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Weitian Chen

Publications and source records attributed to Weitian Chen.

At least 19 recordsLinked to original sources

gMatch: Fine-Grained and Hardware-Efficient Subgraph Matching on GPUs

Subgraph matching is a core operation in graph analytics, supporting a broad spectrum of applications from social network analysis to bioinformatics. Recent GPU-based approaches accelerate subgraph matching by leveraging parallelism but rely on a coarse-grained execution model that suffers from scalability and efficiency issues due to high memory overhead and thread underutilization. In this paper, we propose gMatch, a hardware-efficient subgraph matching approach on GPUs. gMatch introduces a fine-grained execution model that reduces memory consumption and enables flexible task scheduling among threads. We further design warp-level batch exploration and lightweight load balancing to improve execution efficiency and scalability. Experiments on diverse workloads and real-world datasets show that gMatch outperforms state-of-the-art subgraph matching methods, including STMatch, T-DFS, and EGSM, in both performance and scalability. We also compare against state-of-the-art systems for mining small patterns, such as BEEP and G$^2$Miner. While these systems achieve better performance on small datasets, gMatch scales to substantially larger queries and datasets, where existing approaches degrade or fail to complete.

cs.DB

Dipolar order mapping based on spin-lock magnetic resonance imaging

Purpose: Inhomogeneous magnetization transfer (ihMT) effect reflects dipolar order with a dipolar relaxation time ($T_{1D}$), specific to motion-restricted macromolecules. We aim to quantify $T_{1D}$ using spin-lock MRI technique. Methods: In the proposed method, we introduce a $T_{1D}$-specific ratio, denoted as $RATIO_{dosl}$. This ratio is derived from the distinct relaxation rate $R_{dosl}$, calculated as the difference between dual-frequency relaxation $R_{1\rho}^{dual}$ and single-frequency $R_{1\rho}^{single}$ relaxation measurements. A novel rotary-echo spin-lock sequence was developed to enable dual-frequency spin-lock acquisition. We established a framework to estimate $T_{1D}$, as well as the macromolecular pool fraction (MPF) map. The proposed approach was validated via numerical simulations, phantom studies, and demonstrated in vivo in human white matter. Results: Simulations revealed the high sensitivity of $RATIO_{dosl}$ to $T_{1D}$, and substantiated the accuracy and robustness of the proposed methods. Phantom experiments demonstrated robust ihMT contrast and confirmed the capability of $T_{1D}$ quantification via $RATIO_{dosl}$. In vivo studies supported the clinical viability of this approcah, achieving simultaneous $T_{1D}$ and MPF mapping using only three spin-lock prepared images. Across ten healthy volunteers, the mean white matter $T_{1D}$ ranged from approximately 3.70 to 4.80 ms. Conclustion: We propose a novel method for $T_{1D}$ quantification based on spin-lock MRI. By requiring only three contrast-prepared images, this technique provides a promising pathway for robust, rapid, and simultaneous $T_{1D}$ and MPF quantification with fewer confounds

physics.med-ph

Quantitative Macromolecular Proton Fraction Imaging using Pulsed Spin-Lock

Purpose: Recent studies have shown that spin-lock MRI can simplify quantitative magnetization transfer (MT) by eliminating its dependency on water pool parameters, removing the need for a T1 map in macromolecular proton fraction (MPF) quantification. However, its application is often limited by the requirement for long radiofrequency (RF) pulse durations, which are constrained by RF hardware capabilities despite remaining within specific absorption rate (SAR) safety limits. Methods: To address this challenge, we propose a novel method, MPF mapping using pulsed spin-lock (MPF-PSL). MPF-PSL employs a pulsed spin-lock train with intermittent free precession periods, enabling extended total spin-lock durations without exceeding hardware and specific absorption rate limits. A comprehensive analytical framework was developed to model the magnetization dynamics of the two-pool MT system under pulsed spin-lock, demonstrating that MPF-PSL achieves MT-specific quantification while minimizing confounding effects from the water pool. The proposed method is validated with Bloch-McConnell simulations, phantoms, and in vivo studies at 3T. Results: Both Bloch-McConnell simulations and phantom validation demonstrated that MPF-PSL exhibits robust insensitivity to water pool parameters while enabling high-SNR MPF quantification. In vivo validation studies confirmed the method's clinical utility in detecting collagen deposition in patients with liver fibrosis. Conclusion: MPF-PSL presents a practical solution for quantitative MT imaging, with strong potential for clinical applications.

physics.med-ph

Utilizing 3D Fast Spin Echo Anatomical Imaging to Reduce the Number of Contrast Preparations in $T_{1\rho}$ Quantification of Knee Cartilage Using Learning-Based Methods

Purpose: To propose and evaluate an accelerated $T_{1\rho}$ quantification method that combines $T_{1\rho}$-weighted fast spin echo (FSE) images and proton density (PD)-weighted anatomical FSE images, leveraging deep learning models for $T_{1\rho}$ mapping. The goal is to reduce scan time and facilitate integration into routine clinical workflows for osteoarthritis (OA) assessment. Methods: This retrospective study utilized MRI data from 40 participants (30 OA patients and 10 healthy volunteers). A volume of PD-weighted anatomical FSE images and a volume of $T_{1\rho}$-weighted images acquired at a non-zero spin-lock time were used as input to train deep learning models, including a 2D U-Net and a multi-layer perceptron (MLP). $T_{1\rho}$ maps generated by these models were compared with ground truth maps derived from a traditional non-linear least squares (NLLS) fitting method using four $T_{1\rho}$-weighted images. Evaluation metrics included mean absolute error (MAE), mean absolute percentage error (MAPE), regional error (RE), and regional percentage error (RPE). Results: Deep learning models achieved RPEs below 5% across all evaluated scenarios, outperforming NLLS methods, especially in low signal-to-noise conditions. The best results were obtained using the 2D U-Net, which effectively leveraged spatial information for accurate $T_{1\rho}$ fitting. The proposed method demonstrated compatibility with shorter TSLs, alleviating RF hardware and specific absorption rate (SAR) limitations. Conclusion: The proposed approach enables efficient $T_{1\rho}$ mapping using PD-weighted anatomical images, reducing scan time while maintaining clinical standards. This method has the potential to facilitate the integration of quantitative MRI techniques into routine clinical practice, benefiting OA diagnosis and monitoring.

eess.IV

ERANet: Edge Replacement Augmentation for Semi-Supervised Meniscus Segmentation with Prototype Consistency Alignment and Conditional Self-Training

Manual segmentation is labor-intensive, and automatic segmentation remains challenging due to the inherent variability in meniscal morphology, partial volume effects, and low contrast between the meniscus and surrounding tissues. To address these challenges, we propose ERANet, an innovative semi-supervised framework for meniscus segmentation that effectively leverages both labeled and unlabeled images through advanced augmentation and learning strategies. ERANet integrates three key components: edge replacement augmentation (ERA), prototype consistency alignment (PCA), and a conditional self-training (CST) strategy within a mean teacher architecture. ERA introduces anatomically relevant perturbations by simulating meniscal variations, ensuring that augmentations align with the structural context. PCA enhances segmentation performance by aligning intra-class features and promoting compact, discriminative feature representations, particularly in scenarios with limited labeled data. CST improves segmentation robustness by iteratively refining pseudo-labels and mitigating the impact of label noise during training. Together, these innovations establish ERANet as a robust and scalable solution for meniscus segmentation, effectively addressing key barriers to practical implementation. We validated ERANet comprehensively on 3D Double Echo Steady State (DESS) and 3D Fast/Turbo Spin Echo (FSE/TSE) MRI sequences. The results demonstrate the superior performance of ERANet compared to state-of-the-art methods. The proposed framework achieves reliable and accurate segmentation of meniscus structures, even when trained on minimal labeled data. Extensive ablation studies further highlight the synergistic contributions of ERA, PCA, and CST, solidifying ERANet as a transformative solution for semi-supervised meniscus segmentation in medical imaging.

cs.CV

Exploring the MBTI distribution among Chinese undergraduate physics students: the influence of family income on career trajectories

This study investigated the distribution of MBTI personality types among physics undergraduates at Zhejiang University and analyzed their career aspirations, family income and mental health status. A comprehensive survey of 68 questions, including 52 multiple-choice questions and 16 short-answer questions, assessed various personality traits and their correlation with academic intent and emotional state. The results showed that INTJ and INTP personality types showed the most significant tendency to pursue academic research. They usually come from middle and above-class backgrounds. Notably, these two personality types accounted for about 41\% of the total surveyed population, while NT types combined accounted for about 58\%. This indicates that although NT personality is more suitable for academic research, students with introverted tendencies are more suitable. Research has further shown that people with ISTJ personalities often exhibit unexpectedly strong academic interests. In addition, individuals who aspire to enter academia generally maintain a stable state of mind, as evidenced by their consistent work efficiency in the face of personal challenges. Interestingly, although some aspiring academics come from financially stable families, most have encountered financial constraints. These results contribute to a deeper understanding of how personality traits and socioeconomic factors influence the academic career paths of physics students.

physics.ed-ph

A Systematic Post-Processing Approach for Quantitative $T_{1ρ}$ Imaging of Knee Articular Cartilage

Objective: To establish an automated pipeline for post-processing of quantitative spin-lattice relaxation time constant in the rotating frame ($T_{1ρ}$) imaging of knee articular cartilage. Design: The proposed post-processing pipeline commences with an image standardisation procedure, followed by deep learning-based segmentation to generate cartilage masks. The articular cartilage is then automatically parcellated into 20 subregions, where $T_{1ρ}$ quantification is performed. The proposed pipeline was retrospectively validated on a dataset comprising knee $T_{1ρ}$ images of 10 healthy volunteers and 30 patients with knee osteoarthritis. Three experiments were conducted, namely an assessment of segmentation model performance (using Dice similarity coefficients, DSCs); an evaluation of the impact of standardisation; and a test of $T_{1ρ}$ quantification accuracy (using paired t-tests; root-mean-square deviations, RMSDs; and coefficients of variance of RMSDs, $CV_{RMSD}$). Statistical significance was set as p<0.05. Results: There was a substantial agreement between the subregional $T_{1ρ}$ quantification from the model-predicted masks and those from the manual segmentation labels. In patients, 17 of 20 subregions, and in healthy volunteers, 18 out of 20 subregions, demonstrated no significant difference between predicted and reference $T_{1ρ}$ quantifications. Average RMSDs were 0.79 ms for patients and 0.56 ms for healthy volunteers, while average $CV_{RMSD}$ were 1.97% and 1.38% for patients and healthy volunteers. Bland-Altman plots showed negligible bias across all subregions for patients and healthy volunteers. Conclusion: The proposed pipeline can perform automatic and reliable post-processing of quantitative $T_{1ρ}$ images of knee articular cartilage.

eess.IV

Quantifying Knee Cartilage Shape and Lesion: From Image to Metrics

Imaging features of knee articular cartilage have been shown to be potential imaging biomarkers for knee osteoarthritis. Despite recent methodological advancements in image analysis techniques like image segmentation, registration, and domain-specific image computing algorithms, only a few works focus on building fully automated pipelines for imaging feature extraction. In this study, we developed a deep-learning-based medical image analysis application for knee cartilage morphometrics, CartiMorph Toolbox (CMT). We proposed a 2-stage joint template learning and registration network, CMT-reg. We trained the model using the OAI-ZIB dataset and assessed its performance in template-to-image registration. The CMT-reg demonstrated competitive results compared to other state-of-the-art models. We integrated the proposed model into an automated pipeline for the quantification of cartilage shape and lesion (full-thickness cartilage loss, specifically). The toolbox provides a comprehensive, user-friendly solution for medical image analysis and data visualization. The software and models are available at https://github.com/YongchengYAO/CMT-AMAI24paper .

eess.IV

Orientation independent quantification of macromolecular proton fraction in tissues with suppression of residual dipolar coupling

Quantitative magnetization transfer (MT) imaging enables non-invasive characterization of the macromolecular environment of tissues. However, recent work has highlighted that the quantification of MT parameters exhibits orientation dependence in ordered tissue structures, potentially confounding its clinical applications. Notably, in tissues with ordered structures, such as articular cartilage and myelin, the residual dipolar coupling (RDC) effect can arise owing to incomplete averaging of dipolar-dipolar interactions of water protons. In this study, we demonstrated the confounding effect of RDC on quantitative MT imaging in ordered tissues can be suppressed by using an emerging technique known as macromolecular proton fraction mapping based on spin-lock (MPF-SL). The off-resonance spin-lock pulse in MPF-SL could be designed to generate a strong effective spin-lock field to suppress RDC without violating the specific absorption rate and hardware limitations in clinical scans. Furthermore, removing the water signal in MPF-SL enabled the application of a strong effective spin-lock field without any confounding signal from direct water saturation. Our findings were experimentally validated using human knee specimens and healthy human cartilage. The results demonstrated that MPF-SL exhibits lower sensitivity to tissue orientation compared with R2, R1rho, and saturation-pulse-based MT imaging. Thus, MPF-SL could serve as a valuable orientation-independent technique for quantifying MPF.

physics.med-ph

Development and Characterization of a Novel BaTiO3-Based Material for Medium Temperature Applications

Positive temperature coefficient (PTC) materials are extensively utilized in self-regulating temperature applications. Nonetheless, their applicability is typically constrained to low-temperature ranges, rendering them ineffective in medium temperature environments. This study presents a methodology for the fabrication of an innovative PTC material operational at approximately 353~°C, with a thorough investigation of its Curie temperature and resistivity properties. The material formulation incorporates 4~wt\% carbon black (CB), 0.5~wt\% NBT, and 5~wt\% DOP into a BaTiO$_3$-based matrix. The empirical findings reveal that this material exhibits a notably high PTC strength of 5.8 and a comparatively low resistivity of 590~$Ω\cdot$cm at room temperature. Furthermore, the material demonstrated excellent repeatability in PTC strength after thirty cycles of heating and cooling near the Curie temperature. Consequently, this PTC material is deemed highly effective for applications in cold environments, notably for the preheating and initiation of aircraft engines and auxiliary power units (APUs).

cond-mat.mtrl-sci

Chemical Shift Encoding based Double Bonds Quantification in Triglycerides using Deep Image Prior

Fatty acid can potentially serve as biomarker for evaluating metabolic disorder and inflammation condition, and quantifying the double bonds is the key for revealing fatty acid information. This study presents an assessment of a deep learning approach utilizing Deep Image Prior (DIP) for the quantification of double bonds and methylene-interrupted double bonds of triglyceride derived from chemical-shift encoded multi-echo gradient echo images, all achieved without the necessity for network training. The methodology implemented a cost function grounded in signal constraints to continually refine the neural network's parameters on a single slice of images through iterative processes. Validation procedures encompassed both phantom experiments and in-vivo scans. The outcomes evidenced a concordance between the quantified values and the established reference standards, notably exemplified by a Pearson correlation coefficient of 0.96 (p = 0.0005) derived from the phantom experiments. The results in water-oil phantom also demonstrate the quantification reliability of the DIP method under the condition of having a relatively low-fat signal. Furthermore, the in-vivo assessments showcased the method's competency by showcasing consistent quantification results that closely mirrored previously published findings concerning subcutaneous fat. In summary, the study underscores the potential of Deep Image Prior in enabling the quantification of double bonds and methylene-interrupted double bonds from chemical-shift encoded multi-echo magnetic resonance imaging (MRI) data, suggesting potential avenues for future research and clinical applications in the field.

physics.med-ph

The state-of-the-art in Cardiac MRI Reconstruction: Results of the CMRxRecon Challenge in MICCAI 2023

Cardiac MRI, crucial for evaluating heart structure and function, faces limitations like slow imaging and motion artifacts. Undersampling reconstruction, especially data-driven algorithms, has emerged as a promising solution to accelerate scans and enhance imaging performance using highly under-sampled data. Nevertheless, the scarcity of publicly available cardiac k-space datasets and evaluation platform hinder the development of data-driven reconstruction algorithms. To address this issue, we organized the Cardiac MRI Reconstruction Challenge (CMRxRecon) in 2023, in collaboration with the 26th International Conference on MICCAI. CMRxRecon presented an extensive k-space dataset comprising cine and mapping raw data, accompanied by detailed annotations of cardiac anatomical structures. With overwhelming participation, the challenge attracted more than 285 teams and over 600 participants. Among them, 22 teams successfully submitted Docker containers for the testing phase, with 7 teams submitted for both cine and mapping tasks. All teams use deep learning based approaches, indicating that deep learning has predominately become a promising solution for the problem. The first-place winner of both tasks utilizes the E2E-VarNet architecture as backbones. In contrast, U-Net is still the most popular backbone for both multi-coil and single-coil reconstructions. This paper provides a comprehensive overview of the challenge design, presents a summary of the submitted results, reviews the employed methods, and offers an in-depth discussion that aims to inspire future advancements in cardiac MRI reconstruction models. The summary emphasizes the effective strategies observed in Cardiac MRI reconstruction, including backbone architecture, loss function, pre-processing techniques, physical modeling, and model complexity, thereby providing valuable insights for further developments in this field.

eess.IV

$k$-$t$ CLAIR: Self-Consistency Guided Multi-Prior Learning for Dynamic Parallel MR Image Reconstruction

Cardiac magnetic resonance imaging (CMR) has been widely used in clinical practice for the medical diagnosis of cardiac diseases. However, the long acquisition time hinders its development in real-time applications. Here, we propose a novel self-consistency guided multi-prior learning framework named $k$-$t$ CLAIR to exploit spatiotemporal correlations from highly undersampled data for accelerated dynamic parallel MRI reconstruction. The $k$-$t$ CLAIR progressively reconstructs faithful images by leveraging multiple complementary priors learned in the $x$-$t$, $x$-$f$, and $k$-$t$ domains in an iterative fashion, as dynamic MRI exhibits high spatiotemporal redundancy. Additionally, $k$-$t$ CLAIR incorporates calibration information for prior learning, resulting in a more consistent reconstruction. Experimental results on cardiac cine and T1W/T2W images demonstrate that $k$-$t$ CLAIR achieves high-quality dynamic MR reconstruction in terms of both quantitative and qualitative performance.

eess.IV

CAMP-Net: Consistency-Aware Multi-Prior Network for Accelerated MRI Reconstruction

Undersampling k-space data in MRI reduces scan time but pose challenges in image reconstruction. Considerable progress has been made in reconstructing accelerated MRI. However, restoration of high-frequency image details in highly undersampled data remains challenging. To address this issue, we propose CAMP-Net, an unrolling-based Consistency-Aware Multi-Prior Network for accelerated MRI reconstruction. CAMP-Net leverages complementary multi-prior knowledge and multi-slice information from various domains to enhance reconstruction quality. Specifically, CAMP-Net comprises three interleaved modules for image enhancement, k-space restoration, and calibration consistency, respectively. These modules jointly learn priors from data in image domain, k-domain, and calibration region, respectively, in data-driven manner during each unrolled iteration. Notably, the encoded calibration prior knowledge extracted from auto-calibrating signals implicitly guides the learning of consistency-aware k-space correlation for reliable interpolation of missing k-space data. To maximize the benefits of image domain and k-domain prior knowledge, the reconstructions are aggregated in a frequency fusion module, exploiting their complementary properties to optimize the trade-off between artifact removal and fine detail preservation. Additionally, we incorporate a surface data fidelity layer during the learning of k-domain and calibration domain priors to prevent degradation of the reconstruction caused by padding-induced data imperfections. We evaluate the generalizability and robustness of our method on three large public datasets with varying acceleration factors and sampling patterns. The experimental results demonstrate that our method outperforms state-of-the-art approaches in terms of both reconstruction quality and $T_2$ mapping estimation, particularly in scenarios with high acceleration factors.

eess.IV

CartiMorph: a framework for automated knee articular cartilage morphometrics

We introduce CartiMorph, a framework for automated knee articular cartilage morphometrics. It takes an image as input and generates quantitative metrics for cartilage subregions, including the percentage of full-thickness cartilage loss (FCL), mean thickness, surface area, and volume. CartiMorph leverages the power of deep learning models for hierarchical image feature representation. Deep learning models were trained and validated for tissue segmentation, template construction, and template-to-image registration. We established methods for surface-normal-based cartilage thickness mapping, FCL estimation, and rule-based cartilage parcellation. Our cartilage thickness map showed less error in thin and peripheral regions. We evaluated the effectiveness of the adopted segmentation model by comparing the quantitative metrics obtained from model segmentation and those from manual segmentation. The root-mean-squared deviation of the FCL measurements was less than 8%, and strong correlations were observed for the mean thickness (Pearson's correlation coefficient $ρ\in [0.82,0.97]$), surface area ($ρ\in [0.82,0.98]$) and volume ($ρ\in [0.89,0.98]$) measurements. We compared our FCL measurements with those from a previous study and found that our measurements deviated less from the ground truths. We observed superior performance of the proposed rule-based cartilage parcellation method compared with the atlas-based approach. CartiMorph has the potential to promote imaging biomarkers discovery for knee osteoarthritis.

eess.IV

An Uncertainty Aided Framework for Learning based Liver $T_1ρ$ Mapping and Analysis

Objective: Quantitative $T_1ρ$ imaging has potential for assessment of biochemical alterations of liver pathologies. Deep learning methods have been employed to accelerate quantitative $T_1ρ$ imaging. To employ artificial intelligence-based quantitative imaging methods in complicated clinical environment, it is valuable to estimate the uncertainty of the predicated $T_1ρ$ values to provide the confidence level of the quantification results. The uncertainty should also be utilized to aid the post-hoc quantitative analysis and model learning tasks. Approach: To address this need, we propose a parametric map refinement approach for learning-based $T_1ρ$ mapping and train the model in a probabilistic way to model the uncertainty. We also propose to utilize the uncertainty map to spatially weight the training of an improved $T_1ρ$ mapping network to further improve the mapping performance and to remove pixels with unreliable $T_1ρ$ values in the region of interest. The framework was tested on a dataset of 51 patients with different liver fibrosis stages. Main results: Our results indicate that the learning-based map refinement method leads to a relative mapping error of less than 3% and provides uncertainty estimation simultaneously. The estimated uncertainty reflects the actual error level, and it can be used to further reduce relative $T_1ρ$ mapping error to 2.60% as well as removing unreliable pixels in the region of interest effectively. Significance: Our studies demonstrate the proposed approach has potential to provide a learning-based quantitative MRI system for trustworthy $T_1ρ$ mapping of the liver.

physics.med-ph

Uncertainty-weighted Multi-tasking for $T_{1ρ}$ and T$_2$ Mapping in the Liver with Self-supervised Learning

Multi-parametric mapping of MRI relaxations in liver has the potential of revealing pathological information of the liver. A self-supervised learning based multi-parametric mapping method is proposed to map T$T_{1ρ}$ and T$_2$ simultaneously, by utilising the relaxation constraint in the learning process. Data noise of different mapping tasks is utilised to make the model uncertainty-aware, which adaptively weight different mapping tasks during learning. The method was examined on a dataset of 51 patients with non-alcoholic fatter liver disease. Results showed that the proposed method can produce comparable parametric maps to the traditional multi-contrast pixel wise fitting method, with a reduced number of images and less computation time. The uncertainty weighting also improves the model performance. It has the potential of accelerating MRI quantitative imaging.

physics.med-ph

Unsupervised Domain Adaptation for Automated Knee Osteoarthritis Phenotype Classification

Purpose: The aim of this study was to demonstrate the utility of unsupervised domain adaptation (UDA) in automated knee osteoarthritis (OA) phenotype classification using a small dataset (n=50). Materials and Methods: For this retrospective study, we collected 3,166 three-dimensional (3D) double-echo steady-state magnetic resonance (MR) images from the Osteoarthritis Initiative dataset and 50 3D turbo/fast spin-echo MR images from our institute (in 2020 and 2021) as the source and target datasets, respectively. For each patient, the degree of knee OA was initially graded according to the MRI Osteoarthritis Knee Score (MOAKS) before being converted to binary OA phenotype labels. The proposed UDA pipeline included (a) pre-processing, which involved automatic segmentation and region-of-interest cropping; (b) source classifier training, which involved pre-training phenotype classifiers on the source dataset; (c) target encoder adaptation, which involved unsupervised adaption of the source encoder to the target encoder and (d) target classifier validation, which involved statistical analysis of the target classification performance evaluated by the area under the receiver operating characteristic curve (AUROC), sensitivity, specificity and accuracy. Additionally, a classifier was trained without UDA for comparison. Results: The target classifier trained with UDA achieved improved AUROC, sensitivity, specificity and accuracy for both knee OA phenotypes compared with the classifier trained without UDA. Conclusion: The proposed UDA approach improves the performance of automated knee OA phenotype classification for small target datasets by utilising a large, high-quality source dataset for training. The results successfully demonstrated the advantages of the UDA approach in classification on small datasets.

eess.IV