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Weilai Xiang

Publications and source records attributed to Weilai Xiang.

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OrthoDiffusion: A Generalizable Multi-Task Diffusion Foundation Model for Musculoskeletal MRI Interpretation

Musculoskeletal disorders represent a significant global health burden and are a leading cause of disability worldwide. While MRI is essential for accurate diagnosis, its interpretation remains exceptionally challenging. Radiologists must identify multiple potential abnormalities within complex anatomical structures across different imaging planes, a process that requires significant expertise and is prone to variability. We developed OrthoDiffusion, a unified diffusion-based foundation model designed for multi-task musculoskeletal MRI interpretation. The framework utilizes three orientation-specific 3D diffusion models, pre-trained in a self-supervised manner on 15,948 unlabeled knee MRI scans, to learn robust anatomical features from sagittal, coronal, and axial views. These view-specific representations are integrated to support diverse clinical tasks, including anatomical segmentation and multi-label diagnosis. Our evaluation demonstrates that OrthoDiffusion achieves excellent performance in the segmentation of 11 knee structures and the detection of 8 knee abnormalities. The model exhibited remarkable robustness across different clinical centers and MRI field strengths, consistently outperforming traditional supervised models. Notably, in settings where labeled data was scarce, OrthoDiffusion maintained high diagnostic precision using only 10\% of training labels. Furthermore, the anatomical representations learned from knee imaging proved highly transferable to other joints, achieving strong diagnostic performance across 11 diseases of the ankle and shoulder. These findings suggest that diffusion-based foundation models can serve as a unified platform for multi-disease diagnosis and anatomical segmentation, potentially improving the efficiency and accuracy of musculoskeletal MRI interpretation in real-world clinical workflows.

cs.CV

Conditioning Residuals for Diffusion Models via Representation Feedback

Diffusion models now serve as a common foundation for multimedia generation, and useful intermediate representations emerge during their generative training. Standard architectures, however, propagate these representations through the main feature stream, without explicitly reintroducing their encoded semantics to later denoising layers. Meanwhile, such backbones already provide a conditioning pathway for global modulation by predefined inputs. This work examines whether this native pathway can also route internally inferred semantics as evolving, sample-dependent cues. We propose Conditioning Residuals, a lightweight feedback mechanism that converts aggregated features into residuals added to condition embeddings. By feeding back compact feature summaries, it provides adaptive generative guidance and encourages a tighter semantic bottleneck, without external encoders, auxiliary objectives, or sampling-time changes. It supports feedback at one or multiple depths in UNet and DiT backbones, with negligible overhead. Across diffusion formulations, backbone configurations, and datasets, experiments show consistent gains in generative performance, along with stronger representations in downstream linear probing and segmentation. Mechanistic analyses reveal improved generative training dynamics and reshaped feature structure, suggesting a grounded, generalizable way to enhance diffusion backbones from within.

cs.CV

Generate Coherent Rays Directly

The path tracing method generates incoherent rays by randomly sampling directions. This randomness makes it unsuitable for modern processor architectures that rely on coherence to achieve optimal performance. Many efforts have been made to address this issue by reordering rays based on their origin, end, or direction to enhance coherence. However, a drawback of reordering methods is the need to encode and sort rays before tracing, introducing additional overhead. We propose a technique to generate coherent rays directly by reusing the direction. Additionally, we introduce an interleaved reuse domain partition method to mitigate the impact of sampling correlation resulting from direction reuse. We demonstrate the effectiveness of our approach across various scenes, establishing its superiority over reordering methods.

cs.GR

Denoising Diffusion Autoencoders are Unified Self-supervised Learners

Inspired by recent advances in diffusion models, which are reminiscent of denoising autoencoders, we investigate whether they can acquire discriminative representations for classification via generative pre-training. This paper shows that the networks in diffusion models, namely denoising diffusion autoencoders (DDAE), are unified self-supervised learners: by pre-training on unconditional image generation, DDAE has already learned strongly linear-separable representations within its intermediate layers without auxiliary encoders, thus making diffusion pre-training emerge as a general approach for generative-and-discriminative dual learning. To validate this, we conduct linear probe and fine-tuning evaluations. Our diffusion-based approach achieves 95.9% and 50.0% linear evaluation accuracies on CIFAR-10 and Tiny-ImageNet, respectively, and is comparable to contrastive learning and masked autoencoders for the first time. Transfer learning from ImageNet also confirms the suitability of DDAE for Vision Transformers, suggesting the potential to scale DDAEs as unified foundation models. Code is available at github.com/FutureXiang/ddae.

cs.CV

AlignedReID: Surpassing Human-Level Performance in Person Re-Identification

In this paper, we propose a novel method called AlignedReID that extracts a global feature which is jointly learned with local features. Global feature learning benefits greatly from local feature learning, which performs an alignment/matching by calculating the shortest path between two sets of local features, without requiring extra supervision. After the joint learning, we only keep the global feature to compute the similarities between images. Our method achieves rank-1 accuracy of 94.4% on Market1501 and 97.8% on CUHK03, outperforming state-of-the-art methods by a large margin. We also evaluate human-level performance and demonstrate that our method is the first to surpass human-level performance on Market1501 and CUHK03, two widely used Person ReID datasets.

cs.CV