation, calibration, ablation testing, and clinical-utility assessment are required before deployment.

physics.med-ph↗

arXiv2026

Patient-Level Diagnosis of Acute Myeloid Leukemia via Deep Learning Analysis of Bone Marrow Smear

Bone marrow smear review remains important for acute myeloid leukemia (AML) assessment, but manual single-cell interpretation is labor-intensive and patient-level diagnosis requires aggregation of many cellular observations. We present a cell-to-patient deep learning pipeline for AML-assisted diagnosis from bone marrow smear images. The study included 258 patients from six anonymized centers, including a main cohort of 169 patients from Centers 1-3 and an external validation cohort of 89 patients from Centers 4-6. A 16-category cell annotation vocabulary was used to describe the global cellular composition, including granulocytic, monocytic, erythroid, lymphoid, eosinophilic, and other cells. Rather than identifying strict AML blasts or leukemic blasts, the model targets an expert-defined composite category termed Composite Blast-like Cells (CBLC), comprising N, N1, M, M1, R, R1, J, and J1 according to the project-wide morphological standard. A fixed YOLO-based segmentation module detected cells, predicted contours were matched to expert polygon annotations by contour IoU, and standardized single-cell crops were generated. An EfficientNet-B0 classifier was trained through a two-stage GT-to-YOLO and YOLO-to-YOLO strategy with class-imbalance correction, center-border regularization, and morphology-assisted supervision. Cell-level predictions were aggregated into patient-level CBLC ratios for AML-oriented diagnostic support. The pipeline achieved stable internal validation and maintained external generalization, with ensemble weighted F1-scores of 0.9076, 0.8696, and 0.9124 on Centers 4, 5, and 6, respectively.

cs.CV↗

arXiv2025

CueBench: Advancing Unified Understanding of Context-Aware Video Anomalies in Real-World

How far are deep models from real-world video anomaly understanding (VAU)? Current works typically emphasize on detecting unexpected occurrences deviated from normal patterns or comprehending anomalous events with interpretable descriptions. However, they exhibit only a superficial comprehension of real-world anomalies, with limited breadth in complex principles and subtle context that distinguish the anomalies from normalities, e.g., climbing cliffs with safety gear vs. without it. To this end, we introduce CueBench, the first of its kind Benchmark, devoted to Context-aware video anomalies within a Unified Evaluation framework. We comprehensively establish an event-centric hierarchical taxonomy that anchors two core event types: 14 conditional and 18 absolute anomaly events, defined by their refined semantics from diverse contexts across 174 scenes and 198 attributes. Based on this, we propose to unify and benchmark context-aware VAU with various challenging tasks across recognition, temporal grounding, detection, and anticipation. This also serves as a rigorous and fair probing evaluation suite for generative-discriminative as well as generalized-specialized vision-language models (VLMs). To address the challenges underlying CueBench, we further develop Cue-R1 based on R1-style reinforcement fine-tuning with verifiable, task-aligned, and hierarchy-refined rewards in a unified generative manner. Extensive results on CueBench reveal that, existing VLMs are still far from satisfactory real-world anomaly understanding, while our Cue-R1 surpasses these state-of-the-art approaches by over 24% on average.

cs.CV↗